Really horrible news in the Huntington’s field, sounds like the FDA completely chasing their mind about a study designed to they’d previously agreed to: en.hdbuzz.net/uniqure-and-...

Hey that's me! This was a huge and unexpected honor. The HDF and Wexler family has been a huge inspiration for me, and so this couldn't be a nicer recognition to receive.

Huntington's Disease Foundation@hdfcures.bsky.social · 11mo ago

Congrats @jcarroll42.bsky.social, 2025 recipient of the Leslie Gehry Prize for Innovation in Science! Jeff's personal connection to #Huntingtonsdisease has fueled an impactful scientific career and an unwavering commitment to the HD community. We're so proud! Learn more: tinyurl.com/2025-Gehry-P...

Glad to see this out in the world. We observe remarkable rescue in an HD mouse using an ASO targeting intron-1 of Huntingtin, rather than downstream. The intron-1 targeting ASO essentially completely eliminates aggregates, whereas the more distal ASO does nothing: www.biorxiv.org/content/10.1...

Scientists, especially Seattle ones! One of my research scientists is heading to her PhD and we're looking to fill her spot, if not replace her. If you know someone looking to do cool and impactful translational research give them this: uwhires.admin.washington.edu/ENG/Candidat...

And cost of living in several key cities (eg Vancouver and Toronto) not feasible with academic salaries in those towns. Even if you can get a grant!

Ravi Menon@northernthrux.bsky.social · last yr.

You should see how small the choose 🇨🇦 fund is. See the vertical black dividing line? It’s considerably narrower than that.

This sub-title from the @economist.com , ouch! But accurate. www.economist.com/briefing/202...

The big beautiful bill reveals the hollowness of Trumponomics

Republicans mark America’s birthday with a profligate but insubstantial law

economist.com

5. Wars are easy to start and hard to stop

Support the troops baby!!

BWJones@bwjones.bsky.social · last yr.

Also: Apparently, their deployments are broken up into 29 day blocks so DoD doesn't have to pay them active duty benefits INCLUDING no allowance for housing.

Tump's bullying is just his psychopathic personality. Vance is, actually, kind of worse because he's strictly doing it to impress other guys he perceives as tougher. He's like the punk ass kid who takes a kick at someone after the bully knocks him down.

Yashar Ali 🐘@yasharali.bsky.social · last yr.

The Department of Homeland Security and Vice-President JD Vance are publicly targeting @dieworkwear.bsky.social

A hell of a lot of the California National Guard is made up of people from immigrant communities, fwiw.

Good lord, how can anyone serious about science even consider cutting funding for Flybase?

Dmitri Petrov@petrovadmitri.bsky.social · last yr.

Flybase lost all of the NIH support overnight - it is a disaster for the community. Please consider donating. I just did! www.philanthropy.cam.ac.uk/give-to-camb...

Just published, expansion in situ genome sequencing, where you can sequence DNA while still inside the cell, mapping its organization relative to proteins and other markers, with the help of expansion microscopy! Led by @jbuenrostro.bksy.social. www.science.org/doi/10.1126/...

God please. One on every corner.

Dana Goldberg@dgcomedy.bsky.social · last yr.

If someone isn’t parking a TACO food truck outside the White House, what are we even doing with this stupid timeline!?

Amazing news that she’s finally free

KUOW Public Radio@kuow.org · last yr.

After nearly three months in immigration detention, University of Washington employee Lewelyn Dixon was released Thursday to the cheers and hugs of family, co-workers, and a crowd of supporters gathered in Tacoma.

New York Times article on NSF www.nytimes.com/interactive/... 1/2

Trump Has Cut Science Funding to Its Lowest Level in Decades (Gift Article)

The lag in funding extends far beyond D.E.I. initiatives, affecting almost every area of science: chemistry, computing, engineering, materials and more.

nytimes.com

It's painful to read this, 5 years later. Study finds no increase in Covid spread in nursing home after visitation bans were lifted. Implication: The bans, which meant months of isolation for nursing home residents and heartbreak of their families, did no good. pubmed.ncbi.nlm.nih.gov/40383139/

So, if you search google scholar enough it will just flag you as a bot and then there's absolutely no recourse, nor a human that you can prove you're not a bot. Reminding me we shouldn't be outsourcing such a key academic service to a for profit company that normalized not talking to its customers.

30 year Treasury above 5%. Also, I successfully used AI to do a Trump/Truss crossover, putting a Trump wig on a lettuce paulkrugman.substack.com/p/a-liz-trus...

A Liz Truss Moment for America?

Financial indicators are flashing yellow

paulkrugman.substack.com

Although there has been many positive things happening lately for myself and my lab group, this week we've gotten the bad news of a grant termination, as the lead PI is at Harvard (and they've had all their federal funding terminated). It will be tough to stop the work that only last year 1/2

I remember a story in the Army where a commander was dubious about intelligence soldiers working with people who had connections with the Taliban and could we trust people like that and the intel officer replied "the people who don't work with the Taliban have no information about them."

ex-Lethality Jane@lethalityjane.bsky.social · last yr.

People get mad at Atwood's sequel "The Testaments" because they don't think Aunt Lydia "deserves" any sort of redemption but it is much closer to the darker reality that resistance against evil often requires the participation of people who have done awful things.

I'm always intrigued by people who miss very obvious points in art they love. Things like: people who are mad that "Star Trek is woke" or Paul Ryan loving Rage Against the Machine.

Jennifer Ouellette@jenlucpiquant.bsky.social · last yr.

The tech billionaires are missing the point of their favorite sci-fi series. "[Iain M. Banks is an odd choice for a bunch of tech billionaires]. The author, who died in 2013, was a socialist and avowed hater of the super-rich." www.vox.com/culture/4135...

The profile that Vinay Prasad deserves. He's presence in this administration is sign of Trump's commitment to endangering public health. Excellent work @lauralew105.bsky.social ! 🩺 #medsky newrepublic.com/article/1949...

In a medical breakthrough, a team including IGI’s @urnov.bsky.social & @giannikopoulosp.bsky.social created an on-demand #CRISPR therapy for an infant with a deadly gene mutation — developed, approved, and delivered to the patient in just 6 months. Read more: ow.ly/G0Bg50VTonC #RareDisease 🧬

Amazing that this has happened. Maddening that we are actively destroying the capability to do it again. www.nytimes.com/2025/05/15/h...

Baby Is Healed With World’s First Personalized Gene-Editing Treatment

nytimes.com

Some seriously nice biochemistry and cryo-EM of FAN1-PCNA-flapDNA complexes! www.nature.com/articles/s41...

Terrifying

KUOW Public Radio@kuow.org · last yr.

A rock climber who fell hundreds of feet descending a steep gully in Washington’s North Cascades mountains survived the fall that killed his three companions, hiked to his car in the dark, and then drove to a pay phone to call for help, authorities said Tuesday.

NEW: Saturn’s moon Titan has weather similar to Earth’s, but driven by methane evaporation and condensation. Astronomers have found evidence for clouds bubbling up over Titan’s northern hemisphere for the first time, using #NASAWebb and Keck observatory: webbtelescope.pub/3GofvQ1 🔭 🧪

Yesterday, the NIH R35 “Outstanding Investigator” grant to fund scientists in my lab studying antibiotic resistance was terminated for reasons not related to the content of the science, or any actions taken by me or members of my lab

Really appreciate having experts help track this kind of stuff!

KUOW Public Radio@kuow.org · last yr.

The U.S. Food and Drug Administration said Saturday that federal, state and local officials are investigating the outbreak linked to foods produced by Fresh & Ready Foods LLC of San Fernando, California.