Yang et al. show that the secretory pathway kinase Fam20C is retained in the #Golgi via Fam20A-mediated membrane anchoring. Mislocalizing Fam20C alters #secretome phosphorylation, leading to reduced milk quality and subsequent growth retardation in pups. rupress.org/jcb/article/...

1/4 Thrilled to share our new paper on the role of ER-export in multiple myeloma (MM) published in @sigtrans-sttt.bsky.social www.nature.com/articles/s41... Thanks to editors and reviewers for a constructive process. Here is a thread to summarize the major findings #ER_literature #MultipleMyeloma

Targeting endoplasmic reticulum export disrupts metabolic resilience in multiple myeloma - Signal Transduction and Targeted Therapy

Signal Transduction and Targeted Therapy - Targeting endoplasmic reticulum export disrupts metabolic resilience in multiple myeloma

nature.com

Wir gratulieren den 18 aufstrebenden Spitzenforscher:innen, die heute ihre #ASTRA-Preise und damit insgesamt 22 Millionen Euro für Ihre Forschung erhalten! 🪘👏 Unter den Ausgezeichneten sind elf Frauen. 💪 Alle Infos 👉 www.fwf.ac.at/aktuelles/de...

18 FWF-ASTRA-Preise 2026: Eine Million Euro für internationale Forschungstalente in Österreich

Der FWF vergibt 18 FWF-ASTRA-Preise an herausragende Postdocs. Die mit jeweils rund einer Million Euro dotierten Förderungen stärken Spitzenforschung und helfen, internationale Talente für den Forschu...

fwf.ac.at

How do cells control formation of Golgi stacks upon demand? Roman Polishchuk, Franck Perez and collaborators identify a ‘Golgi regulon’ under control of the CREB3L1 transcription factor link.springer.com/article/10.1...

A coordinated transcriptional program controls de novo Golgi biogenesis - The EMBO Journal

The Golgi apparatus expands during differentiation and increased secretory demand, yet the transcriptional mechanisms governing its biogenesis remain poorly defined. To investigate this process, we de...

link.springer.com

Heidelberg University Biochemistry Center @bzh-hd.bsky.social is looking for a #professor of #biochemistry. Please spread the word‼️ www.bzh.uni-heidelberg.de

Scary how well I can relate

Markus Eichhorn@markuseichhorn.bsky.social · 3mo ago

Bingo! Do I win a prize now?

After a very intense and productive lab retreat with Felix Campelo @felixmendu.bsky.social we are now on my terrace in sunny Innsbruck coworking.

We offer a PostDoc position for a fully funded project on lipid-encoded #lipidtime protein quality-control checkpoints at the Golgi: great collaborators, excellent working & living conditions & benchspace with a view ;) Please share and repost!

Postdoc job alert at Institut Jacques Monod in Paris! Interested in fundamental membrane trafficking? We seek a postdoc to study collagen secretion as a model for core principles of how cells and their environment build each other. emploi.cnrs.fr/Offres/CDD/U...

New preprint from @kutseikin.bsky.social showing how pharmacologic inhibition of SLC33A1 activates IRE1/XBP1s signaling. w/ @enriquesaez.bsky.social @chrisgparker.bsky.social @landerlab.bsky.social @forlilab.bsky.social & the Birsoy lab (Rockefeller) Check it out👇 www.biorxiv.org/content/10.6...

Cdc42 is a small GTPase crucial for #CellPolarity, but how does it contribute to #aging when upregulated? This study shows that the ER-anchored chaperone Ydj1 interacts with Cdc42, enhancing its stability & partitioning during asymm #CellDivision & aging in yeast @plosbiology.org 🧪 plos.io/4qz7WaM

Camouflaged nanorobots target and regulate macrophage subcellular organelle crosstalk patterns to promote neural regeneration. Interesting paper on tagelang Ero1 in macrophages by nanorobots. 🤔 rdcu.be/e3Uxw

Our new paper's out: FidlTrack—structure-aware single-particle tracking benchmarks/boost SPT fidelity With it we resolve with sub-organelle res. e.g. BACE1 amyloidogenic APP cleavage #Alzheimers, ER exit events, map nanobody binding in realtime in ER/organelles 🔬🧠#SingleMolecule rdcu.be/e3Ris

☕Donahue et al. show that #aging is associated with changes in ER morphology. ER-phagy drives age-associated ER remodeling through tissue-specific factors. #autophagy #longevity bit.ly/40dNHEE

ER remodelling is a feature of ageing and depends on ER-phagy - Nature Cell Biology

Donahue et al. show that ageing is associated with changes in ER morphology. ER-phagy drives age-associated ER remodelling through tissue-specific factors.

bit.ly

Joe Shen’s and Zaza Gelashvili’s work on the role of the ER in nuclear membrane mechanotransduction finally came out in a journal!

Endoplasmic reticulum disruption stimulates nuclear membrane mechanotransduction

Nature Cell Biology - Shen, Gelashvili and Niethammer developed an inner nuclear membrane tension sensor and demonstrated that ER–nuclear membrane contiguity acts as a mechanical buffer.

rdcu.be

ERC success rates are tanking and the move is... even bigger grants for fewer people? smh

Katherine Stiles@katherinestiles.org · 8mo ago

· #AcademicSky · The European Research Council is launching €7m Plus Grants for ambitious, long‑term research — open to researchers at any career stage but limited to about 30 awards; current ERC grantees and applicants are ineligible, reports @clanicholson.bsky.social.

Nice paper from Kota @saitolab.bsky.social! Balanced phosphorylation of TANGO1 and Sec16A keep ER exit sites stable and functional. Do cells maintain this dynamically to keep secretory machinery primed and responsive to changing cargo loads or environmental signals? www.nature.com/articles/s41...

Delayed weekly selection of articles on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/... Highlight - Pooled overexpression screening identifies PIPPI as a novel microprotein involved in the ER stress response academic.oup.com/nar/article/...

or just q.e.d. it www.qedscience.com

q.e.d Science

Critical Thinking AI for constructive criticism and science evaluation

qedscience.com

Peiyao Fan, Yang Chen et al. @pku1898.bsky.social show that tubular ER extends into retraction fibers and #migrasomes through #microtubule-dependent ER extension and ER-plasma membrane contact sites in migrating cells. rupress.org/jcb/article/... #ER_literature #Migration #Organelles

What do ER exit sites really look like? Using large-scale volume FIB-SEM and a custom 3D-Unet pipeline (ASEM), Nahir et al @kirchhausenlab.bsky.social reveal that ERES are vesicular, abundant & diverse, resolving long-standing morphological discrepancies rupress.org/jcb/article/... #ER_literature

Leukocyte-intrinsic ER stress responses contribute to chemotherapy-induced peripheral neuropathy | Science Translational Medicine www.science.org/doi/10.1126/...

Leukocyte-intrinsic ER stress responses contribute to chemotherapy-induced peripheral neuropathy

Depletion of the ER stress sensor IRE1α can reduce paclitaxel-induced peripheral neuropathy in mice.

science.org

Joel Mokyr, Philippe Aghion and Pewter Howitt share economics prize for work that underlines the importance of investing in research and development. go.nature.com/4hj9NNV

Economics Nobel prize won by researchers who showed how science boosts growth

Joel Mokyr, Philippe Aghion and Pewter Howitt share economics prize for work that underlines the importance of investing in research and development.

go.nature.com

Bei #Grundlagenforschung kürzen? Keine gute Idee! so die Philosophin @asmeincke.bsky.social in ihrem Gastkommentar in @diepressecom.bsky.social. Denn Österreich brauche eine starke und vielfältige Wissenschaft. @fwf-at.bsky.social @oeaw.bsky.social Bessere Ideen 👉 www.diepresse.com/20152064/bei...

Bei Grundlagenforschung kürzen? Keine gute Idee!

Kein Geist, kein Sinn. Österreich braucht keine männliche MINT-Monokultur, sondern eine starke und vielfältige Wissenschaft.

diepresse.com

Check out this new Roadmap, a fantastic team effort by a consortium of ER researchers. Glad we could provide the space for this synthesis, which came out of discussions at a fruitful meeting, see below:

Ishier Raote@ishier.bsky.social · 10mo ago

ER exit sites are dynamic ER subdomains that integrate signals, reshape membranes and steer secretion. Twelve groups in the field came together to map their diversity, regulation, unanswered questions and future directions. www.nature.com/articles/s41...

It was a great pleasure to work on this paper. What started as a small meeting in January this year resulted in this beautiful piece of work.

Ishier Raote@ishier.bsky.social · 10mo ago

ER exit sites are dynamic ER subdomains that integrate signals, reshape membranes and steer secretion. Twelve groups in the field came together to map their diversity, regulation, unanswered questions and future directions. www.nature.com/articles/s41...

The microbial metabolite preQ1 modifies tRNA, reduces cell proliferation, and decreases protein translation. This is mediated by IRE1-dependent cleavage of preQ1-modified tRNAs. rdcu.be/eHw46

Two microbiome metabolites compete for tRNA modification to impact mammalian cell proliferation and translation quality control

Nature Cell Biology - Zhang, Lahry, Cipurko et al. show that the microbial metabolites queuine and preQ1 modify the same host tRNA. PreQ1-tRNA reduces cell proliferation, slows tumour growth,...

rdcu.be

Beautiful work which supports a role for the ER in mechanobiology.

Nature Cell Biology@natcellbio.nature.com · 12mo ago

💫NEW: Das, @fabianspill.bsky.social & co combine intracellular cartography and biophysical modelling to reveal how edge curvature governs endoplasmic reticulum (ER) morphology, showing that curvature-dependent ER reorganization directs distinct modes of epithelial cell migration. bit.ly/3HFAQ8S

Nature research paper: Quantitative imaging of lipid transport in mammalian cells go.nature.com/4mmSygd

Quantitative imaging of lipid transport in mammalian cells - Nature

Directional, non-vesicular lipid transport is responsible for fast, species-selective lipid sorting into organelle membranes.

go.nature.com