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Luay Almassalha

@almassalha.bsky.social

Physician-Scientist studying and applying the rules of the physical genome in development, aging, cancer, and inflammation

203 Posts98 Follower110 Folgt
Simon Gaudin@simongaudin.bsky.social · 3d ago

Now out from Bintu lab: compaction following transient KRAB recruitment tracks long-term epigenetic memory. But K9me3 decays after KRAB release and is replaced by DNA methylation. Does compaction help maintain K9me3, or slow its loss enough to facilitate the handoff to DNAme? tinyurl.com/ycay4mrh

Single-cell chromatin state transitions during epigenetic memory formation

Large-scale chromatin compaction quantitatively predicts the percentage of cells with durable epigenetic memory of gene silencing.

tinyurl.com

Laura Howes@laurahowes.bsky.social · last wk.

Alas poor AlphaFold, we knew you well... This is not entirely surprising to me, as it wasn't clear what more AF could do outside of what Hassabis is trying to build with Isomorphic. But I am interested in people's thoughts here #chemsky #biotech 🧪 www.ft.com/content/61b2...

Google DeepMind dismantles Nobel-winning AlphaFold team in strategy shift

Landmark project that solved protein folding gives way to a wider race to build AI systems for scientific discovery

ft.com

Jan Philipp Kreysing@jpkreysing.bsky.social · 3w ago

Delighted that our story on chromatin architecture inside human cells is now published — the last chapter of my PhD. It was a pleasure working with @sergiocruzleon.bsky.social, @johannesbetz.bsky.social, and everyone involved. #teamtomo www.nature.com/articles/s41...

Molecular architecture of heterochromatin at the nuclear periphery of primary human cells - Nature Communications

The 3D organisation of chromatin inside a human cell is still not fully resolved. Here the authors reveal that in situ cryo-ET resolves individual nucleosomes and predicts DNA linkers, thus showing th...

nature.com

Max Planck Institute of Biophysics@mpibp.bsky.social · 3w ago

How do 2 meters of DNA fit inside a nucleus you can barely see? 🧬 Our new study mapped individual nucleosomes inside human cells.

Jason Tan@yjtan.bsky.social · last mo.

Does every enhancer work with every promoter? With @jengreitz.bsky.social and Will Greenleaf, we revisit this long-debated question and resolve an outstanding contradiction in the field. A tour 🧵👇 www.biorxiv.org/content/10.6...

Intrinsic promoter responsiveness dictates sensitivity to transcriptional activation by enhancers

Enhancers activate specific target promoters, but whether intrinsic enhancer-promoter compatibility contributes to this specificity is debated. Recent studies using different reporter assays have reac...

biorxiv.org

Konrad Chudzik@konrad-chudzik.bsky.social · last mo.

My first PhD paper is out in Nucleic Acids Research! We describe "Ab-trapping" - an antibody artifact that distorts assays relying on antibody diffusion (microscopy, CUT&Tag, CUT&RUN). The revisions made the story much stronger. Check it out! doi.org/10.1093/nar/...

Antibody-trapping presents a widespread pitfall for microscopy and genomics in the nucleus

Abstract. Chromatin has a complex 3D structure and diverse binding proteins that coordinate the genome’s most essential functions. Many microscopy and geno

doi.org

Anders Sejr Hansen@andersshansen.bsky.social · last mo.

Excited to see James' Genome-wide Absolute Quantification of Looping paper out in @natsmb.nature.com : www.nature.com/articles/s41... This has been in collaboration with @lucagiorgetti.bsky.social @leonidmirny.bsky.social @zechnerlab.bsky.social labs. Brief thread below on some key updates

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Anders Sejr Hansen@andersshansen.bsky.social · 2y ago

Excited to share James Jusuf's preprint: By integrating Micro-C with SuperRes Live-Imaging we can calibrate genomics&imaging to perform absolute quantification of looping (e.g. this loop is present 3%) We quantify mESC 36k loops: <loops> are generally rare (2.3%) www.biorxiv.org/content/10.1...

Ceinwen Langley@ceinwenlangley.bsky.social · 2mo ago

I know Calvin’s dad is already having a moment, but every terrible “outsource precious and fleeting moments with your children to tech so that you can spend more time on your work” pitch makes me think of that one strip I never really cared about as a kid, but care a lot about as an adult.

The Calvin and Hobbes strip where Calvin asks his dad to come play in the snow with him. His dad initially says no, because he has to work. Then, angry at himself, his Dad goes out to build a snowman with Calvin. As the Dad works into the night to make up for it, we see Calvin’s mum lifting him up to give one of the few, if only, kisses he ever gives his dad in the Calvin and Hobbes run. His dad is content. It’s a textless comic, and it’s lovely.
Hypervisible @hypervisible.blacksky.app · 2mo ago

“The feature uses a combination of bedtime stories, relaxing sounds, and guided meditations along with scheduling and customization options accessible only to adults.”

Luay Almassalha@almassalha.bsky.social · 2mo ago

I'm so tired of verifying I'm human and doing 2 factor authentication for every basic task. At this rate, verify tech in 20 years will require a full physical exam, blood work, and a notary form every time I need to check my email

Carmelo Ferrai@carmeloferrai.bsky.social · 2mo ago

An immense big thanks goes to @matthiasakyel.bsky.social @yomna96.bsky.social @priyakmr.bsky.social @ana Miguel Fernandes you are absolutely great and you should know how proud I am. Below I post again the link of the publication. Enjoy the reading! advanced.onlinelibrary.wiley.com/doi/10.1002/...

Stem Cell Differentiation Disperses Transcriptional Clusters via a Conserved Surface‐Condensate Trajectory

Stem cell differentiation follows a conserved surface condensate trajectory: H3K27ac super enhancers nucleate large RNA polymerase II clusters that grow and unfold before transcriptional activity dis...

advanced.onlinelibrary.wiley.com

Mir Lab@mirlab.bsky.social · 2mo ago

1/🧵 Can transcription factor condensate formation be explained without phase separation? Our new preprint introduces SPARK, a simulation tool that reproduces condensate behavior (clustering, fusion, FRAP) from diffusion & binding kinetics alone. Movie: 60 sec FRAP sim www.biorxiv.org/content/10.6...

Marek Bartosovic@mardzix.bsky.social · 2mo ago

Thrilled to see nano-CUT&Tag applied in Drosophila for the first time in an exciting collaboration with the lab of Mattias Mannervik! Long story short: It works beautifully Huge kudos to the computational team for turning complex single-cell chromatin data into exciting developmental landscapes.

Mannervik Lab@mannerviklab.bsky.social · 2mo ago

Have you ever wondered how chromatin states shape developmental trajectories? In our preprint, we address this question using single-cell nanoCUT&Tag, a method developed by Marek Bartosovic @mardzix.bsky.social, which simultaneously profiles active H3K27ac and repressive H3K27me3 in the same nucleus