Finally out in Nature genetics! Our results reveal a novel role for the Alzheimer genetic risk factor PLCG2. Its neuronal Downregulation (or very rare Loss-of-function variants) seem to promote increased Aβ secretion, Tau hyperphosphorylation, and synaptic dysfunction www.nature.com/articles/s41...

PLCG2 downregulation impairs synaptic function and increases Alzheimer’s disease hallmarks in neuronal cultures - Nature Genetics

This study demonstrates that downregulation of PLCG2, primarily in neurons, impairs synaptic function and elevates amyloid-β levels and Tau protein phosphorylation.

nature.com

In this preprint, the main consortia working on Alzheimer GWAS combined their efforts to validate an detect new loci associated with AD risk. We observed 91 genome-wide significant signals (16 nove) . Among these 91 loci, 56 of them are specifically detected in clinically diagnosed AD cases.

medRxivpreprint@medrxivpreprint.bsky.social · last yr.

Consensus meta-analysis of genome-wide association studies for Alzheimer's disease and related dementia https://www.medrxiv.org/content/10.1101/2025.10.20.25338060v1

🚨Join our next @DEMONNetworkUK #Genetics and #Omics meeting on THURSDAY 11th September at 2.30 PM (UK Time). Delighted to have @jclambert.bsky.social‬ as invited speaker – “From #GWAS to polygenic risk scores in #Alzheimer's disease” Join the network or DM for more info

In this preprint led by Devrim Kilinc and Pierre Dourlen, we observed that differential expression of BIN1 isoforms in the presynaptic part leads to differential synaptotoxicity. BIN1 isoforms could contribute to the synaptic loss observed in Alzheimer's disease. www.biorxiv.org/content/10.1...

BIN1 expression in the presynaptic compartment leads to isoform-specific synaptotoxicity

Alzheimer’s disease (AD) is characterized by a strong genetic predisposition and by an early loss of synaptic connectivity that strongly correlates with cognitive deficit. Some genetic determinants co...

biorxiv.org

In this preprint, primarily conducted by Dolores Siedlecki, we established a neuron-microglia co-culture model within the synaptic chamber of a microfluidic device. This compartmented approach enables us to study synapse phagocytosis in close proximity to microglia. www.biorxiv.org/content/10.1...

Inflammation-enhanced synapse-specific phagocytosis by adult APP microglia in a microfluidic neuron–microglia co-culture model

Microglia play a critical role in synapse remodeling and neuroinflammation, both of which are dysregulated in Alzheimer′s disease (AD). However, most in vitro models rely on neonatal or immortalized m...

biorxiv.org

Today, our article "The entities enabling scientific fraud at scale are large, resilient, and growing rapidly" is finally published in PNAS. I hope that it proves to be a wake-up-call for the whole scientific community. reeserichardson.blog/2025/08/04/a...

A do-or-die moment for the scientific enterprise

Reflecting on our paper “The entities enabling scientific fraud at scale are large, resilient, and growing rapidly”

reeserichardson.blog

In this new EADB preprint led by Ole Andreassen, we present an improved polygenic hazard score model for AD that demonstrates enhanced predictive accuracy for age of onset in European populations compared to alternative models. www.medrxiv.org/content/10.1...

Polygenic Hazard Score for Predicting Age-associated Risk of Alzheimer’s Disease in European Populations: Development and Validation

Objectives Polygenic hazard score (PHS) models can be used to predict the age-associated risk for complex diseases, including Alzheimer’s disease (AD). In this study, we present an improved PHS model ...

medrxiv.org

Happy cat on my belly

A new EADB paper published in Nature Communications and led by Kristel Van Steen, Cornelia Van Duijn and Valentina Escott-Price. We report that machine learning methods have the potential to uncover novel loci that remain undetected by traditional GWAS in Alzheimer. www.nature.com/articles/s41...

Machine learning in Alzheimer’s disease genetics - Nature Communications

Here the authors apply machine learning approaches to Alzheimer’s genetics, confirm known associations and suggest novel risk loci. These methods demonstrate predictive power comparable to traditional...

nature.com

FromFB: 😂

Finally out in Nature genetics ! A long journey to have this paper published. Led by my team, under the EADB umbrella (eadb.eu), the project involved numerous partners worldwide in assessing the genetic complexity of Alzheimer in populations of diverse ancestries. www.nature.com/articles/s41...

Transferability of European-derived Alzheimer’s disease polygenic risk scores across multiancestry populations - Nature Genetics

Polygenic risk scores for Alzheimer’s disease derived from individuals of European ancestry can show improved performance in multiancestry settings after incorporating genome-wide association summary ...

nature.com

Trump’s cuts to more than 1700 #NIH grants get court hearing www.science.org/content/arti... by @sarareardon.bsky.social @science.org #Alzheimers #dementia #neuroscience #science

Trump’s cuts to more than 1700 NIH grants get court hearing

District judge could declare terminations unlawful—or toss suit based on technicalities

science.org

This is a cumulative maximum intensity projection movie of the endoplasmic reticulum labeled with the membrane marker mEmerald-Sec61B.

Announcing an official fundraising campaign to support my lab’s research on APOE4 and Alzheimer’s disease: joinus.cuimc.columbia.edu/participant/.... This campaign is itself an experiment of sorts. But mostly, it's an attempt to save my lab during an unprecedented time of turmoil in academia. 1/9

Here is a direct link to the open access article ‪@amit-das.bsky.social‬ mentions. alz-journals.onlinelibrary.wiley.com/doi/10.1002/... Tempting to say it feels like a miracle, but this progress always comes down to dedicated study participants, brilliant scientists, and reliably funded science.

The history of Down syndrome–associated Alzheimer's disease; past, present, and future

The landscape of Down syndrome–associated Alzheimer's disease (DSAD) research reflects decades of scientific endeavor and collaborative effort, charting a remarkable journey from initial observation...

alz-journals.onlinelibrary.wiley.com

Amit Das@amit-das.bsky.social · last yr.

This commentary from Maure-Blesa et al. captures the history of #downsyndrome -assoc. #alzheimers disease beautifully. It's been a long journey to get to this point, and there's still a long journey ahead as we push for prevention, but the reason to be hopeful has never been greater! bit.ly/3Hv6qG0

I went in search of cygnets. Still not hatched so had to make do with a heron fishing instead. Look at those feet! #UKWildlife #UKbirding #Birds #Photography #Nature #GreyHeron #photographersunited #PhotographersofBluesky #Sonyalpha

Currently visiting the Medieval Museum in Barcelona. This was painted in 1210…

In this report, to improve our understanding of the genetic architecture of AD in the context of its main genetic driver, the EADB consortium and collaborators performed the largest global genome-wide association studies stratified by ε4 and ε2 carrier status. www.medrxiv.org/content/10.1...

APOE stratified genome-wide association studies provide novel insights into the genetic etiology of Alzheimers’s disease

Among the more than 90 identified genetic risk loci for late-onset Alzheimer’s disease (AD) and related dementias, the apolipoprotein E gene ( APOE ) ɛ2/ɛ3/ɛ4 polymorphism remains the longstanding ben...

medrxiv.org

And definitively accepted after more than a month of editing to meet all the publisher's requirements.

Jean-Charles Lambert@jclambert.bsky.social · 2y ago

Finally accepted “in principle” In Nature Genetics … 18 months of hard works because of massive revisions (that strongly improved the manuscript to be honest). A long journey finally successful. What a relief …

'BIN1 and Alzheimer’s disease: the tau connection' by Pierre Dourlen, Devrim Kilinc, Isabelle Landrieu, Julien Chapuis & Jean-Charles Lambert @jclambert.bsky.social www.cell.com/trends/neuro...

When I was a student, I dreamed of one day publishing in Trends In Neurosciences. So I'm proud that we had the opportunity to write an invited review on BIN1, a major genetic determinant of Alzheimer's disease that we've been working on for over 10 years. www.sciencedirect.com/science/arti...

BIN1 and Alzheimer’s disease: the tau connection

Bridging integrator 1 (BIN1) is a ubiquitously expressed protein that plays a critical role in endocytosis, trafficking and cytoskeletal dynamics. In …

sciencedirect.com

Quick guide to understand your cat

am pleased to share our letter, highlighting that the science does not yet support regulatory approval of amyloid-targeting therapies for AD based solely on biomarker evidence. alz-journals.onlinelibrary.wiley.com/doi/full/10....

The science does not yet support regulatory approval of amyloid‐targeting therapies for Alzheimer's disease based solely on biomarker evidence

Click on the article title to read more.

alz-journals.onlinelibrary.wiley.com

She's 8 years old and it sometimes seems like she still looks like a teenage cat. Admittedly, she's a very small size

Join us at @pasteurlille.bsky.social ! We're hiring a Facility Manager specializing in human iPSCs, organoids, and organ-on-chip technologies. Drive innovation in cutting-edge biomedical research. Apply now! Contact Dr Alexandre Grassart #CDP @univlille.bsky.social @cnrs-hautsdefrance.bsky.social

📣 Stand Up for Science 2025 à l'Institut Pasteur de Lille parce que la science est un bien commun. 📣 Plus d'infos sur le mouvement 👉 standupforscience.fr #pasteurlille

French Senator Claude Malhuret: "Washington has become Nero’s court, with an incendiary emperor, submissive courtiers and a jester high on ketamine... We were at war with a dictator, we are now at war with a dictator backed by a traitor."