Our latest preprint in an awesome collaboration with the Wack Lab @crick.ac.uk. Led by @chrysante-ili.bsky.social, @woutertj.bsky.social and @isobelmouat.bsky.social. We show that monocytes follow a largely conserved differentiation blueprint in the 🫁 when elicited by distinct challenges.

Waggoner Lab@labwaggoner.bsky.social · 5mo ago

@biorxivpreprint.bsky.social Diverse lung challenges elicit a conserved monocyte-to-macrophage differentiation blueprint @bainlab.bsky.social @crick.ac.uk @edinburghuni.bsky.social @chrysante-ili.bsky.social www.biorxiv.org/content/10.6...

@biorxivpreprint.bsky.social Diverse lung challenges elicit a conserved monocyte-to-macrophage differentiation blueprint @bainlab.bsky.social @crick.ac.uk @edinburghuni.bsky.social @chrysante-ili.bsky.social www.biorxiv.org/content/10.6...

Our latest preprint, led by @lizihegarty.bsky.social & aided by @erinwatson.bsky.social shows that fixation time matters when it comes to visualising #macrophages in #salivarygland & other epithelia.We find 1hr allows detection of mac subsets while preserving architecture. With @bainlab.bsky.social

bioRxiv Immunology@biorxiv-immuno.bsky.social · 6mo ago

Fixation matters: duration in fixative prior to immunofluorescent analysis directly impacts macrophage visualisation in epithelial tissues https://www.biorxiv.org/content/10.64898/2026.02.13.705745v1

We have a second paper to share this week, this time investigating the gut-brain axis in stroke. Here we show that stroke is associated with persistent gut structural and microbiome changes, however these changes are distinct in acute and chronic recovery. journals.sagepub.com/doi/10.1177/...

Dynamic changes to the intestinal environment occur throughout recovery from experimental ischaemic stroke - Rachel M L Martin, Isobel C Mouat, Robert J Whelan, Lizi M Hegarty, Lizzie F R Blunt, Chris...

Stroke survivors can experience a plethora of complications throughout their recovery that impair quality of life and impact neurological outcomes. Intestinal d...

journals.sagepub.com

Colonic macrophage heterogeneity revealed by CD11c and CD163 www.mucosalimmunology.org/article/S193...

This collab started when I met Fredi at the 2023 #EMDS meeting. Since then it’s been wonderful working with her, @selmatuzlak.bsky.social & Burkhard to explore these GM-CSF dependent #macrophages in #glands. Delighted to see this published in @natimmunol.nature.com 🥳 www.nature.com/articles/s41...

Adenophages are an atypical macrophage population in exocrine glands sustained by ILC2-derived GM-CSF - Nature Immunology

Here the authors identify adenophages, a previously unknown macrophage population present in exocrine glands in mice and humans. These cells are dependent on ILC2-derived GM-CSF and support glandular ...

nature.com

Tissue resident colonic macrophages persist through acute inflammation and adapt to aid tissue repair in this work from @lizihegarty.bsky.social, @bainlab.bsky.social, and colleagues: www.mucosalimmunology.org/article/S193...

Tissue resident colonic macrophages persist through acute inflammation and adapt to aid tissue repair https://www.biorxiv.org/content/10.1101/2025.09.19.677333v1

📢 Open Positions 📢 We're hiring motivated PhDs & Postdocs to join a cutting-edge research program @VIBLifeSciences @ugent 🔬in vivo CRISPR screens 💻Multi-omics, Modelling & Deep Learning 🧬Macrophages, Liver homeostasis, Regeneration & Metastasis 💶ERC AdG, FWO & Cancer Grant

The New Scientist @newscientistnl.bsky.social has selected me for their Talent in Science competition: Vote for me here! www.newscientist.nl/polls/new-sc... If you need a little convincing, I made a little video explaining why researching mucus is so important youtu.be/dYnXBnq4ttc

Learning about Charcot-Leyden crystals in mucus with Miles and Slime

YouTube video by Helena Aegerter

youtu.be

IRR researchers and colleagues discover that the common childhood virus, RSV, leaves lasting ‘immune memory’ in lungs. Proteins that help fight infection (MHCs) stay elevated, boosting protection for subsequent infections but also increases the risk of allergies. edin.ac/45r7lAN edin.ac/4fJ9cEj

You asked, we listened! We have had multiple requests for late breaking abstracts for #EMDS2025. So, we have managed to squeeze in 15 more opportunities for poster presentation. Submit your abstract at www.emds2025.com - first come, first served. Deadline: 22.08.25 (or when 15 slots allocated!)

🔬Imaging 👩🏻‍🔬micro-dissections 🧙🏻single cell 🦴fate mapping All you KNEEd to know about synovial macrophages. Fantastic collaborators and work with @drbmalengier.bsky.social showing the establishment of protective macrophages in the joint 🐁 How does it look like? When? How? Answers below 👇

bioRxiv Immunology@biorxiv-immuno.bsky.social · last yr.

The synovial lining macrophage layer develops in the first weeks of life in a CSF1- and TGFβ- dependent but monocyte-independent process. https://www.biorxiv.org/content/10.1101/2025.05.21.655269v1

📢 We are hiring…. Looking for a lab technician to join the team to support our efforts investigating myeloid cell functional heterogeneity in health and disease! Interested? Please apply here: jobso.id/mvfh

Lab Technician - VIB

We are looking for a highly motivated and talented lab technician to join our team at the VIB-UGent Center for Inflammation Research which is focused on understanding the functional heterogeneity of m...

jobso.id

📆 Reminder: EMDS Save the Date Quick reminder that the European #Macrophage & #DC Society meeting is taking place in Edinburgh from 16th - 18th September. Great line up of speakers in place. Spaces will be limited, so put in your diary now. Website will go live in the coming weeks!

a blue and white flag with an x on it

ALT: a blue and white flag with an x on it

media.tenor.com

With my first Bluesky post, I am very happy to share our latest study led by PhD student Federico De Ponti and postdoc Ania Bujko www.cell.com/immunity/ful...

Spatially restricted and ontogenically distinct hepatic macrophages are required for tissue repair

scRNA-seq has uncovered ontogenically distinct hepatic macrophage populations, but their functions remain unclear. Here, De Ponti et al. identify recruited LAMs and resident LAM-like KCs in multiple l...

cell.com

REMINDER - EMDS25 The European Macrophage & Dendritic Cell Society (EMDS) meeting will take place in Edinburgh from 16-18th Sept. Website & registration details coming soon. @britsocimm.bsky.social @cytokinesociety.bsky.social @edinuni-irr.bsky.social @uofgsii.bsky.social @cruk-si.bsky.social

Calum Bain@bainlab.bsky.social · 2y ago

‼️ SAVE THE DATE The next EMDS Meeting will take place from 16-18th Sept. 2025 in majestic Edinburgh 🏴󠁧󠁢󠁳󠁣󠁴󠁿. If you love macs, monos &/or DCs, or just want to learn more about them, THIS is the meeting for you. Space limited - so watch out for details. @britsocimm.bsky.social

Great talk by @gastrogrj.bsky.social at #EMDS24 describing our work on itaconate as a molecular handbrake restraining monocyte function in intestinal inflammation. @edinuni-irr.bsky.social @britsocimm.bsky.social @societymucosalimm.bsky.social