Epiblast diversification and blood formation in a human pregastrula. www.nature.com/articles/s41...

Epiblast diversification and blood formation in a human pregastrula - Nature

High-resolution spatial transcriptome analysis of a human embryo at Carnegie stage 6 reveals three distinct developmental trajectories from the epiblast towards amnion, primitive streak and axial meso...

nature.com

A strong hint from human genetics that changes in DNA methylation may be causal for normal aging. This is the direction that aging (and cancer) research needs to go! www.nature.com/articles/s41...

A progeria syndrome links DNA hypermethylation to age-related pathology - Nature Genetics

This study investigates the consequences of hypermethylation in a progeria syndrome caused by gain-of-function DNMT3A mutations, finding effects on adult stem cell function.

nature.com

Non-Mendelian inheritance of DNA methylation patterns in mice www.nature.com/articles/s41...

Non-Mendelian inheritance of DNA methylation patterns in mice - Nature Genetics

Davidovich et al. investigate allele-specific DNA methylation inheritance patterns in mouse liver and muscle. Most patterns are Mendelian, but ~7% are non-Mendelian, including new imprinted genes and ...

nature.com

Exciting #CtrlEpiEdit conference update: Maja Jagodic @ki.se will be joining us in Paris! Check out her fantastic in vivo epigenome editing preprint here: www.biorxiv.org/content/10.6... And register for the symposium here 😉: ctrlepiedit.sciencesconf.org Please repost!

Big news! 🥳 Joanna Szpotkowska, together with Prof. Malgorzata Borowiak, presents Glutathione Peroxidase 2 as a critical regulator of human posterior foregut differentiation, revealing oxidative stress as a key determinant of pancreatic versus non-pancreatic cell fate. Now in Nature Communications!

Oxidative stress and GPX2 control pancreatic vs. non-pancreatic cell fate in human endoderm - Nature Communications

The role of metabolic processes in endoderm differentiation remains elusive. Here, the authors discover that oxidative stress and GPX2 determine whether human stem cells differentiate into pancreatic ...

nature.com

Great news! 🥳 Dr. Anna Baud with Prof. Krzysztof Sobczak showed that insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) positively regulates the noncanonical translation of expanded CGG repeats and may be a promising target for clinical applications. Published in Nature Communications!

IGF2BPs directly regulate the noncanonical translation of toxic proteins from mutant FMR1 mRNA containing expanded CGG repeats - Nature Communications

Expanded FMR1 CGG repeats drive toxic FMRpolyG in premutation disorders. Here, the authors show that IGF2BP3 binds the FMR1 5’UTR to promote non-AUG translation of FMRpolyG and that its loss reduces t...

doi.org

Great news! 🥳 A new study from the group of @piotraz.bsky.social shows that it is possible to precisely control where meiotic recombination occurs in plant genomes using the CRISPR/dCas9 system. Now published in Science Advances! Congratulations Maja Szymańska-Lejman, Piotr Ziolkowski and the crew!

Modifying meiotic recombination by targeting chromatin regulators to crossover hotspots in Arabidopsis

Targeting chromatin modifiers to DNA hotspots reveals causal link between histone marks, transcription, and meiotic recombination.

science.org

New week, insights! ✨ The team led by Kinga Kamieniarz-Gdula (@stoplab.bsky.social) reveals in EMBO Reports how SETD2 acts as a genetic "traffic controller." A vital step in understanding cancer biology! Congrats to @michal-gdula.bsky.social, @agatakstepien.bsky.social, @mgkopczynska.bsky.social! 👏

SETD2 methyltransferase activity promotes correct transcription initiation and termination - EMBO Reports

SETD2 is a methyltransferase responsible for depositing histone H3 lysine 36 trimethylation (H3K36me3). Loss of its enzymatic activity occurs in some cancers, including renal cell carcinoma. SETD2 mut...

link.springer.com

Exciting work! The authors conclude that condensin-mediated loop formation, Aurora B phosphorylation, and core histone deacetylation are not obligatory factors for mitotic chromosome compaction. Our Mg2+ model is discussed as the “last model standing.” www.cell.com/current-biol...

A Transient Rise in Free Mg2+ Ions Released from ATP-Mg Hydrolysis Contributes to Mitotic Chromosome Condensation

How the negatively charged long genomic DNA is organized into mitotic chromosome remains unclear. Using a newly developed Mg2+ indicator, Maeshima et al. demonstrate a transient rise in free Mg2+ rele...

cell.com

Molecular Cell @cp-molcell.bsky.social · 4mo ago

Online Now: A time-resolved atlas of histone modifications during mitotic entry Online now:

Are you a DNMT3 enthusiast wondering how they achieve specificity at CpG islands during development? And why is DNMT3B specifically required for methylation on the inactive X? We set out to dissect the mechanism, now published in Genes & Development genesdev.cshlp.org/content/earl... [1/12]

Tread -1- EpiSci - I am very proud to share with you our new study that you can access on @biorxivpreprint.bsky.social (see link below) "The Interaction with Nanotopographical Environment regulates nuclear mechanoresponse in mESCs via Histone Demethylase KDM3A. www.biorxiv.org/content/10.6...

So the feds ARE NOT considering an mRNA vaccine for the flu, which could save countless lives, but ARE backing research into whether horse dewormer can cure cancer, because the right views vaccines as elite and ivermectin as populist. Cool. kffhealthnews.org/news/article...

FDA won’t review Moderna application for first mRNA-based flu vaccine

The decision, which shocked company officials, comes as the FDA says it will take a stricter approach to federal vaccine approvals.

washingtonpost.com

We’re recruiting! Three-year, fully funded #postdoc opportunity: pancreatic cancer #epigenetics & potential new treatments (funded by @ncn.gov.pl & @dfg.de ). Collaboration with @akispapantonis.bsky.social, University of Göttingen (OPUS-LAP). See the ad & contact me! drive.google.com/file/d/1vrFd...

Check out our new findings showing BRD4's role in preventing the premature activation of developmental transcription factors via #Polycomb, providing new mechanistic insights into the pathogenesis of neurodevelopmental disorder #CdLS #NDDs, #chromatinopathies www.biorxiv.org/content/10.6...

This Friday @uam-ibmib.bsky.social seminar: Maja Szymańska-Lejman @szymanskalejman.bsky.social will tell us about reprogramming meiotic #recombination with dCas9 - Don't miss it! #meiosis

Chromatin Loop prediction via Accessibility Model for Protein-mediated loops github: github.com/chikit2077/...

What drives CGG RAN translation in #FXTAS? Anna Baud & Krzysztof Sobczak with Rajani Gudipatti & Malgorzata Borowiak all from @uam-ibmib.bsky.social just published at Nature Communications : IGF2BP3 regulates FMRpolyG—promising FXTAS target. www.nature.com/articles/s41...

Deep-learning prediction of gene expression from personal genomes link.springer.com/article/10....

Structural organization and function of telomeric chromatin [Review by Ruben van der Lugt & Jacqueline Jacobs] www.nature.com/articles/s41...

We are looking for a Postdoc at the Center for Gene Expression in Copenhagen. Deadline for applications is the 11th of January. If you are interested in 3D chromatin, SMC complexes, and super-resolution microscopy, join us. www.nature.com/naturecareer...

Postdocs at Center for Gene Expression in Department of Cellular and Molecular Medicine - Copenhagen, Hovedstaden (DK) job with University of Copenhagen | 12849488

We are looking for 2 or more highly motivated postdocs interested in ribosome biology, 3D chromatin organisation, or regulation of protein turnove...

nature.com

In the most recent episode of the Epigenetics Podcast, we talked with Mitch Guttman from Caltec about ChIP-DIP (Done In Parallel). #podcast #epigenetics Listen here: activemotif.com/podcasts-mit...

Excellent @activemotifusa.bsky.social epigenetics podcast w @andersshansen.bsky.social It’s interesting, while going through specific projects and lines of questioning, the conversation acts as a nice reflection of the state of our field (fields?) Lots of ideas! open.spotify.com/episode/19Nd...

Region Capture Micro-C and 3D Genome Structure (Anders Sejr Hansen)

open.spotify.com

@science.org Multistep genomics on single cells and live cultures in subnanoliter capsules | Science www.science.org/doi/10.1126/...

Multistep genomics on single cells and live cultures in subnanoliter capsules

Single-cell sequencing methods uncover natural and induced variation between cells. Many functional genomic methods, however, require multiple steps that cannot yet be scaled to high throughput, inclu...

science.org

@science.org Chromatin buffers torsional stress during transcription | Science www.science.org/doi/10.1126/...

Chromatin buffers torsional stress during transcription

During eukaryotic transcription, Pol II must overcome nucleosome obstacles and, because of DNA’s helical structure, must also rotate relative to DNA, generating torsional stress. However, there is lim...

science.org

Very happy to share our paper rdcu.be/eUImj out today in @natcellbio.nature.com 🎉🎉🎉 We uncover an unexpected role for endogenous Xist RNA in regulating X-linked genes that escape X-inactivation.

Escape from X inactivation is directly modulated by Xist noncoding RNA

Nature Cell Biology - The authors show that increased Xist RNA levels can induce de novo silencing of genes that normally escape X inactivation. SPEN depletion prevents the silencing of escape...

rdcu.be

Can't believe it's that time of year - registration already open for next year's Transcription & Chromatin meeting. Almost half the talks are selected from the abstracts, so register soon before it fills up. This is a very lively meeting, with plenty of time to discuss over dinner & at the bar

EMBL Events@events.embl.org · 8mo ago

Are you ready for the 17th edition of 'Transcription and chromatin'? Our conference remains a must-attend event for anyone engaged in the forefront of transcription research and we hope you can join us! 🧬 25 – 28 August 2026 Submit your abstract by 25 May: s.embl.org/trm26-01-bl #EMBLTranscript

An early Christmas present for those interested in chromatin and transcription! Fantastic work from @au-ho-yu.bsky.social and @aleksszczurek.bsky.social . Thanks to Inge and Michiel for their help. Please repost! www.biorxiv.org/content/10.6...

SET1/MLL complexes control transcription independently of H3K4me3

Histone H3 lysine 4 trimethylation (H3K4me3) at gene promoters is thought to play a central role in gene transcription. H3K4 methylation is deposited by the SET1 (A/B) and MLL (1-4) multi-protein comp...

biorxiv.org

Very happy to share our 'Evoscape' paper, now published in PNAS ! www.pnas.org/doi/10.1073/...

Generative epigenetic landscapes map the topology and topography of cell fates | PNAS

Epigenetic landscapes were proposed by Waddington as the central concept to describe cell fate dynamics in a locally low-dimensional space. In mode...

pnas.org

so many grand gestures welcoming US researchers - neglecting the fact that funding in Canada, Australia, Europe and China is already fiercly competitive. This is not the solution. #standupforscience

👉 Chromatin Summer School 2026 – Apply Now! Join us in Munich 17–29 August 2026 for an immersive program on chromatin biology: 🔬 Expert lectures 🧪 Hands-on training 🤝 Global networking Open to 14 PhD students worldwide (sponsorship available) 👉 Apply here: bit.ly/4oGDR8f #ChromatinBiology

Summary - Summer School on Chromatin Biology: A Hands-On Expedition

bit.ly