Arkadiy Garber

@ironark.bsky.social

PhD, Microbiology MS, Geological Sciences BS, Neuroscience Founder of MAB: midauthorbio.com GitHub: https://github.com/Arkadiy-Garber https://github.com/Middle-Author-Bioinformatics Google Scholar: https://scholar.google.com/citations?user=SGPloYgAAA

The last chapter of my PhD work is now live on MBE. This has been an incredible project, combining genomics, proteomics, as well as transcriptomics that resolves total mRNA from ribosome-associated mRNA (which we infer to be in the process of translation).

Molecular Biology and Evolution@molbioevol.bsky.social · 3w ago

@ironark.bsky.social et al. measured transcript abundance, ribosome-associated RNA, and protein abundance in bacterial endosymbionts, suggesting a mechanism for aberrant pseudogene-derived protein removal. 🔗 doi.org/10.1093/molbev/msag153 #societyjournal #evobio #molbio

MBE | The transcriptional and translational outcomes for pseudogenes in bacterial endosymbionts

The artist formerly known as #thatmitoriboguy has now become #thatchlororiboguy Check out some cool tomo from @florentwaltz.bsky.social @phaips.vd.st

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Florent Waltz@florentwaltz.bsky.social · last wk.

This story is now published in @natplants.nature.com ! 🎉🎩 Check out the final article here: nature.com/articles/s41477-026-02361-1 Very similar to the original bioRxiv preprint, with the addition of some cool polysome analysis (in the supplementals)! Thanks and congrats to everyone involved! 🙏

Advanced access peer-reviewed version: academic.oup.com/mbe/advance-... We transcriptionally and translationally profiled symbionts with thousands of pseudogenes. We show that pseudogenes are not only transcribed, but their transcripts bind ribosomes to attempt translation. What happens next...

The transcriptional and translational outcomes for pseudogenes in bacterial endosymbionts

Abstract. Intracellular bacteria in the early stages of host adaptation often show extraordinarily disrupted genomes, where up to half of their ancestral g

academic.oup.com

Arkadiy Garber@ironark.bsky.social · 6mo ago

Happy to share a preprint—the last chapter of my dissertation with @mcsymbiont.bsky.social and Co—on what happens when bacterial endosymbionts accumulate huge numbers of pseudogenes during early genome reduction. www.biorxiv.org/content/10.6...

Diagram illustrating early genome erosion during the transition from a free-living Sodalis bacterium to two host-associated endosymbionts inside the long-tailed mealybug. Circular genomes show intact genes in blue and pseudogenes in red, highlighting increased pseudogene accumulation in symbiotic forms. Caption asks: “What are the downstream molecular consequences of early genome erosion?”

Microbes that have the greatest genomic potential for secondary metabolism tend to be multicellular. Here, we show that signatures of ancestral BGC expansions within 3 bacterial phyla and 2 fungal lineages coincide with origins of complex multicellularity [1/12] 🧵 www.nature.com/articles/s41...

Complex multicellularity is linked with expanded specialized metabolite production in microorganisms - Nature Microbiology

The evolutionary emergence of complex multicellularity in bacteria and fungi, such as the ability for mycelial growth, is strongly associated with increased genomic carriage of biosynthetic machinery ...

nature.com

Advanced access peer-reviewed version: academic.oup.com/mbe/advance-... We transcriptionally and translationally profiled symbionts with thousands of pseudogenes. We show that pseudogenes are not only transcribed, but their transcripts bind ribosomes to attempt translation. What happens next...

The transcriptional and translational outcomes for pseudogenes in bacterial endosymbionts

Abstract. Intracellular bacteria in the early stages of host adaptation often show extraordinarily disrupted genomes, where up to half of their ancestral g

academic.oup.com

Arkadiy Garber@ironark.bsky.social · 6mo ago

Happy to share a preprint—the last chapter of my dissertation with @mcsymbiont.bsky.social and Co—on what happens when bacterial endosymbionts accumulate huge numbers of pseudogenes during early genome reduction. www.biorxiv.org/content/10.6...

Diagram illustrating early genome erosion during the transition from a free-living Sodalis bacterium to two host-associated endosymbionts inside the long-tailed mealybug. Circular genomes show intact genes in blue and pseudogenes in red, highlighting increased pseudogene accumulation in symbiotic forms. Caption asks: “What are the downstream molecular consequences of early genome erosion?”