"Here we describe a systematic effort (‘Codebook’) to determine the sequence specificity of 332 putative and poorly characterized human TFs." www.nature.com/articles/s41...

An expanded codebook of human transcription factor DNA-binding specificity - Nature

Results from a panel of assays that analyse different aspects of DNA sequence specificity reveal more than 100 new motifs to aid the characterization of putative human transcription factors.

nature.com

🎯 With absolut joy we share our newest #NucleicAcidsResearch on Glucocorticoid Receptor Multimerization. Enormous team work by Pablo Fuentes, Gordon Hager, Alba Jiménez, Andrea Alegre, Agustina Lafuente, Tom Johnson Nuria Peralta, Diego Presman, JRecio, Jaime Rubio, Pilar Montanyà, Josep Ponsetí 🥳🚀

📢 Read our new bioRx in colab with Gordon Hager NIH @PabloFuentesP #FRecio @aguslafuent @PresmanLab @WaghKaustubh #IGoldstein et al where we found glucocorticoid receptor GR self-assembly, chromatin binding & activity is modulated by bile acids binding to a novel druggable site

🎯 We will be able to doing Science for the next 3 years ✨️🎊🪁💎🌈 @biologiaub.bsky.social @ibub-ub.bsky.social @DeptBioquímicaBiomedicinaMolecular

🎯 We are so thrilled our new paper @narjournal.bsky.social is out! Fantastic collab with the labs of Gordon Hager NIH & Franck Dequiedt. Heaviest lifting from Greg Fettweiss, Kaustub Wagh, Diana Stavreva & Alba Jiménez-Panizo. Big thanks to Andrea Alegre-Marti JdC 🥳✨️ academic.oup.com/nar/article/...

🎯 Immune system's Granzymes are 5 human enzymes tailored to taking down infected or cancer cells. When these molecular assassins go rogue drive severe chronic inflammation & autoimmune diseases 👇On the structure and function of granzymes, the deadly squad of cytotoxic lymphocytes lnkd.in/e_NgfPHg

Our last contribution is out. A short review asking a simple question : do the multiple Mediator complex functions reflect an expansion of its activity as a complex, or the emergence of specialized functions at the level of individual subunits? portlandpress.com/biochemsoctr...

Ovarian cancer cell glucocorticoid receptor activation increases myeloid-derived suppressor cell tumor infiltration Get access Arrow. Read more in #Endocrinology: https://bit.ly/49I6u02 #OvarianCancer #NuclearHormoneReceptor #Cytokines @endocrinesociety.bsky.social

Ovarian cancer cell glucocorticoid receptor activation increases myeloid-derived suppressor cell tumor infiltration

Abstract. High ovarian cancer cell glucocorticoid receptor (GR) expression is associated with reduced progression-free survival (PFS) despite standard debu

bit.ly

Asthma & Obesity New research presented at #ECO2026 shows the use of the new GLP-1 class of obesity drugs by people with asthma is associated with a 26% fall in the number of asthma exacerbations & a 14% drop in use of asthma inhaler relievers.

Study links use of new obesity drugs to reduction of asthma exacerbations and inhaler use – ECO 2026 Newsletter

New research presented at ECO shows the use of the new GLP-1 class of obesity drugs in people with asthma is associated with a 26% fall in the number of asthma exacerbations and a 14% drop in use o…

eco-newsletter.co.uk

Exciting breakthrough technology from the lab, now live in @cellcellpress.bsky.social ! Instead of cutting the genome where proteins bind (e.g., Cut&Tag), D&D-seq scars the DNA with a deaminase, allowing single cell genome mapping of TFs and chromatin remodellers!

#UB575 | 🎓 La #UniBarcelona organitza el I Congrés Internacional de Recerca, un fòrum per debatre sobre el paper de les universitats intensives en recerca en un context global en transformació ➡️ La conferència inaugural va ser a càrrec Kurt Deketelaere, secretari general de la #LERU tuit.cat/tkW6u

⚡New preprint from the lab⚡: A key early checkpoint in gene expression is promoter proximal pausing of RNA polymerase II. For over 20 years, we as field have not been able to recreate pausing under realistic cellular conditions. @robertovn.bsky.social shows that ELOF1 is the missing piece.

Roberto Vázquez Núñez@robertovn.bsky.social · 2mo ago

🚨 New preprint: GATO-seq did it again! ELOF1 is the missing promoter-proximal factor that confers RNA Pol II resistance to TFIIF. Including ELOF1, DSIF, and NELF in GATO-seq reactions recapitulates promoter-proximal pausing in vitro at physiological conditions for the 1st time. tinyurl.com/ELOF1

Structural Biology ❤️ @ibub-ub.bsky.social @biologiaub.bsky.social @bqbiomedmolub.bsky.social 💎⚡️#ALBA-Cells synchrotron

📣 Very proud our young & talented lab members will be presenting at the IBUB-OBD Early Career Day 22nd May 2026 - Faculty of Chemistry UB. They will present their outstanding work published in NAR, Sci Adv & Prot Soc Trans @ibub-ub.bsky.social @bqbiomedmolub.bsky.social @biologiaub.bsky.social

🎯 Teaching period at @biologiaub.bsky.social This year we are a class of students from our university UB different "Bio" degrees, from UPC and Erasmus from all over the world (Iran, Sweden, Germany, Turkey, Syria, Finland, Italy, Lebanon, France). Wishing they will make a better & peaceful world 🚀🌍

Scientists say they have made some of the first direct measurements of how long it takes an individual, ordinary protein to fold – and the results were surprising. go.nature.com/3N4UrSD

How fast does a protein fold? Real-time technique captures the moment

Proteins assume complex 3D shapes even faster than does DNA, which is a simpler molecule.

go.nature.com

🎯 Our team is honoured to participate in the workshop on Rare Diseases at the @biologiaub.bsky.social showing our research done at @ibub-ub.bsky.social on the molecular mechanisms of rare syndromes Androgen Insensitivity and Chrousos generalized glucocorticoid resistance 🧩📌

New paper out in Nature Communications: www.nature.com/articles/s41... We found >250 metabolic enzymes on chromatin. Only ~20 had been reported before. This means hundreds of metabolic enzymes may have unexplored nuclear roles.

Native chromatome profiling reveals hundreds of metabolic enzymes in the nucleus across tissues - Nature Communications

Here proteomic chromatome analysis shows metabolic enzymes widely localize to chromatin in cancer in a tissue-specific manner. Nuclear enzymes affect DNA damage/repair and transcription, revealing non...

nature.com

🔬 Recerca UB | IV Jornada sobre Recerca en Malalties Rares. Una iniciativa de la Càtedra @ub.edu en Malalties Rares per compartir avenços en recerca. 📅 05/03 ⏰ 09:00 📍 Aula Magna Ramon Parés, Facultat de Biologia Acte obert a tot el públic 🔗 Més informació a https://f.mtr.cool/onjapobfyu

Very excited to share my postdoc research in the @jesserdixon.bsky.social lab at @salkinstitute.bsky.social, out online at @natgenet.nature.com today! www.nature.com/articles/s41... We investigated the function of the cohesin accessory protein NIPBL, making two particularly interesting findings:

Acute NIPBL depletion reveals in vivo dynamics of loop extrusion and its role in transcription activation - Nature Genetics

Acute depletion of NIPBL reveals a class of chromatin loops that are independent of NIPBL for their maintenance but not their establishment and that NIPBL is necessary for the expression of lineage-de...

nature.com

Check out our new findings showing BRD4's role in preventing the premature activation of developmental transcription factors via #Polycomb, providing new mechanistic insights into the pathogenesis of neurodevelopmental disorder #CdLS #NDDs, #chromatinopathies www.biorxiv.org/content/10.6...

Latest publication from our lab! A part of our ongoing efforts to identify estrogen receptor ligands that influence structural and oligomeric states in unique ways. pubs.acs.org/doi/10.1021/...

Allosteric Induction of Estrogen Receptor Ligand Binding Domain Tetramerization by a Distinct Complete Estrogen Receptor Antagonist

Complete estrogen receptor antagonists (CERANs) are effective against advanced estrogen receptor-positive (ER+) breast cancers, but current chemical scaffolds limit our ability to explore the full ran...

pubs.acs.org

AlphaFold protein interaction modeling tutorial and workshop thenode.biologists.com/https-www-yo...

AlphaFold protein interaction modeling tutorial and workshop - the Node

This video is the culmination of several years attempting to: (1) Figure out best practices for modeling protein-protein interactions; (2) Understand the This video is the culmination of several years...

thenode.biologists.com

Our new review, looking into the roles of SWI/SNF in the chromatin environment around centromeres, is just out in Open Biology! @kezlane.bsky.social @thedownslab.bsky.social

Karen Lane@kezlane.bsky.social · 8mo ago

Some Friday reading...new review in Open Biology where we discuss how SWI/SNF maintains the chromatin environment around centromeres, building on recent work from ourselves and others. Lots of fun putting this together with @alison-harrod.bsky.social and @thedownslab.bsky.social!

Online now! Online now! An interactive resource mapping the proteome and reactive cysteine landscape across the NCI-60 reveals cell and tissue-specific profiles #chembiol

An interactive resource mapping the proteome and reactive cysteine landscape across the NCI-60 reveals cell and tissue-specific profiles

Montaño et al. generate an integrated proteomic and cysteine reactivity resource for the NCI-60 cancer cell line panel, offering quantitative data on over 12,000 proteins and 36,000 cysteines to enable future studies on protein function, cysteine biology, and covalent drug discovery.

dlvr.it

Is arginine the new cysteine?! Check out our lab's latest in collaboration with @ianseiple.bsky.social's team where we introduce ninhydrin as a selective covalent warhead and probe targeting reactive arginines. www.biorxiv.org/content/10.6...

Ninhydrin as a covalent warhead for chemical proteomic-enabled discovery and selective engagement of reactive arginines

Covalent molecules have emerged as next-generation therapeutics and as powerful tools for perturbing fundamental biological processes. Chemical proteomic methods to screen for reactive proteinaceous a...

biorxiv.org

Evidence suggests that transcriptionally similar cells can be functionally diverse go.nature.com/3N4lT2d

Does a cell’s gene expression always reflect its function?

Transcriptionally similar neurons can be functionally diverse.

go.nature.com

We look very much forward to keeping doing Science together in 2026! ✨️🎄🚀🪐 Stay tunned 🪇 @ibub-ub.bsky.social @bqbiomedmolub.bsky.social @ub.edu