Florian I. Schmidt lab
@fischmidtlab.bsky.social
Cell Biology meets Immunology and Virology, spiced up with nanobodies
To the leadership of the American Diabetes Association: Dear Mr. Henderson and Dr. Kalyani, By now, you have probably received plenty of missives about the police action against scientists and clinicians with your own organization at your national meeting. 1/
If you are interested in molecular regulation of innate immunity or nanobody technology, we have a few exciting postoc positions to fill in the Schmidt lab @unibonn.bsky.social in the context of @immunosens.bsky.social. Please share!
If you are interested in molecular aspects of innate immunity or nanobody technology, we have a few exciting postdoc positions to fill in the Schmidt lab @unibonn.bsky.social in the context of @immunosens.bsky.social. Please share!
This yearˋs Löffler-Frosch-Medal for his lifetime achievements and contributions to virology goes to our former president Prof. Ralf Bartenschlager @ciid-heidelberg.bsky.social @uniheidelberg.bsky.social! So greatly deserved, congratulations, Ralf! #gfv2026
We're thrilled to share the lab's latest publication demonstrating how caspase-4 and the non canonical inflammasome recognize cytosolic LPS by preferentially binding to the convex portions of membranes - both bacterial and micelles @cp-immunity.bsky.social www.sciencedirect.com/science/arti...
Caspase-4 binds to LPS membranes with positive curvature for non-canonical inflammasome activation
The non-canonical inflammasome, comprising caspase-4 in humans, initiates pyroptosis upon sensing cytosolic lipopolysaccharide (LPS) from Gram-negativ…
sciencedirect.com
Early weekend read: Our new review on #antiviral #inflammasomes spearheaded by Jennifer Wuerth with some recommendations for inflammasome detection is out! @unibonn.bsky.social @immunosens.bsky.social www.mdpi.com/1999-4915/18...
Cryo-EM structure reveals how influenza A virus NEP binds the viral polymerase at a regulatory hotspot, coordinating RNA synthesis and nuclear export. Fantastic collaboration with @loiccarrique.bsky.social and Jon Grimes. www.science.org/doi/10.1126/...
Ever wondered how you can specifically inhibit #AIM2 #inflammasomes? @y-m-tesfamariam.bsky.social generated inhibitory AIM2 #nanobodies to dissect inflammasome responses to #poxvirus infections in human #PrimaryCells @unibonn.bsky.social @immunosens.bsky.social link.springer.com/article/10.1...
Poxvirus dsDNA genomes differentially activate AIM2 or NLRP3 inflammasomes in human primary cells - The EMBO Journal
The innate immune system is known for its ability to recognize cytosolic DNA as evidence of infection, but detailed studies of this process have been mostly limited to mice and cell lines. To investig...
link.springer.com
Looking for passionate candidate to apply to PhD fellowship to University of Murcia call: www.um.es/documents/d/... Interested students contact me!
um.es
🚨 New in The EMBO Journal! Loss of BBS8 disrupts ciliary Hedgehog signaling, switching adipocyte precursors into fibrogenic cells—remodeling adipose tissue before obesity begins. 🔬 #BBS #cilia @for5547.bsky.social @sfb1454.bsky.social @batenergy.bsky.social 📄 www.embopress.org/doi/full/10....
BBS8-dependent ciliary Hedgehog signaling governs cell fate in the white adipose tissue | The EMBO Journal
imageimageDisruption of ciliogenesis in Bardet-Biedl syndrome (BBS) leads to obesity and disrupted adipogenesis. This study reveals that ciliary dysfunction in a mouse model of BBS induces a a cell fa...
embopress.org
Thrilled to start the 2nd Bonn #Organoid Day with more than 100 participants at @unibonn.bsky.social!
KSHV miRNAs target STING to evade innate immunity and facilitate KSHV lytic reactivation from latency @cp-cellreports.bsky.social www.cell.com/cell-reports...
David Liu @harvard.edu beautifully articulates the criticality of basic science funding for developing revolutionary therapeutics like life-saving base editors 👏 youtu.be/8YhJM6zxYDw?...
Breakthrough Prize-Winning Biochemist on the Deadly Cost of Funding Cuts | Amanpour and Company
YouTube video by Amanpour and Company
youtu.be
Hurray! ImmunoSensation will go on! 🥳 The @dfg.de just announced that ImmunoSensation3, focussing on Immune Diversity will be funded! Let us #celebrate 7 more years of #immunology in #Bonn 🎉 www.immunosensation.de/news/immunos...
Excellence Strategy Funds Bonn Cluster for Immune Research
The Bonn Cluster of Excellence ImmunoSensation will be funded for a further seven years as part of the Excellence Strategy of the German federal and state…
immunosensation.de
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This work was spearheaded by @florianngohr.bsky.social at @unibonn.bsky.social. He is an outstanding immunologist/virologist currently looking for #postdoc opportunities!
Florian I. Schmidt lab@fischmidtlab.bsky.social · last yr.Late #WeekendRead: We describe a novel reporter to visualize endogenous #inflammasome assembly. Suitable for cell lines, primary cells, and tissues as well as quantification by #microscopy and #flowcytometry. Happy to share. www.biorxiv.org/content/10.1...
Late #WeekendRead: We describe a novel reporter to visualize endogenous #inflammasome assembly. Suitable for cell lines, primary cells, and tissues as well as quantification by #microscopy and #flowcytometry. Happy to share. www.biorxiv.org/content/10.1...
Let's not forget that apart from science advocacy the Rauch lab also does kick-ass science! Together with the @psmitchej.bsky.social and Tait Wojno labs, we show that #tuftcells can induce specific protective signaling after recognition of intracellular bacterial infection via the #inflammasome!
Journal of Experimental Medicine@jem.org · last yr.First authors Madeline Churchill and Ankit Pandeya @nkeet50.bsky.social from @rauchlab.bsky.social show that tuft cells, known for their role in anti-parasite defenses, can also contribute to anti-bacterial responses in the small intestine. rupress.org/jem/article/... #InfectiousDisease
