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Jesse Garcia Castillo, PhD

@jgcastillo.bsky.social

CRI Irvington Postdoctoral Fellow/Jeroen Roose’s lab at UCSF. HHMI Gilliam Fellow'21. Berkeley MCB PhD alum/Michel DuPage’s Lab. Cal State LA alum. 🏳️‍🌈🇲🇽 (He/His/Him). Interested in all things immunology, but T cells are my favorite!

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Center for Cancer Immunotherapy and Immunobiology@ccii-kyoto.bsky.social · last wk.

What's in a name? Quite a lot: for cancer immunotherapy, it is vital that researchers & clinicians know when they are talking about the same cells (or not). CCII's Kenji Chamoto participated in this effort to standardise T cell nomenclature. #Immunology @natrevimmunol.nature.com

Guidelines for T cell nomenclature - Nature Reviews Immunology

This Consensus Statement clarifies the existing subset-based nomenclature for T cells. Furthermore, it proposes an alternative modular nomenclature that is designed to be brief and flexible and to avo...

nature.com

Immunity@cp-immunity.bsky.social · 3w ago

Stem-like precursors of exhausted Th cells upheld by a Tox-Myb-Eomes transcriptional hierarchy propagate Th cell responses in chronic infection

CD4+ T helper cells are essential for adaptive immunity; however, factors governing their maintenance and function during chronic antigen exposure remain unclear. Wen et al. identify a precursor T cell population, dependent on TOX, EOMES, and MYB, that emerges during high viral exposure and sustains helper T cell responses in chronic infection.

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Fabian Rivera-Chávez@fabianrchavez.bsky.social · 4w ago

1/ Excited to share a new preprint! My PhD student Claire asked why neonatal mice become resistant to experimental cholera as they age. Turns out, early-life acquisition of maternally transmitted lactobacilli helps protect against experimental cholera www.biorxiv.org/content/10.6...

Early-life acquisition of Lactobacillaceae protects against experimental cholera

Cholera causes severe diarrheal illness in young children, but the mechanisms underlying age-dependent susceptibility remain unclear. Experimental cholera in neonatal mice recapitulates age-dependent ...

biorxiv.org

Immunity@cp-immunity.bsky.social · last mo.

Online now: Extracellular ATP-P2RY2 signaling drives intratumoral prostaglandin E2 accumulation and adaptive resistance to immunotherapy in solid tumors

Extracellular ATP-P2RY2 signaling drives intratumoral prostaglandin E2 accumulation and adaptive resistance to immunotherapy in solid tumors

Extracellular ATP (eATP) is associated with immune suppression in the tumor microenvironment (TME) via its metabolite adenosine. Hu et al. find that immunotherapy increases eATP within the TME and drives immune suppression through direct binding of the purinergic receptor P2RY2, driving pathological COX-1- and COX-2-PGE₂ hyperactivation in solid tumors. This self-reinforcing circuit promotes adaptive resistance to immunotherapy.

dlvr.it

Immunity@cp-immunity.bsky.social · last mo.

Online now: B cell-derived type I interferon sustains T cell functionality upon strong TCR stimulation during chronic infection

B cell-derived type I interferon sustains T cell functionality upon strong TCR stimulation during chronic infection

Extrinsic factors that support CD8+ T cell responses during chronic viral infection are incompletely defined. Gago da Graça et al. identify a crucial role for B cells in triggering type I interferon production, thereby promoting T cell effector formation in response to high antigen exposure, as seen in chronic infection.

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Harmit Singh Malik@harmitmalik.bsky.social · last mo.

I know it seems like a heretical idea, but one way to figure out if a preprint is really interesting (to you) is... to read the preprint. Then, in the spirit of sharing, send a note to authors: a simple kudos or a more detailed question. I do this a dozen times a year. It's awesome. Try it.

Jeff Spence@jeffspence.github.io · last mo.

Excited to see @jonj-udd.bsky.social's fantastic work out @genetics-gsa.bsky.social. Selection in _heterozygotes_ is the primary force shaping allele frequencies of loss-of-function mutations in humans, even in genes only associated with purely recessive diseases. 🧪🧬 doi.org/10.1093/gene...

Allele Frequencies at Recessive Disease Genes are Mainly Determined by Pleiotropic Effects in Heterozygotes

Abstract. The classic theory of mutation-selection balance predicts the equilibrium frequency of genetic variation under negative selection. The model pred

doi.org

Elizabeth Jacobs, PhD@elizabethjacobs.bsky.social · last mo.

The theft of money from NSF to give to venture capital firms is a pretty accurate depiction of how this administration views science. In their view, science done for the betterment of human knowledge, health and the environment is not worthy of investment. It has to make a profit.

Andreas Bäumler@abaumler.bsky.social · 2mo ago

Is colorectal cancer driven by a disruption of anaerobiosis? A recent study by Spiga et al. makes this idea walk and talk like a duck. Read more here: www.sciencedirect.com/science/arti...

An anaerobic pathogen rewires host metabolism to fuel oxidative growth in the inflamed gut

To colonize their host and cause disease, enteric pathogens must deploy their virulence factors to establish distinct nutrient niches. How anaerobic p…

sciencedirect.com

Immunity@cp-immunity.bsky.social · 2mo ago

Dendritic cells shape and sustain fibroblast niches

Fibroblasts are highly attuned for immune crosstalk within lymphoid tissues. In this issue of Immunity, Alouche et al. provide insight into how fibroblast immunoregulatory phenotypes are acquired and maintained, revealing that Ccl19hi fibroblastic reticular cells require continuous signaling via Notch2. Dendritic cells produce Notch ligands to promote CCL19-rich stromal niches, which cluster CD8+ T cells centrally in lymph nodes.

dlvr.it