Our method of identifying Highly Cited Researchers includes not only publication and citation counts but other considerations such as researchers’ community-wide impact, their contemporary influence and the production of original research. #HighlyCited2025 clarivate.com/academia-gov...

Honored to be selected as #HighlyCited2025 researcher by @clarivateag.bsky.social. Grateful for my present and past lab members, institutions and funding agencies who make our work possible. @um.es

Clarivate for Academia & Government@clarivateag.bsky.social · 9mo ago

Did you know? Our #HighlyCited2025 list names 6,868 individuals with 7,131 Highly Cited Researcher awards. For deeper insight into the list, read our 2025 Analysis: clarivate.com/highly-cited...

Honored to be selected as #HighlyCited2025 researcher by @clarivateag.bsky.social. Grateful for my present and past lab members, institutions and funding agencies who make our work possible. @um.es @erc.europa.eu @horizoneu.bsky.social @umudivulga.bsky.social clarivate.com/highly-cited...

Today we announce the Highly Cited Researchers 2025 list—celebrating 6,868 individuals from over 1,300 institutions across 60 countries. #HighlyCited2025 Read the full press release: clarivate.com/news/clariva...

#ToPrimeOrNotToPrime, this is the question! Excited for our new review @cp-trendsimmuno.bsky.social with @oceanedufies.bsky.social in which we discuss what is “priming” for the #NLRP3 #inflammasome & how we can harness this knowledge to better control human diseases! #InflammasomePower! #Free 👇👇👇

#Nature #NewsFeature 7 basic science discoveries that changed the world. Ozempic, MRI machines and flat screen televisions all emerged out of fundamental research decades earlier. www.nature.com/articles/d41... cc @lluismontoliu.bsky.social

#InflammasomePower! 💥New paper alert💥 How is NLPR3 primed & activated in chronic non-communicable inflammatory diseases? With @oceanedufies.bsky.social &co we show that chronic exposure to oxPAPC drives NRF2 activation that primes & activates NLRP3 sustaining #atherosclerosis in mice & humans! 👇👇👇

Chronic sensing of host-derived lipids is an all-in-one signal that primes and activates NLRP3.

Activation of the NLRP3 inflammasome leads to the production of bioactive interleukin (IL)-1β fostering atherosclerosis. The current dogma is that NLRP3 must be first primed by microbial stimuli, know...

biorxiv.org

#SpookyInflammasome 🎃 With @lozanzi.bsky.social &co, we show that sustained NRF2 activation by endogenous oxidized phospholipids primes and activates the NLRP3 inflammasome 🔥 to drive atherosclerosis. ... more to come on the priming !

Ivan Zanoni@lozanzi.bsky.social · 9mo ago

#InflammasomePower! 💥New paper alert💥 How is NLPR3 primed & activated in chronic non-communicable inflammatory diseases? With @oceanedufies.bsky.social &co we show that chronic exposure to oxPAPC drives NRF2 activation that primes & activates NLRP3 sustaining #atherosclerosis in mice & humans! 👇👇👇

Thank you to our editor, Kirsty Minton, and the staff at NRI for the opportunity to share our thoughts on this emerging topic.

Nature Reviews Immunology@natrevimmunol.nature.com · 9mo ago

NEW Perspective by @alazozcan.bsky.social, Tommaso Vicanolo, Veronique Angeli, Yuval Rinkevich & @drusqui.bsky.social presents a model of immune cells as architects of tissue barriers, by depositing matrix components or by interactions with structural cells and the ECM #structuralimmunity #immunosky

Fantastic new story @jkagan1.bsky.social & friends showing that human dendritic cells can become hyperactive activating the inflammasome without dying, & that this approach can be used in mice and NHPs to potentiate anti-influenza vaccine responses! 👇👇👇

Jonathan Kagan@jkagan1.bsky.social · 11mo ago

An NLRP3 stimulatory universal influenza vaccine. We report an NLRP3 stimulus that generates hyperactive dendritic cells (hDCs). journals.asm.org/doi/10.1128/...

Looking for passionate candidate to apply to PhD fellowship to University of Murcia call: www.um.es/documents/d/... Interested students contact me!

www.linkedin.com/posts/albert...

Intrahepatic donor microbiota-based metataxonomic signature detected in organ preservation solution enables prediction of short-term liver transplant outcomes | Alberto Baroja-Mazo

Thrilled to share that our latest work has just been published in Gut 🚀 We show that donor intrahepatic microbial DNA signatures, detected in organ preservation solution, can predict post-transplant o...

linkedin.com

Cheng, Qiu et al @jhu.edu provide new insights into the molecular mechanism of #phagosome maturation and the dynamics of host defense response following phagosome-mediated bacterial degradation in peritoneal #macrophages. rupress.org/jem/article/... #InnateImmunity #inflammation #InfectiousDisease

So excited that this study is now online! It's been a pleasure to work with BioAge Labs and our collaborators on this story. We characterise a new class of #NLRP3 inhibitors with translational potential for so many inflammatory diseases.

Journal of Experimental Medicine@jem.org · 11mo ago

#NLRP3 is a target for antiinflammatory therapies & can be inhibited by the tool compound MCC950. Wilhelmsen, @colllab.bsky.social et al characterize new small-molecule inhibitors, BAL-0028 & BAL-0598, that have a distinct mechanism of action & binding site. rupress.org/jem/article/... #Inflammasome

#NLRP3 is a target for antiinflammatory therapies & can be inhibited by the tool compound MCC950. Wilhelmsen, @colllab.bsky.social et al characterize new small-molecule inhibitors, BAL-0028 & BAL-0598, that have a distinct mechanism of action & binding site. rupress.org/jem/article/... #Inflammasome

Review @natimmunol.nature.com The expanding role of the NLRP3 inflammasome from periodic fevers to therapeutic targets www.nature.com/articles/s41...

#InterferonPower! Thrilled for our latest work @cp-cell.bsky.social! With @danielboehmer.bsky.social, we dug into tons of papers & created what we hope will be a go-to resource for immunologists & non-immunologist about type I, II, III (& IV😉) #interferons! Free👉 authors.elsevier.com/a/1leKGL7PXu...

🚨It’s out @embojournal.org 🚨 Cardiolipin inhibits Caspase-4/11! Huge thanks to my brilliant supervisors Kate & Pablo, to @s-burgener.bsky.social & Mercedes and all the @inflammasomelab.bsky.social, it was a joy working and laughing with you, and to @brozlab.bsky.social & Si Ming lab.

Broz Lab@brozlab.bsky.social · last yr.

Congrats to @malvinapiz.bsky.social and @inflammasomelab.bsky.social on their new paper on the role of cardiolipin in non canonical inflammasome activation. We’re happy to have contributed to the story 🎉🦠!! www.embopress.org/doi/full/10....

Have you ever wondered whether pyroptotic corpses have functions beyond the grave? We made the surprising discovery that pyroptotic corpses are flagged by #filopodia to alert #DendriticCells they need autopsy. A short Bluetorial (1/13)👇with movies! Link: rdcu.be/d2mjm

Pyroptotic cell corpses are crowned with F-actin-rich filopodia that engage CLEC9A signaling in incoming dendritic cells

Nature Immunology - Pyroptotic cell death results in inflammation. Here the authors find that F-actin-rich structures formed during macrophage pyroptosis persist after cell death to activate...

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