ZATELLITE: a toolkit to visualize and manipulate human centromeres in live cells using synthetic zinc fingers https://www.biorxiv.org/content/10.64898/2026.08.04.742839v1
Sylvia Erhardt
@erhardtlab.bsky.social
Centromeres, Repetitive RNAs, Epigenetic inheritance and everything chromatin-related. Professor @ kit.edu/. Love my girls and running hills. She/Her. Personal account (views are mine).
These two reviews on centromeres and kinetochores in @natrevmcb.nature.com cap off @andrea-musacchio.bsky.social sabbatical at @stanfordbiochem.bsky.social from @valleefoundation.bsky.social. Long time in the making! Non-paywall versions rdcu.be/fxD9V, rdcu.be/fxEar
Structure and function of the centromere and inner kinetochore
Nature Reviews Molecular Cell Biology - The kinetochore is a macromolecular complex that assembles on centromeric chromatin and connects spindle microtubules to the chromosome. This Review...
rdcu.be
Japan has now joined Horizon Europe. Japan’s researchers can now partner with teams across the EU. Together, we will advance global research in health, digital technologies, and climate neutrality ↓ link.europa.eu/YP7MtB
Discovery of molecular glues that bind FKBP12 and structurally distinct targets using DNA-encoded libraries
Discovery of molecular glues that bind FKBP12 and structurally distinct targets using DNA-encoded libraries - Nature Communications
In this study, authors screen a 3.2 million member FKBP scaffold-directed DNA-encoded library and identify FKBP12-binding molecular glues for both bromodomain-containing protein 9 (BRD9) and quinoid d...
nature.com
Funded by CERN, an intergovernmental organization
Daniel Lakens@lakens.bsky.social · 5d agoLet's take Zenodo - the platform we will all use in the future to share our data (sorry, OSF). en.wikipedia.org/wiki/Zenodo A major investment from European science funding. John Arnold and the OSF is small potatoes compared to just this single infrastructure.
The #ISSCR2026 Anne McLaren Memorial Keynote is delivered by Azim Surani. Learn more about Azim's life and career in this @dev-journal.bsky.social interview by Ashley Moffett and @geraldinejowett.bsky.social.
An interview with Azim Surani
Professor Azim Surani is the Director of Epigenomics and Germline Imprinting at the Gurdon Institute in Cambridge, UK. He is this year's recipient of both the prestigious Kyoto Prize and the Paul Ehrl...
doi.org
Wie können wir die Wissenschaftsfreiheit gegen zunehmende Angriffe schützen? Ein neues Positionspapier einer DFG-Senats-AG zeigt auf, wie Resilienz von Wissenschaft & Wissenschaftssystem gestärkt werden kann & wie auch Politik, Wirtschaft & Gesellschaft unterstützen können: sohub.io/9tje
Meiotic CENP-C supports #centromere assembly and #kinetochore recruitment in #spermatogenesis. New study form Rachel S. Keegan, Dina Malkeyeva, Meg B. Weever, and Elaine M. Dunleavy @uniofgalway.bsky.social: rupress.org/jcb/article/... #CellCycle #CellDivision #Development #Meiosis #Drosophila
We are looking for someone to lead the new Facility for Protein Biochemistry & Biophysics at the MPI of Immunobiology and Epigenetics in Freiburg — please spread the word and apply if you are interested!
Max Planck Institute of Immunobiology and Epigenetics@mpi-ie.bsky.social · last mo.🚀 Job alert: We’re starting a new Facility – and you can lead it! The MPI-IE & @mariekeoudelaar.bsky.social are hiring a Head of Protein Biochemistry & Biophysics to launch and lead a brand-new Core Facility in Freiburg 🇩🇪. Once-in-lifetime-chance. Details ⬇️ jobs.ie-freiburg.mpg.de/jobposting/b...
Hey #nucleus nerds, the JCS Special Issue on the Cell Biology of the Nucleus is now live! This was a pleasure to co-edit with Megan King @luskinglab.bsky.social.
Journal of Cell Science@jcellsci.bsky.social · last mo.Our Special Issue: Cell Biology of the Nucleus is complete Explore our Toc: journals.biologists.com/jcs/issue/13... Our cover image shows the posteriorly positioned nuclei (Nup50-mCherry - pink) of notochord cells in Ciona embryos. See article by Peng et al. journals.biologists.com/jcs/article/...
Jeremy Hollis’ detective story on centromeric histone chaperones (HJURP/Cal1) is now published after peer review with a few extra goodies. @jeremyahollis.bsky.social @nlehrbach.bsky.social @cbmoens.bsky.social @irinakitop.bsky.social @basicsci.fredhutch.org www.science.org/doi/10.1126/...
Remote homology and functional genetics unmask deeply preserved Scm3/HJURP orthologs in metazoans
Animals encode a rapidly evolving, essential cell cycle gene previously thought to be absent.
science.org
Jeremy Hollis@jeremyahollis.bsky.social · 5mo agoWe have some genetic sleuth work to share with you! What started as a rotation project turned into nothing short of an amazing collaboration between 4 labs in the zoo that is @basicsci.fredhutch.org. We found an essential histone chaperone long thought to be missing in most animals 🕵️♂️ bit.ly/4uf8sxz
Nice article from The Scientist about the antibody "problem". www.the-scientist.com/altered-anti... @reeserichardson.bsky.social @sholtodavid.bsky.social @jwoodgett.bsky.social @mbonini.bsky.social @bwjones.bsky.social
Altered Antibody Validation Data on Vendor Sites Alarms Researchers | The Scientist
After several examples of undisclosed alterations in reagent suppliers’ antibody catalogues surfaced, researchers call for transparency to rebuild trust.
the-scientist.com
Desert Breath,1995-97, monumental land art, Eastern Sahara, Egypt, by Danae Stratou, Alexandra Stratou, Stella Constantinides, covering 25 acres of the Egyptian desert #WomensArt
I know it seems like a heretical idea, but one way to figure out if a preprint is really interesting (to you) is... to read the preprint. Then, in the spirit of sharing, send a note to authors: a simple kudos or a more detailed question. I do this a dozen times a year. It's awesome. Try it.
NO NO NO NO NO NO Ranking science with AI-based metrics is a slippery slope. Everyone should reject it right now.
Oded Rechavi@odedrechavi.bsky.social · last mo.Gloves are off! TODAY WE RELEASE THE 1% A list of the year’s very best papers 👇 (see thread)
Please share this gift article from The New York Times with friends, family, sceptics, and People who think that studying weird things is a waste of money. Then follow up with meaningful discussion about what I call 'free range science'. Free without subscription. www.nytimes.com/2026/06/20/o...
Opinion | The Science That Turned Lizard Venom Into GLP-1s Is Under Attack
nytimes.com
Excited to share this preprint!! with @brandonscooper.bsky.social and Bill Sullivan We tested whether endosymbiotic Wolbachia can alter host gene expression through chromatin modifications that persist from spermatogenesis to adulthood.
bioRxivpreprint@biorxivpreprint.bsky.social · 2mo agoWolbachia-induced cytoplasmic incompatibility produces heritable chromatin modifications that suppress position-effect variegation https://www.biorxiv.org/content/10.64898/2026.06.12.731975v1
Very pleased to have been part of this fantastic collaborative project. Read on if you want to know about what DNA methylation changes might be doing in aging.
Dan Sarni@dansarni.bsky.social · 2mo agoWhat if DNA methylation changes aren’t just ticking of our biological clock but rather the rust breaking the gears? Very excited to share our work - how DNA methylation contributes to stem cell dysfunction and aging, published in @natgenet.nature.com doi.org/10.1038/s415... #epigenetics #aging 1/11
Interactome mapping has been stuck at a few hundred baits over months. HIP-MS changes the regime: ~10,000 pulldowns/week at 500 samples/day, fully automated. A new era for interactomics — and a precursor to high-throughput proteomics writ large. 📄 doi.org/10.64898/202...
HIP-MS: An ultra-high-throughput, sensitive, and versatile affinity enrichment platform for static and dynamic interactome profiling
Although protein-protein interactions govern virtually all cellular processes, systematic interactome mapping by affinity enrichment mass spectrometry (AE-MS) is constrained by manual sample preparati...
doi.org
Happy to share my first publication in @nanoscale-journals.rsc.org from @kit.edu , based on my postdoctoral work ! Thanks @centersyngen.bsky.social for funding. Feel free to reach out if you find this work interesting. @erhardtlab.bsky.social pubs.rsc.org/en/content/a...
Structural dynamics in the CENP-A nucleosome impacted by protein-protein interactions with centromere protein N
Noncanonical nucleosomes at the centromere contain the histone variant CENP-A, playing a crucial role in chromosome segregation. CENP-A is highly regulated, including by the centromere protein N (CENP...
pubs.rsc.org
#postdoc #fellowship available in my lab (1year renewable) to investigate #chromatin mediated #epigenetic mechanisms of #sexbias in #autoimmunity and the role of long #mcRNA #XIST. Please RT!
If you see this image and think "ha, fly testis!", you know your stuff. If you also know how transcription clusters form and disperse during sperm precursor formation, maybe don't read our new Advanced Science paper, out today 😉 advanced.onlinelibrary.wiley.com/doi/10.1002/...
Deadline alert ⏰⌛- if you want to present a poster or short talk at our conference in September, please submit your abstract by next Sunday, June 14! The template is available for download on the conference website 👉tinyurl.com/rtg2355conf
RTG 2355@rtg2355.bsky.social · 3mo ago🎉Now OPEN FOR REGISTRATION - join us Sep 14-16 in Giessen for the RTG 2355 International Conference as we explore RNA’s critical functions! Register 👉tinyurl.com/rtg2355conf We have slots for short talks and a poster session in the "Palmenhaus", so submit an abstract to present your own work!
We are recruiting a Junior PI to join CRC 1664 @snp2prot.bsky.social, funded through the FEM POWER programme supporting women in STEM. own budget, a funded PhD position, outstanding infrastructure + supportive colleagues. More information: snp2prot.uni-halle.de/2026/06/05/j...
1/n What fraction of the human genome is essential for cells? Excited to share our preprint that explores this question by combining an unusual CRISPR system, phage promoters, and thousands of deletion launchpads. @sudpinglay.bsky.social @jshendure.bsky.social www.biorxiv.org/content/10.6...
