Benoit Danilo 🦠
@individualpttrn.bsky.social
Molecular biology, directed evolution, recombinant proteins, genome editing and some ghoulish tinkering. Formerly @INRAE_PACA and @Michiganstateu . Now @LRSV_Toulouse
Out in @natplants.nature.com, mapping of brassinosteroid chemical features required for (1) receptor binding, (2) ligand positioning and (3) co-receptor recruitment. Fantastic work by Alberto Caregnato & @hmchen93.bsky.social and our friends in Olomouc. Funding:@snf-fns.ch -> doi.org/10.1038/s414...
Nature research paper: Miniaturizing and modifying natural proteins with Raygun go.nature.com/4w2usM2
Miniaturizing and modifying natural proteins with Raygun - Nature
Probabilistic sequence encoding from language model embeddings within a generative AI framework enables protein miniaturization, modification and augmentation while maintaining native architecture and functional integrity.
go.nature.com
Grande découverte dans la bibliothèque familiale
Our ProteinGuide paper is finally out! Thanks to all the co-authors @junhaobearxiong.bsky.social, @ishangaur.bsky.social, @hnisonoff.bsky.social, @loltrogge.bsky.social, @jlistgarten.bsky.social, @savagecatsonly.bsky.social! @innovativegenomics.bsky.social www.nature.com/articles/s41...
Property guidance for protein sequence generative models with ProteinGuide - Nature Biotechnology
On-the-fly conditioning of pretrained protein generative models guides protein generation toward specific properties.
nature.com
14-3-3 λ suppresses ethylene-mediated root growth inhibition through EIN3/EIL1 in Aratbidopsis (Zhi-Xin Xiang , Yong-Lun Lv , Ying-Rui Li , Yi-Feng Zhou , Yan-Ke Lu , Meng Xu , Feng Ding) doi.org/10.1093/plph... #PlantScience @aspbofficial
14-3-3 λ suppresses ethylene-mediated root growth inhibition through EIN3/EIL1 in Aratbidopsis
Binding of a plant protein to key transcription factors dampens the ethylene signal, preventing roots from halting their growth.
doi.org
The new laws break away from 20-year-old restrictive GMO directives to give an official nod to plants made with new genomic techniques www.nature.com/articles/s41...
EU relaxes rules for gene-edited crops - Nature Biotechnology
The new laws break away from 20-year-old restrictive GMO directives to give an official nod to plants made with new genomic techniques.
nature.com
Ever had issues with contamination in #Marchantia or #liverwort tissue culture? We've developed a protocol that is simple and low-effort (albeit slow) to get rid of fungi and bacteria: dx.doi.org/10.17504/pro.... Work led by Isaac Coven and supported by Chetan Pandey, myself & @dromius.bsky.social.
Fascinating paper on the progression of women in academia. 👩🏻🔬 ⚛️ 🧪 #AcademicSky docs.iza.org/dp18477.pdf?... Here's an excerpt from the conclusion:
Precise manipulation of large genomic fragments through TJ-PE in rice Liu et al. nph.onlinelibrary.wiley.com/share/SEXRUQ...
How does a geminivirus replicate its genome using a pick&mix strategy with host proteins? 🦠🦠🌱🧬 Our new preprint identifies plant proteins repurposed by geminiviruses to carry out rolling-circle replication. Congrats @chaonan123.bsky.social , who spearheaded this work! www.biorxiv.org/content/10.6...
Smokes from the Girondes Fire. And I’m at least 250km from them…Terrifying.
CRISPR-mediated centromere fission generates neochromosomes with distorted meiotic inheritance in Arabidopsis biorxiv.org/content/10.6... new preprint from us - includes changing the Arabidopsis karyotype from 5 -> 6 chromosomes using Cas9 & outcomes of 5/6 chromosome hybrid meiosis
Exclusive: A cutting-edge gene-editing trial in China went disastrously wrong. A family wants accountability. https://scim.ag/3RuHuDB
Exclusive: Death of girl in Chinese gene-editing trial was never made public
Parents want accountability after study went disastrously wrong, Science and Retraction Watch investigation reveals
scim.ag
Our AI-guided design of RNA-guided nucleases is now out in @science.org 💻🧬 We used structure and evolutionary data to generate minimal, active and divergent gene editors! www.science.org/doi/10.1126/... Congrats to @petrskopintsev.bsky.social @isabelesain.bsky.social @evandeturk.bsky.social & team!
Structure and evolution-guided design of minimal RNA-guided nucleases
The design of RNA-guided nucleases with properties not limited by evolution can expand programmable genome-editing capabilities. However, generating diverse multidomain proteins with robust enzymatic ...
science.org
Plant Science Research Weekly -- R2 retrotransposons enable efficient site-specific genome editing in plant (Nature Biotechnology) (Summary by Ching Chan @ntnuchanlab.bsky.social) buff.ly/JNltSt7 #PlantaePSRW
R2 retrotransposons enable efficient site-specific genome editing in plants | Plantae
A major challenge in plant genome engineering is the precise insertion of large DNA sequences into a defined genomic location, preferably without involving a double-strand break.
buff.ly
Sedimentary ancient DNA reveals rhizosphere-like plant-microbe association signals in a 2-million-year-old Arctic ecosystem https://www.biorxiv.org/content/10.64898/2026.07.05.735348v1
Retargeted serine integrases for one-step, precise integration of large DNA sequences in human cells www.nature.com/articles/s41...
Retargeted serine integrases for one-step, precise integration of large DNA sequences in human cells - Nature Biotechnology
Serine integrases are retargeted to streamline genomic integrations of DNA.
nature.com
#PlantScienceClassics #6: The T-DNA. In a 1977 paper, Mary-Dell Chilton & colleagues identify the Transferred DNA (T-DNA), the bit of DNA that Agrobacterium tumefaciens inserts into the plant genome, to kick off the race toward the first transgenic plant. doi.org/10.1016/0092...
RIP Mary-Dell Chilton, without her no genetic plant transformation using Agrobacterium. Stable incorporation of plasmid DNA into higher plant cells: the molecular basis of crown gall tumorigenesis: Cell www.cell.com/cell/fulltex...
Stable incorporation of plasmid DNA into higher plant cells: the molecular basis of crown gall tumorigenesis
Evidence is presented that crown gall tumors are caused by the incorporation of part of a virulence plasmid carried by the inciting bacterium, Agrobacterium tumefaciens. The rate of reassociation of l...
cell.com
Epi(c) Editing...✂️🧬🌱 Hirata et al have developed a novel #DNAmethylation editing tool in #Arabidopsis & demonstrate its potential for #epigenome editing in #plantscience through the targeted de novo methylation of specific sites in FWA doi.org/10.1093/pcp/... #PlantEpigenetics
When you turn on the incubator and it’s already at 35 degrees Celsius.
Man Sweating on a Hot Day
ALT: Man Sweating on a Hot Day
static.klipy.com
This article in Le Monde about French research in general and the CNRS in particular has a few depressing graphs www.lemonde.fr/sciences/art...
🌺 How does a hibiscus flower pattern its petals? A new computational model reveals hidden "boundary" cells can spontaneously emerge during flower development, helping to create stable petal patterns. Prediction confirmed experimentally! 🔗 www.slcu.cam.ac.uk/news/how-hib... #PlantsInTheSpotlight
From love songs to lullabies, songs spanning the globe—despite their diversity—exhibit universal patterns, according to the first comprehensive scientific analysis of the similarities and differences of music across societies around the world. Learn more on #WorldMusicDay: https://scim.ag/43Ct5Ib
