Enya Weidner

@eweidner1.bsky.social

PhD || neuroscience of emotions in Bielefeld || artist in Dortmund || birds

I've always found the AI obsession with "general intelligence" frustratingly incoherent and uncomfortable...I'm realizing that a large part of that stems from a eugenics fueled human obsession with "general intelligence" that is equally incoherent and uncomfortable...

angela zhou@angelamczhou.bsky.social · 3w ago

Man I got so much stuff to do I dont have the time to write a "Eugenics is bad. Factor analysis is useful sometimes. We shouldn't write papers that celebrate eugenics in the second paragraph, even if the rest of the paper is about something else"

Happy to share our newest preprint! I always wondered whether the (alleged) subcortical route of fear perception responds to newly acquired threat associations. Our research suggests that it does indeed, how cool! www.biorxiv.org/content/10.6...

Distinct visual pathways of threat retrieval in fear-conditioned faces

Numerous studies have demonstrated rapid (< 100 ms) visuo-cortical differentiation of threat-associated faces. This may be due to low-spatial frequency (LSF) visual information originating from magnocellular pathways. Yet it remains unclear whether potentially magnocellular fear signals extend beyond evolutionarily prepared emotional faces and whether they are subject to short-term neuroplasticity. If so, spatial frequency characteristics should modulate processing of faces with newly acquired threat-relevance. Furthermore, it is unknown whether sub-bands of the visual spectrum are associated with autonomic arousal. Using a differential fear-conditioning paradigm, this study tested whether early visual attentional capture, indicated by the P1 event-related potential component, prioritizes LSF information of threat-associated faces with neutral expressions. Additionally, it was tested whether such effects would be paralleled by threat signals in the skin conductance response (SCR). For contingency aware participants, stimulus ratings confirmed successful fear conditioning and participants showed a selective left-hemispheric enhancement of the P1 in response to LSF threat-faces. By contrast, CS differentiation in the SCR was not modulated by spatial frequencies but by stimulus duration, with longer CS presentations resulting in larger SCR to threat compared to neutral faces. For contingency unaware participants, trial-by-trial amplitudes of P1 and SCR were positively correlated. Data support the notion that magnocellular-cortical pathways adapt quickly to novel threat-associations and facilitate rapid threat retrieval even for perceptually neutral faces. However, at least in the short term, these signals do not necessarily associate with anticipatory arousal in SCR. ### Competing Interest Statement The authors have declared no competing interest.

biorxiv.org

New lab paper drop, this one has been a long time coming! Driven by Rob Aukema (now a postdoc with Kerry Ressler) this paper in Science Advances answered the lingering question of what role the amygdala plays in stress-induced neuroendocrine responses. www.science.org/doi/10.1126/...

A network of basolateral amygdala projection neurons contributes to stress-induced activation of the hypothalamic-pituitary-adrenal axis

A network of basolateral amygdala neurons, but not singular projections, contributes to the neuroendocrine response to stress.

science.org

How does human amygdala circuitry develop through adolescence to support affective and cognitive control processes? Excited to share recent work from my dissertation, now out in Cell Reports, that uses longitudinal, multimodal neuroimaging at 7 Tesla to answer this question! A 🧵 tinyurl.com/5aaf9fpv

Human amygdala nuclei show distinct developmental trajectories from adolescence to adulthood in functional integration with prefrontal circuitry

Ojha et al. use longitudinal 7 T neuroimaging to characterize distinct developmental trajectories of fronto-amygdala connectivity across nuclei through adolescence. They identify how age-related conne...

cell.com

This took a WHILE but here it is!! The last part of my PhD work is now published @commsbio.nature.com 🕊 We uncovered the temporal and spatial context that define the mTL's role in fear processing. Huge thank you to my co-authors, reviewers, editors, and participants 💖 rdcu.be/exQKb

Fear perception as a function of hemisphere- and time-specific dynamics in the medial temporal lobes

Communications Biology - Electrophysiology from resection patients reveals lateralized, temporally specific functions of the medial temporal lobes in fear perception: the right enhances early fear...

rdcu.be