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Parthive Patel

@gutstresslab.bsky.social

Patel lab, School of Cellular and Molecular Medicine, University of Bristol

37 Posts119 Follower 147 Folgt

Andrew Lin @andrewclin.bsky.social · 4w ago

We're hiring! Join us as a postdoc to study how the brain is optimised for sensory coding and memory Please spread the word! Apply at jobsite.sheffield.ac.uk/job/Research... Deadline: 5 October 2026 Learn more at: www.aclinlab.org

Research Associate: Neuroscience (2 Posts)

jobsite.sheffield.ac.uk

Junior European Drosophila Investigators @fly-jedi.bsky.social · 4w ago

Dear #Drosophila and #NewPI community, the mentee survey for this great mentorship program is still open!

Shefali@iamshef.bsky.social · 4w ago

Hey #Drosophila folks - the #flycross #mentee survey is open for #grad students, #postdoc and #pretenure faculty. ~95 mentors from across the world, with diverse expertise. The co-chairs @shyama13.bsky.social and @jocmcdonald.bsky.social have done a phenomenal work in taking the program forward 🎉

Parthive Patel @gutstresslab.bsky.social · last mo.

I am excited to share our work, recently published in PLOS Biology, in which we uncover a mechanism by which intestinal stem cells (ISCs) recognise pathogenic bacteria following infection and promote intestinal regeneration. journals.plos.org/plosbiology/...

Recognition of pathogenic bacteria by intestinal stem cells promotes adult Drosophila midgut regeneration

Bacteria infecting the intestinal epithelium are recognized by epithelial and immune cells, however the role of intestinal stem cells (ISCs) remains unclear. This study shows that adult Drosophila mid...

journals.plos.org

PLOS Biology@plosbiology.org · last mo.

Bacteria infecting the #intestine are recognized by epithelial and immune cells. This study by @gutstresslab.bsky.social shows that adult #Drosophila midgut intestinal stem cells recognize pathogenic bacteria via the PGRP proteins, promoting #regeneration. 🧪 #AcademicSky plos.io/3SuoWnG

Recognition of pathogenic bacteria by adult Drosophila intestinal stem cells shapes the regenerative microenvironment. Credit: Marie Srotyr.

This image can be published under the Creative Commons Attribution License, CC BY 4.0.

@bilderlab @bilderlab.bsky.social · 2mo ago

Now out in Annu Rev Cancer Biol: "Beyond Mice and Men." We think of cancer as a disease of humans, as well as pets 🐈‍⬛ 🐕 & lab mice. But cancer is found across the animal tree of life, including clams and fruit flies. Comparative oncology has a lot to teach us. 🧵 www.annualreviews.org/content/jour...

Beyond Mice and Men: Alternative Vertebrate and Invertebrate Models in Cancer Biology

While cancer looms large in the public and scientific minds, this can result in a quite narrow view of its range and manifestations. The centering of human clinical investigations and the popularity o...

annualreviews.org

François Leulier @francoisleulier.bsky.social · 2mo ago

Latest from the lab in its final form. We revisit the #Decretin concept in the light of growth adaptation to protein intake. PhD work of @longweibai.bsky.social at @igflyon.bsky.social #Drosophila

PLOS Biology@plosbiology.org · 2mo ago

Animals can modulate the pace of their #development when #nutrition is limited, but how? This study in #Drosophila larvae uncovers a nutrient-sensitive gut–brain endocrine circuit that slows development and enhances survival under fluctuating nutritional conditions. 🧪 #AcademicSky plos.io/4z9O8QG

Schematic model illustrating the gut–brain axis regulating larval adaptation to nutritional stress.
Compared with normal fed conditions, undernourished germ-free (GF) status or severe malnutrition associated with LpWJL induces Lst expression in a small population of midgut EECs. Once induced, gut-derived Lst acts systemically to suppress the circulating levels of dIlp2. This EEC-specific Lst up-regulation is triggered by reduced amino acid availability through a multi-organ relay involving the fat body and IPCs in the brain. Consequently, Lst orchestrates a feedback control loop that temporarily attenuates developmental progression upon sensing systemic nutrient shortages. This bidirectional gut–brain axis ultimately enables Drosophila larvae to preserve viability under severe nutritional stress. Created in BioRender. Leulier, F. (2026) https://BioRender.com/.

Parthive Patel @gutstresslab.bsky.social · 2mo ago

Excited to share our new work in The EMBO Journal! We show that intestinal stem cells directly sense tissue damage via phosphatidylserine on dying cells, activating Draper-Src-Shark-STAT signalling to drive their proliferation and shape local tissue responses to promote regeneration.

The EMBO Journal@embojournal.org · 2mo ago

Damage recognition by intestinal stem cells via Draper promotes adult Drosophila midgut regeneration Parthive Patel and coworkers @gutstresslab.bsky.social link.springer.com/article/10.1...

Irene Miguel-Aliaga @irenemiguel-aliaga.bsky.social · 2mo ago

Read about our latest work here www.cell.com/cell/fulltex... or let Alessandro tell you all about it (link below)!

The sex and reproductive plasticity of intestinal muscles instruct gut size

Adult intestinal size plasticity is driven not only by epithelial stem cells but also by remodeling of the surrounding visceral musculature. Sex- and reproduction-dependent muscle remodeling controls ...

cell.com

The Francis Crick Institute@crick.ac.uk · 2mo ago

“I believe my findings are just the tip of a bigger iceberg.” Read more about the work from Alessandro, a postdoc in our Organ Development and Physiology Lab led by @irenemiguel-aliaga.bsky.social, who studied changes in the female intestine during and after reproduction: https://bit.ly/4bElX2u

Bardin Lab @bardinlab.bsky.social · 2mo ago

A huge congratulations to Zheng and the entire Guo lab for this beautiful story! Very cool mechanism! www.nature.com/articles/s41...

Intestinal stem cells count self-renewal divisions to switch multipotency - Nature

In Drosophila, cell fate switching in adult intestinal stem cells is determined through an epigenetic mechanism in which these cells count divisions, switching from producing enterocytes to producing ...

nature.com

Perrimon Lab @perrimonlab.bsky.social · 3mo ago

New paper: Lipid metabolism of hepatocyte-like cells supports intestinal tumor growth in Drosophila. Huang K, Miao T, Chen Y, Dantas E, Sanford J, Asara JM, Moon SJ, Hu Y, Wang K, Han M, Goncalves M, Perrimon N. Nat Commun. 2026 Jul 3. doi: 10.1038 s41467-026-75074-w.

Irene Miguel-Aliaga @irenemiguel-aliaga.bsky.social · 3mo ago

Lab's latest: sculpting sex-biased metabolic territories in the intestine by tuning ploidy and lipid metabolism. Myc is to blame; Laura, Pedro and Chris found out www.cell.com/developmenta...

Myc sustains sex-biased organ zonation in the Drosophila intestine

Amourda, Blackie, Gaspar, et al. show that sex-biased activity of Dsx and Myc shapes intestinal zonation and lipid metabolism in Drosophila. Elevated Myc activity in female enterocytes increases ploid...

cell.com

Junior European Drosophila Investigators @fly-jedi.bsky.social · 7mo ago

Calling all #Drosophila #NewPI #researchers! A few spots remain for the upcoming JEDI Conference - and you won’t want to miss this! Every attendee gives a talk, making the exchange dynamic, personal, and highly interactive - all at a stunning venue that inspires collaboration and creativity.

View of the historic hotel Pousada Castelo in Palmela.

Fillip Port @crisprflydesign.bsky.social · 7mo ago

Join us in Heidelberg for your PhD! If you are excited about CRISPR genome engineering and would like to develop and apply new methods to investigate Wnt signaling in different model systems, than this project is for you. More info here: my-hbigs.uni-heidelberg.de/site/index.p... 🧪🧬🔬

Header image for the PhD position "Advanced genome engineering to investigate Wnt signaling in animals."

Rangan Lab @ranganlab.bsky.social · 7mo ago

Amazing new work from the Hurd lab:Sperm keep their mitochondria but lose their mitochondrial genomes. This new preprint identifies the nuclease responsible — and shows it reads DNA structure, not sequence. tinyurl.com/3npwwk37

tinyurl.com

Parthive Patel @gutstresslab.bsky.social · 7mo ago

A big thank you to Laura Buttitta @buttittalab.bsky.social and the Department of Molecular, Cellular and Developmental Biology at the University of Michigan for inviting me this week to present our lab’s work at the University of Bristol. I had a lovely visit.

Parthive Patel @gutstresslab.bsky.social · 7mo ago

Very proud of Martina Legido and Marie Srotyr from our lab for their excellent presentations of their work last week at the GSA Drosophila Research Conference (Dros26) in Chicago. 👏

Harmit Singh Malik @harmitmalik.bsky.social · 11mo ago

Are you an early-stage graduate student (2nd or 3rd year) or early-stage postdoc based in the US or Canada, working primarily in Drosophila? Would you like to help improve the experience of all trainees working in Drosophila research? If so, read on. (Please repost to reach a broad audience.)

Rachel Smith-Bolton @rachelsmithbolton.bsky.social · 9mo ago

I’d like to highlight @felicityhsu.bsky.social ‘s recently publish work in @dev-journal.bsky.social ! She showed that the regeneration blastema consists of concentric zones of differential growth and translation driven by Myc and Tor. journals.biologists.com/dev/article/...

Bardin Lab @bardinlab.bsky.social · 9mo ago

Happy 2026 everyone- the time has come to apply! Registration for this exciting Dev Bio conference is until the end of January!

Bardin Lab@bardinlab.bsky.social · 10mo ago

Come join us in beautiful Roscoff for this Conference Jacques Monod on Developmental regulation: from molecular to ecological niches May 18-22, 2026 Roscoff, France Abstract deadline: January 31, 2026 Apply here: cjm.sb-roscoff.fr/en

Giorgio Gilestro @giorgio.gilest.ro · 10mo ago

Want to carry a PhD in London, in one of the best Universities in the world? We have two calls for PhD students to join our lab at Imperial College. Deadline January 12th. More details for applications in the link below. Feel free to keep in touch!

Available Jobs – gilestro laboratory

lab.gilest.ro

Bardin Lab @bardinlab.bsky.social · 10mo ago

Mark Peifer (He, him)@peiferlabunc.bsky.social · 10mo ago

Drosophila colleagues--Please submit nominations for the Larry Sandler Award. which recognizes excellent recent graduates who have completed a PhD in Drosophila research. Details are below and at this link: genetics-gsa.org/drosophila-2...

The Larry Sandler Award recognizes excellent recent graduates who have completed a PhD in Drosophila research. The awardee will receive a fantastic opportunity to present the Larry Sandler Memorial Lecture at the 67th Annual Drosophila Research Conference in Chicago, IL!

The deadline to nominate is December 15, 2025.

Nominate Here
Eligibility
Any student completing a PhD in an area of Drosophila research between July 2024 and December 2025 is eligible. Students may be nominated by their thesis advisor, department chair, or supervisory committee member.

Nominations
Nominations may be submitted by the student’s thesis advisor, department chair, or supervisory committee member, and should include the following:
Nominee's CV
Nominee's thesis abstract of 1–2 pages
A nomination letter directly answering the following questions:
What are the main discoveries in the nominee's thesis?
What are the intellectual and experimental contributions of the nominee to the project?
How does the thesis work advance what was previously known in the field and to previous work from your lab?

Society for Developmental Biology @socdevbio.bsky.social · 11mo ago

✨A gut feeling you’ll love this one 🐛 The anterior midgut of a Drosophila melanogaster 🪰larva puts on a confocal glow show! 🟢 Adult midgut progenitors 🔴 Actin 🔵 Nuclei 📸Image by Sapna Krishnakumar #FluorescenceFriday #Microscopy #DevBio

Genetics Society of America @genetics-gsa.bsky.social · 11mo ago

Calling thesis advisors, department chairs, and supervisory committee members! 📣 Nominate an outstanding PhD/PhD candidate working with Drosophila for the Larry Sandler Award. They'll present at #Dros26. Learn more and submit a nomination: buff.ly/mtfDbBD @peiferlabunc.bsky.social

Bardin Lab @bardinlab.bsky.social · 12mo ago

Starting Monday!!! If you are in Paris, feel free to drop in for this exceptional course!

Bardin Lab@bardinlab.bsky.social · last yr.

Students (Master's/PhD), do not miss this fantastic Developmental Biology course of @sorbonne-universite.fr and @institutcurie.bsky.social - It is FREE and open to international students, however, room and board + travel are not included. training.institut-curie.org/courses/deve...

Liam Faller @liamfaller.bsky.social · 12mo ago

First ad for a position in my new lab at the University of Bristol! If you are looking for a fully funded PhD in cutting edge science that will be based in a supportive environment, and in a great city, check out the link below! www.findaphd.com/phds/project...

Funded PhD: Understanding the role of the ribosomal P-stalk in immune responses at University of Bristol on FindAPhD.com

PhD Project - Funded PhD: Understanding the role of the ribosomal P-stalk in immune responses at University of Bristol, listed on FindAPhD.com

findaphd.com

Bardin Lab @bardinlab.bsky.social · last yr.

The PhD work of @bboumard.bsky.social officially out in print! Happy to share this issue with our downstairs colleagues in the BDD @frelab.bsky.social @robinjournot.bsky.social www.cell.com/developmenta...

Cell-type-specific nucleotide sharing through gap junctions impacts sensitivity to replication stress in Drosophila

Boumard et al. demonstrate gap-junction-dependent tissue-scale nucleotide sharing, which impacts cellular sensitivity to perturbation of nucleotide homeostasis and replication stress. Drosophila wing ...

cell.com

Alex Gould Lab @alexgouldlab.bsky.social · last yr.

Passionate about doing a PhD on metabolism in neural stem cells and their niche? The call just opened for applications for a PhD position in our lab @crick.ac.uk in London. Please repost. tinyurl.com/ysnkdrmw

The Francis Crick Institute@crick.ac.uk · last yr.

Motivated graduates with backgrounds in biological or biomedical sciences, physics, chemistry, mathematics, engineering and/or computer science are invited to apply to our 4-year fully funded PhD programme. Apply by 05 November 2025 www.crick.ac.uk/careers-and-...

Parthive Patel @gutstresslab.bsky.social · last yr.

Thank you for hosting me! It was a lovely visit.

Development, Regeneration and Neurophysiology@drn-sheffield.bsky.social · last yr.

Today’s speaker in our DRN external seminar series is Dr Parthive Patel @gutstresslab.bsky.social (University of Bristol) Sponsored by the Physiological Society @physoc.bsky.social Host: Kyra Campbell @kyracampbelllab.bsky.social All welcome!

Mark Peifer (He, him)@peiferlabunc.bsky.social · last yr.

The community of Drosophila researchers is amazing, mutually supportive and collaborative. Right now a key resource for our community, @flybase.bsky.social , is threatened by the cancellation of its NIH grant and is seeking community help in raising short term funds 1/n 🧪 please share

Dear Fly Community,

In May 2025, the NIH terminated all grant funding to Harvard University, including the NHGRI grant that supported FlyBase. This grant also funded FlyBase teams at Indiana University (IU) and the University of Cambridge (UK), and as a result, their subawards were also canceled.

The Cambridge team has secured support for one to two years through generous donations from the European fly community, emergency funding from the Wellcome Trust, and support from the University of Cambridge. At IU, funding has been secured for one year thanks to reserve funds from Thom Kaufman and a supplement from ORIP/NIH to the Bloomington Drosophila Stock Center (BDSC).

Unfortunately, the situation at Harvard is far more critical. Harvard University had supported FlyBase staff since May but recently denied a request for extended bridge funding. As a result, all eight employees (four full-time and four part-time) were abruptly laid off, with termination dates ranging from August to mid-October depending on their positions. In addition, our curator at the University of New Mexico will leave her position at the end of August. This decision came as a shock, and we are urgently pursuing all possible funding options.

To put the need into perspective: although FlyBase is free to use, it is not free to make. It takes large teams of people and millions of dollars a year to create FlyBase to support fly research (the last NHGRI grant supported us with more than 2 million USD per annum).

To help sustain FlyBase operations, we have been reaching out to you to ask for your support. We have set up a donation site in Cambridge, UK, to which European labs have and can continue to contribute, and a new donation site at IU to which labs in the US and the rest of the world can contribute. We urge researchers to work with their grant administrators to contribute to FlyBase via these sites if at all possible, as more of the money will go to FlyBase. However, we appreciate that some fu…

https://wiki.flybase.org/wiki/FlyBase:Contribute_to_FlyBase

Our immediate goals are:

1. To maintain core curation activities and keep the FlyBase website online

2. To complete integration with the Alliance of Genome Resources (The Alliance).

Integration with the Alliance is essential for FlyBase’s long-term sustainability. For nearly a decade, NHGRI/NIH has supported the unification of Model Organism Databases (MODs) into the Alliance, which we aim to achieve by 2028. Therefore, securing bridge funding to sustain FlyBase over the next three years is crucial for successful integration and the long-term access to FlyBase data.

At present, our remaining funds will allow us to keep the FlyBase website online for approximately one more year. Beyond that, its future is uncertain unless new funding is secured. We will, of course, continue pursuing additional grant opportunities as they arise.

Given the uncertainty of future NIH or alternative funding sources, we are relying on the Fly community for support. Your contributions will directly help us retain the staff needed to complete this transition and to secure ongoing fly data curation into the Alliance beyond 2028.

We at FlyBase are incredibly grateful for the outpouring of support from the community during this challenging time. Your encouragement has strengthened our resolve and underscores how vital this resource remains to Drosophila research worldwide.

Sincerely,
The FlyBase Team

Elizabeth Rideout @ejrideout.bsky.social · last yr.

I watched the video and donated - it was super easy! Please donate if you’re able, and help spread the word so that we can keep this essential resource going.

FlyBase@flybase.bsky.social · last yr.

FlyBase needs your help! We ask that European labs continue to contribute to Cambridge, UK FlyBase, whereas US and other non-European labs can contribute to US FlyBase. For more information and how to donate: wiki.flybase.org/wiki/FlyBase...