🔬Check out this clever approach for 3D SMLM by Yoav Shechtman @technion.bsky.social and @gustavssonlab.bsky.social ... stunning images! 👉🏻 doi.org/10.64898/202...

Excited to see this collaboration now in print. Dye chemistry meets AI-designed proteins. Three small, orthogonal tags; lifetime modulation; split versions. Request the free dyes at dyes.janelia.org www.science.org/doi/10.1126/...

De novo design of orthogonal far-red, orange, and green fluorophore-binding proteins for multiplexed imaging

Fluorescent proteins and small-molecule dyes offer complementary advantages for biological imaging: proteins are amenable to genetic tagging, whereas dyes provide superior brightness and photostabilit...

science.org

We're thrilled to unveil our fantastic line-up of selected speakers for SMLMS 2026 at smlms.org Huge congratulations to them! 🎉 Missed the deadline? Good news! Registration and poster abstract submission have been extended until 31st July! 🔬✨

🚀 We're hiring! Join the founding Digital Twin Team at the SCALE Cluster of Excellence @goetheuni.bsky.social Apply by: 31 August 2026 For more information: scale-frankfurt.org/wp-content/u... Full position description: scale-frankfurt.org/wp-content/u... Descriptions below 🧵:

Juliette Griffié@juliettegriffie.bsky.social · 3w ago

🚨 Last day to register and submit abstract to SMLMS 2026. 🚨 More info at smlms.org Join us in Stockholm for some exciting science and fun!!

Interested in RNA and proteins? Perfect! 😀 We seek to fill a fully funded 3+ years PhD position for a project on pre-mRNA splicing regulation using structural biochemistry in combination with cell biology and bioinformatics. Find more information on our lab's homepage and get in contact via e-mail!

Interested in single molecule localisation microscopy? 🔬 Don't miss #SMLMS2026, hosted in by SciLifeLab, KTH and Stockholm University, with contributions from our Swedish NMI Node colleagues! 🗓️ August 26-28 in Stockholm 🇸🇪 More⤵️ smlms.org

👇🏻 don't miss this one if you're into single-molecule microscopy, computational/AI analysis tools and new discoveries in biology 🔬 www.smlms.org

Ricardo Henriques@henriqueslab.bsky.social · 2mo ago

SMLM people, ASSEMBLE!! 🔬 The single-molecule localization crowd descends on Stockholm this August (26-28). MINFLUX, DNA-PAINT, blinking dyes, the lot. Properly good line-up and registration's still open. Don't sit this one out 👇 smlms.org

How can a splicing factor bind to thousands of exons but regulate only a few of them? In our new preprint, we show that SRSF6 resolves this paradox through two distinct binding modes. @lab-nmr.bsky.social & @julianvonehr.bsky.social. Check it out: www.researchsquare.com/article/rs-9...

WORK: our Bionanoscience department at TU Delft is looking to hire an Assistant Professor in Biophysics of Living Systems. Apply! Deadline 30 July careers.tudelft.nl/job/Delft-As... RT=nice

Assistant Professor in Biophysics of Living Systems

Assistant Professor in Biophysics of Living Systems

careers.tudelft.nl

Just in time for the RNA localisation conference, we uploaded a manuscript describing the link between endosomal mRNA transport and local mitochondrial activity. Great collaboration during MibiNet www.biorxiv.org/cgi/content/... @mibinet.bsky.social #EMBOrnaLocalization

Excited that our work on versatile and scalable micromirror inserts that enable high-contrast and high-resolution single-objective light sheet microscopy in conventional sample chambers is now published in Nano Letters! doi.org/10.1021/acs.... @pubs.acs.org #soTILT3D #soLLS #microscopy #nanoscale

Versatile and Scalable Reflective Micromirrors for Single-Objective Light Sheet Microscopy

We present a tunable microfabrication pipeline for creating robust, reflective inserts that adapt conventional commercial imaging chambers for single-objective light sheet (LS) illumination. This system reduces the complexity associated with dual-objective LS setups and specialized LS chambers while retaining the native functionality and biocompatibility of the original chambers. The fabricated insert features a metalized, 3D nanoprinted micromirror with an angled reflective surface, enabling alignment of a thin LS for sectioning and imaging throughout mammalian cells. Using this pipeline, we demonstrate that single-objective LS illumination achieves an over 4X improvement in the signal-to-background ratio compared with conventional widefield epi-illumination in both fixed and live cell samples. Furthermore, we show substantial resolution enhancement for single-molecule localization microscopy compared to epi-illumination for improved imaging at the nanoscale. The versatile and scalable design offers an easily implemented approach to bring the benefits of single-objective LS microscopy to a wide array of biological studies.

doi.org

Seeking a post-doc for the LaJoie lab at the Human Technopole, Milan, Italy! We are looking for candidates from the fields of biochemistry, cell biology, and proteomics, who are interested in studying protein interactions of the nucleus 🤓 lnkd.in/dTG2CgXF

Make HDAC6 visible again! 6SiR-C3-NextA is a selective far-red probe for imaging endogenous HDAC6 in living cells across diverse mammalian cell types. Done by @vanthang.bsky.social at @mpi-nat.bsky.social Now in JACS @pubs.acs.org pubs.acs.org/doi/10.1021/...

📢 We are looking for a Junior Group Leader to join us at @institutcurie.bsky.social! Having joined the department just over a year ago, I can honestly say that it is an exceptionally stimulating and supportive scientific environment, filled with outstanding colleagues — all in the heart of Paris.

Want to build some of the most advanced light-sheet microscopes in the world to watch life assemble itself cell by cell? The Royer Lab @ Biohub is hiring an Optical Engineer (Advanced Light Sheet Microscopy). 🧪🔬💻🔧 #Hardware + #Python + Advanced #Optics job-boards.greenhouse.io/biohub/jobs/...

Optical Engineer, Advanced Light Sheet Microscopy

San Francisco, CA (Hybrid)

job-boards.greenhouse.io

🚨Our #NIMSB PhD fellowship call closes on Friday! We're recruiting for 5 fantastic PhD projects + welcome applicants from diverse backgrounds: #biologists #computerscientists #physicists #engineers If you want to work on cutting-edge science, we'd love to hear from you 🚀 👉https://sl1nk.com/vog901g

Estibaliz Gómez de Mariscal, PhD@gomez-mariscal.bsky.social · 3mo ago

Want to do a PhD in biomedical research and explore the exciting world of AI, microscopy and cell biology?👾🧠🧫🔬 In a research environment of high excellence🌟 and in beautiful Portugal🏄🌸? PhD fellowships are now open at #NIMSB from May-4 til June-5 👉 APPLY lnkd.in/eqkYreFi Reach out if interested!✉️

Thousandfold Expansion Microscopy https://www.biorxiv.org/content/10.64898/2026.05.31.729018v1

🔬👇🏻 cannot resist to re-advertise this meeting ... because it's just a great one.

SMLMS 2026@smlms2026.bsky.social · 3mo ago

🚨 Don't forget about our submission deadlines! Register now at smlms.org and don't miss the opportunity to connect with the SMLM community in Stockholm this summer.

We enjoyed putting our heads together with the Jakob and Freddolino labs to find that polyphosphate modulates the formation of functional RNA-protein condensates in response to nitrogen-starvation stress! journals.plos.org/plosbiology/...

Amazing job opportunity at Brandeis - we are looking for a new manager of our Light Microscopy Facility! Cool instruments, a great community to work with, lots of opportunities for growth - please circulate! brandeis.wd5.myworkdayjobs.com/en-US/Jobs/j...

Light Microscopy Facility Manager

The main purpose of this job is to bring cutting-edge light microscopy research approaches to Brandeis researchers and oversee the day-to-day operations of the Brandeis light microscopy facility. The ...

brandeis.wd5.myworkdayjobs.com

Great line-up, great science, great venue #IAC2026Oslo. Good to meet many colleagues again, and to get to know new. Looking forward to the next days & thanks to the organizers!

Marina García Macia@juanaloca2002.bsky.social · 2mo ago

We are starting this amazing meeting!! #IAC2026Oslo @arcticautophagy.bsky.social @womeninautophagy.bsky.social

Glycan Atlassing is online at @natnano.nature.com! Thanks to everyone involved, especially to @dijo-mj.bsky.social and @nazlicanyurekli.bsky.social who spearheaded the work. Read the paper here: dlvr.it/TSXNDb #Glycotime

Glycan atlassing enables functional tracing of cell state - Nature Nanotechnology

Multiplexed super-resolution microscopy of DNA-barcoded lectins and metabolically incorporated unnatural sugars quantitatively links the nanoscale spatial relationships of glycocalyx organization and ...

dlvr.it

Nazlican Yürekli@nazlicanyurekli.bsky.social · 3mo ago

Thrilled to announce that our paper on Glycan Atlassing is officially published in Nature Nanotechnology!🧬🍭 We developed "Glycan Atlassing," a method to map the glycocaly at nanometer resolution. This allows us to trace cellular states and opens new avenues for diagnostics and therapy..

Excited to share our latest work in @ScienceAdvances! 🔬 We’ve developed "dynaMIET"—a new spectroscopy technique that finally allows us to simultaneously measure 3D membrane dynamics in live cells with nanometer precision. www.science.org/doi/10.1126/...

Quantifying 3D live-cell membrane dynamics using dynamic metal-induced energy transfer spectroscopy (dynaMIET)

dynaMIET enables simultaneous measurement of lateral diffusion and vertical membrane fluctuations in live cells.

science.org

Congratulations to Soohyen Jang on successfully defending her doctoral thesis on #singlemolecule #biophysics! 🥳 We’re excited to celebrate her as the second doctoral graduate of the IMPRS-CBP! 🎉 👏 We warmly congratulate her on this important milestone! 🎓 #phd @heilemannlab.bsky.social #imprs_cbp

🎉 Congratulations, Dr. Soohyen Jang! 🎉 Soo established fluorophore-binding enzymes for single-molecule super-resolution microscopy 🙏 great collaborations @juliankompa.bsky.social @kjohnsson.bsky.social Yoav Shechtman @technion.bsky.social &🙏 grad school @imprs-cbp.bsky.social @goetheuni.bsky.social

We invented “triplet tumbling microscopy” (TTM) to track protein-protein interactions in living cells! Tag your protein with GFP and see it interact with *untagged* binding partners www.biorxiv.org/content/10.6...

www.cell.com/molecular-ce... check this beautiful paper

Alu repeat-containing RNAs spatially organize actively transcribed genomic regions around nuclear speckles

Liu et al. identify nuclear speckle-enriched Alu repeat-containing RNAs that facilitate the organization of actively transcribed genes at speckles by binding Alu sequences and promoting speckle assemb...

cell.com

(1/n) Super excited to share that our preprint is out today in @natsmb.nature.com with a new name "Integrated MINFLUX tracking reveals two distinct chromatin dynamics classes across cell types" and more than 2x more data: www.nature.com/articles/s41... See also MIT News news.mit.edu/2026/how-chr...

Anders Sejr Hansen@andersshansen.bsky.social · last yr.

(1/n) Thread @matteomazzocca.bsky.social @domenicnarducci.bsky.social Simon Grosse-Holz @jessematthias.bsky.social preprint Q: how does chromatin move? Using MINFLUX, SPT & SRLCI, we track chromatin dynamics across 7 orders of magnitude in time to provide answers www.biorxiv.org/content/10.1...

📣📣📣 We are recruiting a PhD student to join the Chromatin Biophysics team! 🧬🧬🧬 Apply below if you are interested in DNA-protein interactions on the single-molecule level. www.ru.nl/en/working-a... #phd #biophysics #chromatin

PhD Position: Single Molecule Biophysics | Radboud University

Do you want to work as a PhD Position: Single Molecule Biophysics at the Faculty of Science? Check our vacancy!

ru.nl