The Moser Group is presenting our work on Wednesday afternoon at #FENS2026! •Mechanism for L-R sweeps •Attention modulation of sweeps •Grid/place remapping rules & dynamics •”Mega torus” as a hi-capacity memory space •Moving the grid bump •Development of tori & rings •RSC/HC pops. in a spatial task

Toroidal manifolds abruptly emerge at P10 in rat pups! 🤪🍩 Several days later, space is *gradually* anchored to these tori when the puppachino actively navigates Congrats to the big boss @matteoguardamagna.bsky.social 🤠

Edvard I Moser@edvardmoser.bsky.social · 5mo ago

Is spatial navigation innate 🧠? Using #NeuroPixels we show that the #torus 🍩 underlying the #GridCell map exists already on day 10 in rats — before pups open eyes and ears and before they start upright walking. 🧵1:4 👇 www.biorxiv.org/content/10.6...

🚀 New preprint from the lab! Our first foray into the subiculum uses in vivo whole-cell recordings to show that dendritic plateaus are a prominent, learning-dependent signaling mode of subicular neurons. Feedback is welcome! www.biorxiv.org/content/10.6...

Excited to share our study in Neuron led by @travisgoode.bsky.social, a K99 PDF (interviewing for Faculty) and Sahay lab team with collaborators at BROAD, Hopkins, and UW Seattle, defining a neural circuit that links prior experience with feeding behavior. Open Access: sahaylab.com/publications

Do you love quantifying animal behavior as much as we do? We have just the tool for you! Presenting #OCTRON - a pipeline that helps you create rich annotation data and enables training of custom segmentation models. Have a look, particularly if you work with non-model / invertebrate organisms!

*First preprint from our lab* !!!!! How does the brain learn to anchor its internal sense of direction to the outside world? 🧭 led by Mark Plitt @markplitt.bsky.social & Dan Turner-Evans, w/ Vivek Jayaraman: “Octopamine instructs head direction plasticity” www.biorxiv.org/content/10.6... Thread ⬇️

Your stomach called – your striatum picked up! But does this actually happen in humans? Using simultaneous dopamine PET/fMRI, we show that the gut hormone ghrelin helps the brain adjust motivation to current metabolic need. Here’s what we found👇 Preprint: shorturl.at/pq4A3 #neuroskyence #🩺

🧠📢 New preprint alert Large-scale ephys is exploding but spike sorting remains the computational bottleneck. A 2-hr, 6-probe Neuropixels 2.0 Quad Base session can take over a week to sort on a single machine. Here's a better solution. 🧵 #neuroskyence #compneurosky

Still at SfN on the last day? During the morning session on the 19th, 8:00AM - 12:00PM, come check out our posters from the Moser, Zong, and Gonzalo Cogno groups in row QQ ('Grid cells and spatially modulated cells'). Ephys, imaging, remapping, development, sweeps and more! 🧠 Detailed thread below 👇

SFN 2025 let’s gooo!! Moser group posters are held Wednesday morning (QQ), so if you’re leaving early feel free to come find us to chat :)

Thrilled to share that our work is now published in Science! ✨ We found a preference for visual objects in the mouse spatial navigation system where they dynamically refine head-direction coding. In short, objects boost our inner compass! 🧭 www.science.org/doi/10.1126/... 🧵1/

“If everything is everywhere, why have distinct areas? Here we show that the function of a brain area is more related to how different types of information are combined (formatted) in neural representations than merely whether that information is present.”

Marlene Cohen@marlenecohen.bsky.social · 2y ago

New results for a new year! “Linking neural population formatting to function” describes our modern take on an old question: how can we understand the contribution of a brain area to behavior? www.biorxiv.org/content/10.1... 🧠👩🏻‍🔬🧪🧵 #neuroskyence 1/

Our collaboration - from PhD work - examining input-specific (EC L3) contributions to rate and temporal coding in CA1 place cells is now out in @natcomms.nature.com 🔬🧠 rdcu.be/evWtz

Direct entorhinal control of CA1 temporal coding

Nature Communications - Temporal coding in the hippocampus is thought to be key for memory and predictions. Here, the authors show that blocking one entorhinal input affects two aspects of...

rdcu.be

Amazing study: @tamir-eliav.bsky.social from the Ulanovsky lab describes replay events in a large scale environment (200 m tunnel). 🦇 www.cell.com/cell/abstrac...

Fragmented replay of very large environments in the hippocampus of bats

Hippocampal replays in bats flying in a 200-m tunnel depict short fragments of long flight trajectories, suggesting constraints on the mechanisms and functions of replay.

cell.com

(1/6) Thrilled to share our triple-N dataset (Non-human Primate Neural Responses to Natural Scenes)! It captures thousands of high-level visual neuron responses in macaques to natural scenes using #Neuropixels.

bioRxiv Neuroscience@biorxiv-neursci.bsky.social · last yr.

Triple-N Dataset: Non-human Primate Neural Responses to Natural Scenes https://www.biorxiv.org/content/10.1101/2025.05.06.652408v1

Check out my preprint on hippocampal ripple diversity, with @vitorlds.bsky.social and David Dupret at the MRC BNDU, where we reveal that distinct CA1 laminar profiles of ripples are associated with different reactivation dynamics: www.biorxiv.org/content/10.1...

1/ Our paper appeared in @Nature today! www.nature.com/articles/s41... w/ Fiete Lab and @khonamikail.bsky.social . Explains emergence of multiple grid cell modules, w/ excellent match to data! Novel mechanism for applying across vast systems from development to ecosystems. 🧵👇

Global modules robustly emerge from local interactions and smooth gradients - Nature

The principle of peak selection is described, by which local interactions and smooth gradients drive self-organization of discrete global modules.

nature.com

Every scientist, long before they were a scientist, was a little kid who stood in front of a fish tank or stared up at the stars or turned over a rock to look at the bugs underneath and said “wow”. On the best days, working in science still feels like that.

Congratulations Abe and Rich!!

Edvard I Moser@edvardmoser.bsky.social · 2y ago

Grid cells have a geometry in time. Thanks to @azvollan.bsky.social l & @rjgardner.bsky.social for this heroic discovery. @ercresearch.bsky.social #KiloNeurons @m-bmoser.bsky.social @kavlintnu.bsky.social @nature.com @kavlifoundation.bsky.social www.nature.com/articles/s41...

We are still taking applications!

Lisa Genzel (she/her)@lgenzel.bsky.social · 2y ago

We have an open post doc position funded by an ERC Consolidator grant. It is 3 years full-time and we are looking for someone with expertise in molecular methods (engram tagging/opto/DREADDs/Immunohistochemistry) to join our big, team-science projects. www.genzellab.com/we-are-hiring

It’s an incredible feeling to see something you’ve poured your heart into come to life. This work was born from my curiosity about hippocampal “cognitive tuning.” Our interpretation of the environment depends on our actions, constantly evolving as we pursue our goals www.nature.com/articles/s41...

Hippocampal neuronal activity is aligned with action plans - Nature

Using high-density electrophysiological recordings, how internally generated cell assemblies are updated by action plans to meet external goals is explored.

nature.com

Our paper on ketamine’s effect on astrocytes and behavior is out in Neuron by Marc Duque, Alex Chen, Eric Hsu, and colleagues @marcduque.bsky.social @alexbchen.bsky.social @ehsu6.bsky.social, with the Engert, Fishman, & Bergles labs, www.sciencedirect.com/science/arti...

Ketamine induces plasticity in a norepinephrine-astroglial circuit to promote behavioral perseverance

Transient exposure to ketamine can trigger lasting changes in behavior and mood. We found that brief ketamine exposure causes long-term suppression of…

sciencedirect.com

celebrating another year of excellent science, happy animals, and *happy people* at the kavli ❤️✨ @kavlintnu.bsky.social

Do octopuses dream? In any case, can't get enough of watching them sleep 😴🐙 Look at this symphony of patterns and movements! Incredible. youtu.be/006DjAixu9E?...

Do octopuses dream? Brain recordings provide the first clues

YouTube video by nature video

youtu.be

In those animals we didn't observe a correlation between ripples and glucose fluctuations. To me, this strongly suggested pancreatic insulin release is a mechanistic intermediate

Wow, thanks so much Adrien! It was such an exciting project to work on, and many directions to follow up. Another *really hidden gem (it didn't end up in the paper), we (@jocarpenter and I) treated three rats with streptozotocin which effectively kills beta cells in the pancreas...

Awesome pub looking at the unique role of AD- and M2-projecting RSC circuits from Xiaoxiao Lin et al. #neuroskyence www.nature.com/articles/s41...

Projection-specific circuits of retrosplenial cortex with differential contributions to spatial cognition - Molecular Psychiatry

Molecular Psychiatry - Projection-specific circuits of retrosplenial cortex with differential contributions to spatial cognition

nature.com

Thankful for a loving family, all of my super funny friends, a happy and collaborative lab environment, and my rat Rafael for giving me some beautiful data tonight 🤩🥰🍗

While this result is really exciting, the paper also contains some hidden gems. Ext Data Fig. 3, for instance, show the power spectrum of ripple occurrence. It reveals that ripple rates fluctuate not only on a 24-hour circadian cycle but also on a 4-hour ultradian cycle. 5/

Very timely piece. With 3-4 probes per rat and ultra long recordings, I’ve already generated 95TB of data for a single project. Thinking lots these days about how to store and publish all of this… 😬😬 Raw files vs. spike times x behavior or something in between?? Or both?

Liset M. de la Prida@lmprida.bsky.social · 2y ago

Happy to contribute to this @thetransmitter.bsky.social piece by @neurovium.bsky.social about challenges and opportunities on open data www.thetransmitter.org/the-big-pict...