Excited for this summer’s NYC Chromatin Club! Grad students & postdocs: submit your abstracts for a chance to present a poster or talk. Come connect w/ fellow epigenetic New Yorkers! #NYCChromatinClub @dshechter.bsky.social @vivrisca.bsky.social @epicypher.bsky.social @kjarmache.bsky.social

🚨 New meeting this fall in Brussels! 🚨 Cutting-edge science, amazing colleagues, & a RARE career development workshop for trainees-covering pharma, consulting, writing, start-ups & more 🤩 #epigenetics2025 Registration is open!! @epicypher.bsky.social xcellsconferences.com/epigenetics2025

NOAA Cuts Leave Wind Chimes As Sole Predictor Of Approaching Hurricanes

NOAA Cuts Leave Wind Chimes As Sole Predictor Of Approaching Hurricanes

SILVER SPRING, MD—As mass firings of career experts and scientists continued to roil the federal government, officials confirmed Friday that cuts to the National Oceanic and Atmospheric Administration...

theonion.com

Very sad to see that #RareDiseaseDay event at FDA-NIH has been cancelled. Cuts that limit rare disease research and cures (1) leave patients behind, and (2) forfeit precious opportunity to learn more about common human diseases. udnf.org/udnf-stateme...

Here we characterize PRDM10 as an essential maternal transcription factor and dissect its role in regulating oocyte maturarion and oocyte-to-embryo transition! On to the next! Congrats to Daniel Messerschmidt the true mastermind behind this work and the whole team! www.nature.com/articles/s41...

Maternal PRDM10 activates essential genes for oocyte-to-embryo transition - Nature Communications

The oocyte-to-embryo transition marks the beginning of development but the mechanisms underlying this process are incompletely described. Here they show that PRDM10 activates Septin11 and is required ...

nature.com

NYC!!! Start spreading the news, show up! If you can make it here, you'll make it anywhere! ! It's up to you, New York, New York!! www.eventbrite.com/e/stand-up-f...

Another article detailing anxiety among young researchers. Future careers are at stake with the US funding cuts, and talented young researchers are already being driven to pursue opportunities abroad. www.nature.com/articles/d41...

Postdocs and PhD students hit hard by Trump’s crackdown on science

As US federal grants remain frozen and budget cuts loom, anxiety and fear grip early-career researchers.

nature.com

Now more than ever the message is: this research can soon have an impact on people’s lives. Proud of this rewarding collaboration with former Sinai colleague @kimioishi and the whole #RNA modulation for therapeutics Lab (kudos to JinRong in particular!) www.journal-of-hepatology.eu/article/S016...

Developing splice-switching oligonucleotides for urea cycle disorder using an integrated diagnostic and therapeutic platform

Citrin deficiency (CD) is an autosomal recessive urea cycle disorder caused by biallelic loss-of-function variants in the SLC25A13 gene, leading to life-threatening hyperammonemia and hypoglycemia. Va...

journal-of-hepatology.eu

The Trump administration's efforts to slash research funding have US graduate students, postdocs and other early-career scientists fearing for their careers. Some might leave the country -- or abandon research altogether. https://go.nature.com/43ao2zq

Postdocs and PhD students hit hard by Trump’s crackdown on science

As US federal grants remain frozen and budget cuts loom, anxiety and fear grip early-career researchers.

go.nature.com

Celebrating the Nature Genetics manuscript on CRC OncoFetal reprogramming. Good to smile together and be reminded that what makes our jobs rewarding is being surrounded by talented smart people who are very committed to what they do! Especially in the current climate!

Epigenetics Update - Oncofetal reprogramming drives phenotypic plasticity in WNT-dependent colorectal cancer go.nature.com/40W2vry Slim Mzoughi and Ernesto Guccione reporting in Nature Genetics #Epigenetics #Cancer #Reprogramming --- Discover the Paired-tag breakthrough at epigenome.us

Donald Trump and Elon Musk’s idea of efficiency is stopping research on curing cancer.

What an amazing cover! Congrats @gloglita.bsky.social

❗Don't miss the Research Briefing❗ ⬇️ www.nature.com/articles/s41...

Oncofetal reprogramming induces phenotypic heterogeneity in colorectal cancer - Nature Genetics

Phenotypic plasticity of cancer cells is increasingly recognized as a mechanism of tumor escape from targeted therapies. Yet, the phenotypic heterogeneity of colorectal cancer remains poorly explored....

nature.com

📢ONLINE @naturegenet.bsky.social 📰Oncofetal reprogramming drives phenotypic plasticity in WNT-dependent colorectal cancer. By @sleemmz.bsky.social, @guccionelab.bsky.social and colleagues. ⬇️ www.nature.com/articles/s41...

Oncofetal reprogramming drives phenotypic plasticity in WNT-dependent colorectal cancer - Nature Genetics

Oncofetal (OnF) reprogramming, driven by YAP and AP-1, induces phenotypic plasticity and therapy resistance in WNT-dependent colorectal cancer (CRC). Targeting the OnF state in combination with chemot...

nature.com

1) Huge thanks to @guccionelab.bsky.social @nickbarker @marinelab.bsky.social @ggargiul.bsky.social @owensansom 4 the fantastic collaboration. NIH funding #EarlyStageInvestigator. Towards #BetterTherapeuticStrategies 4 #CRC patients #Oncofetal #CRC #IntratumoralHeterogeneity #PhenotypicPlasticity

Amazing to see this out. A mechanistic study with deep implications for future clinical work. Cannot be prouder.A huge thanks to all our collaborators an to Slim for driving this project www.nature.com/articles/s41... @sleemmz.bsky.social @ggargiul.bsky.social

Oncofetal reprogramming drives phenotypic plasticity in WNT-dependent colorectal cancer - Nature Genetics

Oncofetal (OnF) reprogramming, driven by YAP and AP-1, induces phenotypic plasticity and therapy resistance in WNT-dependent colorectal cancer (CRC). Targeting the OnF state in combination with chemot...

nature.com

First post on Bluesky: Finally out! If you look for a reliable reporter system for your Nucleic Acid Therapeutics needs, we got you covered! The NATURA system is available (Addgene or reach out). Congrats to Tommaso Tabaglio for leading this incredible effort! www.sciencedirect.com/science/arti...

Unveiling sequence-agnostic mixed-chemical modification patterns for splice-switching oligonucleotides using the NATURA platform

Chemical optimization of ribose has significantly advanced nucleic acid therapeutics (NATs) by improving the stability, specificity, and safety of the…

sciencedirect.com