La saliva, clave contra la alergia al cacahuete, según el hospital La Princesa y la Universidad de Canadá: okdiario.com/salud/saliva...

Alergia al cacahuete: la ciencia mira a la boca para frenar la enfermedad

La saliva, clave contra la alergia al cacahuete, según el hospital La Princesa de la Comunidad de Madrid y la Universidad de Canadá

okdiario.com

Muy agradecidos a El Mundo por divulgar nuestro trabajo en @cp-cellhostmicrobe.bsky.social donde demostramos que #bacterias orales degradan #alérgenos alimentarios, modulando respuestas #IgE y #anafilaxia. www.elmundo.es/ciencia-y-sa...

Una bacteria de la saliva 'protege' de la alergia al cacahuete, destruyendo en la boca las proteínas dañinas

Dos personas alérgicas a un mismo alimento pueden tener reacciones de diferente intensidad. Lo que una tolera sin problemas, en otra desencadena una fuerte respuesta. Entre las...

elmundo.es

Excessive #inflammation? We uncover @cp-immunity.bsky.social that #IFN-I via #ISG15 in macrophages lowers #mitochondrial membrane potential, boosts #efferocytosis, and self limits #ISG amplification: a built in brake that promotes resolution. Open-access: www.cell.com/immunity/ful... #immunosky

🧵 1/6 Vaccinating allergic patients carries risks: the patient’s IgE recognizes allergen extracts and can trigger severe adverse reactions. To address this, Dr. Roy Patterson (1970s) proposed an innovative approach: modifying the extracts by polymerizing them with glutaraldehyde.

Preprint: Type I IFN activates border-associated macrophages to drive MHC-I–dependent immune surveillance after stroke www.researchsquare.com/article/rs-8...

@salva-iborra.bsky.social and Co in @jem.org elegantly sow that plasmacytoid DCs expand tissue-resident memory CD8+ T cell responses during viral reinfection rupress.org/jem/article/...

My main PhD paper is finally out! 🎉 After ~5 years, it’s published today in 𝘕𝘢𝘵𝘶𝘳𝘦 𝘐𝘮𝘮𝘶𝘯𝘰𝘭𝘰𝘨𝘺. @natimmunol.nature.com It all started with an unexpected observation 🔍: 👉 Mice lacking the dendritic cell receptor DNGR-1 developed tumours earlier ⏩ and more frequently 📈 than wild-type mice. 1/11 🧵

On the use of murine models: Results should be interpreted with caution. Batf3-deficient mice have been traditionally used as a model to study the function of cDC1; however, this transcription factor seems to play other essential roles in other immune populations👇

Pedro Papotto@ph-papotto.bsky.social · 8mo ago

Isn't this the coolest Christmas present (or miracle) for a #gdTcell aficionado?! Our latest preprint showing the role of BATF3 on gd T cells is ou on bioRxiv: www.biorxiv.org/content/10.6...

Isn't this the coolest Christmas present (or miracle) for a #gdTcell aficionado?! Our latest preprint showing the role of BATF3 on gd T cells is ou on bioRxiv: www.biorxiv.org/content/10.6...

BATF3 controls the homeostatic maintenance and function of innate-like γδ T cells

γδ T cells compose an evolutionarily conserved lineage of lymphocytes, with both adaptive- and innate-like characteristics, contributing to tissue homeostasis, immune surveillance, and rapid responses...

biorxiv.org

Qian Zhang et al. @casanovalab.bsky.social @rockefeller.edu report a fatal case of avian #influenza #H5N1 infection caused by autoantibodies neutralizing type I IFNs. These rogue autoantibodies are common, especially in elderly people. rupress.org/jem/article/... (1/2) 🧵 👇

Feel better during the day than at night during #influenza? Find out the “Role of IL-10 signaling in the #circadian control of host response to influenza infection” www.mucosalimmunology.org/article/S193...

mRNA vaccines 💉don't cause death but prevent it Massive study from France showed that mRNA vaccines reduced deaths and saved lives @mahmoudzureik.bsky.social @jama.com jamanetwork.com/journals/jam...

Fascinating study revealing how NK cells can eliminate intracellular E. coli infecting the urothelium. -Just a comment on the NK depletion experiment, NK1.1 is also expressed by ILC1s, NKT and most γδ T1 cells (IFN-γ producers).

Waggoner Lab@labwaggoner.bsky.social · 8mo ago

Autophagy-driven MHC-I downregulation enables NK cell-mediated clearance of intracellular uropathogenic E. coli in urinary tract infection www.tandfonline.com/doi/full/10....

👇No os lo perdáis! Hoy, a las 19:00 h, Oscar Palomares hablará en Allergotrends (Inmunotek) sobre los"Avances en inmunidad innata entrenada en inmunoterapia específica de alérgeno: Vacunas bacterianas para la prevención y tratamiento del asma alérgica". eventos.quodem.com/allergotrend...

Gracias @larazonlr.bsky.social ! Por hacerse eco de nuestra investigación. www.larazon.es/salud/que-ma...

¿Por qué es más difícil reinfectarnos de un virus que ya hemos tenido?

Científicos españoles descubren cómo refuerza el sistema inmunitario la defensa del organismo frente a patógenos como la gripe

larazon.es

..cross your 't's folks.. here's how! www.nature.com/articles/s41...

Guidelines for T cell nomenclature - Nature Reviews Immunology

This Consensus Statement clarifies the existing subset-based nomenclature for T cells. Furthermore, it proposes an alternative modular nomenclature that is designed to be brief and flexible and to avo...

nature.com

Delighted to have written this Insight article together with @victor-bosteels.bsky.social and Will Stainier about a cool new story by Tam et al. And with a title to honour Jason Cyster’s heritage.

Rockefeller University Press@rupress.org · 9mo ago

Insights @jem.org: Bosteels, Stainier, and @reisesousalab.bsky.social highlight work by Tam et al. (rupress.org/jem/article/...) revealing that GPR34, a lysophosphatidylserine receptor, promotes apoptotic cell uptake and cross-presentation by type 1 #DendriticCells. rupress.org/jem/article/...

In @jem.org, Hernández-García, Iborra and colleagues show that #plasmacytoid dendritic cells amplify the response of tissue-resident memory CD8⁺ T cells (#Trm) during viral reinfection, enhancing local #antiviral protection. rupress.org/jem/article/... #MucosalImmunology

pDCs amplify tissue-resident memory CD8+ T cell responses during viral reinfection @jem.org rupress.org/jem/article-...

Excited to share our new paper in @jem.org! 🎉 We reveal a key mechanism showing how tissue-resident memory CD8⁺ T cells (#Trm) amplify antiviral protection during reinfection. #immuno 🧵👇1/6

Journal of Experimental Medicine@jem.org · 8mo ago

Hernández-García, Iborra and colleagues show that #plasmacytoid dendritic cells amplify the response of tissue-resident memory CD8⁺ T cells (#Trm) during viral reinfection, enhancing local #antiviral protection. rupress.org/jem/article/... #MucosalImmunology

@biorxivpreprint.bsky.social TGF-β triggers IFN-λ from intestine plasmacytoid DCs at homeostasis, contributing to tonic localized innate immune responses www.biorxiv.org/content/10.1...

Aemet confirma que la ola de calor de agosto ha sido la más intensa desde que hay registros

Aemet confirma que la ola de calor de agosto ha sido la más intensa desde que hay registros

La Agencia de Meteorología española advierte de que los datos registrados y las previsiones hasta el día 31 de este mes hacen prever que este será uno de los veranos más calurosos de la historia. "¿Y ...

eldiario.es

Our latest review: Inborn errors of immunity affecting the MHC class I pathway for antigen presentation url: rupress.org/jhi/article/...

David Sancho@sancholab.bsky.social · last yr.

💥 A gut microbe metabolite that drives #atherosclerosis? Yes—Imidazole propionate (ImP) triggers vascular inflammation without changing cholesterol. 🧪 We show the pathway—and how to block it. nature.com/articles/s41... #OpenAccess at @Nature @CNIC_CARDIO #CVD #immunosky #cardiosky #microbiomesky

🧬 A new study by David Sancho at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) links the gut-derived metabolite imidazole propionate (ImP) to #atherosclerosis. The research explores ImP as a potential marker & contributor to early disease development. 👉 europa.eu/!wBktrm

Are you interested in antifungal immunity in the skin? Then, this postdoc position may be of interest to you 👇 #Immunology #immunosky

Neil Gow@neil-gow.bsky.social · last yr.

Please repost: We have a postdoc position in Antifungal Immunity Research available to study T cell responses and fungal sensitization in atopic dermatitis. @lableibundgut.bsky.social @neil-gow.bsky.social @mrccmm.bsky.social For more details, visit: jobs.exeter.ac.uk/hrpr_webrecr...

Wild mice reveal surprising immune system differences! 🐭🔬 Discover how wild mouse bone marrow composition contrasts with lab mice, unlocking new immunology insights. Read here: https://bit.ly/4jtlZeC #Immunology #InnateImmunity

I’m pleased to share my latest work, published in Science Advances. In this study, we investigated how fibroblastic reticular cells (FRCs) that populate the white pulp of the spleen regulate immune responses to viral infections. #immunology #immunosky www.science.org/doi/10.1126/...

Splenic fibroblastic reticular cells orchestrate dendritic cell maturation and facilitate CD8+ T cell priming and protective memory

Fibroblastic reticular cells of the spleen coordinate inflammation for optimal antiviral T cell responses and protective memory.

science.org

As the USA shuts down programs to develop HIV vaccines, we have exiting news from Australia of new work delivering RNA encoding bits of HIV to T cells #Immunosky 🧪🧵

Breakthrough in search for HIV cure leaves researchers ‘overwhelmed’

Exclusive: Melbourne team demonstrates way to make the virus visible within white blood cells, paving the way to fully clear it from the body

theguardian.com

More evidence of the link between microbiome and immune function as excess antibiotics impair response to vaccines in infants and those with Bifodibacterium in the gut did better with vaccine responses🧪

Neonatal antibiotics impair infant vaccine responses - Nature Reviews Immunology

A prospective observational study of human immune responses to vaccination after early-life antibiotic exposure shows that neonatal exposure reduces the immune response to several vaccine antigens and...

nature.com