Investigator Scientist Roving Researcher

Investigator Scientist (Roving Researcher) (LMS 2369) Salary £42,159 – 44,801 plus London Allowance (£5,560) per annum | 2 years fixed term | Full time | Closing Date: 21 June

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Genome instability triggers intercellular DNA transfer between human cells

Mammalian cells can pass damaged pieces of their genome directly to neighboring cells via contact-dependent, nanotube-like connections. These transferred DNA fragments persist and function, revealing ...

cell.com

Microtubule dynamics control the direction of cardiomyocyte growth

The adult heart grows by the addition of sarcomeres along the length or width of individual cardiomyocytes, yet how directional growth is spatially coordinated remains unclear. We found that microtubu...

science.org

RNA-triggered cell killing with CRISPR–Cas12a2 - Nature

Cas12a2 enables RNA-triggered, sequence-specific killing of eukaryotic cells via widespread DNA shredding, allowing selective elimination of cells on the basis of gene expression, including virus-infe...

nature.com

Endosome maturation is orchestrated by inside-out proton signaling through a Na+/H+ exchanger and pH-dependent Rab GTPase cycling - Nature Communications

The role of lumen acidification during endosome maturation has been unclear. Here, the authors show that proton efflux via a Na+/H+ exchanger is detected by a pH-sensitive Rab GAP, which promotes endo...

nature.com

Toward life with a 19–amino acid alphabet through generative artificial intelligence design

Because all known living organisms are made from at least 20 canonical amino acids, the feasibility of life using a more simplified alphabet remains unclear. In this work, we leveraged computational d...

science.org

Nuclear N-glycosylation maintains H3K9me3 heterochromatin and genomic stability - Nature Cell Biology

Tang, Dai, Qing, Zhang and colleagues describe a role for N-glycosylation in the nucleus: N-glycans modify inner nuclear membrane proteins, and the modification is implicated in the maintenance of H3K...

nature.com

Mechanical load inhibits cancer growth in mouse and human hearts

The heart rarely develops cancer, and, at the same time, it lacks regenerative capacity, as cardiomyocytes stop proliferating after birth. This suggests that mechanisms limiting cardiac regeneration m...

science.org

Nuclear envelope budding enables export of large transcripts in muscle cells

During myogenesis, inner nuclear membrane buds export extremely long sarcomeric transcripts. UIF controls RNA cargo targeting into these buds, and ESCRT-III remodeling is required to internalize UIF a...

cell.com

Daraxonrasib Demonstrates First-Line Activity With/Without Chemotherapy in Metastatic PDAC | OncLive

Phase 1/2 data from 2 separate studies have shown signals of improved survival and safety with the agent, supporting its evaluation in a phase 3 trial.

onclive.com

PNAS

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

pnas.org

A pro-carcinogenic bacterial toxin binds claudin-4 to cleave E-cadherin - Nature

CRISPR screening shows that claudin-4 is a receptor for the pro-carcinogenic B. fragilis toxin on colonic epithelial cells, and that this interaction promotes cleavage of E-cadherin, le...

nature.com

Visualizing suborganellar lipid distribution using correlative light and electron microscopy - Nature Cell Biology

Lennartz et al. introduce a correlative light and electron microscopy workflow, Lipid-CLEM, combining near-native lipid probes and on-section labelling via click chemistry. Lipid-CLEM quantitatively a...

nature.com

The dynamics of centromere assembly and disassembly during quiescence

Marescal et al. show that quiescent cells disassemble their centromeres through the transcriptional downregulation of most centromere proteins while preser

rupress.org

A single-nucleotide enhancer mutation overrides chromosomal sex to drive XX male development - Nature Communications

A single base pair insertion in the Sox9 enhancer, Enh13, mediates XX female-to-male sex reversal. This subtle non-coding mutation reconfigures transcriptional regulation, enhances Sox9 expression, re...

nature.com

Scientists invented a fake disease. AI told people it was real

Bixonimania doesn’t exist except in a clutch of obviously bogus academic papers. So why did AI chatbots warn people about this fictional illness?

go.nature.com

Control of the signaling of RAS proteins by modulating their palmitoylation

Zhu et al. report an approach to reversibly control protein S-palmitoylation by fusing the depalmitoylase APT1 to target proteins. Using RAS proteins, they show that this approach enables the dynamic modulation of RAS palmitoylation and membrane localization by an APT1 inhibitor, and offers a platform for screening RAS palmitoyltransferase inhibitors.

dlvr.it

KRAShing pancreatic cancer before takeoff

Drugs that inhibit KRAS signaling delay the development of pancreatic cancer in mice

scim.ag

De novo design of Ras isoform selective binders

Zhang et al. use deep learning-based protein design to create isoform-specific Ras binders that selectively target the disordered C termini. These tools enable precise dissection of Ras isoform functions and uncover distinct Ras dependencies that emerge during RasG12C inhibitor resistance.

dlvr.it

Targeting ubiquitin signaling vulnerabilities in KEAP1-inactivated lung cancer - The EMBO Journal

Lung cancer cells rely on protein homeostasis regulators, particularly the ubiquitin-proteasome system (UPS), to sustain malignancy. Genetic alterations in UPS components, such as E3 ubiquitin ligases...

link.springer.com

Ca²⁺ leakage is a conserved signal for non-canonical ATG8/LC3 lipidation and membrane repair - The EMBO Journal

Endomembrane damage of intracellular vesicles triggers signals that activate membrane repair in mammalian cells to restore homeostasis. However, the signals that drive diverse membrane repair recruitm...

link.springer.com

Structural basis for prostaglandin and drug transport via SLCO2A1

Nature Communications - SLCO2A1 (also known as OATP2A1) is responsible for the transport of eicosanoids, including prostaglandins (PGs), as well as of a subset of nonsteroidal anti-inflammatory...

nature.com

My PI is not offering any support or guidance on my PhD project, what should I do?

A safety engineer feels abandoned by their principal investigator. How should they find support?

nature.com