I'm in Toronto for the Alzheimer’s Association International Conference. Looking forward to a great week!
Jackie Eissman, PhD
@jackieeissman.bsky.social
Associate Research Scientist at Columbia University | Statistical Genetics & Multi-Omics | Vanderbilt Ph.D. '23 | Vanderbilt B.S. '19 | All views are my own. https://www.linkedin.com/in/jaclyneissman/
Hi Bluesky. Happy Friday! I am excited to share two of my first-author papers that went live in the last week on medRxiv. (1/3)
Sex-Specific Genetic Drivers of Memory, Executive Functioning, and Language Performance in Older Adults #NeuroDegeneration 🧪🧠 http://medrxiv.org/cgi/content/short/2025.05.26.25328369v1
Sex-Specific Genetic Drivers of Memory, Executive Functioning, and Language Performance in Older Adults https://www.medrxiv.org/content/10.1101/2025.05.26.25328369v1
Biological Age and Age Acceleration Predict Alzheimer's Disease Plasma Biomarker Levels #NeuroDegeneration 🧪🧠 http://medrxiv.org/cgi/content/short/2025.05.22.25328181v1
Biological Age and Age Acceleration Predict Alzheimer's Disease Plasma Biomarker Levels https://www.medrxiv.org/content/10.1101/2025.05.22.25328181v1
This past week, I was very grateful to have the opportunity to present at the AD/PD - Advances in Science & Therapy conference in Vienna, Austria. It was such a lovely week, learning from and connecting with so many talented scientists. #ADPD2025
Sex chromosomes and sex hormones differently shape microglial properties during normal physiological conditions in the adult mouse hippocampus jneuroinflammation.biomedcentral.com/articles/10....
Sex chromosomes and sex hormones differently shape microglial properties during normal physiological conditions in the adult mouse hippocampus - Journal of Neuroinflammation
The brain presents various structural and functional sex differences, for which multiple factors are attributed: genetic, epigenetic, metabolic, and hormonal. While biological sex is determined by bot...
jneuroinflammation.biomedcentral.com
Hi Bluesky! I'm excited to have been selected for the Advanced Gene Mapping Course taking place at Rockefeller University this week. Check out what I'll be learning about all week! statgen.us/Advgenemap2025
Advgenemap2025 - Statistical Genetics Courses
statgen.us
The maternal X chromosome impairs cognition and speeds up brain aging. Check out our latest @nature.com @ucsfhealth.bsky.social www.nature.com/articles/s41... www.nature.com/articles/d41...
The maternal X chromosome affects cognition and brain ageing in female mice - Nature
The maternal X chromosome in female mice impairs cognition through the silencing of certain genes and accelerates ageing of the hippocampus.
nature.com
Male-Female comparisons are powerful in Biomedical Research. More on this and what is a "Pink Box Warning"?? From @ctmurphy1.bsky.social @bbparis1984.bsky.social Yousin Suh and me in the latest issue of Neuron www.sciencedirect.com/science/arti...
Biological sex matters in brain aging
Every cell in the body has a biological sex. The expansion of aging research to investigate female- and male-specific biology heralds a major advance …
sciencedirect.com
🚨 Our latest RADC publication on social activity and dementia risk! First authored by my amazing mentee Yi Chen, we show that the mean age of dementia onset for the least socially active older adults was 5 years earlier than the most socially active @anacapuano.bsky.social doi.org/10.1002/alz....
Late‐life social activity and subsequent risk of dementia and mild cognitive impairment
INTRODUCTION Social activity is associated with better cognitive health in old age. To better translate epidemiological research for public health communication, we estimated relations of levels of ...
doi.org
Many of the coolest ideas from the Dec 2024 NASEM report on Research Priorities to Accelerate Progress to Prevent and Treat Dementia are in the questions and research ideas that are associated with each of the big picture priorities. Start on pg 352 of the report. #EpiSky #EndAlz
Preventing and Treating Dementia: Research Priorities to Accelerate Progress
Read online, download a free PDF, or order a copy in print.
nap.nationalacademies.org
Cross-disease modeling of peripheral blood identifies biomarkers of type 2 diabetes predictive of Alzheimer's disease https://www.biorxiv.org/content/10.1101/2024.12.11.627991v1
Our latest review-with @bonniee-leee.bsky.social where we pour our ❤️🧠 & soul to outline our position on why we are so passionate about harnessing the power of sex differences & within sex diff to propel precision medicine forward let us know if we convince you www.nature.com/articles/s41...
Leveraging research into sex differences and steroid hormones to improve brain health - Nature Reviews Endocrinology
This Review outlines how the effects of steroid hormones on hippocampal neuroplasticity across the adult lifespan differ between the sexes, highlighting the importance of considering sex and steroid h...
nature.com
Interesting read, hot off the press from Vanderbilt Memory & Alzheimer's Center, where I did my PhD: rdcu.be/d1HzD
Pathologic and clinical correlates of region-specific brain GFAP in Alzheimer’s disease
rdcu.be
Happy to share a new paper from the lab, published in Alzheimer’s & Dementia: APOE4-associated heterogeneity in neuroimaging biomarkers across the Alzheimer’s disease continuum alz-journals.onlinelibrary.wiley.com/doi/full/10.... 1/7
APOE ε4–associated heterogeneity of neuroimaging biomarkers across the Alzheimer's disease continuum
INTRODUCTION While the role of apolipoprotein E (APOE) ε4 in Alzheimer's disease (AD) susceptibility has been studied extensively, much less is known about the differences in disease presentation in...
alz-journals.onlinelibrary.wiley.com
Daily neuroscience-related posts on Bluesky this week have increased more than 400 percent, on average, compared with October. By @callimcflurry.bsky.social www.thetransmitter.org/community/hu...
‘Huge influx’ of neuroscientists migrates to Bluesky
Daily neuroscience-related posts on the social-media platform this week have increased more than 400 percent, on average, compared with October.
thetransmitter.org
Bluesky is the new destination for X/Twitter’s health and science community. Here’s why www.statnews.com/2024/11/21/b...
Bluesky is the new destination for X/Twitter’s health and science community. Here's why
#MedTwitter is migrating en masse from X to Bluesky, suddenly making it an essential hub for scientific discourse. Here's why.
statnews.com
Dr Barnes, our great pioneer in this field, created a brain health equity starter pack! Follow these important researchers! Also, in my mission to help seniors, I taught Lisa how to create a starter pack and share it 🤣 Just kidding, Lisa!!! Don’t kill me!
Lisa Barnes@beyoung40.bsky.social · 2y agoHey equity folks! I created a starter pack for brain health equity. Please join and share your work with us to amplify the messages!
We love seeing the #genomics community growing so quickly on Bluesky. Here is a helpful list of Genomics Starter Packs: 🧬https://blueskydirectory.com/starter-packs/all?q=genomics What do you like better about Bluesky so far, compared to X/Twitter?
All - Bluesky Directory
A curated collection of all things relating to the Blue Sky social media platform.
blueskydirectory.com
We used #ADNI data and @EMBIC_DCBs #cognitive biomarkers to predict status over 36 months - first paper in #Alzheimer's and Dementia 🥳 alz-journals.onlinelibrary.wiley.com/share/RQYPUD... #ENDAlz
alz-journals.onlinelibrary.wiley.com
Cognitive reserve against #Alzheimers pathology is linked to brain activity during memory formation www.nature.com/articles/s41... #dementia #neuroscience #science
Cognitive reserve against Alzheimer’s pathology is linked to brain activity during memory formation - Nature Communications
Here, the authors identify a cognitive reserve-related activity pattern underlying successful memory encoding. They further derive individual reserve scores that predict the maintenance of cognitive p...
nature.com
I thought it could be nice to connect the community of researchers in human genetics, so here is the Genetics Starter Pack! 🧬 #academicsky Let me know if you would like to be added or know someone to add. Enjoy and share! go.bsky.app/LN2NRuB
Get excited, #ISTAART #ADSexGenPIA members!! We have our very first Year in Review presentation on 22nd January! Presented by the amazing Dr Brooke Brady, a postdoctoral fellow based at UNSW. Details coming soon.
For anyone interested, I wrote this piece recently: www.thetransmitter.org/sex-differen... #Alzheimers #womensbrainhealth
Brains, biases and amyloid beta: Why the female brain deserves a closer look in Alzheimer’s research
New results suggest the disease progresses differently in women, but we need more basic science to unpack the mechanisms involved.
thetransmitter.org