New preprint out!🧬 How do cells keep replicated sister chromatids linked for DNA repair while folding 3D loops for gene expression? Extrusion folds DNA but separates sisters, while cohesion connects them, risking mutual interference. How do they coexist?🧵👇 🔗 doi.org/10.64898/2026.05.02.722390 1/6

81 years after Italy’s Liberation, the lesson remains unchanged: freedom is never guaranteed. Today more than ever before. Fascism belongs in the past only if we keep it there, through memory, vigilance, and action. La libertà va difesa ogni giorno. #25aprile #Liberazione

I am really happy to share this fantastic work by @mfdspicer.bsky.social (and just as honoured to be his desk neighbour!). A beautiful study showing how DNA fragments are contained in apoptotic cells to prevent their spread. Check it out!

Gerlich Lab@gerlichlab.bsky.social · 5mo ago

1/New preprint just dropped! 🔥🔥 We investigate how the genome is destroyed in apoptotic cells in a way that prevents DNA fragments from spreading beyond the dying cell 🧬⚰ Done here at @imbavienna.bsky.social & in the super @rcollepardo.bsky.social & Rosen labs: www.biorxiv.org/content/10.6...

I am excited to share the first paper from the Saldivar lab! A special thank you to all who contributed. Precise control of transcription condensates across S phase balances linker histone expression with DNA replication, ensuring genome stability: Molecular Cell www.cell.com/molecular-ce...

Precise control of transcription condensates across S phase balances linker histone expression with DNA replication, ensuring genome stability

Marmolejo et al. uncover transcription condensate dynamics at histone locus bodies across the cell cycle. These dynamics are governed by cell cycle (DDK and CDK1/2) and checkpoint (ATR-CHK1) kinases t...

cell.com

Please share! My group at @zmbp-tuebingen.bsky.social is offering a post-doctoral position (4 years). We look for a structural biologist with experience in Cryo-EM/Cryo-ET to investigate the mechanisms of host invasion by pathogenic fungi. Deadline February 28th! uni-tuebingen.de/universitaet...

The (Yoav) Voichek lab has opened its gates at the Weizmann Institute, and is actively recruiting students and researchers at all levels - come explore gene regulation and computational genomics in a fun, friendly sprouting lab 🤗🥼⚗️🧪 www.weizmann.ac.il/plants/voichek

SMC and recombination enthusiasts: we updated our work describing the loop extrusion properties of budding yeast condensin and its function in biasing donor usage for mating-type switching. Lots of cool new data, check it out! www.biorxiv.org/content/10.1...

Are you planning your summer ahead and are interested in immersing yourself in some intense weeks of research, science and fun? Then this might be for you: Check out the amazing summer course offerings @mblscience.bsky.social, including the #Zebrafish course! www.mbl.edu/education/ad...

Course Offerings | Marine Biological Laboratory

mbl.edu

New Online! Organization of replicated chromosomes by DNA loops and sister chromatid cohesion

Organization of replicated chromosomes by DNA loops and sister chromatid cohesion

Nature Reviews Molecular Cell Biology, Published online: 02 January 2026; doi:10.1038/s41580-025-00933-1Cohesin complexes regulate genome architecture through DNA loop extrusion and sister chromatid cohesion. The Review discusses how these two cohesin activities mediate the organization of replicated chromosomes and their segregation in mitosis and meiosis, DNA break repair, and age-related aneuploidy in oocytes.

bit.ly

We are looking for a Postdoc at the Center for Gene Expression in Copenhagen. Deadline for applications is the 11th of January. If you are interested in 3D chromatin, SMC complexes, and super-resolution microscopy, join us. www.nature.com/naturecareer...

Postdocs at Center for Gene Expression in Department of Cellular and Molecular Medicine - Copenhagen, Hovedstaden (DK) job with University of Copenhagen | 12849488

We are looking for 2 or more highly motivated postdocs interested in ribosome biology, 3D chromatin organisation, or regulation of protein turnove...

nature.com

🚨 Alarm!!! 🚨 AI/ML course for microscopy image analysis!!! 🧐 In 2026 at Janelia (@hhmijanelia.bsky.social), no tuition, housing and meals provided! Isn’t that borderline unbelievable?!? 20 students, ~14 TAs and lecturers 🗓️ June 4-18 2026 ✍️ Jan 15 2026 ✍️ 🔁 pls!! www.janelia.org/you-janelia/...

Deep Learning for Microscopy Image Analysis

Topics The following will be covered extensively during lectures, exercises, and project work: Image denoising and restoration (fully supervised and self-supervised) Image translation (e.g.,

janelia.org

1/ Can #Axolotls teach us new things about #HeartRegeneration? A great collaboration between Elly Tanaka and Miguel Torres labs. We’re happy to share our new work in which we ask how axolotls regenerate their hearts and could they help mammals with that? doi.org/10.64898/202...

a cartoon of an axolotl blowing a kiss with a heart in the background .

ALT: a cartoon of an axolotl blowing a kiss with a heart in the background .

media.tenor.com

Very happy to share my postdoc work (on preprint), where we try to understand a long-standing transcription-silencing paradox, and uncovered a hidden RNA decay arm of nuclear piRNA pathway, see detailed threads quoted from @juliusbrennecke.bsky.social

Julius Brennecke@juliusbrennecke.bsky.social · 8mo ago

Intrigued by a long-standing conundrum in small RNA biology—how nuclear Argonaute proteins silence transposons when they *need* target transcription for their own recruitment—we studied the piRNA pathway. And found a hidden RNA-decay axis from Piwi to the RNA exosome.

A major output of the 4D Nucleome project appeared today. This is the joint effort of many scientists working together and (publicly) sharing data and results for several years. We hope this is of interest to many genome biologists! www.nature.com/articles/s41...

An integrated view of the structure and function of the human 4D nucleome - Nature

The 4D Nucleome Project demonstrates the use of genomic assays and computational methods to measure genome folding and then predict genomic structure from DNA sequence, facilitatin...

nature.com

The last EDRA webinar of the year is today at 4 pm with Julian Stingele presenting the role of RNA damage in chemotherapy, followed by Andre Bortolini Silveira on BER and MMR converge, and Nicola Pietro Montaldo on Mitochondrial DNA Repair and Parkinson's Disease @edra-webinars.bsky.social

Extrusive and cohesive cohesin cooperate to repair double-strand breaks in DNA. Learn more in a new #SciencePerspective: https://scim.ag/3XKbhb6

A tale of two forms of cohesin in DNA repair

Extrusive and cohesive cohesin cooperate to repair double-strand breaks in DNA

scim.ag

Can one map the genome-wide binding (1) and its protein partners (2) simultaneously from the same sample? Yes, one can. with CUT&ID ✂️🪪 Spearheaded — singlehandedly — by @annanordin.bsky.social No need of transgenesis, cloning and overexpression. Check it out, it's fast and its works.

bioRxivpreprint@biorxivpreprint.bsky.social · 8mo ago

CUT&ID for simultaneous profiling of protein-DNA and protein-protein interactions https://www.biorxiv.org/content/10.64898/2025.12.11.693662v1

🚨New paper out! In our @MolCellNews paper, we solve a piece of the puzzle of how our genome folds. We found the two specific molecular "brakes" in the CTCF protein that stop DNA loop extrusion. One of the final pieces of my PhD! tinyurl.com/29uuc5by

this is amazing they show some compelling evidence for 3' to 5' translation #RNASky #RNABiology 🧪 www.biorxiv.org/content/10.6...

3' to 5' Translation of Circular RNAs?

For decades, the 5' to 3' direction of translation has been a central dogma of molecular biology. Here we present evidence that eukaryotic circular RNAs (circRNAs) can serve as templates for 3' to 5' ...

biorxiv.org

A key step towards human genome synthesis. With thanks to @wellcometrust.bsky.social @mrclmb.bsky.social #SynHG doi.org/10.1126/scie...

High-fidelity human chromosome transfer and elimination

The synthesis of human genomes and other gigabase-scale genomes will require new strategies. Here, we realized key steps in our pipeline for building synthetic human chromosomes. We established: (i) t...

doi.org

The Vienna BioCenter Summer School 2026 call is now open for talented undergrads, it's a great for those interested in graduate study in the life sciences. Daniel Gerlich from Institute of Molecular Biotechnology is recruiting! Please share https://training.vbc.ac.at/summer-school/

🚨 New Science paper from the Gerlich lab! The team shows how cohesin helps broken DNA find the right template: by opening local DNA loops to shrink the search area and by keeping the damaged strand close to its sister copy: science.org/doi/10.1126/science.adw0566

I am happy to share that my postdoctoral work in the @gerlichlab.bsky.social at @imbavienna.bsky.social is finally out 🎉! Our study reveals how cohesin guides focused and accurate homology search. Read more 👉 www.science.org/doi/10.1126/... Follow along for key insights and updates! 🧵

Cohesin guides homology search during DNA repair using loops and sister chromatid linkages

Accurate repair of DNA double-strand breaks (DSBs) is essential for genome stability, and defective repair underlies diseases such as cancer. Homologous recombination uses an intact homologous sequenc...

science.org

Registration is open!🧬 Join us at Egmond aan Zee (April 19–24, 2026) for the next DNA Repair Meeting. We have an amazing line-up of speakers. 📅 Deadline for early registration: Jan 10, 2026 🔗 dnarepairmeeting-egmond2026.com

Our Spatial Genome Organisation 2025 attendees! Fantastic presentations, discussions & collaborations have taken place over the past 2 days, with plenty more to come. Its been a pleasure working with Karim, Irene & Matthias, looking forward to what the future holds for this brilliant series. #SGO25

Thrilled to share this collaborative work, including our @gerlichlab.bsky.social, uncovering a fundamental charge-based principle of centromere positioning! Check it out 👇

Gerlich Lab@gerlichlab.bsky.social · 11mo ago

1/ New preprint alert! In collaboration between the Rosen, Redding, Collepardo-Guevara & Gerlich labs, we uncover a surprising principle of chromosome organisation: electrostatic repulsion positions centromeres at the chromosome surface during mitosis. 🔗 doi.org/10.1101/2025...

We found a new asymmetry in the large-scale chromosome structure: sister chromatids are systematically shifted by hundreds of kb in the 5′→3′ direction of their inherited strands! The work was led by Flavia Corsi, in close collaboration with the Daniel Gerlich lab. www.biorxiv.org/content/10.1... 1/

Delighted to share that the results of my main postdoc project are now published in @nature.com 🔗 doi.org/10.1038/s415...

Multigenerational cell tracking of DNA replication and heritable DNA damage - Nature

A multigenerational single-cell tracking approach provides a framework to dissect phenotypic plasticity at the single-cell level, offering insights into cellular processes that may resemble early even...

doi.org

Today marks the 80th anniversary of Italy’s Liberation Day, commemorating the end of the Nazi-fascist regime. The freedom we inherited must be protected every day, because fascism doesn’t belong in the past, unless we keep it there. La libertà va difesa ogni giorno. #25aprile #liberazione

Now with the proper working link, sorry for the trouble! doi.org/10.1101/2025...

Cohesin guides homology search during DNA repair via loops and sister chromatid linkages

Accurate repair of DNA double-strand breaks (DSBs) is essential for genome stability, and defective repair underlies diseases such as cancer. Homologous recombination uses an intact homologous sequenc...

doi.org

Federico Teloni@fedeteloni.bsky.social · last yr.

New preprint from the @gerlichlab.bsky.social @imbavienna.bsky.social! How do DNA breaks locate homology sites in the vast space of the human genome? We show how cohesin guides homology search for faithful repair! Read more 👉 https://doi.org/10.1101/2025.02.10 Follow along for key insights! 🧵