Translational bottlenecks in blood-based proteomics - Hope there is something inspiring and informative for you in our recent comment at this inflection point. @embomolmed.org @hupo-org.bsky.social @proteinatlas.bsky.social link.springer.com/article/10.1...

Translational bottlenecks in blood-based proteomics - EMBO Molecular Medicine

EMBO Molecular Medicine - The translation of blood-based proteomics into healthcare is no longer constrained primarily by technological limitations, but by unresolved challenges in standardization,...

link.springer.com

Today we're launching Deliverome Bio, a focused research organization tackling one of the biggest bottlenecks in medicine: getting therapeutics to tissues beyond the liver.

A Meta-Analysis of 515 Human Proteomes Defines the Core Composition and Contaminants of Plasma Extracellular Vesicles isolates www.biorxiv.org/cont... --- #proteomics #prot-preprint

SciLifeLab seeks nominations for the next Campus Solna Director! 🧪 Campus Solna brings together the collective strength of @ki.se, KTH and @stockholm-uni.bsky.social, creating a unique interdisciplinary environment. Read more & nominate ↓ www.scilifelab.se/career/scili...

SciLifeLab seeks the next Campus Solna Director (Föreståndare)

SciLifeLab seeks the next Campus Solna Director (Föreståndare) SciLifeLab was founded in 2010 through a visionary partnership between Karolinska Institutet (KI), KTH Royal Institute of Technology (KTH...

scilifelab.se

Postdoc position available! Are you a highly motivated biochemist or analytical chemist with proven expertise in proximity labelling, mass spectrometry and proteomics? Then join our team! www.uu.nl/en/organisat...

Postdoc Position in Proteomics and Immuno-Oncology

Interested in revealing immune–tumor communication with innovative quantitative proximity proteomics? Join us using mass spectrometry to tackle these challenges

uu.nl

🚨 New preprint from the lab! We’re excited to share “Improving population-scale disease prediction through multi-omics integration” by Ng et al. www.medrxiv.org/content/10.1...

Interested in pleiotropy dissection but not sure where to start, which methods are useful, which studies offer illustrative examples, or how to robustly validate your results? Look no further 👀 rdcu.be/eSfAZ

Dissecting pleiotropy to gain mechanistic insights into human disease

Nature Reviews Genetics - Genome-wide association studies of increasing scale have revealed the prevalence of pleiotropic genetic variants that affect multiple traits. In this Review, the authors...

rdcu.be

Finally, someone has solved a real problem with AI! No more having to take a paper in the format for a journal that rejected you, and reformat it for a new journal. Well done!! formatmypaper.com

🚨 A new open-access resource of @proteinatlas.bsky.social A human pan-disease🩸 atlas of the circulating proteome 👉 www.proteinatlas.org/humanproteom... 📖 www.science.org/doi/10.1126/... 🤩 @buenoalvez.bsky.social and many more! @kawresearch.bsky.social @scilifelab.se @kthuniversity.bsky.social

Current landscape of plasma proteomics from technical innovations to biological insights and biomarker discovery - probably the currently most comprehensive comparison of plasma proteomics platforms! Congrats to Sara and her team! www.nature.com/articles/s42...

Current landscape of plasma proteomics from technical innovations to biological insights and biomarker discovery - Communications Chemistry

Plasma proteome profiling has surged as a promising avenue for biomarker discovery, yet comprehensive platform comparisons remain scarce. Here, the authors evaluate eight proteomics platforms, revealing key differences and complementary strengths, providing crucial insights for researchers into coverage trade-offs and implicating biomarker discovery and clinical applications.

nature.com

🚨 Exciting to share our recent global team effort on "A standardized framework for circulating blood proteomics" that just came out in Nature Genetics: rdcu.be/eHK4v.

A standardized framework for circulating blood proteomics

Nature Genetics - The field of blood proteomics faces an upsurge of data with the challenge of cross-study comparisons. This Perspective offers an in-depth analysis and proposes reference materials...

rdcu.be

Metformin treatment affects the circulating proteome (such as GDF15) in persons with and without diabetes. Great outcome of a close collaboration of the IMI-DIRECT, IMI-RHAPSODY and SCAPIS-Wellness consortia, studying multiple cohorts by advanced proteomics. www.sciencedirect.com/science/arti...

The influence of metformin treatment on the circulating proteome

Metformin is one of the most used drugs worldwide. Given the increasing use of proteomics in trials, bioresources, and clinics, it is crucial to under…

sciencedirect.com

Are you curious about blood microsampling to monitor changes in the circulating proteome? Then check our team science study recently published in @diabetologiajnl.bsky.social where we study the effects of virus induced immune response and disease onset. link.springer.com/article/10.1...

Frequent longitudinal blood microsampling and proteome monitoring identify disease markers and enable timely intervention in a mouse model of type 1 diabetes - Diabetologia

Aims/hypothesis Type 1 diabetes manifests after irreversible beta cell damage, highlighting the crucial need for markers of the presymptomatic phase to enable early and effective interventions. Curren...

link.springer.com

🚨Industry PhD position on advanced (proteo)omics data-driven analyses to study the molecular effects of #medication with #Pfizer. Apply 👉 www.pfizer.com/about/career... to join the SciLifeLab & Wallenberg National Program for Data-Driven Life Science. @scilifelab.se @kthuniversity.bsky.social

Explore our new preprint featuring novel data generated on the Nautilus Proteome Analysis Platform! The preprint covers how we use Iterative Mapping to quantify tau proteoforms at the single-molecule level: www.biorxiv.org/content/10.1... #Proteomics #Neuroscience #Proteoforms #AlzheimersDisease

Congratulations Dr Vincent from the @mannlab.bsky.social 🎓

Epitope Effect Prevalence in Affinity-based pQTL studies https://www.biorxiv.org/content/10.1101/2025.06.20.660695v1

Illumina picks up proteomics developer SomaLogic from Standard BioTools for $425M | www.fiercebiotech.co... --- #proteomics #prot-article

Back from #EUPA2025 in a Saint Malo and am so impressed by the ECR talks, and so happy we gave them to opportunity to be on stage and shine ✨! Keep up the great work! You are the future of #proteomics… Also thanks to my excellent session co-chair @maurinefucito.bsky.social for making this fun!

Perspectives and tides of proteomics at #EUPA2025 in beautiful Saint-Malo

Great outcome of a wonderful collaboration with @erikmelen.bsky.social and team! A very thoughtful approach to the biomarker challenge!

@erikmelen.bsky.social · last yr.

MMP-10 as a new biomarker for Type 2 inflammation in asthma? Surely promising. Please have a look at our recent Allergy paper! @jochwenk.bsky.social onlinelibrary.wiley.com/doi/10.1111/...

Looking forward to a Sunday on #genetics at #ESHG2025 and inspire to try #proteomics - @scilifelab.se #HumanProteinAtlas @kthuniversity.bsky.social

ICYMI:

Signalling from adipose tissue to the brain is not just about leptin

Nature Metabolism, Published online: 15 April 2025; doi:10.1038/s42255-025-01277-yA Nature Metabolism study shows that, under acute stress, fatty acids liberated by lipolysis of white fat cells cause release from local macrophages of the growth-differentiation factor GDF15, which, in turn, binds to the receptor GFRAL in the brain, evoking anxiety.

bit.ly

Another great #pQTL study, which, and among many things, expands the utility of dried blood spot #proteomics into #GWAS analyses. More to come…

Daniel Drucker@danieljdrucker.bsky.social · last yr.

Newborns at high risk #T1D colocalization of pQTLs for CTRB1, APOBR, IL7R, CPA1, and PNLIPRP1 with Type 1 diabetes GWAS signals, with Mendelian randomization causally implicates each of these proteins in the aetiology of Type 1 #diabetes @natcomms.nature.com www.nature.com/articles/s41...

Spread the news! Grants available to recruit scientists from outside of Europe to Sweden 🇸🇪 🧠 Please re-post.

New grant for recruiting researchers active outside Europe

In mid-April, the Swedish Research Council will issue a call for grants of 2 million SEK to enable Swedish higher education institutions and other research organisations to recruit prominent researche...

vr.se

A change of perspective expands your horizon - exciting two (and hopefully more) years ahead of working more closely with @erikmelen.bsky.social and team at Sachsska Children's and Youth #Hospital on implementing #proteomics into #clinical research and decision making! @kthuniversity.bsky.social

As my first post on @bsky.app I am happy to share our paper in Nature Reviews Genetics on how biobanking coupling genetic data with phenotypes at scale shapes precision medicine and global health go.nature.com/3AS54C0. Grateful to Scott Gallagher and Anji Musick for the All of Us Research Program.

Biobanking with genetics shapes precision medicine and global health - Nature Reviews Genetics

Biobanks help centralize specimen collections, store and disseminate data, and facilitate large-scale analyses. This Review discusses how biobanks facilitate genetics research towards advancing precis...

go.nature.com

Out today in Nature Genetics: Using MS-based proteomics, we mapped 1,200+ plasma proteins in 2,100+ children, showing how genetics & development shape blood protein levels during childhood. nature.com/articles/s41588-025-02089-2 #PediatricProteomics #pQTL First author @liliniu.bsky.social explains ⬇️

Plasma proteome variation and its genetic determinants in children and adolescents - Nature Genetics

This mass spectrometry-based proteomic study profiles the plasma proteome in 2,147 children and adolescents and reveals its association with age, sex, puberty, body mass index and genetics.

nature.com

The German language can explain complex events in one word. Today's contribution is "Klebefehler" or "sticking error": The slight misplacement of a tape strip or glue that, upon removal, will irreversibly damage the material you are trying to fix, leaving the task unfinished.

my thoughts on the destructive chaos targeting university research right now. Btw I've left @forbes and moved to @SubstackInc, where all my content is free: stevensalzberg.substack.com/p/the-pointl...

The pointless destruction of the world's leading scientific and medical research system

No one benefits from this

stevensalzberg.substack.com