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Ewan Harrison

@ewanharrison.bsky.social

Microbiologist at the Wellcome Sanger Institute and University of Cambridge.

26 Posts361 Follower540 Folgt
Daniela Robles-Espinoza@daniela-oaks.bsky.social · 6mo ago

We are very happy to see our study finally appear online @nature.com! This has been work of nearly 10 years in collaboration with the National Institute of Genome Medicine 🇲🇽, the National Cancer Institute 🇲🇽, the @sangerinstitute.bsky.social and others ⬇️ www.nature.com/articles/s41...

Ancestry and somatic profile indicate acral melanoma origin and prognosis - Nature

Analysis of the somatic and transcriptomic profile of 123 acral melanoma samples from Mexican patients helps understand tumour origins and prognosis, and highlights the importance of including samples...

nature.com

John Lees@johnlees.bacpop.org · 7mo ago

Our new preprint which reimplements "the NFDS model" (of Corander et al) to forecast populations after vaccination as a compartmental model, and uses new bioinformatic tools to create and process the pangenome data We look at which surveillance strategies are best to correctly forecast changes

Leonie Lorenz@leonielorenz.bsky.social · 8mo ago

Very happy to share our preprint on a mathematical model for Streptococcus pneumoniae population dynamics after vaccine introductions. It's a reusable model that describes vaccine replacement dynamics and can help to determine strategies for genomic surveillance: doi.org/10.64898/2025.12.18.695090

Ewan Harrison@ewanharrison.bsky.social · 8mo ago

Great to share the latest work from our group and collaborators. First CARRIAGE study paper led by @drdaggarwal.bsky.social and the heroic efforts of Katie Bellis and Beth Blane in the lab plus all the team at @cambridge-ceu.bsky.social Huge thanks goes to the 22,000 participants of the study

Wellcome Sanger Institute@sangerinstitute.bsky.social · 8mo ago

People who persistently carry the bacterium Staphylococcus aureus have a much less diverse community of bacteria in their nose, while certain species may help keep it out. 🦠 These findings offer insight into who may be at higher risk of infection. 👇 www.sanger.ac.uk/news_item/la...

Josie Bryant@josiebryant.bsky.social · 8mo ago

Really pleased to share the first paper to come out of the lab. We found that hospital patients were frequently colonised with P. aeruginosa and that the same clone was shared between the gut and the lung. The phylogenies indicate that the clones moved from lung->gut www.nature.com/articles/s41...

High frequency body site translocation of nosocomial Pseudomonas aeruginosa - Nature Communications

Here, the authors report within-host diversity and body site translocation dynamics in hospital samples of Pseudomonas aeruginosa and reveal that body site sharing was likely due to within-patient tra...

nature.com

Josie Bryant@josiebryant.bsky.social · 10mo ago

New respiratory 🫁 infection and microbiomes conference in Hinxton with stellar line up of speakers. 🚨 Submit your abstracts now! 🚨 Please RT coursesandconferences.wellcomeconnectingscience.org/event/air-20...

AIR 2026: Genomic and Systems Approaches to Respiratory Infection, Microbiomes and Immunity — 20260211

Course exploring how genomics, microbiome profiling, and systems biology reshape our understanding of respiratory infections and immune dynamics.

coursesandconferences.wellcomeconnectingscience.org

Wellcome Sanger Institute@sangerinstitute.bsky.social · 10mo ago

Samples from 1917 have helped identify the genetic culprits responsible for the spread of treatment-resistant infections 🔎 By mapping plasmid evolution since the pre-antibiotic era, experts found that a minority of plasmids cause most of the multidrug resistance in the world 🧵

Carlos Serna@cserna.bsky.social · last yr.

Our paper “Global dissemination of npmA mediated pan‑aminoglycoside resistance via a mobile element in Gram‑positive bacteria” is now in @natcomms.nature.com. Part of my freshly defended PhD, so doubly happy! 😄🎉 🧵 (1/14) www.doi.org/10.1038/s414...

Global dissemination of npmA mediated pan-aminoglycoside resistance via a mobile genetic element in Gram-positive bacteria - Nature Communications

The authors investigate the distribution of the aminoglycoside resistance gene npmA in Gram-positive bacteria via a mobile genetic element, highlighting its global presence and cross-species transfer ...

doi.org

Pathoplexus@pathoplexus.org · last yr.

📢Today Pathoplexus announces the inclusion of 2 new viral pathogens: RSV (A & B) and HMPV. These respiratory viruses cause a serious health burden, particularly in infants & the vulnerable, & Pathoplexus aims to support sequence sharing to improve understanding & response. 1/4

Screenshot of the homepage of Pathoplexus, showing tiles to navigate to the supported pathogens CCHF, Ebola Sudan, Ebola Zaire, HMPV, Mpox, RSV-A, RSV-B, and West Nile virus.
Ewan Harrison@ewanharrison.bsky.social · last yr.

Happy to share our first preprint looking at the nasal microbiome in ~1000 healthy adults from the CARRIAGE study of 20,000 healthy blood donors to understand nasal colonisation by Staphylococcus aureus. Ten years in the making! doi.org/10.21203/rs....

The nasal microbiome redefines Staphylococcus aureus colonisation

Staphylococcus aureus colonises the nose in humans, with individuals defined as persistent, intermittent or non-carriers. Unlike the gut microbiome, the nasal microbiome has not been studied in large ...

doi.org

Gabriele Pollara@gpollara.bsky.social · last yr.

If you can't afford to use a diagnostic test, then its relative performance characteristics become irrelevant. Important issue raised re blood cultures 👇 @lancetmicrobe.bsky.social #ClinMicro #IDSky #AMR www.thelancet.com/journals/lan...

The cost of blood cultures: a barrier to diagnosis in low-income and middle-income countries

The recent Editorial by The Lancet Microbe, titled Rethinking blood culture, highlights the blood culture bottle shortage in the USA and the overreliance on single manufacturers.1 The shortages of blo...

thelancet.com

Kai Kupferschmidt@kakape.bsky.social · last yr.

There were more than 125,000 measles cases in the WHO European region in 2024 - the highest number since 1997! 38 deaths have been reported so far, every single one of them preventable. Worth remembering this also as we report on the measles outbreak in the US. 🧪 #IDsky

Kristian G. Andersen@kgandersen.bsky.social · last yr.

Weeks ago I highlighted the false balance of “if only scientists could communicate better”. One OpEd writer kindly reached out to me and I want to share my main response to them because I find it remarkable that people still can’t see what we are now all seeing has been under way for years. 🧵👇

Ewan Harrison@ewanharrison.bsky.social · 2y ago

Our paper investigating the mutational landscape during Staphylococcus aureus during colonisation is out now rdcu.be//d55l3 @fcic.bsky.social @sangerinstitute.bsky.social @ibv-csic.bsky.social University of Cambridge @julianparkhill.bsky.social

The mutational landscape of Staphylococcus aureus during colonisation

Nature Communications - The authors applied a genomic and evolutionary approach to study Staphylococcus aureus in host adaptation during colonisation revealing signals of adaption in metabolic...

rdcu.be