Multi-modal comparison of primary and stem cell-derived β-cells nominates targets for maturation

Stem-cell-derived β-like-cells (SCβ-cells) provide a promising platform for diabetes modelling and cell replacement therapy, but their incomplete functional maturation remains a challenge. Here, we co...

biorxiv.org

Police Removed Prominent Scientists from the ADA Meeting. Researchers Respond | The Scientist

The organizers of the American Diabetes Association meeting had a group of researchers removed from the event for sharing an editorial about negative impacts of policy changes to research funding.

urldefense.com

Beta cell function and mass in individuals with and without remission of type 2 diabetes after Roux-en-Y gastric bypass - Diabetologia

Aims/hypothesis In people with type 2 diabetes and obesity, Roux-en-Y gastric bypass (RYGB) can induce remission of diabetes. While RYGB has been reported to improve beta cell function in individuals ...

link.springer.com

Quantitative analysis of human adult pancreatic histology reveals separate fatty and fibrotic phenotypes in type 2 diabetes - Diabetologia

Aims/hypothesis The role of intra-pancreatic lipid and collagen in type 2 diabetes pathogenesis remains unclear. We sought to examine this in pancreases from organ donors with and without diabetes. Me...

link.springer.com

Defining the role of β-cell IRE1α/XBP1 pathway and its gene regulatory network components in non-obese diabetic mice - Nature Communications

Modulating the unfolded protein response (UPR) can induce protective dedifferentiation of β-cells in non-obese diabetic mice. Here, the authors show that β-cell deletion of UPR transcription factor XB...

nature.com

Bri2 BRICHOS domain inhibits IAPP amyloid formation and improves beta cell function in stem cell-derived islets under metabolic stress - Diabetologia

Aims/hypothesis Accumulation of islet amyloid polypeptide (IAPP) and amyloid formation is associated with beta cell dysfunction and cell death in human islets and may also contribute to graft failure ...

link.springer.com

link.springer.com

Tuning insulin receptor signaling using de novo-designed agonists

Wang, Cardoso, and Cai et al. design synthetic insulin receptor agonists that impose distinct receptor conformations, leading to modulated signaling. These agonists outperform insulin in metabolic con...

cell.com

A programmed decline in ribosome levels governs human early neurodevelopment - Nature Cell Biology

Ni, Wei, Vona and colleagues use human brain organoids to dissect patient AIRIM variants associated with neurodevelopmental features. A subset of variants impaired ribosome production and protein synt...

bit.ly

Amylin receptor subunit interactions are modulated by agonists and determine signaling

Agonist-dependent interactions between a GPCR and its accessory proteins affect signaling by peptide hormones.

science.org

Gut substrate trap of D-lactate from microbiota improves blood glucose and fatty liver disease in obese mice

D-lactate from the gut microbiota influences blood glucose and fatty liver disease. Trapping D-lactate in the gut improves blood glucose and lowers liver inflammation and fibrosis during obesity.

cell.com

Loss of Insulin-Positive Cell Clusters Precedes the Decrease in Islet Frequency and β-Cell Area in Type 1 Diabetes

In type 1 diabetes (T1D), insulin (INS) deficiency results from immune-mediated destruction of β-cells. The majority of functional β-cell mass is typically

diabetesjournals.org

JCI - Trapα deficiency impairs the early events of insulin biosynthesis and glucose homeostasis

jci.org

ER stress disrupts insulin release in murine models of type 2 diabetes by impairing retromer action and constitutive secretion

Using in vitro models of lipotoxicity and islets from the db/db mouse model of type 2 diabetes (T2D), we show that endoplasmic reticulum (ER) stress i…

sciencedirect.com

Amylin: emergent therapeutic opportunities in overweight, obesity and diabetes mellitus - Nature Reviews Endocrinology

Amylin is a peptide hormone involved in satiation. Amylin mimetics have potential as therapies for obesity and diabetes mellitus, but clinical development has proven challenging. This Review discusses...

nature.com

Tools for transformation: a teaching toolkit and research pocket guide for advancing equity, diversity, and inclusion in science and engineering

Advancing equity, diversity, and inclusion (EDI) in scientific fields is an outstanding challenge. While there is growing awareness of barriers and challenges to EDI across science, technology, engine...

facetsjournal.com

Genetic protection from type 1 diabetes resulting from accelerated insulin mRNA decay

Insulin gene variation predisposes individuals to type 1 diabetes (T1D). We report a new mechanism of genetic protection from T1D in which insulin mRNA with a protective SNP is broken down by IRE1α, t...

cell.com

Islet single-cell transcriptomic profiling during obesity-induced beta cell expansion in female mice

Targeting beta cell proliferation is an appealing approach to restore glucose control in type 1 diabetes. However, the underlying mechanisms of beta cell proliferation remain incompletely understood, ...

cell.com

Assistant or Associate Professor - Western College of Veterinary Medicine

Tenure track position in physiology, pharmacology and/or toxicology at the Western College of Veterinary Medicine

wcvm.usask.ca

Targeting the NLRP3 inflammasome–IL-1β pathway in type 2 diabetes and obesity - Diabetologia

Increased activity of the NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome–IL-1β pathway is observed in obesity and contributes to the development of type 2 diabetes and its compli...

tinyurl.com