Happy to share the first preprint from our lab, led by @arrosan.bsky.social, in collaboration with @ccb-lab.bsky.social. We identify a conserved cohesin-interacting motif in Red1 required for its recruitment, DSB formation, and Mek1 activation. www.biorxiv.org/content/10.6... #meiosis #recombination

Cohesin–axis interaction via a conserved Red1 motif promotes domain-specific DSB formation and Mek1 activation

Faithful chromosome segregation during meiosis I requires tight control of interhomolog recombination. In budding yeast, the meiotic chromosome axis, built on Rec8-containing cohesin together with Red...

biorxiv.org

Fantastic work coming out of Neil Hunter’s lab! www.nature.com/articles/s41...

Protecting double Holliday junctions ensures crossing over during meiosis - Nature

Conditional ablation experiments show that key components of the synaptonemal complex protect double Holliday junction recombination intermediates to ensure their resolution into crossover products, which are required for accurate chromosome segregation during meiosis.

nature.com

Paper alert! 📢 How do cells strike the perfect balance during meiosis? ⚖️ A new study from the Matos lab in @natureportfolio.nature.com uncovers how Holliday junctions and the synaptonemal complex safeguard crossovers ➡️ tinyurl.com/2k4mmpzu @univie.ac.at @meduniwien.ac.at

🚂 The T2T train keeps rolling: "The formation and propagation of human Robertsonian chromosomes" with Gerton and Garrison labs is out! What's a Robertsonian chromosome? Let Jen tell you herself in this great video, or read our paper: [1/3] 📺 youtu.be/JmlY5omxQVc 📄 www.nature.com/articles/s41...

How Stowers Scientists Found the DNA Site Where Robertsonian Chromosomes Fuse

YouTube video by Stowers Institute for Medical Research

youtu.be

Delighted to finally announce a preprint describing the Q100 project! “A complete diploid human genome benchmark for personalized genomics” For which we finished HG002 to near-perfect accuracy: www.biorxiv.org/content/10.1... 🧵[1/14]

A complete diploid human genome benchmark for personalized genomics

Human genome resequencing typically involves mapping reads to a reference genome to call variants; however, this approach suffers from both technical and reference biases, leaving many duplicated and ...

biorxiv.org

Transcription and recombination are two universal DNA-dependent processes, but how they are coordinated remains largely unknown. Here we characterized transcription-recombination priority rules in yeast. 🧵 www.embopress.org/doi/full/10....

A project five years in the making, we've now published complete "T2T" genomes for six additional ape species! It turns out that finishing (and analyzing) six genomes is slightly more work than one... doi.org/10.1038/s415...

Check this out if you ever wondered what intercellular bridges might be doing during meiosis! Happy to have played a small role! Congrats!!! @thejainlab.bsky.social

Devanshi Jain@thejainlab.bsky.social · 2y ago

For my first science post here, I’m proud to advertise our latest work exploring why germ cell connectivity is really important for meiosis 🐁 Done with some awesome colleagues @florpratto.bsky.social www.nature.com/articles/s41...

This is an important shift - the long awaited new Ensembl web site is ready for beta testing - is smooth, scrollable genome loveliness +clean views of the complex information - but @ensembl.bsky.social needs your help to get all the use cases out. Come to the webinar, and check out beta.ensembl.org

Ensembl@ensembl.org · 2y ago

Join us for our first webinar of 2025, where we will introduce you to the new Ensembl browser and demonstrate how to navigate the website to retrieve genomic data. Registration is free but essential: tinyurl.com/4bb4m8e4 #Bioinformatics #Ensembl #EMBL-EBI @training.ebi.embl.org

Excited to share the first paper from my lab 🤩 - a great collaboration with Dani Fachinetti lab - we discover a #mechanosensitive nuclear envelope #checkpoint that arrests cells directly post chromosome mis-segregation rdcu.be/d5AC9 👇🧵 #cancer #mechanics #p53 #chromatin

Happy new year to all! I am delighted to say that our new preprint went on @biorxiv-genetic.bsky.social today! The work was a labor of love for Mercedes Carro from my lab and Alexis Dzuibek from Andrew Grimson's lab - congrats to all! #meiosis #meiosis4eva #RNA biorxiv.org/cgi/content/...

Argonaute proteins regulate the timing of the spermatogenic transcriptional program

Argonaute proteins are best known for their role in microRNA-mediated post-transcriptional gene silencing. Here, we show that AGO3 and AGO4, but not AGO2, localize to the sex chromatin of pachytene sp...

biorxiv.org

Home sweet home... New Year in the summer! #puntadeleste #uruguay

New preprint! How does meiosis work in non-model organisms? Together with Susana Coelho at the MPI for Biology Tübingen @mpi-bio-fml.bsky.social , we took a look at the proteins of the meiotic axis in the brown alga Ectocarpus www.biorxiv.org/content/10.1...

Exploring Meiosis in Brown Algae: Meiotic Axis Proteins in the model brown alga Ectocarpus

Most extant eukaryotic systems share core meiosis-specific genes, suggesting meiosis evolved only once in the last eukaryotic common ancestor (LECA). These genes have been characterized as master regu...

biorxiv.org

Uff Botafogo! 1 player down, 2 goals up! #CopaLibertadores

2024 Mid-Atlantic Meiosis Mini-Symposium!! 🐭🪱🪰🧬🦠Co-organized with @scienceleah.bsky.social and @florpratto.bsky.social at NIH. Amazing talks from trainees and new PIs🎉 #meiosis4eva

Crossover recombination between homologous chromosomes in meiosis: recent progress and remaining mysteries. #CrossoverRecombination #Chromosomes #Meiosis #TrendsInGenetics www.cell.com/trends/genet...

Crossover recombination between homologous chromosomes in meiosis: recent progress and remaining mysteries

Crossing over between homologous chromosomes in meiosis is essential in most eukaryotes to produce gametes with the correct ploidy. Meiotic crossovers are typically evenly spaced, with each homolog pa...

cell.com

The Chromosome Biology Department of @raphmercier.bsky.social here at the Max Planck Institute for Plant Breeding Research Cologne (@maxplanck.bsky.social) is looking for a new group leader! jobs.mpipz.mpg.de/jobposting/8... #PlantScience #PlantSciJobs #GroupLeader #NewPI #PlantChromosomalBiology

Group Leader Position in Plant Chromosome Biology (m/f/d)

jobs.mpipz.mpg.de

Fantastic resource for bio icons: NIH Bioart Source Build figures, presentations, and illustrations with 2,000+ science and medical art visuals. This collection of high-quality, scientifically accurate vectors, #icons, and brushes is freely available within the public domain. bioart.niaid.nih.gov

It's #InternationalNachoDay! This graphic on kitchen chemistry hacks in @cenmag.bsky.social features tips on making a creamy nacho sauce as well as a guac that doesn't brown: cen.acs.org/food/food-sc...

🧪What a beautiful work has just been published. This study reveals the mechanisms behind egg release during ovulation. Looking at those images and videos is like visiting a museum. Pure art! 🔗 www.nature.com/articles/s41...

Picaña al gancho! Not many grilling days left this year...

“I quickly learned most undergraduates in my classes still hold the pre-Lewontin belief that human genetic variation predominately sorts geographically. Many students also thought race was based in genetic differences & that single mutations could explain complex traits in humans”

People Are Not Peas—Why Genetics Education Needs an Overhaul

The dated genetics taught in U.S. schools stokes misconceptions about race and human diversity. A biological anthropologist calls for change.

sapiens.org

Two new chapters from my free online book in human genetics out this weekend! These complete Part 3 of the book, on human population structure and history: 3.3: Human prehistory [separate thread] 3.4: Ancient DNA: a genetic time capsule [this thread] web.stanford.edu/group/pritch...

Jonathan Pritchard@jkpritch.bsky.social · 3y ago

I'm delighted to release the first half of my new textbook in human genetics: web.stanford.edu/group/pritch... "An Owner's Guide to the Human Genome: an introduction to human population genetics, variation and disease"

The final program for the conference is now up: events.columbia.edu/cal/event/ev...

Molly Przeworski@mollyprz.bsky.social · 2y ago

Stream or attend a conference on Frontiers in Human Genetics at Columbia University (Oct 10 & 11), by registering here: events.columbia.edu/cal/event/ev...

So cool!

Adam Phillippy@aphillippy.bsky.social · 2y ago

"Epigenetic control and inheritance of rDNA arrays" New preprint from the T2T acrocentrics team! We find a tight link between methylation and transcription of the rDNAs, including the occasional silencing of entire arrays www.biorxiv.org/content/10.1...

A familial, telomere-to-telomere reference for human de novo mutation and recombination from a four-generation pedigree https://www.biorxiv.org/content/10.1101/2024.08.05.606142v1

A familial, telomere-to-telomere reference for human de novo mutation and recombination from a four-generation pedigree https://www.biorxiv.org/content/10.1101/2024.08.05.606142v1

Using five complementary short- and long-read sequencing technologies, we phased and assembled >95%

biorxiv.org

Insights into non-crossover recombination from long-read sperm sequencing https://www.biorxiv.org/content/10.1101/2024.07.05.602249v1

Insights into non-crossover recombination from long-read sperm sequencing https://www.biorxiv.org/content/10.1101/2024.07.05.602249v1

Meiotic recombination is a fundamental process that generates genetic diversity by creating new comb

biorxiv.org

Insights into gene conversion and crossing-over processes from long-read sequencing of human, chimpanzee and gorilla testes and sperm https://www.biorxiv.org/content/10.1101/2024.07.05.601967v1

Insights into gene conversion and crossing-over processes from long-read sequencing of human, chimpanzee and gorilla testes and sperm https://www.biorxiv.org/content/10.1101/2024.07.05.601967v1

Homologous recombination rearranges genetic information during meiosis to generate new combinations

biorxiv.org

Join the T2T consortium next Thursday, Apr 4, 12-4pm EDT for a webinar focused on the wet side of ultra-long read sequencing. We will have a half-day of seminars from top experts in the field sharing their advice plus a Q&A. Free and open to all. Register here: ucsc-seqtech-events.online

One of the perks of being at NIH! Peak blossom 🌸🌸!