Folk not using headphones on trains remain the absolute worst
Matt McFarland
@emseefarlandee.bsky.social
Postdoc in the Kulathu lab at the MRC PPU. Bright Clubber. Runner. Goes on trains a lot. General purpose nerd. Views own, and probably rubbish.
Nothing says "We care about the #CommonwealthGames" like sticking it on Channel 5.
Team science preprint, exploring the capabilities and limitations of Alphafold3 across different application areas, including protein-RNA, protein-lipid, ubiquitination,TCR and antibody recognition with @ninjani.bsky.social @labvanni.bsky.social @dgfeller.bsky.social www.biorxiv.org/content/10.6...
Capabilities, specificity gaps and training-data dependence of AlphaFold3 across diverse application areas
Structure prediction models have moved from single proteins to assemblies that include diverse biomolecules and their modifications. AlphaFold3 (AF3) and related models extended structural modelling v...
biorxiv.org
As we kick off the Round of 32, I give you what these matchups are really about: 1. Canada 🇨🇦 vs. South Africa 🇿🇦 - Battle of the Commonwealth nations 2. Brazil 🇧🇷 vs. Japan 🇯🇵 - Battle of the Portuguese Jesuit "colonies" 3. Germany 🇩🇪 vs. Paraguay 🇵🇾 - Battle of *chuckles nervously* (1/x)
A lot of people don't realise this but in the UK we have to replace our Prime Minister every two or three years or else the rights revert back to Marvel
In accordance with ancient tradition, our next Prime Minister is announced to the nation while standing between a furry and a man with a bin on his head.
This is a ridiculous paper in the category of "computational bestiary" but Fig. 1 is wonderful: fcampelo.github.io/EC-Bestiary/
A very happy Scottish bank holiday Monday to all except Susanna Reid. ♥️
Delighted that this is now out in its final form! 🥳 It's a fun story about an EF hand that doesn't bind Ca2+, but instead works as a ubiquitin-binding domain. Huge thanks to the rest of YK lab, the @mrcppu.bsky.social, and our collaborators (@sebastianglatt.bsky.social)!
EMBO Reports@emboreports.org · 2mo agoLee Armstrong, Yogesh Kulathu @kulathu.bsky.social and co-workers show that MINDY3's EF-hand domain is a novel #ubiquitin binding domain. It not only enables chain-length-dependent deubiquitination but also binds to DNA repair factors RAD23A/B. -> link.springer.com/article/10.1...
Thermo Fisher now has a page up in response to our observations. They flatly deny that images were manipulated or fabricated while repeating that images were "optimized for presentation and clarity on the website", no lie, six times. www.thermofisher.com/us/en/home/l...
thermofisher.com
Reese Richardson@reeserichardson.bsky.social · 2mo agoThe Thermo Fisher situation keeps getting worse. We've now collected 450+ problematic images presented as verification data in TF's antibody catalog. This includes: 🖌️ Dozens more images with duplications or painting 🖨️ Hundreds of blots that all share the same background (behold slideshow below)
The Thermo Fisher situation keeps getting worse. We've now collected 450+ problematic images presented as verification data in TF's antibody catalog. This includes: 🖌️ Dozens more images with duplications or painting 🖨️ Hundreds of blots that all share the same background (behold slideshow below)
Mammalian gene naming conventions and the potential for this kind of mistaken identity have long been a pet hate of mine. There will definitely be other examples of this out there.
Sholto David@sholtodavid.bsky.social · 2mo agoToday I'm posting a new blog about an astonishing scientific own goal. Hundreds of papers have reported using a totally wrong antibody to investigate the tumor suppressor p16. This mistake has happened because scientists have muddled the names of two proteins. forbetterscience.com/2026/06/02/m...
Popped in past my parents' last night just in time to spot this guy angling for a takeaway from the bird feeder
I wish whoever decided to stick picture-in-picture ads into the ITV #SixNations coverage during play nothing but the worst
🚨⚠️ New Preprint Alert! ⚠️ 🚨 www.biorxiv.org/content/10.6... Screening p97 cofactors, @prithadg.bsky.social identified FAF2 as the strongest activator of the p97-UFD1-NPL4 complex. Leveraging her mechanistic descoveries, we designed 𝘥𝘦 𝘯𝘰𝘷𝘰 binders that could also enhance p97 substrate unfolding.
It was so bright leaving for work this morning I actually thought I'd massively slept in
After a brief memorial, laz lit the cigarette at 6:00am. The 2026 Barkley Marathons has begun. #BM100
I never thought I'd find myself rooting for Ryanair but these are the #UnprecedentedTimes we find ourselves in
SAVE THE DATE! The EMBO workshop "Ubiquitin and Ubiquitin-like proteins in Health and Disease" will be on September 2026. Exciting line up of talks and an amazing location! Organised by @kulathu.bsky.social, @merbllab.bsky.social, @simonapolo.bsky.social, Claudio Joazeiro. Registration open soon.
This was a proper wee surprise. Wasn't on the radar at all. Very fun, and it did more to get me invested in this bunch of idiots in 10 hours than some other games are doing in 60. Second season, when?
AdHoc Studio@adhocstudio.com · 10mo ago📷 Dispatch is OUT NOW on Steam and PS5! Clock in and manage your team of ex-villains in our superhero workplace comedy where choices matter.
Teasing there's a team that's making their first appearance, but it's just another Oxbridge college is such a bait and switch #UniversityChallenge
TFW the only thing you paid attention to in biology class was “the mitochondria is the powerhouse of the cell”
Clay Ranck@clayranck.bsky.social · 11mo agowtf is this nonsense? He thinks he can understand kid’s “mitochondrial challenges” just by looking at them? This is an insane person.
The EF-hand domain of MINDY3 is a Ubiquitin and RAD23 UBL-binding domain https://www.biorxiv.org/content/10.1101/2025.07.16.665128v1
New entry for coolest pint glass I own. 😎 Super happy to have been involved with what was a cracking set of talks on day 2 in Dundee. #pint25
Hot off the (Portland) press, @kulathu.bsky.social and I wrote a review on branched #ubiquitin and the tools and strategies out there for studying it. Some really cool stuff going on right now and I'm really excited to see where things go from here. #BiochemSocTrans portlandpress.com/biochemsoctr...
Emerging tools and methods to study cell signalling mediated by branched ubiquitin chains
Branched ubiquitin chains are complex molecular structures in which two or more ubiquitin moieties are attached to distinct lysine residues of a single ubiquitin molecule within a polyubiquitin chain....
portlandpress.com
The Vatican reclaims its title as the most densely pope-ulated country on Earth.