Join is in Budapest in October! For the 6th time, all things epigenetics, gene and genome regulation and more. A fantastic opportunity to present, to talk to speakers and colleagues in a friendly, informal setting at a great location. Please note, travel grant deadline will expire soon.

📣 New PRBB-CRG conference 📋 Mapping progenitor niche dynamics for regulation of cell fate 🗣️ Francesca Spagnoli (@labspagnoli.bsky.social) - @kingscollegelondon.bsky.social  📆 May 22 - ⏰ 12:00 hosted by: @jorge-ferrer.bsky.social  - @crg.eu    📍 #PRBB Maria Skłodowska-Curie room

TF-MAPS: fast high-resolution functional and allosteric mapping of DNA-binding proteins by @XianghuaLi2 Are Transcription Factors really 'undruggable'? www.biorxiv.org/content/10.1...

TF-MAPS: fast high-resolution functional and allosteric mapping of DNA-binding proteins

Transcription factors (TFs) bind specific DNA sequences to control gene expression. Modulating TF activity is of considerable therapeutic interest but very few TFs have been successfully drugged. TF D...

biorxiv.org

Many exciting opportunities for a PhD in Life Sciences in CRG, Barcelona. If you are interested in Genomics of Diabetes check out the offer for a fully funded fellowship in our lab - we will consider candidates with experimental or computational backgrounds. Please spread the word!

Centre de Regulació Genòmica (CRG)@crg.eu · 10mo ago

Are you looking for a PhD? Join us in Barcelona! You'll dive into a community of >100 PhD students from 30 countries exploring the frontiers of biology. You can also join an online workshop on 6 November (15:00 CET) to learn how to find the right lab for you. More info: www.crg.eu/en/content/t...

The Gaza Famine is the world’s famine. A preventable, predictable famine. Enough. Ceasefire. Open all crossings, north and south. Let us get food in, unimpeded and at massive scale.

A HNF1A-A1CF transcription-splicing axis is suppressed in β cells from #T2D individuals, while genetic variants reducing pancreatic islet A1CF are associated with increased glycemia and T2D susceptibility www.cell.com/cell-metabol...

HNF1A and A1CF coordinate a beta cell transcription-splicing axis that is disrupted in type 2 diabetes

Bernardo et al. uncover a transcription-splicing regulatory axis driven by HNF1A and A1CF in pancreatic β cells. Targeted perturbations, single-cell studies, and human genetic evidence demonstrate tha...

cell.com

An HNF1A-A1CF transcription splicing axis regulates insulin secretion, and breaks down in T2D. Amazing work led by Edgar Bernardo + Matias de Vas + major contributions from Diego Balboa, Silvia Bonas, Mirabai Cuenca, Fanny Mollandin, Merce Planas, Miquel Torrent, MA Maestro and many others

HNF1A and A1CF coordinate a beta cell transcription-splicing axis that is disrupted in type 2 diabetes

Bernardo et al. uncover a transcription-splicing regulatory axis driven by HNF1A and A1CF in pancreatic β cells. Targeted perturbations, single-cell studies, and human genetic evidence demonstrate tha...

cell.com

SUM-seq out @natmethods.nature.com !
 🚀 Ultra-high-throughput Multiplexed snATAC+RNA Used to: ⏳ link temporal macrophage GRNs to immune disease genetics 🩸 map T cell regulatory landscapes 🧬✂️ dissect TF function in hiPSC differentiation via CRISPRi/a screens doi.org/10.1038/s41592-025-02700-8 🧵

Single-cell ultra-high-throughput multiplexed chromatin and RNA profiling reveals gene regulatory dynamics - Nature Methods

This work presents SUM-seq, an ultra-high-throughput method for co-profiling chromatin accessibility and gene expression in single nuclei across multiplexed samples, advancing the study of gene regula...

doi.org

These are VERY rough estimates, but here's life expectancy after diagnosis of type-I diabetes over the past 150 years. It was Banting and Best's discovery of how to isolate insulin in 1921 — not some fucking cooking class — that gave people including my daughter a new lease on life.

Congratulations for this study in @Dev_journal, no small feat in Argentina's anti-Science climate

Santiago Rodríguez Seguí@rseguilab.bsky.social · last yr.

Thrilled to announce a major milestone for our lab @ifibyne @Exactas_UBA — our paper on the glucocorticoid receptor's role in early pancreas development is now published in @Dev_journal! Huge thanks to @vallierlab.bsky.social for this long-term collaboration!👇🧵 🔗 doi.org/10.1242/dev....

Want to improve your protein or genomic language model’s performance at zero-shot variant effect prediction? We propose a simple adjustment to likelihood-based predicton

Charlie Pugh@cwjpugh.bsky.social · last yr.

New preprint in collaboration with @paulinanunezv.bsky.social supervised by @jonnyfrazer.bsky.social and Mafalda Dias – we propose a simple approach to improving zero-shot variant effect prediction in pre-existing protein and genome language models: 🧶 1/n www.biorxiv.org/content/10.1...

📣 Join us @ ALMU! If you have expertise in SMLM, experience in building bespoke microscope systems -or you're excited to start building- are familiar with Python, and have a passion for optical microscopy, we’d love to hear from you! 👇 recruitment.crg.eu/content/jobs... Reposts appreciated-Thanks!

Tracing human clones and lineages with DNA methylation. Congratulations for this fascinating breakthrough!

Lars Velten@larsplus.bsky.social · last yr.

Out @nature.com: Clonal tracing with somatic epimutations 🧬 Single cell methylome encodes cell state & clonal identity 🔨 EPI-Clone reads out both (+mutations, +RNA) at scale 🩸 Clonal expansions of HSCs are universal from age 50, not driven by CH mutations doi.org/10.1038/s415... 🧵

Happy to share a work from the Helman lab on how beta cells sense and control their insulin secretion by Krell et al. in @CellReports. Beta cells intrinsically sense and limit their secretory activity via mTORC1-RhoA signaling: Cell Reports www.cell.com/cell-reports...

Beta cells intrinsically sense and limit their secretory activity via mTORC1-RhoA signaling

Krell et al. show that mTORC1 in β cells acts as an activity sensor, activated by the same signals that trigger insulin secretion. This activation, in turn, inhibits insulin release via RhoA-dependent...

cell.com

Molecular Correlates of Glycine Receptor Activity in Human β Cells https://www.sciencedirect.com/science/article/pii/S2212877825000638

Just heard from the VP research that my grant with @dgrand.bsky.social, "Promoting Accurate Information on Social Media" was terminated as well

Lisa Fazio@lkfazio.bsky.social · last yr.

Can confirm that my NSF grant "How False Beliefs Form & How to Correct Them" was cancelled today because it is "not in alignment with current NSF priorities" Shocking that understanding how people are misled by false information is now a forbidden topic. Our work will continue but at a smaller scale

Is the genome just a bag of genes? A new paper in Science now reports that for two thirds of an organisms' genes the position along the chromosome is actually very tightly constrained! Amazing work from my favorite night scientist Martin Lercher and his team! www.science.org/doi/10.1126/...

🚨🚨 New pre-print from the lab. led by the amazing @alejotorrescano.bsky.social ! Alejo & Co. elegantly decode the spatial logic of progenitor cell organization in the developing pancreas — from individual cells to structured cellular communities 🔬🔬🧫🧪 Check-it out ⤵️

bioRxiv Developmental Biology@biorxiv-devbio.bsky.social · last yr.

Spatially organized cellular communities shape functional tissue architecture in the pancreas https://www.biorxiv.org/content/10.1101/2025.04.16.649169v1

@elpais.com Many established US scientists are taking a bold decision to move to Europe. EU is devoting funding to this but should be more ambitious elpais.com/ciencia/2025...

Hablan los científicos que quieren emigrar a España por Trump: “Tengo miedo al fascismo”

Centros punteros de Barcelona y Madrid reciben decenas de solicitudes de investigadores en Estados Unidos

elpais.com

Accuracy of gene regulatory network inference is increased by combining multiome single-cell and atlas-scale bulk data go.nature.com/43YySqO rdcu.be/ebBio

Inferring gene regulatory networks from single-cell multiome data using atlas-scale external data - Nature Biotechnology

Accuracy of gene regulatory network inference is increased by combining multiome single-cell and atlas-scale bulk data.

go.nature.com

We are looking for a keen bioinformatician for a fully funded PhD position! Drop me an email with your CV! www.findaphd.com/phds/project...

PhD Opportunity in Bioinformatics – Fully Funded for UK Home Fee Students at University of Birmingham on FindAPhD.com

PhD Project - PhD Opportunity in Bioinformatics – Fully Funded for UK Home Fee Students at University of Birmingham, listed on FindAPhD.com

findaphd.com

*last day* to register and submit your work in topics relevant to liver and islets in metabolic disease, including… - organoid models, regeneration, and synthetic biology - disease mechanisms and therapies - genome regulation - ….others

EMBO@embo.org · last yr.

Sign up now: registration and abstract submission deadline approaching. EMBO Workshop Liver and pancreas in metabolic disease: from pathways to therapies Sant Feliu de Guíxols (Girona), Spain, 2 – 4 April 2025 Deadline: 6 March meetings.embo.org/event/25-liv... #EMBOliverPancreas 🧪

Join the exciting EMBO Workshop on Liver and Pancreas in Metabolic Disease, which brings together top-tier speakers in an outstanding seaside venue in April 🌊🌅. We’ve designed an interactive and engaging program—register now before it’s too late! ⏳👉 meetings.embo.org/event/25-liv...

Liver and pancreas in metabolic disease: from pathways to therapies

The liver and pancreas arise from a common developmental origin and are controlled by shared gene regulatory programs.These organs are central to two of the most common and devastating metabolic dise…

meetings.embo.org

EMBO@embo.org · last yr.

Sign up now: registration and abstract submission deadline approaching. EMBO Workshop Liver and pancreas in metabolic disease: from pathways to therapies Sant Feliu de Guíxols (Girona), Spain, 2 – 4 April 2025 Deadline: 6 March meetings.embo.org/event/25-liv... #EMBOliverPancreas 🧪

Great work by @sviatoslavsidorov.bsky.social !

@sviatoslavsidorov.bsky.social · 2y ago

Our new preprint is out: biorxiv.org/content/10.1... We computationally investigated properties of alternative coding isoforms of human TF genes. Huge thanks to my collaborator Dr Koustav Pal and my supervisors Professors Nicholas Luscombe and @borislenhard.bsky.social!

Still time to apply! Applications from US welcome – four years can feel longer or shorter depending on where you are 😉

Jorge Ferrer@jorge-ferrer.bsky.social · 2y ago

📣 Hiring, please forward widely!! Two postdoc openings to work on genomics of diabetes 1. Computational regulatory genomics/statistical genetics. 2. Experimental cell-based modeling DM if interested @crg.eu shorturl.at/O3wMi shorturl.at/ieyZy

Application deadline is get closer - make sure you do not miss this exciting EMBO workshop on liver and pancreatic biology and disease 😉 meetings.embo.org/event/25-liv...

Liver and pancreas in metabolic disease: from pathways to therapies

The liver and pancreas arise from a common developmental origin and are controlled by shared gene regulatory programs.These organs are central to two of the most common and devastating metabolic dise…

meetings.embo.org

If the past two meetings are any indication, this promises to be another great genome regulation workshop

Rada-Iglesias Lab@radaiglesiaslab.bsky.social · 2y ago

Together with @smandrup.bsky.social and Minna Kaikkonen we are happy to announce the 3rd Edition of the EMBO Workshop on #Enhancers and #Enhanceropathies. This time we will meet during the beautiful Danish summer (June 16-21). Book the dates and register soon!!! meetings.embo.org/event/25-enh...

Two great articles in Mol Cell about enhancer cooperativity & long-range enhancer activation by @chribue.bsky.social & Wysocka labs: www.sciencedirect.com/science/arti... www.sciencedirect.com/science/arti... Dimitra and I had the pleasure to write a Preview: www.sciencedirect.com/science/arti...

Bridging the gap: How enhancers cooperate to regulate gene expression over large genomic distances

By building synthetic regulatory landscapes, Jensen et al.1 and Thomas et al.2 demonstrate in this issue of Molecular Cell that gene expression levels…

sciencedirect.com

Join us in Belfast for our #epigenetics meeting and hear from fantastic speakers. Submit an abstract until 26 Jan and register until 23 Feb! Don't miss this chance to share your research & network with experts in the field. genetics.org.uk/events/epige...

Epigenetics-2025, from mechanisms to disease | Genetics Society

Meeting background This international conference will bring together leading experts to foster dynamic discussions on the latest breakthroughs in epigenetics. It will cover mechanisms of epigenetic re...

genetics.org.uk

If you’re interested in doing Postdoc work in Vancouver this is a great opportunity, check out our website and get in touch soon (www.betacell.ca)!

Lara Green@laragreen.bsky.social · 2y ago

ATTN Canadian and International trainees! The J. Andrew McKee Fellowship is open. Notice of intent is due JAN 30, 2025!! Supported by Breakthrough T1D Canada and Stem Cell Network of Canada, this PDF brings aspiring scientists to the BT1D Centre of Excellence at UBC! t.co/dDWHluBbrX