Check out our News and Views in Nature Nanotech led by postdocs @htjeong.bsky.social and @jiwon-kim.bsky.social , highlighting deformable microparticles that transduce mechanical compression into MRI contrast, mapping dynamic stresses deep inside tumors @natnano.nature.com rdcu.be/XyYh3fHsAD4a
Ian Wong Lab at Brown University
@ianywonglab.bsky.social
Biomedical engineering lab at Brown University. Biomaterials, mechanobiology and computer vision for cancer cell invasion. Also, micro / nano fab and 3D printing.
Visited Harvard to give a Squishy Physics talk. Reminiscing about my early days learning from this incredibly talented group - Margaret Gardel, Megan Valentine, Cliff Brangwynne, Jennifer Shin, Dave Weitz and so many others.. @squishycell.bsky.social, @brangwynnelab.bsky.social
Hibbitt Postdoc Jiwon Kim was selected as a ⭐2026 Rising Stars Women in Engineering⭐ by the Asian Deans’ Forum. This workshop is organized by leading engineering schools in the Asia Pacific region. Kim, of @ianywonglab.bsky.social, was also a 2025 MIT Rising Star in Mechanical Engineering.
Neutrophils remodel their actin cytoskeleton rapidly as they navigate narrow capillaries of varying sizes, enabling them to squeeze through without causing blockages. Learn more in #ScienceImmunology: https://scim.ag/4xwpB7e
Associate Professor Ian Y. Wong (@ianywonglab.bsky.social) has been named to the editorial board of the @annualreviews.bsky.social of Biomedical Engineering. engineering.brown.edu/news/2026-07...
Wong joins Editorial Board of Annual Review of Biomedical Engineering
engineering.brown.edu
🧪 @aicjanelia.bsky.social and @scientistrachel.bsky.social have just published a new quantitative tool, OpticalFlow3D, for tracking amorphous motion in 3D. Try it out and let us know what you think! tinyurl.com/OpticalFlow3D
looking forward to my online talk for the Journal of Biological Physics on 23 July at 4:00 PM (Europe/Berlin). cassyni.com/events/GVxaf...
Collective transitions from orbiting to matrix invasion in three-dimensional multicellular spheroids
Coordinated cell rotation along a curved matrix interface can sculpt epithelial tissues into spherical morphologies. Subsequently, radially oriented invasion of multicellular strands or branches can o...
cassyni.com
New preprint! We show all-electrical, label-free imaging of single cell migration on a CMOS chip - no optics whatsoever! Fun collaboration led by Hyuntae Jeong with Pushkaraj Joshi and Jacob Rosenstein @htjeong.bsky.social @brownengineering.bsky.social www.biorxiv.org/content/10.6...
Label-Free All-Electrical Tracking of Individual and Collective Cell Migration on a Megapixel CMOS Capacitance Sensor https://www.biorxiv.org/content/10.64898/2026.06.16.731623v1
Very excited to be sharing our new paper, just out in Nature Cell Biology! The big question we investigate: How do migrating cells put their front 🔴 and back 🔵 in the right place?
Rodriguez, C., Jeong, H., Kim, J., ... & Guo, M. (2026). Expression of vimentin intermediate filaments in epithelial cells promotes cell migration and cell matrix interaction in 3D. Biophysical Journal. #EpithelialMechanics doi.org/10.1016/j.bp...
Delighted to share our latest views on our favourite cancer cells Well done @ritoghose.bsky.social 👏 @icr.ac.uk @breastcancernow.bsky.social Amoeboid cancer cells at a glance journals.biologists.com/jcs/article/...
Amoeboid cancer cells at a glance
Summary: Amoeboid cancer cells exploit actomyosin contractility, metabolic adaptability and immune evasion to drive metastasis, representing a distinct and therapeutically targetable state within the ...
journals.biologists.com
Enjoyed a stimulating cell migration + math bio conference at the Banff International Research Station. Many thanks to the organizers and congratulations to @htjeong.bsky.social and @jiwon-kim.bsky.social for great talks! Look forward to visiting again soon!
Editor Spotlight: Leah Edelstein-Keshet University of British Columbia “MBoC provides excellent examples of quantitative reasoning in cell biology and helps advance this growing area of the field.” Explore the journal and submission opportunities at molbiolcell.org
Very nice cover picture for the next GRC in #CellMigration, chaired by @robinsall.bsky.social #AnaMariaLennon & @djcohen.bsky.social www.grc.org/directed-cel...
What does it take to truly understand #cancer in all of its complexity? Delighted to share our Review in Cell "Cancer ecosystems: A dynamic interplay across scales" with Daniela Quail, where we propose a multi-scale framework connecting tumor ecology with physiology 🧪⚕️ www.cell.com/cell/fulltex...
Tumor cells often metastasize in clusters with other cells, offering novel targets for treatments. Learn more: https://scim.ag/4vGFV50
Much remains to be explored. What happens when the tissue geometry is more complex? Does this occur more broadly for other biomaterials? Could we one day control collective orbiting for development and disease? We are excited to chat about epithelial mechanobiology www.instagram.com/reel/DQUBGUE...
How does an orbiting spherical tissue suddenly break symmetry and sprout invasive strands? We can predict this behavior from the initial morphology! Hi, I’m @jiwon-kim.bsky.social from @ianywonglab.bsky.social.
Partial EMT Drives Persistent Collective Migration via Collision Guidance in Heterogeneous Populations https://www.biorxiv.org/content/10.64898/2026.04.07.714519v1
Kim, J., Jeong, H., Falcó, C., Hruska, A. M., Martinson, W. D., Marzoratti, A., ... & Wong, I. Y. (2026). Collective transitions from orbiting to matrix invasion in three-dimensional multicellular spheroids. Nature Physics, 1-12. #EpithelialMechanics buff.ly/ChmS1uW
Delighted to announce the Microtechnologies in Medicine and Biology (MMB 2026) conference in Maui this December 7-11 (mmb2026.org) - continuing a series of Hawaii conferences that bring together thought leaders in tiny technologies to transform biomedicine. Abstracts due July 1, 2026.
Collective migration is not just about leaders at the front, but about coordination across the group. Always exciting to see these dynamics visualized. Many thanks to @jcb.org for featuring our work 🐸🔬🌹
🔬 From our March issue (rupress.org/jcb/issue/22...): Epithelial neural collectives undergoing #chemotaxis, stained for phospho-#myosin (magenta), #actin (cyan), and nuclei (yellow). From @jorgediazfuentes.bsky.social and @mayorlab.bsky.social: rupress.org/jcb/article/...
Of the many impressive acrobatic qualities of cats, perhaps their most spectacular is their ability to right themselves midair so they always seem to land on their feet. The trick lies in a hyperflexible region of their backbone known as the thoracic spine, a new study finds. https://scim.ag/4rlHodw
a temporary addition to the campus architecture..
What music should we play to our cells? This was the start of an amazing journey from @ivaskalab.bsky.social at @turkubioscience.bsky.social with Jasmin Kaivola and collaborators @sarawickstrom.bsky.social and others to explore larynx cancer mechanosensitivity! www.nature.com/articles/s41...
Restoring the tumour mechanophenotype of vocal fold cancer reverts its malignant properties - Nature Materials
Vocal fold cancer tumours lose some of their malignant traits when mechanically stimulated by physiological stretch or vibrations, mimicking the opening and closing of vocal folds and phonation.
nature.com
Today at Cell: A new #HallmarksofCancer review by Doug Hanahan: www.cell.com/cell/fulltex... This review marks 25 years since the original seminal Cell review by Hanahan & Robert Weinberg and its impactful follow up in 2011. @cp-cell.bsky.social @cellpress.bsky.social
Hallmarks of cancer—Then and now, and beyond
Hanahan revisits the evolving framework of cancer hallmarks, synthesizing 25 years of conceptual refinement into a multidimensional view of tumor biology. This review highlights how aberrant capabilit...
cell.com
and the Brown news release on our Nature Physics paper: www.brown.edu/news/2026-01...
The shape of things to come: How spheroid geometry guides multicellular orbiting and invasion
In research that could shed light on the growth and formation of complex tissue architectures, Brown University engineers show how cells orbit and reconfigure their surroundings to venture outward fro...
brown.edu