Riboseek is a fast RNA/DNA search. More sensitive than nhmmer at 250x speed. Structure-aware realignment produces MSAs approaching rMSA quality. Plus 1.7M precomputed RNA MSAs, and an API to search your own 📄 www.biorxiv.org/content/10.6... 💾 github.com/steineggerla... 🌐 search.foldseek.com/riboseek

And 2 complementary 📜: 1️⃣ Cyanobacterial & vascular plant chlororibos🌿 (by @michaelwebster.bsky.social, with contrib from @sofie-dot-rec.bsky.social, @cellarchlab.com & I): biorxiv.org/content/10.64898/2026.07.03.736309v1 2️⃣ Marchantia chlororibos 🥬: biorxiv.org/content/10.64898/2026.07.14.738477v2

The artist formerly known as #thatmitoriboguy has now become #thatchlororiboguy Check out some cool tomo from @florentwaltz.bsky.social @phaips.vd.st

Florent Waltz@florentwaltz.bsky.social · last wk.

This story is now published in @natplants.nature.com ! 🎉🎩 Check out the final article here: nature.com/articles/s41477-026-02361-1 Very similar to the original bioRxiv preprint, with the addition of some cool polysome analysis (in the supplementals)! Thanks and congrats to everyone involved! 🙏

We’re delighted to welcome @computingcaitie.bsky.social to the FMI next year! Her work will bring an interdisciplinary perspective spanning structural biology, quantitative imaging and computational analysis to our institute, opening exciting new ways to study ciliary structure and dynamics.

Caitie McCafferty@computingcaitie.bsky.social · last mo.

Happy to finally share that I will be starting my independent group at the @fmiscience.bsky.social in Feb 2027 in a vibrant new environment. We will use integrative in situ structural cell biology methods to investigate ciliary structure and dynamics in several model (and non-model 👀) systems!!

New Assistant (tenure-track) or Associate Professor position in Climate #Biophysics! Join our international research community to explore fundamental molecular mechanisms underlying climate-relevant biological processes. Apply by 7 Sept 2026! www.biozentrum.unibas.ch/de/open-posi...

Super excited to launch this search for a new endowed professor at the @biozentrum.unibas.ch! Join us to build a research cluster in Climate Biophysics! 🌍🌊🌾🔬🧪 This is a unique opportunity to create a community in Basel🇨🇭working together on this timely topic! ⏳🌡️ Questions? Please reach out! 👩‍🔬👨‍🔬

Biozentrum, University of Basel@biozentrum.unibas.ch · last mo.

New Assistant (tenure-track) or Associate Professor position in Climate #Biophysics! Join our international research community to explore fundamental molecular mechanisms underlying climate-relevant biological processes. Apply by 7 Sept 2026! www.biozentrum.unibas.ch/de/open-posi...

Caitie’s a lion 💪♌️🦁🐥. Go work with her to do and learn cool stuff. I’d consider myself… but photosynthesis > cilia 😉@sofie-dot-rec.bsky.social . Congrats Caitie!

Caitie McCafferty@computingcaitie.bsky.social · last mo.

Happy to finally share that I will be starting my independent group at the @fmiscience.bsky.social in Feb 2027 in a vibrant new environment. We will use integrative in situ structural cell biology methods to investigate ciliary structure and dynamics in several model (and non-model 👀) systems!!

I will be hiring at all levels so if you are interested and want to learn more, please get in touch! 📻 ❄️ 🔬 🦠 🧬 #cilia #cryoet #proteomics #exm #protistsonsky

Soooo proud! I can't recommend Caitie enough as a scientist, mentor and overall amazing and creative person - go send in your applications if you love silly-ats (she also made all these awesome animations #ciliagirl )

Caitie McCafferty@computingcaitie.bsky.social · last mo.

Happy to finally share that I will be starting my independent group at the @fmiscience.bsky.social in Feb 2027 in a vibrant new environment. We will use integrative in situ structural cell biology methods to investigate ciliary structure and dynamics in several model (and non-model 👀) systems!!

“the best way to work with cryoET data is to engage with it directly, […] build familiarity with what is actually there. As tempting as it sometimes is to lean in to automation entirely, we cannot do visual proteomics by relying blindly on automation.” mgflast.github.io/easymode/use...

Postdoc opportunity at FMI + Novartis Biomedical Research 🧬 The Dahmane lab (FMI) & Farady lab (Novartis) are seeking a postdoctoral researcher to study how extracellular inflammasome particles propagate inflammation during neurotropic RNA virus infection. Apply by May 31: www.fmi.ch/education-ca...

The 14th International Conference for Plant Mitochondrial Biology😍🍜🍀 My first trip to Japan and my first presentation award! Many thanks to the organizers, my supervisor, @florentwaltz.bsky.social, and our wonderful collaborators! I was happy to present my work in beautiful Kagoshima🌋

Oxygen gradients reshape cross-feeding through emergent spatial organization of gut commensal bacteria www.biorxiv.org/content/10.6... Use of isotope labels and cryo-CLEM-FIB-SIMS to study microbial communities by Hannah Ochner. Collaboration with @kiranrpatil.bsky.social @jmghigolab.bsky.social

MissAlignment is out!!! Our new software that improves reference-free tilt series alignment by mimicking human intuition. Check out Dimitry's beautiful thread for a quick summary! And the preprint for more details: www.biorxiv.org/content/10.6... The program: github.com/warpem/miss-...

Dimitry Tegunov@dtegunov.bsky.social · 3mo ago

We're super excited to share MissAlignment: a new ML-based approach to reference-free tilt series alignment, spearheaded by @martenchaillet.bsky.social. We think it's going to make your cryo-ET life a lot better. Preprint: www.biorxiv.org/content/10.6... Code: github.com/warpem/miss-... 🧶 Thread:

We're super excited to share MissAlignment: a new ML-based approach to reference-free tilt series alignment, spearheaded by @martenchaillet.bsky.social. We think it's going to make your cryo-ET life a lot better. Preprint: www.biorxiv.org/content/10.6... Code: github.com/warpem/miss-... 🧶 Thread:

1/ Excited to share our preprint! 🥳 Degradation of aromatic compounds, including BTEX pollutants, requires highly endergonic aromatic ring reduction. Using #cryoEM and in situ #cryoET, we show how BCRII couples electron bifurcation modules in one giant redox machine www.biorxiv.org/content/10.6...

It’s done!! Molecular architecture of the ciliary base in mammalian multiciliated cells! A study 13 years in the making 👴, thanks to collab with @stearnslab.bsky.social + @centriolelab.bsky.social & visionary work by @computingcaitie.bsky.social, who integrated native #cryoET with #XLMS & #UExM 🧪🧶🧬🔬

Caitie McCafferty@computingcaitie.bsky.social · 4mo ago

I am excited to share our most recent work collaborating with @centriolelab.bsky.social and @stearnslab.bsky.social to look at the ciliary base of mammalian multiciliated cells w/ cryo-ET, XL/MS, and U-ExM www.biorxiv.org/content/10.6...

Crazy things have been happening in cilia world, catch up on them in Caitie's new paper! 🪱

Caitie McCafferty@computingcaitie.bsky.social · 4mo ago

I am excited to share our most recent work collaborating with @centriolelab.bsky.social and @stearnslab.bsky.social to look at the ciliary base of mammalian multiciliated cells w/ cryo-ET, XL/MS, and U-ExM www.biorxiv.org/content/10.6...

To supplement our cryo-ET and generate candidates for proteins that localize to different ciliary regions, we took a trip to the local butcher to pick up some cow trachea to build a mammalian multiciliated cell interactome using XL/MS (enjoy this vid of @cellarchlab.com shaking cilia off trachea)

Not a nudi, but a sacoglossan sap-sucking sea slug, Elysia coodgeensis. 10/10 for alliteration, 12/10 for being tiny & stylish. The R package is just in need of some testing, and in the meantime, more palette-cards coming soon! 🎨 #MarineLife #invertebrates 🦑🐙🧪

New protein complex stoichiometry prediction tool from talent PhD student @daniil-litvinov.bsky.social, check out the thread below!

Daniil Litvinov@daniil-litvinov.bsky.social · 5mo ago

I'm excited to share *Stoic*, a method for fast and accurate protein complex stoichiometry prediction directly from sequence. Preprint: www.biorxiv.org/content/10.6... 🧵👇(1/10)

I'm excited to share *Stoic*, a method for fast and accurate protein complex stoichiometry prediction directly from sequence. Preprint: www.biorxiv.org/content/10.6... 🧵👇(1/10)

Exciting opportunity to work in a lab that’s pushing the boundaries of environmental sampling and work with an amazing scientist!!! 👩‍🔬🔬

Manon Demulder@manondemulder.bsky.social · 5mo ago

Excited to announce I’m starting a new lab at @gmivienna.bsky.social (Vienna BioCentre) in Sept 2026 We study how carbon fixation is inherited and maintained in algae using cryo-ET, imaging, environmental sampling&more Looking for people who want to build the lab together, get in touch! #teamtomo

I mean Vienna is not a bad place to be, but working and building and expanding and Cryo-ETing with @manondemulder.bsky.social can only make it a billion time better....

Manon Demulder@manondemulder.bsky.social · 5mo ago

Excited to announce I’m starting a new lab at @gmivienna.bsky.social (Vienna BioCentre) in Sept 2026 We study how carbon fixation is inherited and maintained in algae using cryo-ET, imaging, environmental sampling&more Looking for people who want to build the lab together, get in touch! #teamtomo

Excited to announce I’m starting a new lab at @gmivienna.bsky.social (Vienna BioCentre) in Sept 2026 We study how carbon fixation is inherited and maintained in algae using cryo-ET, imaging, environmental sampling&more Looking for people who want to build the lab together, get in touch! #teamtomo

New paper from my team detailing a greatly expanded genomic database of Asgard archaea revealing of high energy metabolism those related to eukaryotes! Led by @katyappler.bsky.social lots of help from @jameslingford.bsky.social @valdeanda.bsky.social @kassipan.bsky.social doi.org/10.1038/s415...

A 🆕 #Ichthyosporea story Led by@margaridaaraujo.bsky.social, in Co. @gautamdey.bsky.social & @hiralshah.bsky.social+🔥team across @embl.org & @sciencesunige.bsky.social We finally have a look at what #microtubules are doing during #cellularization in #Sphaeroforma ▶️ tinyurl.com/MTSARC #ProtistsOnSky

When all the female grad students tell you a candidate seems arrogant & smarmy & they don’t like him, but it’s all vibes, maybe hire one of the other candidates who are just as amazing researchers, but don’t give off bad vibes. Cuz in my experience those vibes have proven right 100% of the time.

BWJones@bwjones.bsky.social · 6mo ago

That leads to another rule when hiring: When trusted people around you get strong negative vibes, listen to them.

There are far more talented candidates than there are tenure-track jobs. Mentoring students is a major component of a faculty position. It is entirely possible to pick talented candidates who aren’t weird assholes, it just requires hiring committees to value interpersonal skills.

Natalie Wright, Ph.D.@coereba.bsky.social · 6mo ago

When all the female grad students tell you a candidate seems arrogant & smarmy & they don’t like him, but it’s all vibes, maybe hire one of the other candidates who are just as amazing researchers, but don’t give off bad vibes. Cuz in my experience those vibes have proven right 100% of the time.

Long in the making, but happy to present the Chlamydomonas chlororibosome! Cryo-ET🔬reveals a large new domain on the small subunit, built from multiple extensions in conserved ribosomal proteins. bioRxiv 📖: shorturl.at/q44tG This suggests greater chlororibosome diversity than expected! 1/n 🧵