PLEASE SHARE! New job openings in my lab @zmbp-tuebingen.bsky.social. We have a broad interest into the mechanistic basis of how molecular complexes are rewired during cellular development in plants and during invasion by pathogens. 🌱🍄🔬 See details below 👇 #PlantSciJobs

Interesting. Full deletion of all introns in yeast was actually my project in the Staley lab, *20 years ago*. I actually found a bunch of phenotypes. We did this in collaboration with the Guthrie lab. www.cell.com/cell/abstrac...

A spliceosome-independent eukaryote generated by complete intron removal

Elimination of all spliceosomal introns reveals a spliceosome-independent eukaryote.

cell.com

Amazing #epigenetics #symposium at a great place #freiburg

Max Planck Institute of Immunobiology and Epigenetics@mpi-ie.bsky.social · 3w ago

Big conferences are impressive. But how often do you actually meet someone there? 🤔 The Epigenetics Meeting was created differently. We have a great line-up of speakers with exciting research topics, ample time for discussion, and very familiar setting. Join us now: events.ie-freiburg.mpg.de

Introns have a hidden regulatory role! 🧬🎉 Delighted to share our latest paper showing that inefficiently spliced introns and spliceosomal proteins direct RNA methylation, engaging RNAi to silence retrotransposons and regulate gene expression nature.com/articles/s41...

www.cell.com/molecular-ce... I'm happy to see our work published! If you are interested in transposons, transcriptional regulation and Pol III come and check it out 👀 🧫 🧬

ChAHP silences SINE retrotransposons by inhibiting TFIIIB recruitment

SINEs are short transposable elements that make up large fractions of mammalian genomes. Known to be transcribed by RNA polymerase III, their regulation has remained largely unexplored. Schnabl-Baumga...

cell.com

RNA can build. A short RNA self-assembles into a 60-subunit icosahedral cage like a viral capsid, but made entirely of RNA. The striking preprint also reveals a 57-nt RNA filament at ~2.7 Å. Congratulations, Lin Huang and colleagues! www.biorxiv.org/content/10.6...

Excited to share our new preprint led by Fred and me in collaboration with the archaeal community! We found that the molecular foundation of histone-based chromatin has pre-eukaryotic roots in Asgard archaea. (1/4) #ArchaeaSky www.biorxiv.org/content/10.6...

Emergence of histone-based chromatin complexity in Asgard archaea

The emergence of the eukaryotes coincided with the diversification of histone proteins and their post-translational modifications by enzymes that constitute the core of eukaryotic chromatin. Yet the e...

biorxiv.org

I am thrilled to share our paper out in @cp-cell.bsky.social : "Systematic Discovery of Pathogen Effector Functions across Human Pathogens and Pathways." (1/4) www.cell.com/cell/fulltex...

Systematic discovery of pathogen effector functions across human pathogens and pathways

The eORFeome, a large-scale collection of open reading frames encoding viral proteins and secreted bacterial and parasite effectors, enables functional genomics across diverse pathways and pathogens. ...

cell.com

🆕 publication! How do cells build their molecular machines? Tsimafei Navalayeu (Ameres lab) in @embojournal.org maps the stepwise assembly of the RNA exosome in mammalian cells, revealing the quality control mechanisms that ensure this essential complex is built correctly ➡️ tinyurl.com/84c2298e

Online Now: Longitudinal monitoring of cytoplasmic RBP-RNA interactions and transcriptome in living cells by engineered protein nanocages Online now:

Longitudinal monitoring of cytoplasmic RBP-RNA interactions and transcriptome in living cells by engineered protein nanocages

Hu et al. develop POND-seq, a nanocage-based strategy that exports RNA information from living cells without disruption. This approach enables repeated sampling of the same cell population to track transcriptome and RNA-protein interactions over time and supports scalable analysis of RNA-binding protein variants.

dlvr.it

The labs of Julius Brennecke and Clemens Plaschka reveal a molecular decision point that determines whether RNA molecules are exported for use or targeted for destruction. Now published in Nature: www.nature.com/articles/s41...

a small attempt to capture this enormous loss and what Greg meant and means to so many. www.cell.com/cell/fulltex...

Gregory J. Hannon (1964–2026)

Gregory J. Hannon passed away in April 2026 at the age of 61. A towering figure in modern molecular biology, Greg influenced remarkably diverse areas of science. His work reshaped our understanding of...

cell.com

📣 POSTDOC position available in the Feschotte Lab at Cornell to work on #TRANSPOSONS! More details below. Pls send informal application or inquiry ASAP by DM or email to cf458_at_cornell.edu. Pls spread the word 🙏 #TEsky www.thefeschottelabatcornell.com

We're happy to announce our new preprint! 🐸 easymode: general pretrained networks for cellular cryo-ET. Segment ~20 cellular features – ribosomes, microtubules, mitochondria, nuclei & more – with zero model training. 🔗 doi.org/10.64898/202... 🧵👇

Ida Jentoft won a Birnstiel Award for her outstanding doctoral research in 2023. Do you know an exceptional PhD student? The Birnstiel Award has an open call! 📅 Nominate by 30 June: https://www.imp.ac.at/achievements/birnstiel-award

Wrote a short piece on Transposable Elements as catalysts of evolutionary innovation for a forthcoming special issue of @naturerevgenet.bsky.social on, duh, Evolutionary Innovation! www.nature.com/articles/s41...

Transposable elements as catalysts of evolutionary innovation - Nature Reviews Genetics

In this Comment, Cedric Feschotte highlights evidence from diverse lineages showing that transposable elements are key drivers of evolutionary innovation, repeatedly introducing regulatory and coding ...

nature.com

Excited to share a preprint which is currently under revision! Together with the amazing @ymzhan.bsky.social in @patrick-cramer.maxplanck.de lab, we describe that the +1 nucleosome actively regulates the transition from transcription initiation to elongation www.biorxiv.org/content/10.6... 1/

#RIP Pierre Chambon (1931-2026) 1963 PARP 1970 RNA Pol II 1975 Nucleosome 1977 Split genes 1980 Promoter 1983 enhancer 1986 Nuclear receptor

If you want to know what 3′UTRs with long conserved sequence stretches do, check out our BioRxiv preprint doi.org/10.64898/202.... They form functional intermolecular 3′UTR-3′UTR interactions that enable co-folding of proteins to rapidly induce transcriptional programs.

🔬 Science came to life at the Long Night of Research 2026! With over 950 visitors at the @vbcscitraining.bsky.social, the Max Perutz Labs sparked curiosity with five interactive stations and more than 30 Perutz scientists on site. It was a night full of discovery and excitement ✨ (c) Zsolt Marton

In this interview, @juliabatki.bsky.social, FMI’s newest group leader, reflects on the early curiosity that drew her to science, why FMI is the right home for her lab, how studying cell clearance could help us understand disease, and her love of improv. www.fmi.ch/news-events/...

Curiosity, cell clearance, and improv: A chat with Julia Batki

In this interview, Julia Batki, FMI’s newest group leader, reflects on the early curiosity that drew her to science, why FMI is the right home for her lab, how studying cell clearance could help us un...

fmi.ch

Devastating to learn of Greg Hannon's passing, who made several seminal discoveries in the field of RNA. What a loss. www.cruk.cam.ac.uk/news/in-memo...

🔬 Passionate about RNA biology? Join the lab of @sebastianfalk.bsky.social for your Master's project to explore the function of proteins and protein complexes using cutting-edge biochemical, structural, and cell biology approaches ➡️ tinyurl.com/3k7upan4

ICYMI: New online! How classical genetics uncovered key determinants of TE silencing

Germ cells have their own versions of core transcription factors and fertility depends on them. We're hiring a PhD student to figure out how! 📢 Fly genetics + proteomics + genomics. Fully funded. Aarhus University 🇩🇰 Deadline May 1 👇 Please share with anyone who might be interested!

New #preprint 😍‼️ led by 2 incredible postdocs @ninizhani.bsky.social & Ranj Papareddy: transforming #UFMylation from a local ribosome rescue pathway to systems level regulator of mRNA splicing www.biorxiv.org/content/10.6... A short 🧵

New preprint from our lab! An H3.3 knockout does two things at once: it removes H3.3 from chromatin and destabilizes DAXX. We disentangle those functions and find that DAXX-mediated H3.3 deposition can be uncoupled from ERV silencing. www.biorxiv.org/content/10.6...

Which transcription factors control transposable element expression during zygotic genome activation? Gain-of-function screen by @metorrespadilla.bsky.social and coworkers identifies TBP as direct regulator of mouse endogenous retrovirus-like elements link.springer.com/article/10.1...

TBP regulates transposable element expression in early mouse embryos - The EMBO Journal

The activation of the embryonic genome is a crucial step in development. In addition to thousands of genes, many transposable elements (TEs) are robustly transcribed during early mammalian development...

link.springer.com

Online Now: LENG8 mediates RNA nuclear retention and degradation in eukaryotes Online now:

LENG8 mediates RNA nuclear retention and degradation in eukaryotes

Tian et al. identify LENG8 as a conserved RNA quality-control factor that prevents nuclear export of misprocessed mRNAs and noncoding RNAs. This study provides fundamental insight into how the surveillance machinery monitors RNA processing status to determine nuclear retention, degradation, or export.

dlvr.it

We are looking for a new group leader to join the IGH (Montpellier, France). I can’t wait to meet my future colleague! Apply :-) More infos here: igh.cnrs.fr/join-igh-as-...

Join IGH as Group Leader - IGH

The Institute of Human Genetics invites applications for a Principal Investigator position in its main research areas. Read more...

igh.cnrs.fr