🚨Preprint alert 🚨 We identify riboflavin (vitamin B₂) as a key modulator of ferroptosis sensitivity via stabilizing FSP1 & recycling lipid-soluble antioxidants. www.biorxiv.org/content/10.1.... pls check @olzmannlab.bsky.social www.biorxiv.org/content/10.1... #ferroptosis #FSP1 #antioxidants

Riboflavin metabolism shapes FSP1-driven ferroptosis resistance

Membrane protection against oxidative insults is achieved by the concerted action of glutathione peroxidase 4 (GPX4) and endogenous lipophilic antioxidants such as ubiquinone and vitamin E. Deficienci...

biorxiv.org

Highly recommended read to debunk outdated myths about discontinuous versus continuous epitopes 🤓 www.pepperprint.com/downloads-re...

Linear vs. conformational epitope mapping: Methods, differences, and strategic use in drug development

Explore the critical distinctions between linear epitope and conformational epitope mapping in our comprehensive guide. Learn how epitope mapping techniques—ranging from peptide microarrays with overl...

pepperprint.com

Heading back from the SYNABS & Generate Symposium - beautiful venue, friendly atmosphere. Big thanks to the organizers Christian Geis, Frank Leypoldt, and their teams for making it such a wonderful event. #autoimmunity

Just reviewed @elife.bsky.social Epitope Sequence and Modification Fingerprints of Anti-Aβ Antibodies Resource & deep dive into how therapeutic & research #Antibody detect key #AmyloidBeta variants in #AlzheimersDisease Thanks @unimedizin-goe.bsky.social, @mpi-nat.bsky.social & @uni-wuerzburg.de !

Ivan Talucci@ivantalucci.bsky.social · last yr.

Happy to share the positive review for "Epitope Sequence and Modification Fingerprints of Anti-Aβ Antibodies" doi.org/10.7554/eLif... Now online in @elife.bsky.social Looking forward to sharing the revised version!🔜 @hmariclab.bsky.social @uni-wuerzburg.de @maxplanck.de @unimedizin-goe.bsky.social

Happy to share the positive review for "Epitope Sequence and Modification Fingerprints of Anti-Aβ Antibodies" doi.org/10.7554/eLif... Now online in @elife.bsky.social Looking forward to sharing the revised version!🔜 @hmariclab.bsky.social @uni-wuerzburg.de @maxplanck.de @unimedizin-goe.bsky.social

Our eSylites are on the cover of the current #JACS issue! Check it out 👇

Journal of the American Chemical Society (JACS)@jacs.acspublications.org · last yr.

On the cover of this week's #JACS: "eSylites: Synthetic Probes for Visualization and Topographic Mapping of Single Excitatory Synapses" Read it here 🔗 buff.ly/tunBPI2 #ChemSky

Happy to share the positive review for "Epitope Sequence and Modification Fingerprints of Anti-Aβ Antibodies" doi.org/10.7554/eLif... Now online in @elife.bsky.social Looking forward to sharing the revised version!🔜 @hmariclab.bsky.social @uni-wuerzburg.de @maxplanck.de @unimedizin-goe.bsky.social

👇👇👇

Itai Yanai@itaiyanai.bsky.social · last yr.

🔥New Night Science paper!! Discovery happens when your initial plans fall apart but it requires you to have a particular mindset: it's not extraverted, orderly, neurotic or agreeable that's the most important – discovery requires an OPENNESS to new ideas and unexpected insights.

Make sure not to miss our latest paper out now in #JACS - presenting eSylites - small, peptide-based probes for precise mapping of neurons, etc.! Microscale thermophoresis (MST) played a huge part in optimizing the probes structure and sequence for binding affinity. #ChemicalBiology #Synapse

Maric Lab@hmariclab.bsky.social · 2y ago

🚀 Excited to share our latest work in #JACS on eSylites! —Synthetic, high-affinity #ChemicalBiology probes for #SuperResolution #Synapse visualization & precise mapping in neurons and brain slices—without the need for antibodies, tags, or transfection! 📢 Read more: pubs.acs.org/doi/10.1021/...

🚀 Excited to share our latest work in #JACS on eSylites! —Synthetic, high-affinity #ChemicalBiology probes for #SuperResolution #Synapse visualization & precise mapping in neurons and brain slices—without the need for antibodies, tags, or transfection! 📢 Read more: pubs.acs.org/doi/10.1021/...

eSylites: Synthetic Probes for Visualization and Topographic Mapping of Single Excitatory Synapses

The spatiotemporal organization of the postsynaptic density (PSD) is a fundamental determinant of synaptic transmission, information processing, and storage in the brain. The major bottleneck that prevents the direct and precise representation of the nanometer-scaled organization of excitatory glutamatergic synapses is the size of antibodies, nanobodies, and the genetically encoded fluorescent tags. Here, we introduce small, high affinity synthetic probes for simplified, high contrast visualization of excitatory synapses without the limitations of larger biomolecules. In vitro binding quantification together with microscopy-based evaluation identified eSylites, a series of fluorescent bivalent peptides comprising a dye, linker, and sequence composition that show remarkable cellular target selectivity. Applied on primary neurons or brain slices at nanomolar concentrations, eSylites specifically report PSD-95, the key orchestrator of glutamate receptor nanodomains juxtaposed to the presynaptic glutamate release sites that mediate fast synaptic transmission. The eSylite design minimizes a spatial dye offset and thereby enables visualization of PSD-95 with improved localization precision and further time-resolved discrimination. In particular, we find that individual dendritic spines can contain separate nanodomains enriched for either PSD-95 or its closest homologues, PSD-93 or SAP102. Collectively, these data establish eSylites as a broadly applicable tool for simplified excitatory synapse visualization, as well as a high-end microscopy compatible probe for resolving the PSD organization with unprecedented resolution.

pubs.acs.org

🚨Preprint 🚨 Epitope Sequence and Modification Fingerprints of Anti-Aβ Antibodies. This resource aims to advance AD diagnostics & therapeutics. Looking forward to reviewer feedback! Audio summary: sciencecast.org/casts/ca9qhd... #AlzheimersDisease #aducanumab #donanemab #lecanemab

When it comes to discovery, we need to remember that our instincts often create an illusion that misleads us into believing that we understand something completely, even though there are many things about it that we don’t and we need to figure out how to ask the right questions!

Single-cell RNA sequencing of immune cells for over 1,000 people age 18-97 years. A clock of our immune system aging. Tells us about an individual's response to infection, vaccination, Long Covid. Towards an immunome. www.nature.com/articles/s43...

🚨Preprint 🚨 Epitope Sequence and Modification Fingerprints of Anti-Aβ Antibodies. This resource aims to advance AD diagnostics & therapeutics. Looking forward to reviewer feedback! Audio summary: sciencecast.org/casts/ca9qhd... #AlzheimersDisease #aducanumab #donanemab #lecanemab

Epitope Sequence and Modification Fingerprints of Anti-Aβ Antibodies https://www.biorxiv.org/content/10.1101/2025.02.26.640323v1

There are many large language models to choose from; some excel at coding, whereas others are better for synthesizing information https://go.nature.com/4hGYf6q

What are the best AI tools for research? Nature’s guide

There are many large language models to choose from; some excel at coding, whereas others are better for synthesizing information.

go.nature.com

Plasma proteomic evidence for increased β-amyloid pathology after SARS-CoV-2 infection www.nature.com/articles/s41...

Plasma proteomic evidence for increased β-amyloid pathology after SARS-CoV-2 infection - Nature Medicine

Blood biomarkers in a middle-aged population suggest that SARS-CoV-2 infection is associated with greater brain β-amyloid plaque accumulation.

nature.com

Out now in Nature Human Behaviour: Our 68-country #survey on public attitudes to #science 📣 It shows: People still #trust scientists and support an active role of scientists in society and policy-making. #OpenAccess available here: www.nature.com/articles/s41... @natureportfolio.bsky.social (1/13)

An #antibody is a protein generated in a patterned immune response. Exposure to #antigens from external sources (from bacteria, virus, vaccines..) or from inside (e.g. cell components not in their usual locations, self components not recognised as intrinsically you) starts the machinery going....

Climate change is driving global extinction risks, with 1.6% of species threatened at 1.3°C of warming and risks escalating to 29.7% at 5.4°C, according to a new meta-analysis in Science encompassing more than 30 years of research. Read more:

Climate change extinctions

Climate change is expected to cause irreversible changes to biodiversity, but predicting those risks remains uncertain. I synthesized 485 studies and more than 5 million projections to produce a quantitative global assessment of climate change ...

scim.ag

MIT researchers introduce Boltz-1, a fully open-source model for predicting biomolecular structures With models like AlphaFold3 limited to academic research, the team built an equivalent alternative, to encourage innovation more broadly www.eurekalert.org/news-release...

MIT researchers introduce Boltz-1, a fully open-source model for predicting biomolecular structures

Researchers in the MIT Jameel Clinic for Machine Learning in Health developed a fully open-source biomolecular structure prediction model that achieves state-of-the-art performance, at the level of Al...

eurekalert.org

What an amazing read (h/t Jeff Flier) - esp @michaelmina.bsky.social which felt especially raw. #biosky #medsky www.harvardmagazine.com/2025/01/harv...

Harvard Professors Leaving for Private Sector Research | Harvard Magazine

Three distinguished scientists on leaving academia to advance biomedical research

harvardmagazine.com

Temporally overlapping mechanisms diversify clonal B cell responses in vivo www.biorxiv.org/content/10.1...

Researchers decipher MIS-C, the scary illness that followed COVID in some kids www.npr.org/sections/sho...

Researchers decipher MIS-C, the scary illness that followed COVID in some kids

Some children who had COVID developed a severe inflammatory response that could put them in the ICU. Scientists have learned why it happens.

npr.org

Our study just out! "Disease-associated B cells and immune endotypes shape adaptive immune responses to SARS-CoV-2 mRNA vaccination in human SLE". 🔗 * rdcu.be/dZWI9 * lnkd.in/desv-ZrV #SLE | #Autoimmunity | #mRNAvaccines | Disease-associated #Bcells shape anti-vaccine immunity in SLE. 👩‍🔬 💉💉💉 🦠

Disease-associated B cells and immune endotypes shape adaptive immune responses to SARS-CoV-2 mRNA vaccination in human SLE

Nature Immunology - SLE is a heterogeneous disorder that is characterized by different immune endotypes. Faliti et al. follow the immune memory responses upon mRNA COVID-19 vaccinations in a large...

rdcu.be

A Practical Guide to Dissertation and Thesis Writing #scisky Free Download cambridgescholars.com/resources/pd...

EMBL scientists discovered that dextromethorphan (DXM) may treat lung #fibrosis. 🫁 DXM is an @fda.gov-approved active ingredient in nonprescription cough syrups. This study, published in Science Translational Medicine, shows how this drug may reduce lung scars. 🧪💊 www.embl.org/news/science...

The distriction between epigenetics and epigenomics @cp-trendsgenetics.bsky.social

The distinction between epigenetics and epigenomics

‘Epigenetics’ is the process by which distinct cell types or cell states are inherited through multiple cell divisions. ‘Epigenomics’ refers to DNA-associated physical and functional entities including histone modifications and DNA methylation, not concepts of inheritance. Conflating epigenetics and epigenomics is confusing and causes misunderstanding of a fundamental biological process.

cell.com

Earlier this year in Science, researchers generated a nanoscale-resolution reconstruction of a millimeter-scale fragment of human cerebral cortex, giving an unprecedented view into the structural organization of brain tissue at the supracellular, cellular, and subcellular levels. scim.ag/3BjR7xa

Having a color-blind colleague is a good reminder that we need to be more careful when designing figures for scientific publication 🧪 My lab has found this page especially useful for selecting color palettes, used in combination with different symbols: thenode.biologists.com/data-visuali...

Color blind friendly palettes for data visualizations with categories

A discussion of color blind friendly palettes for labeling unique catergories in data visualization.

thenode.biologists.com