For 40 years the 8-nt ‘Kozak Sequence’ was thought to mark sites of translation initiation. In a new study, we revise this model by identifying an ~80-nt sequence—the extended Translation Initiation Sequence (eTIS)— that guides ribosomes to correct start sites. 🧵 www.biorxiv.org/content/10.6...

Are you in years 3-8 of an independent faculty position? The Emerging Leader Award was built to give you the research runway you need. The award now offers $1M over 4 years and is open to investigators worldwide!🌎 Apply by April 30: themarkfoundation.org/emerging-lea... #ResearchFunding

Emerging Leader Award | The Mark Foundation for Cancer Research

themarkfoundation.org

There are Science papers and then there are *I just dropped and shattered my mug of coffee Usual Suspects style* Science papers www.science.org/doi/10.1126/...

Human DHX29 detects nonoptimal codon usage to regulate mRNA stability | @science.org www.science.org/doi/10.1126/...

Human DHX29 detects nonoptimal codon usage to regulate mRNA stability

Synonymous codon usage controls global gene expression in both prokaryotic and eukaryotic species. Nonoptimal codons are known to induce mRNA decay; however, the underlying molecular mechanism remains...

science.org

Mammalian cells form hibernating disomes akin to those in bacterial cells - but connected via ribosomal RNA www.science.org/doi/10.1126/... co-first with: @andschwarz.bsky.social with: @lea-dietrich.bsky.social, @sgiando.bsky.social, @erin-schuman.bsky.social and many more 🧵 0/6 #MolBio 🧪

We are recruiting a computational scientist for a postdoc position to work on detecting RNA modifications using nanopore sequencing: tinyurl.com/RiboComp Deadline March 4th. Please share and repost! More on the group: www.bric.ku.dk/research-gro...

Computational Postdoc in Ribosome Specialization at the Biotech Research and Innovation Centre

We are looking for a highly motivated and dynamic computational postdoc for a 3-year position to join the Lund Group. Our research Our team aims to understand h

tinyurl.com

Happy holiday ❄️⛄🎅! Global protein synthesis rates can fluctuate dramatically as a function of food intake, infections, energy resources, etc. Wondering whether/how protein elimination routes adapt to these changes to maintain proteome homeostasis ? Find out here: www.cell.com/cell-systems....

Vaults. They are cell biology's greatest puzzle! This preprint from Martin Beck's lab shows them docked on ER membranes with a ribosome inside. What on earth is going on there?? #CellBiology #WTFology www.biorxiv.org/content/10.6...

The vault associates with membranes in situ

The eukaryotic vault particle is a giant ribonucleoprotein complex that assembles into an iconic barrel-like cage. Its cellular function has remained elusive despite extensive characterization. Using ...

biorxiv.org

New preprint out! Our latest work on how ZAKα is activated by stalled or/and collided ribosomes is now online🎉. #Ribosome #RibotoxicStressResponse #ZAKα #Translation #mRNA www.biorxiv.org/content/10.1...

ZAKα is a sensor of mRNA stasis at the ribosomal exit channel

Despite a growing interest in the ribotoxic stress response (RSR), it remains unknown how the upstream p38 and JNK-activating MAP3 kinase ZAKα senses translational impairment. Combining Alphafold3 pre...

biorxiv.org

How does the kinase ZAK sense ribosome collisions? Find out in our latest collaboration with the @greenlab.bsky.social @doubleshuang.bsky.social @Vienna Huso: 1/4 rdcu.be/eRmJl #ribosome #cryoEM #LMU #JHMI

eIF2B Selectively Anchors and Activates Mutant KRAS www.biorxiv.org/content/10.1...

eIF2B Selectively Anchors and Activates Mutant KRAS

We demonstrate that the translation initiation factor eIF2B, best known for its guanine nucleotide exchange (GEF) function in mRNA translation initiation, also acts as a potent inducer of mutant KRAS ...

biorxiv.org

First ad for a position in my new lab at the University of Bristol! If you are looking for a fully funded PhD in cutting edge science that will be based in a supportive environment, and in a great city, check out the link below! www.findaphd.com/phds/project...

Funded PhD: Understanding the role of the ribosomal P-stalk in immune responses at University of Bristol on FindAPhD.com

PhD Project - Funded PhD: Understanding the role of the ribosomal P-stalk in immune responses at University of Bristol, listed on FindAPhD.com

findaphd.com

Colliding ribosomes are potent signals of cellular stress. But do cells use ‘programmed’ ribosome collisions to regulate gene expression? I’m excited to present a new story from my lab led by Frederick Rehfeld(@fred-rehfeld.bsky.social) which revealed that the answer is YES! Read on to find out how👇

Oxidative stress sensing by the translation elongation machinery promotes production of detoxifying selenoproteins

Selenocysteine, incorporated into polypeptides at recoded termination codons, plays an essential role in redox biology. Using GPX1 and GPX4, selenoenzymes that mitigate oxidative stress, as reporters,...

biorxiv.org

First ad for a position in my new lab at the University of Bristol! If you are looking for a fully funded PhD in cutting edge science that will be based in a supportive environment, and in a great city, check out the link below! www.findaphd.com/phds/project...

Funded PhD: Understanding the role of the ribosomal P-stalk in immune responses at University of Bristol on FindAPhD.com

PhD Project - Funded PhD: Understanding the role of the ribosomal P-stalk in immune responses at University of Bristol, listed on FindAPhD.com

findaphd.com

We have an exciting PhD opportunity to study ribosome hibernation in archaea using cryo-electron microscopy, tomography, microfluidics, omics, and confocal imaging. @daumlab.bsky.social, @lsiexeter.bsky.social Apply via: www.exeter.ac.uk/study/fundin... Any questions, IM me.

We’re excited to report work led by postdoc Jennifer Porat in the lab, finding that DNA accumulates on the surface of living cells and that the secreted extracellular protein DNASE1L3 can modulate its levels on B and T cells. With a new twist for ATAC-seq as well www.biorxiv.org/content/10.1...

DNASE1L3 surveils mitochondrial DNA on the surface of distinct mammalian cells

The extracellular space is a critical environment for discriminating self versus non-self nucleic acids and initiating the appropriate immune responses through signaling cascades to relay information ...

biorxiv.org

Ooohhh....GCN1 couples GCN2 to ribosomal state to initiate amino acid response pathway signaling | Science www.science.org/doi/10.1126/...

GCN1 couples GCN2 to ribosomal state to initiate amino acid response pathway signaling

During nutrient deprivation, activation of the protein kinase GCN2 regulates cell survival and metabolic homeostasis. In addition to amino acid stress, GCN2 is activated by a variety of cellular stres...

science.org

“Riding a bike is associated with a 19% lower risk of all-cause dementia and a 22% lower risk of Alzheimer’s disease, compared with taking nonactive travel modes such as a car, bus or train…” #ISOGG #DNA #epigenetics www.cnn.com/2025/09/20/h...

Cycling linked with lower dementia risk, study finds | CNN

Cycling instead of driving has been linked with a lower risk of dementia and Alzheimer’s disease, a large study has found.

cnn.com

Here's the latest from the lab! In it we dive into the role of ribosomal proteins in antigen processing and presentation! academic.oup.com/narcancer/ar...

Loss of ribosomal protein uL14 enables tumor escape from T cell immunosurveillance

Abstract. The presentation of peptides on HLA molecules is essential to CD8+ T cell responses. Here, we show that loss of uL14 significantly downregulates

academic.oup.com

Very cool stuff on the co-translational folding of dimers by Sander Tans and his team @amolf-nl.bsky.social: www.nature.com/articles/s41...

Co-translational ribosome pairing enables native assembly of misfolding-prone subunits - Nature Communications

Protein complexes are essential for cell function. Here, authors show that paired ribosomes can help each other’s nascent chains fold correctly, enabling proper dimer assembly and preventing misfoldin...

nature.com

'Cancer Research UK told The Observer that several pieces of research had been affected by...immigration costs, which have risen by 126% since 2019 and are up to 17 times higher than the average of comparable countries including France, Australia, the US and South Korea.' Not only cancer research.

Cancer research ‘set back years’ as visa fees drive scien...

With vital studies being shelved and foreign experts turning down jobs, leading charity urges ministers to act

observer.co.uk

This preprint from Helen Sakharova is one of the coolest things to come out of my lab: “Protein language models reveal evolutionary constraints on synonymous codon choice.” Codon choice is a big puzzle in how information is encoded in genomes, and we have a new angle. www.biorxiv.org/content/10.1...

Protein language models reveal evolutionary constraints on synonymous codon choice

Evolution has shaped the genetic code, with subtle pressures leading to preferences for some synonymous codons over others. Codons are translated at different speeds by the ribosome, imposing constrai...

biorxiv.org

In a new study by our @pelleeas.bsky.social, we reveal how Mrx4 organizes translational regulation of cytochrome b synthesis at the mitoribosomal tunnel exit. Thanks @kawresearch.bsky.social for funding and @stirlingchurchman.bsky.social for the fun collaboration! academic.oup.com/nar/article/...

A molecular switch at the yeast mitoribosomal tunnel exit controls cytochrome b synthesis

Abstract. Mitochondrial gene expression needs to be balanced with cytosolic translation to produce oxidative phosphorylation complexes. In yeast, translati

academic.oup.com

Here, we show that bacterial ribosomes—often viewed as conserved drug targets—actually vary across species due to extensive sequence variation in their drug-binding residues. In some cases, this divergence may lead to intrinsic drug resistance in certain bacterial clades: doi.org/10.1016/j.ce...

I'm reading the report behind these headlines about glyphosate and it may be the most scientifically illiterate thing I've come across (although it's a close thing with the recent MAHA report). 1/n

Identified in the 1970s, the precise molecular function of the alternative initiation factor eIF2A has remained unclear. Here, we map its interactome and uncover a surprising role in ribosome-associated quality control (RQC) upon ribosome stalling. 1/x www.biorxiv.org/content/10.1...

The alternative initiation factor eIF2A regulates 40S subunit turnover in ribosome-associated quality control

The noncanonical translation initiation factor eIF2A plays critical roles in diverse cellular processes, including the integrated stress response, neurodegeneration and tumorigenesis. However, the pre...

biorxiv.org

Delighted to share paper on translational activity of 80S monosomes across different tissues in 🪰 in @narjournal.bsky.social thanks to fabulous team Albert Blandy Tayah Hopes Elton Vasconcelos @amy-turner96.bsky.social Bulat Fatkhullin Michaela Agapiou Juan Fontana academic.oup.com/nar/article/...

Translational activity of 80S monosomes varies dramatically across different tissues

Abstract. Translational regulation at the stage of initiation can impact the number of ribosomes translating each mRNA molecule. However, the translational

academic.oup.com

🧵5 Top Free Alternatives to BioRender for Scientific Illustrations! These five websites offer free scientific illustrations for biologists. Great for presentations, research papers and other research communication needs. Save and share the post!

New paper from the lab! Want to know if there is a difference in ribosome collisions between your samples? We show that you can detect this in the rRNA reads in your ribosome profiling data. academic.oup.com/nargab/artic...

Detecting ribosome collisions with differential rRNA fragment analysis in ribosome profiling data

Abstract. It has become clear in recent years that ribosomes regularly stall during translation. Such translation impairment has many causes, including exp

academic.oup.com

ZNF574 is a quality control factor for defective ribosome biogenesis intermediates www.sciencedirect.com/science/arti...

ZNF574 is a quality control factor for defective ribosome biogenesis intermediates

Eukaryotic ribosome assembly is an intricate process that involves four ribosomal RNAs, 80 ribosomal proteins, and over 200 biogenesis factors that pa…

sciencedirect.com