Hannah Garner
@hannahgarner.bsky.social
Assistant Professor at McGill University/ Goodman Cancer Institute studying myeloid cells in breast and ovarian cancers. 🇬🇧 in 🇨🇦
Congratulations to the 2026 Terry Fox New Investigator Awardees! With $3.5M in support, they’ll launch labs, build research teams and advance bold ideas, from AI to next-gen mRNA tech, to transform how cancer is understood, prevented and treated. Learn more: www.tfri.ca/updates/news...
Excited to share this highlight of a beautiful study into how myeloperoxidase acts as a chromatin transformer
Trends in Immunology@cp-trendsimmuno.bsky.social · 9mo agoMyeloperoxidase transforms chromatin into an immune weapon #immunology
As a final note, this whole process is highly relevant not only for killing pathogens, but also in autoimmune diseases. We could also show that sputum of cystic fibrosis patients contains high levels of MPO functionalised NET-like structures.
Delighted to share that our work “Uridine Phosphorylase-1 supports metastasis by altering immune and extracellular matrix landscapes” was published today in @emboreports.org, describing how neutrophil metabolism influences niche priming to support metastasis (1/14) www.embopress.org/doi/full/10....
Uridine phosphorylase-1 supports metastasis by altering immune and extracellular matrix landscapes | EMBO reports
imageimageMetastatic primary tumours upregulate Upp1 in neutrophils, which elevates circulating uracil. UPP1-expressing neutrophils accumulate in the lung where they inhibit CD8+ T cells, promote fibr...
embopress.org
🥳🥳🥳Countless years in the making and there it is 🫶🏻 Exceptionally proud of my lab and especially Lance who was driving this project for the last years! 🏎️Thank you to all the fantastic collaborators ♥️ I hope everyone enjoys reading our little story! www.nature.com/articles/s41...
Response of spatially defined microglia states with distinct chromatin accessibility in a mouse model of Alzheimer’s disease - Nature Neuroscience
The dynamics of microglia states adjacent to or far from amyloid-beta plaques are unclear. Here the authors show that non-plaque-associated microglia modulate the cell population expansion in response...
nature.com
Are you an established PI that studies the human immune system and looking for a change of location? If the answer is yes, #McGill has an amazing opportunity to provide long-term funding at a world class institution. Apply now!!!! Please repost!!! mcgill.wd3.myworkdayjobs.com/en-US/McGill...
Canadian Excellence Research Chair (CERC) in Human Immunology
Please refer to the How to Apply for a Job (for External Candidates) job aid for instructions on how to apply. If you are an active McGill employee (ie: currently in an active contract or position at ...
mcgill.wd3.myworkdayjobs.com
Thank you to Lai Guan Ng and Lihui Dong for highlighting our work! www.cell.com/cancer-cell/...
Tumor neutrophils rewired from birth
Systemic responses during tumor progression reshape granulopoiesis. In this issue of Cancer Cell, Garner et al. show that tumor-derived signals reprogram neutrophil development early in myelopoiesis. ...
cell.com
Our latest work on how nerves safeguard lung fibrosis. Congrats to Dr. Hiroki and collaborators. @cp-immunity.bsky.social @kavithascranton.bsky.social @hotchkissbrain.bsky.social @ucalgary.bsky.social @ucalgarymed.bsky.social @libininstitute.bsky.social www.cell.com/immunity/abs...
Nociceptor neurons suppress alveolar macrophage-induced Siglec-F+ neutrophil-mediated inflammation to protect against pulmonary fibrosis
Sensory innervation impacts several lung diseases, but whether it influences pulmonary fibrosis (PF) is unclear. Hiroki et al. report that depletion of TRPV1+ nociceptors leads to worsening of inflamm...
cell.com
Une étude mené par @hannahgarner.bsky.social (ICG), montre que les précurseures des #neutrophiles reçoivent des signaux des tumeurs mammaires et aident les #métastases. Collaboration avec @nkinl.bsky.social, Moreno Martinovic, Karin de Visser et @dewitlab.bsky.social. Détails: tinyurl.com/4b5n5psu
Signaux longue distance et métastases de cancer du sein : une histoire de neutrophiles | Institut du cancer Goodman
Une nouvelle étude menée par Hannah Garner, Ph.D., nouvellement chercheuse à l’Institut du cancer Rosalind et Morris Goodman (ICG), publiée dans le journal Cancer Cell, a montré que les cellules...
tinyurl.com
A new study co-led by GCI member @hannahgarner.bsky.social showed how #neutrophil precursors receive signals from mammary tumours and promote #metastasis. Incredible collaboration with @nkinl.bsky.social, Monreno Martinovic, Karin de Visser and @dewitlab.bsky.social. Details: tinyurl.com/4c2snae6...
Long distance signalling and breast cancer metastatic spread: a neutrophil story | Goodman cancer Institute
A recent study from Hannah Garner, Ph.D. and new member of the Rosalind and Morris Goodman Cancer Institute (GCI), published in Cancer Cell, showed that neutrophil precursors located in the bone marrow receive signals from mammary tumours and promote metastasis.
tinyurl.com
💥 Really excited to say that our paper with Karin de Visser and @dewitlab.bsky.social is now online! A beautiful story to culminate years of great collaboration and teamwork at the @nkinl.bsky.social. A 🧵 www.sciencedirect.com/science/arti...
Understanding and reversing mammary tumor-driven reprogramming of myelopoiesis to reduce metastatic spread
Tumor-induced systemic accumulation and polarization of neutrophils to an immunosuppressive phenotype is a potent driver of metastasis formation. Yet,…
sciencedirect.com
#LocationLocationLocation! @labphan.bsky.social @ramadhenni.bsky.social Hoppé &co show @cp-cell.bsky.social that subcapsular sinus macrophages interact with memory B cells, positioning them in a subcapsular niche that favors their rientry in germinal centers & more rapid antibody responses!
Macrophages direct location-dependent recall of B cell memory to vaccination
Vaccines generate long-lived plasma cells and memory B cells (Bmems) that may re-enter secondary germinal centers (GCs) to further mutate their B cell…
sciencedirect.com
New evidence @nejm.org today that age-related clonal hematopoiesis (CHIP) has a driver role in evolution of solid cancers www.nejm.org/doi/full/10.... www.nejm.org/doi/full/10....
Clonal Hematopoiesis as a Driver of Solid Tumors | NEJM
Clonal hematopoiesis is the expansion of a genetically related population of hematopoietic stem and progenitor cells that disproportionately contribute to blood-cell production.1 Clonal hematopoies...
nejm.org
Online Now: The Terry Fox Research Institute Marathon of Hope Cancer Centres Network: A pan-Canadian precision oncology initiative
The Terry Fox Research Institute Marathon of Hope Cancer Centres Network: A pan-Canadian precision oncology initiative
The Marathon of Hope Cancer Centres Network (MOHCCN), led by the Terry Fox Research Institute and the Terry Fox Foundation, unites researchers, clinicians, patients, funders, and other partners across Canada to accelerate precision oncology, promote collaboration and data sharing, and ultimately improve patient outcomes. This overview outlines the Network’s goals, history, and challenges and opportunities. We also highlight progress toward the “MOHCCN Gold Cohort,” a shared resource of clinical and genomic data from 15,000 patients.
dlvr.it