Thanks very much to the @kempnerinstitute.bsky.social for supporting our work! I’m excited to see what we will learn about cell biology of the synapses by modeling pairs of synaptic proteins that interact in BioPlex. Congratulations also to all the other award recipients!

Kempner Institute at Harvard University@kempnerinstitute.bsky.social · 6d ago

Announcing the newest #KempnerInstitute Accelerator Award recipients! Congratulations to Maha Farhat, Wade Harper (@harperlabhms.bsky.social) & Edward Huttlin (@edhuttlin.bsky.social), Noor Youssef & Debora Marks (@deboramarks.bsky.social), and Samuel Kou. 🎊 Learn more ➡️ bit.ly/4wyuaxx

I haven’t logged onto BlueSky in a while, so I’m way behind on this, but I was happy to play a small part in this cool project with @dschweppe.bsky.social, @keribackus.bsky.social, and @oligopain.bsky.social. See their threads below for the details!

Devin Schweppe@dschweppe.bsky.social · 3mo ago

With a few days since it's been out @keribackus.bsky.social @oligopain.bsky.social and I wanted to highlight a few of our favorite aspects of POCA for photocatalytic proximity labeling of DNA, RNA or proteins. (1) POCA builds on standard in situ hybridization and immunofluorescence workflows.

With a few days since it's been out @keribackus.bsky.social @oligopain.bsky.social and I wanted to highlight a few of our favorite aspects of POCA for photocatalytic proximity labeling of DNA, RNA or proteins. (1) POCA builds on standard in situ hybridization and immunofluorescence workflows.

Keri Backus@keribackus.bsky.social · 3mo ago

Super excited to launch POCAxOMAP with @dschweppe.bsky.social and @oligopain.bsky.social and led by Eli Biletch, Conor Herlihy and Lidan Li. If you’ve ever wanted to do proximity labeling on DNA, RNA, or protein without genetic engineering, look no further. www.biorxiv.org/content/10.6...

The next iteration of O-MAP targeting genomic loci is now at eLife!! DNA O-MAP enables proximity labeling at specific DNA loci took a ton of work from many lab members and collaborators, so it's really exciting to wrap up this paper with @oligopain.bsky.social! elifesciences.org/articles/102...

DNA O-MAP uncovers the molecular neighborhoods associated with specific genomic loci

DNA O-MAP enables proximity labeling at specific genomic loci in fixed cells using programmable oligonucleotides, revealing locus-proximal proteomes and chromatin interactions without genetic modifica...

elifesciences.org

We are delighted to announce that Paola Picotti has been awarded the Otto Naegeli prize for biomedical research! otto-naegeli-preis.ch

Excellent visualization of the true distance between the Earth and our moon: #artemis #AGoodPlace Source: www.reddit.com/r/BeAmazed/s...

To better understand the ubiquitin-proteasome system, Suzanne Elsasser, Dan Finley, and the Human Proteostasis Consortium have systematically surveyed its components: www.biorxiv.org/content/10.6... I would encourage you to check out this valuable resource! @harvardcellbio.bsky.social

This morning’s course on studying protein-protein interactions is well on its way at #USHUPO2026! I just wrapped up my talk on AP-MS, and now Lan Huang is talking about crosslinking MS. This afternoon Ling Hao will be talking about proximity labeling as well. @us-hupo.org

Applications are now open for @olgavitek.bsky.social 's May Intitute on computation and statistics for mass spectrometry and proteomics at @northeasternu.bsky.social ! --> computationalproteomics.khoury.northeastern.edu

Unexpected Kid Math Question: how many digits of pi do you need to look at to find the series “67”? Answer: 100 If you’ve been wondering, you’re welcome!

Christmas concert season is here! Tonight I played a concert with the New England Brass Band.

I am looking for a PostDoc to join my group at Genentech to drive the development of proteomics technologies to fuel target and therapeutic discovery and development. Check out the link below! careers.gene.com/us/en/job/20...

Congratulations to Bill Noble on receiving the 2026 Gil Omenn Computational Proteomics Award from US HUPO! us-hupo.org/Computationa...

US HUPO - Computational Proteomics Award

us-hupo.org

Congratulations to Mike MacCoss on receiving the Donald F. Hunt Distinguished Contribution in Proteomics Award from US HUPO! us-hupo.org/Distinguishe...

US HUPO - Distinguished Contribution Award

us-hupo.org

If you’re at #HUPO2025, be sure to stop by my poster and learn about the latest developments in the BioPlex project!

#HUPO2025 I Our CTDP poster was very well-received! Thank you all for coming! It is free to join CTDP! If you are interested in learning more about #topdownproteomics, please join our talks tomorrow 😀❤️ @proteoforms.bsky.social @nlkproteomics.bsky.social @edhuttlin.bsky.social

Ying Ge@yingge2121.bsky.social · 9mo ago

#HUPO2025 interested in #topdownproteomics please come to join us in the Friends of HUPO reception 18:45-19:45 pm Westin Frontenac Ballroom Foyer 😀❄️ @nlkproteomics.bsky.social @proteoforms.bsky.social @jyates.bsky.social @hecklab.bsky.social #teammassspec

Kudos to the organizers (Jennifer Geddes-McAlister, @mlaval6.bsky.social, Marie Brunet) for arranging snow to coincide with the start of HUPO 2025 in Toronto!

I’m at the airport a and ready to fly to Toronto for this year’s HUPO conference. I’m looking forward to talking about AP-MS tips and tricks at tomorrow’s pre-conference workshop on protein-protein interactions and sharing our latest BioPlex results in a poster on Wednesday!

We are ready for Halloween!

Check out this thread from @haopengxiao.bsky.social on his recent paper! I’m happy I was able to help out on what has turned out to be a really cool story.

Haopeng Xiao@haopengxiao.bsky.social · 11mo ago

We developed a MS and machine learning approach to globally identify protein regulators of metabolism. We found protein LRRC58 controls cellular cysteine catabolism by mediating degradation of CDO1, the rate-limiting enzyme of the catabolic cysteine shunt to taurine. www.nature.com/articles/s41...

Hey @haopengxiao.bsky.social - it’s great to see you on BlueSky! Could your new account be a sign you might have something cool to announce soon???? ;-)

Excited to share a new preprint from the lab. We show that PTMs like phosphorylation & glycosylation dynamically reshape proteome-wide ligandability in cells, including proteins like KRAS. Great collaboration with the Huang Lab, @forlilab.bsky.social and BMS. www.biorxiv.org/content/10.1...

Post-Translational Modifications Remodel Proteome-Wide Ligandability

Post-translational modifications (PTMs) vastly expand the diversity of human proteome, dynamically reshaping protein activity, interactions, and localization in response to environmental, pharmacologi...

biorxiv.org

Thoughts from our own Tom Rapoport on the role of basic science in curing disease. magazine.hms.harvard.edu/articles/rev...

“Revolutionary Science Comes from Unexpected Angles”

magazine.hms.harvard.edu

Not really an overstatement to say that the test of a free society is whether or not comedians can make fun of the country's leader on TV without repurcussions.

If you’re at #ASMS2025, stop by the Protein-protein and Protein-ligand Interactions section this afternoon and hear how we are leveraging our BioPlex network and AlphaFold structural models for drug discovery!

If you're going to #ASMS2025, don't miss these Gygi lab presentations! You'll learn about TMT, chemoproteomics, GoDig for targeted proteomics, leveraging BioPlex interactions for drug discovery, new instrumentation, and more! @amandalsmythers.bsky.social @asms.org @harvardcellbio.bsky.social

#ASMS2025 is fast approaching, and I'm looking forward to catching up with friends and seeing a lot of great mass spectrometry research. If you’re there, check out my Tuesday talk (TOE 3:10 PM) to learn how BioPlex is enhancing drug discovery!

Harvard's president tells NPR he finds Trump's recent measures "perplexing." "Why cut off research funding? Sure, it hurts Harvard, but it hurts the country," he said, adding that those dollars are awarded to efforts deemed "high-priority work" by the government. https://n.pr/43hPDhX

New work @harvard by Miguel Gonzalez-Lozano @harperlabhms.bsky.social & @ernstschmid.bsky.social in Johannes Walter lab charts structural interactome of endosomes. #XL-MS #Alphafold Funded by @asapresearch.parkinsonsroadmap.org & NIH. Science continues-despite attacks www.nature.com/articles/s41...

EndoMAP.v1 charts the structural landscape of human early endosome complexes - Nature

A study presents EndoMAP.v1, a resource that combines information on protein interactions and crosslink-supported structural predictions to map the interaction landscape of early endosomes.

nature.com

NIH's work saves lives—& Trump is gutting it. Straight from D.C. I headed to Seattle Children's to hear from researchers & patients alike about the importance of NIH funding—it's not just about lines in a budget, it's about lifesaving discoveries. We ALL need to speak up to save it.