Jake McKinlay

@jakemckinlay.bsky.social

Professor, Biology, Indiana University Bacterial physiology and cross-feeding interactions Artist: https://bit.ly/3oy86jf Sheltering under solar panels. Posts are my own.

Excited to share that I've been awarded a 5-year NIH MIRA (R35) from the National Institute of General Medical Sciences! The lab is growing! We're recruiting postdocs and research techs interested in microbial ecology, quantitative microscopy, microfluidics, and molecular biology. Please share!

🚨 HEADS UP: If you haven't submitted a comment on the OMB proposal yet, there's still time - but it's running out! There are only 7 days left to push back against Russell Vought's attempt to give political appointees unprecedented control over federal research funding. Take Action: zurl.co/2sCF2

Graphic from Stand Up for Science urging action on a federal funding proposal. Large text reads: "7 Days Left" and "Help Us Stop Vought From Destroying American Science." A portrait of Russell Vought appears beside the U.S. Capitol. A banner along the bottom reads: "Submit a comment on the OMB proposal | Link in bio to take action." The Stand Up for Science logo appears in the top left.

I just submitted my public comment on OMB-2026-0034 (grants can be canceled at any time, no funding for publications, conferences, intl collaborations, etc). 9 days remain if you want to do the same. Happy 4th.

Stand Up for Science!@standupforscience.net · 2mo ago

Our official guide to help you write a public comment on the OMB-2026-0034 is here: zurl.co/XgyzA Submit your comment and take additional actions here: zurl.co/RiDuv #StandUpForScience #OMB #Vought #SaveScience #FundScience

The graphic displays an image of the SUFS Foundation logo, a hand holding pen, and hands over a type writer. The graphic reads: "The SUFS Guide to Writing Public Comments, Written by: Cole Donovan, Director of Policy and Advocacy and Colette Delawalla, PhD, CEO. BOTTOM LINE UP FRONT: This is an opportunity to tell YOUR government that the OMB-2026-0034 "Regulation for Federal Financial Assistance" is wrong. https://zurl.co/XgyzA "

🚨 HEADS UP: If you haven't submitted a comment on the OMB proposal yet, there's still time - but it's running out! There are only 11 days left to push back against Russell Vought's attempt to give political appointees unprecedented control over federal research funding. Take Action: zurl.co/R83IO

Graphic from Stand Up for Science urging action on a federal funding proposal. Large text reads: "11 Days Left" and "Help Us Stop Vought From Destroying American Science." A portrait of Russell Vought appears beside the U.S. Capitol. A banner along the bottom reads: "Submit a comment on the OMB proposal | Link in bio to take action." The Stand Up for Science logo appears in the top left.

Comparative analysis of monocultures vs cocultures for >600 generations reveals that cross-feeding can limit the emergence of loss-of-function mutations. Congrats to Dr. Ying-Chih (Ella) Chuang and coauthors (@megbehri.bsky.social +others)! journals.asm.org/doi/10.1128/...

Reciprocal cross-feeding between bacteria can limit the emergence of metabolic dependencies | Applied and Environmental Microbiology

Bacteria commonly engage in cross-feeding, where nutrients are transferred between neighbors. Cross-feeding is thought to alleviate energy expenditures for genes whose role can be met by cross-fed nutrients, leading to eventual gene loss. However, few examples have been documented, especially in comparison to monocultures that lack a cross-feeding partner. We grew cocultures pairing phototrophic Rhodopseudomonas palustris with fermentative Escherichia coli alongside corresponding monocultures for 650–800 generations. While coculture conditions required obligate exchange of nitrogen and carbon, additional cross-feeding of adenine and iron likely occurred. Contrary to expectations, dependencies for iron and unknown compounds emerged in monocultures, but expected iron and adenine dependencies were not observed in cocultures. Low expression of iron scavenging and adenine synthesis genes in cocultures suggested that cross-feeding repressed expression, thereby lowering gene cost. Thus, although cross-feeding can sometimes make costly genes dispensable, there are also cases where cross-feeding lowers gene cost, thereby promoting gene retention.

journals.asm.org

Last month, we had the pleasure of celebrating Lars Peter Nielsen's 40-year anniversary at Aarhus University 🎉 The day was celebrated with colleagues, collaborators, friends and family, with music, food and a number of speeches. Congratulations to Lars Peter on 40 outstanding years👏🥂

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Another paper on a topic we never worked on before: a new ribosomal hibernation! Under the leadership of the super-postdoc Diorge, Davis Lab (ribo-cryoEM master), and @vikramalva.bsky.social (protein-evo whisperer), we identified AHA (not the song, but archaeal hibernation AMPKγ factor). (1/2)

Diorge Souza@diorgeps.bsky.social · 5mo ago

A new preprint from the @archaeon-alex.bsky.social and Joey Davis (MIT) labs! We solved the structure of the ribosome from the archaeon Haloferax volcanii and discovered a new highly conserved ribosome hibernation factor that we named AHA (AMPKγ–HPF from Archaea) 🧵⬇️ www.biorxiv.org/content/10.6...

Excited to share this new Preprint from our lab led by PhD Candidate Carl Stone (defending Tuesday). Here we present a framework for longitudinal rbTn-Seq and apply it to the Microbial extended growth curve to resolve the fitness seascape through growth, death, and long-term stationary phase!

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bioRxiv Evolutionary Biology@biorxiv-evobio.bsky.social · 6mo ago

Bayesian analysis of longitudinal RB-TnSeq resolves the fitness seascape in fluctuating environments https://www.biorxiv.org/content/10.64898/2026.02.11.703069v1

NSF GRFP applicants (and mentors): Was your application Returned Without Review and deemed ineligible despite fitting in the allowed topics? 1) Write NSF 2) Write your Congressperson 3) CC us at grfp@grant-witness.us so we can compile + follow up Details and template at grant-witness.us/grfp-letter

A year ago this week, an Executive Order came out on a Friday afternoon/evening that reduced all indirect costs rate recovery to 15% the following Monday. In this article I discuss what would have happened across the U.S. if this had not been halted. www.psychologicalscience.org/publications...

Cutting Indirect Costs for Universities Impacts More Than Research

Incoming APS President Pamela Davis-Kean describes the role indirect costs play in the U.S. research landscape and the economies of university communities.

psychologicalscience.org

I am beyond excited to announce that the Bisson Lab has a new home!!! Starting January 2026, I will join the Biology Department at Indiana University Bloomington as Associate Professor with tenure. I am actively recruiting scientists across all levels. More in our website: bissonlab.com/join [1/4]

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Our manuscript on the microbiome of a stingless bee hive is out! 🦠🐝 So excited! Here’s a short thread with some findings, going from the assembly of a consistent multi-kingdom microbiome to discussions on host traits that contribute to it. Please take a look and share : ) rdcu.be/eVNFJ

Spatial segregation and cross-kingdom interactions drive stingless bee hive microbiome assembly

Nature Communications - Here, the authors characterize the microbiome assembly across an entire stingless bee colony, revealing site-adapted within-hive communities, and showing that nest...

rdcu.be

Need a (graduation) gift for a microbiologist? This is a colorful graphic novel following an E. coli cell through a cholera outbreak. Hand-drawn on paper and manually colored in photoshop. 30% off today enter 'BOOKGIFT30' at checkout www.lulu.com/spotlight/ww...

Jake McKinlay@jakemckinlay.bsky.social · 11mo ago

'A Bacterium in Bangladesh' is now available in multiple formats: www.lulu.com/search?contr... With Appendix: US30, EU29 Appendix-Free: US20, EU19 e-Appendix Only: few $ Posters (US site; EU site pending): sci-hustle.myspreadshop.com