My incoming spam phonecalls and texts just happened to drop from 5-10/day to zero www.tomshardware.com/tech-industr...

Russia's Yandex bot traffic nearly eliminated overnight after Ukraine drone strikes cripple multiple of 'Russia's Google' data centers — Ukraine intensifies bombing of Yandex data centers in response ...

The world is getting a break from Russian bots thanks to Kyiv.

tomshardware.com

Just out in Nature Structural and Molecular Biology! CPGE scientists Vadim Backman and Luay Almassalha and colleagues present a framework for understanding how mechanical signals modulate cellular structure, identity and function in the context of cell memory. rdcu.be/wzhynmEQWQaa...

It’s the last days of Childhood Cancer Awareness Month, and our fundraising with Alex’s Lemonade Stand Foundation will soon be coming to an end. Anything from donations, to reposts, to supporting another peds cancer effort is much appreciated! www.alexslemonade.org/2026/macquar...

MacQuarrie Lab

Every day, there are almost 800 new cases of childhood cancer around the world. This adds up to an estimated 300,000 new cases of cancer that affect children under the age of 20 each year worldwide. A...

alexslemonade.org

"Philosophy of Biology: The power of theory in the life sciences" elifesciences.org/articles/112... @zdblount.bsky.social shared this thought-provoking paper with the lab group.

Philosophy of Biology: The power of theory in the life sciences

Theory can help address cell and molecular biology’s major challenges, particularly those arising from large omics datasets.

elifesciences.org

The 4DN Center for 3D Structure and Physics of the Genome proudly presents: "Stepwise reorganization of chromosome conformation and nuclear organization during stem cell differentiation". www.biorxiv.org/content/10.6...

“…the push by AI companies to solve mathematical problems as a benchmark is detrimental to the science of mathematics, and to the mathematical community. The goals of the AI companies and the goals of the mathematical community are severely misaligned.“

Terence Tao@teorth.bsky.social · last mo.

A group of 25 Fields Medalists, including myself, have made a joint declaration on Math and AI: mathandai.org . We welcome additional signatories. See also this article in the Economist announcing the declaration: www.economist.com/science-and-...

Our paper on euchromatin and cohesin is now published!!🙌 Euchromatin forms condensed domains, and cohesin constrains their local mixing. This organization maintains transcriptional insulation. This work was truly a team effort, and I’m grateful to everyone who contributed to it.

Kazuhiro Maeshima@kazu-maeshima.bsky.social · last mo.

Is euchromatin really “open”? 🧬 Using super-resolution imaging🔬 our new study @natgenet.nature.com reveals: Euchromatin forms condensed domains in live cells. Cohesin constrains them and prevents domain mixing for proper transcriptional insulation🚧 🔗 www.nature.com/articles/s41... (1/2)

Latest #CDlab paper on BioRxiv: www.biorxiv.org/content/10.6... 1st author Eva Bertosin developed huge DNA origami nanopores that can dilate and constrict in size. With diameters up to 87 nm, they can insert into lipid membranes, showing selective transport when filled with nuclear pore proteins.

https://www.biorxiv.org/content/10.64898/2026.09.03.749129v1

biorxiv.org

Check this exciting study from @gabrijelad.bsky.social and colleagues: www.nature.com/articles/s41...

The periphery of nuclear speckles defines a spatially and temporally regulated compartment of long-lived intron-retained RNAs that resolves during mitosis - Nature Cell Biology

Biayna, Baranovskii and colleagues report that intron-retained RNAs derived from cell cycle- and genome maintenance-related genes are pooled at the periphery of nuclear speckles and undergo synchronou...

nature.com

I'm super excited for our new season of #FragileNucleosome seminars, which kicks off tomorrow with @mpalamin.bsky.social and @robertovn.bsky.social!

FragileNucleosome@fnucleosome.bsky.social · last mo.

🎤 #FragileNucleosome is back next Wednesday! Hope you enjoyed the summer!Join us next 📅Wednesday to hear about 🧬fascinating research from @mpalamin.bsky.social from Krebs lab and @robertovn.bsky.social from Vos lab. To register if you haven't before: us06web.zoom.us/webinar/regi...

It's worth reading the entire letter. The correct link is here. cims.nyu.edu/~tristanb/st...

Quantian@quantian.bsky.social · last mo.

Dancing very very VERY close to saying “OpenAI stole our almost-complete proof of Navier-Stokes from internal access to our ChatGPT sessions because they were desperate to scoop Anthropic” which is absolutely 100% a believable thing OpenAI would do right now cims.nyu.edu/~tristanb/st...

my papr was just published! 🧪 #RNABiology #tunnelingnanotubes www.cell.com/cell-reports...

Complementation of a human disease phenotype by intercellular mRNA transfer

Intercellular mRNA transfer between mammalian cells in vitro occurs via tunneling nanotubes to express functional proteins upon translation that complement genetic mutation. Complementation via RNA tr...

cell.com

Is euchromatin really “open”? 🧬 Using super-resolution imaging🔬 our new study @natgenet.nature.com reveals: Euchromatin forms condensed domains in live cells. Cohesin constrains them and prevents domain mixing for proper transcriptional insulation🚧 🔗 www.nature.com/articles/s41... (1/2)

Has this been discussed here? #AcademicSky #Academia #ECR #HigherEducation www.nature.com/articles/s41...

How contemporary academic structures constrain scientific creativity and hold back early-career researchers - Nature Human Behaviour

In this Perspective, Haubrock et al. argue that today’s scientific structures constrain creativity and that strategic conformity is a rational response. They discuss how this holds back early-career r...

nature.com

1/ out in @science.org! We found a new asymmetry in large-scale chromosome structure: sister chromatids are shifted by hundreds of kb in the 5′→3′ direction of their inherited strands! A close collaboration w/ @gerlichlab.bsky.social , led by @flaviacorsi.bsky.social www.science.org/doi/10.1126/...

wait, wait, what ????? protein-coding chimeric mRNAs 🤯 www.nature.com/articles/s41...

Functional chimeric mRNAs encode proteins in mammalian immunity - Nature

Inflammation induces interchromosomal DNA interactions that bring parent genes into close proximity, facilitating the formation of chimeric mRNAs that encode physiologically relevant, functional prote...

nature.com

Come and join us in the beautiful city of Porto in April 2027 for what promises to be a great meeting!

A win for our state. NSF’s recognition of Northwestern’s Center for Genome Intelligence Engineering is a validation of the innovation we’re doing here to understand how cells function to prevent decline. We’re fostering the research and science needed to lead in Illinois.

Illinois DCEO@illinoisdceo.bsky.social · last mo.

🏆Led by Northwestern University, the Center for Genome Intelligence Engineering was awarded $30M from the National Science Foundation.    Learn more

AlBawardi et al, 2026. Irregular nucleosome positioning governs a crystalline to liquid-like phase transition and tunes chromatin accessibility www.biorxiv.org/content/10.6... ▶️heterochromatin-like sequences produce compact fibres ▶️positional irregularity (>2-3 bp) triggers a state transition

The NSF has awarded Northwestern $30 million to launch the Center for Genome Intelligence Engineering (GENIE). By treating the genome as a physical and a computational system, GENIE will harness cellular memory to combat injury, disease, aging and more www.mccormick.northwestern.edu/news/article...

Northwestern to Launch $30 Million Center to Unlock Genome’s Hidden Code

Led by Northwestern Engineering’s Vadim Backman, the multi-institutional Science and Technology Center will integrate experts in physics, biology, engineering, AI, and medicine to understand how the g...

mccormick.northwestern.edu

Very happy to announce that I’ll be launching my lab at WashU in 2027! We’ll build on this work to uncover the mechanisms and diversity of epigenetic memory and its role in human disease. Hiring at all levels to start early 2027 — learn more or reach out: nagarajalab.org

Surya Nagaraja@snaga13.bsky.social · 7mo ago

A little late to Bluesky but my postdoc work w/ @jbuenrostro.bsky.social now out in @nature.com "Epigenetic memory of colitis promotes tumour growth" www.nature.com/articles/s41... We wanted to understand how transient inflammation can create an increase in cancer risk, even after full recovery 🧵

🧵 What if one reason fertility declines with age isn’t just genetic-but mechanical? Thrilled to share our new paper in @NatureCellBio : Elevated contractility drives implantation failure in mouse embryos from aged females… here’s what we found 👇 www.nature.com/articles/s41... 1/11

Elevated contractility drives implantation failure in mouse embryos from aged females - Nature Cell Biology

Cavanaugh et al. show that embryos from aged mice have increased contractility and tissue viscosity on embryonic day 4.5, which leads to poor spreading and attachment. Similar age-associated mechanica...

nature.com

Blood of Crom! "It is clear that many of these vendors are using the same images as one another for their own versions of the same product. For instance, this HAS1 antibody from Thermo Fisher uses the same Western blot image as similar products from Millipore Sigma, Novus (R&D Systems) & Boster Bio"

At least 15 companies are selling antibodies using faked validation data

Popular vendors’ catalogs feature more than 18,000 manipulated images

reeserichardson.blog

we all have mental rolodexes of patients we never forget as an ER doc, I've taken care of quite a few patients where we found new -- almost always advanced -- pancreatic cancer this is great news and a nice reminder of why we all chip in and hire the best scientists to find new & better tools

Kevin M. Kruse@kevinmkruse.bsky.social · 2mo ago

My grandma died of pancreatic cancer and, as I recall, it's one of the swifter, more devastating forms of cancer. She was gone within a couple months of the diagnosis. This is absolutely incredible.

Excited to share our paper in @natgenet.nature.com on the de novo design of tissue-specific mammalian enhancers that function in vivo in mouse embryos. 🧬🐭 www.nature.com/articles/s41...

How do nuclear compartments form inside cell nuclei? We show RNA glues certain loci together to form a nuclear compartment. This involves special GC-rich regions of highly expressed genes that also associate with nuclear speckles, but interactions between these loci are independent of speckles!

bioRxiv Genomics@biorxiv-genomic.bsky.social · 2mo ago

Formation of an RNA-mediated nuclear compartment https://www.biorxiv.org/content/10.64898/2026.08.20.746005v1

Hiring for research scientists in expansion chemistry and optical physiology at mindspan.org with @eboyden3.bsky.social, Yongxin Zhao, Xue Han. We will build tools to analyze the human brain. We are into compiling arxiv.org/abs/2603.25713. We are into cutting edge technology.

mRNA vaccines vs cancer success —melanoma (Phase 3, RCT, definitive, announced today) —triple negative breast cancer —pancreatic cancer —non-small cell lung cancer —glioblastoma

Inferring transcription factor activity: use ATAC-seq, reporter assays, or both? link.springer.com/article/10.1...

Systematic comparison of estimates of transcription factor activity by ATAC-seq and multiplexed reporter assays - Molecular Systems Biology

Transcription factors (TFs) are central to gene regulation and play critical roles in development, cellular homeostasis and disease. The ability to accurately measure TF activity is essential to under...

link.springer.com

“Super-enhancer hubs are rare, nonspecific, and neither necessary nor sufficient for transcriptional bursting” www.cell.com/cell-genomic...

Single-cell 3D genome imaging shows super-enhancer hubs are rare, nonspecific, and neither necessary nor sufficient for transcriptional bursting

Super-enhancers have been proposed to cluster in the nucleus when compared to other genomic elements. Le et al. found that super-enhancer clustering was rare and driven by non-specific interactions. P...

cell.com