I’m very happy to share that our work looking at the role of B cell lipid metabolism in driving response to vaccination during immunosuppression is now (finally!) out online and published as an in press preview at JCI - www.jci.org/articles/vie...
Elizabeth Thompson
@e-thompson-lab.bsky.social
Assistant Professor at Johns Hopkins Bloomberg School of Public health using #vaccinology to better understand human #immunology and #immunometabolism
Celebrating two years as a PI here at Hopkins with a surprise cake from the best lab!
Did you know the Bloomberg School of Public Health houses one of the largest insectaries in the US? Learn more about the insectary: publichealth.jhu.edu/malaria-rese... @jhmrimalaria.bsky.social
Did you know the Bloomberg School of Public Health houses one of the largest insectaries in the US?
YouTube video by Johns Hopkins Bloomberg School of Public Health
youtube.com
Another year of tough competition for the @johnshopkinsmmi.bsky.social annual Halloween costume contest! The Thompson lab was well represented as the Immune Squad and an evil measles virus!
Zambia has become the 24th country to introduce malaria vaccines with Gavi support! 🧵⬇️ @unicef.org @who
Looking forward to this week's MMI Thursday Seminar featuring @gwu1821.bsky.social School of Medicine's Associate Professor Rebecca Lynch! 📆 Thursday, Oct. 16 ⏰ 12:00 - 1:00 p.m. 📍 @johnshopkinssph.bsky.social 🏢 Sommer Hall E2014/E3018
“In an unusual act of public protest, more than 340 scientists and staff at the National Institutes of Health today released a statement charging NIH officials and their superiors with politicizing science.” www.science.org/content/arti... #StandUpForScience #BethesdaDeclaration
NIH staff and biomedical community sound alarm about agency politicization, funding slowdown
In test of NIH director’s support of dissent, NIH staff sign Bethesda Declaration urging reversal of grant cuts and freezes
science.org
Multiple generations of the Loré lab represented at the keystone vaccine conference!
Postdoc opening in Pia Dosenovic's lab at Karolinska Institutet, "B cell-mediated immunity with a focus on basic immunological questions related to vaccine development" #Immunology #ScienceJobs #ImmunoSky ki.varbi.com/what:job/job...
Postdoctoral studies in Immunology (scholarship)
Do you want to contribute to top quality medical research? The Department of Microbiology, Tumor and Cell Biology (MTC) at Karolinska Institutet conducts research and teaching within immunology, inf
ki.varbi.com
⏳ 2 days until the #WorldMalariaDay Symposium! We’re bringing together global minds to rethink mosquito biology, gene editing, and malaria elimination. Don't miss it! 📍 @JohnsHopkinsSPH 📅 April 25 #BuildABetterMosquito
I don't get how anyone can possibly be okay with ending the WHI. This study has accrued decades of data from 42000 women and it is still going. It helps to address critical research gaps that have been allowed to go unfilled because of durable misogyny and provides invaluable insight into aging.
NIH cancels its first and largest study centered on women
The Women’s Health Initiative has produced numerous influential findings
science.org
B cells modulate lung antiviral inflammatory responses via the neurotransmitter acetylcholine www.nature.com/articles/s41... @natimmunol.bsky.social
The Thompson lab has won their first major award! First place in the second floor women’s march madness bracket competition! Next year we are going for gold in both brackets 💪🏻🥇
The unusual metabolism of germinal center B cells #immunology
The unusual metabolism of germinal center B cells
In the germinal center (GC), B cells undergo rounds of somatic hypermutation (SHM), proliferation, and positive selection to develop into high-affinity, long-lived plasma cells and memory B cells. It is well established that, upon activation, B cells significantly alter their metabolism, but until recently little was understood about their metabolism within the GC. In this review we discuss novel in vivo models in which GC B cell (GCBC) metabolism is disrupted; these have greatly increased our understanding of B cell metabolic phenotype. GCBCs are unusual in that, unlike almost all other rapidly proliferating immune cells, they use little glycolysis but prefer fatty acid oxidation (FAO) to fuel ATP synthesis, whilst preferentially utilizing glucose and amino acids as carbon and nitrogen sources for biosynthetic pathways.
dlvr.it
Good day to remember that a US President has no inherent power over tariffs whatsoever. It’s not like war powers or pardons. It’s entirely delegated by Congress to deal with emergencies. GOP Congress cld modify that law tonight and bring this to a screeching halt.
A recent study found that cervical cancer deaths in young women have plummeted since the introduction of the human papillomavirus vaccine.
As Cervical Cancer Deaths Plummet, Experts Credit HPV Vaccine
HPV can cause a variety of cancers, including cervical. New mortality data for women under 25 point to the success of the HPV vaccine.
buff.ly
Had a great and inspiring day in dc for #standupforscience2025 we need to keep the momentum going and help the public understand what is at stake!
It’s 2025 and children are dying from diseases we've known how to prevent for decades—because too many have chosen ideology over evidence. Measles outbreaks. Canceled vaccine programs. RFK Jr. at HHS. A public health crisis, engineered. #PublicHealth #Immunosky #HealthPolicy #medsky #IDsky #EpiSky
When Politics Trumps Public Health: Vaccine Crisis in America
Political interference in public health is fueling vaccine hesitancy, outbreaks, and policy failures—at the cost of preventable lives.
travisjoseph.com
The Thompson lab will be headed to the Stand Up for Science event in DC together with the Klein and Davis labs! Hope to see you all there
Stand Up for Science!@standupforscience.net · 2y agoWHERE WILL YOU BE ON MARCH 7TH!? Head to www.standupforscience2025.org/local-event-information/ or the link in our bio to find your closest event—or add one if you're hosting one! #standupforscience2025
Everyone who ever got funding through NIAID should be aware of this bill and start sending messages to their US legislators. The bill intends to dissolve NIAID. This is Project 2025 www.congress.gov/bill/119th-c...
congress.gov
Among all the scary and unsettling news these days science does go on, and we have had a big week in the lab! My new co-mentee had their PhD candidacy celebration, we finally got our second hood installed (!!), and today I will hit submit on a paper I’ve spent the better part of 4 years working on!
not paying indirect costs for research is like only paying the players in the Super Bowl. can't have a Super Bowl without coaches, referees, security, janitors, announcers, stadium staff, and a stadium - and you can't have research without supporting people and facilities
Exciting collaboration with the Jackson, Pardoll, Yegnasubramanian, and Bettegowda Labs - now published in Science! Grateful for the contributions of our current and past group members: Runzhe Li, Zhicheng Ji, Wenpin Hou, and Wentao Zhan. #TeamScience
It is simply not enough for universities to say, “Our grants & research offices are looking into how research will be affected by the latest directive.” University leaders must actively and very publicly make the case for the kind of work many of us do. The silence on this front is deafening.
Distinct myeloid-derived suppressor cell populations in human glioblastoma doi.org/10.1126/scie...
Distinct myeloid-derived suppressor cell populations in human glioblastoma
The role of glioma-associated myeloid cells in tumor growth and immune evasion remains poorly understood. We performed single-cell RNA sequencing of immune and tumor cells from 33 gliomas, identifying...
doi.org
Anyway, betwixt everything, here is a really cool discovery that could potentially really help in the treatment of cancer in the future: Tumors prevent effective immune responses from T cells by transferring their mitochondria (which have mutations) and having those replace...
Immune evasion through mitochondrial transfer in the tumour microenvironment - Nature
Mitochondria with mutations in their DNA from cancer cells can be transferred to T cells in the tumour microenvironment, which leads to T cell dysfunction and impaired antitumour immunity.
nature.com
“The impact of the collective executive orders and directives appears devastating.” scim.ag/40ureTO
Trump hits NIH with ‘devastating’ freezes on meetings, travel, communications, and hiring
Researchers facing
scim.ag