Chaperonin recognition of protein dynamics drives drug resistance https://www.biorxiv.org/content/10.64898/2026.06.03.729952v1
Joao V. Rodrigues
@jrodrigues.bsky.social
Biochemist. Scientist at Generate Biomedicines. Shakhnovich lab@Harvard postdoc alumnus. Interested in enzymes, experimental evolution, cell-free protein synthesis, automation.
Generate Biomedicines: "Today, we announced the initiation of SOLAIRIA, the first global Phase 3 studies of a long-acting anti-TSLP antibody for #SevereAsthma. " Learn more about SOLAIRIA → lnkd.in/eMTCZpXC Read our full announcement → lnkd.in/e2Q9K7-Y
#generativebiology #severeasthma #asthma #phase3 #clinicaltrials #respiratoryhealth | Generate:Biomedicines
Progress in #GenerativeBiology becomes real when a molecule performs exactly as it was designed. Today, we announced the initiation of SOLAIRIA, the first global Phase 3 studies of a long-acting ant...
linkedin.com
Generate Biomedicines Launches Global Phase 3 Trials for GB-0895 to Combat Severe Asthma #USA #Somerville #Clinical_Trials #Asthma_Treatment #GB-0895
Generate Biomedicines Launches Global Phase 3 Trials for GB-0895 to Combat Severe Asthma
Generate Biomedicines unveils plans for two global Phase 3 trials assessing GB-0895 treatment for severe asthma, showcasing AI innovation in healthcare.
third-news.com
Generate Biomedicines tested the first AI-designed COVID-19 antibody in humans. In 51 healthy adults, the antibody GB-0669 was safe, lasted about 54 days in the body, and neutralized Omicron variants for at least two weeks, supporting Phase 2 trials. www.medrxiv.org/content/10.1...
First-in-Human Study of a First-in-Class AI-Designed Monoclonal Antibody (GB-0669) Against the Conserved SARS-CoV-2 Spike S2 Stem Helix
Background Antibodies against the SARS-CoV-2 spike receptor-binding domain provided effective COVID-19 treatment until resistant variants emerged. GB-0669 is a half-life extended monoclonal antibody o...
medrxiv.org
Estação de metro de Harvard sq (Cambridge, MA), 8 da manhã, 10 Junho dia de Portugal, cheira-me a sardinhas assadas! Serão saudades?
Yesterday, the NIH R35 “Outstanding Investigator” grant to fund scientists in my lab studying antibiotic resistance was terminated for reasons not related to the content of the science, or any actions taken by me or members of my lab
The Institut Pasteur has decided to leave X (formerly Twitter) to join BlueSky! 🦋 The Institut Pasteur made this decision due to several serious issues observed on the X platform since its acquisition. Join us here to continue advocating for science. www.pasteur.fr/en/home/pres...
Institut Pasteur decides to leave X
The Institut Pasteur, a research organization which for more than 130 years has been committed to tackling infectious diseases, sharing knowledge and defending science, has decided to leave X because ...
pasteur.fr
Check out the putative MOA of Generate Biomedicines's GB-0895, our monoclonal antibody for optimally inhibiting TSLP, a cytokine that drives asthma symptoms like shortness of breath. www.youtube.com/watch?v=KyR4...
GB-0895 (anti-TSLP) Putative MOA Video
YouTube video by Generate:Biomedicines
youtube.com
E. coli transcription factors regulate promoter activity by a universal, homeostatic mechanism doi.org/10.1101/2024...
A few more letters... and we can finally write amino acid sequence with protein structure encoded by amino acid sequence? 🧬🤔😀 @chrisfrank662.bsky.social , Dominik Schiwietz, Lara Fuss, Hendrik Dietz www.biorxiv.org/content/10.1...
How do you tell bots apart from real people on this app? For me it's seeing an obscene number of very niche and cryptic hash tags in their bio. 100% that's a scientist
Bluesky tops 20M users, narrowing gap with Instagram Threads
Bluesky tops 20M users, narrowing gap with Instagram Threads
Bluesky, the social network and X competitor has been benefiting from a surge of departures from the Elon Musk-owned app formerly known as Twitter. Today, Bluesky has hit a major milestone: it’s topped 20 million users. What’s more, new data indicates the…
tcrn.ch
Highly multiplexed design of an allosteric transcription factor to sense new ligands doi.org/10.1038/s414...
The Virtual Lab, an AI-human research collaboration, was applied to design nanobody binders for recent variants of SARS-CoV-2. The designed nanobodies were experimentally validated, revealing a range of functional nanobodies with promising profiles. www.biorxiv.org/content/10.1...
The Virtual Lab: AI Agents Design New SARS-CoV-2 Nanobodies with Experimental Validation
Science frequently benefits from teams of interdisciplinary researchers. However, most scientists don't have access to experts from multiple fields. Fortunately, large language models (LLMs) have rece...
biorxiv.org
Já estou há algum tempo com actividade regular no BlueSky e ainda não vi ninguém a ser baleado na rua, ou a ficar paralisado, não vi dois jovens à porrada até um bater com a cabeça no chão, já não sei o que são posts ultra nacionalistas, não tenho sido ofendido… Isto não vai a lado nenhum.
Heard at the conference bar: “How many starter packs are you part of?”
Dizem-me que está em acesso 🔒 porque também foi publicado em papel Partilho com os primeiros pedidos via DM, basta deixarem o e-mail
Joana G Sa@joanagsa.bsky.social · 2y agoO orçamento para a Ciência em Portugal não existe: lendo o OE e a nota explicativa é dolorosamente óbvio que o dinheiro é pouco, mal gasto e para "inovação" A cada ano, uma oportunidade perdida Grata à Teresa Firmino e @tiagoramalho.bsky.social por conversas e edições www.publico.pt/2024/11/14/c...
Bluesky adds 700,000 new members as users flee X after the US election | Bluesky | The Guardian
Bluesky adds 700,000 new members as users flee X after the US election
Social media platform has become a ‘refuge’ from the far-right activism on X, experts say, after Elon Musk teamed up with Donald Trump
buff.ly
I thought about putting together an ex-academic scientist starter pack, but I quit that too.
The US is an outlier among wealthy democracies in having a government that, on average, continues to get older.
2️⃣ Maud Leonora Menten 🇨🇦 (1879-1960) #womeninSTEM Canadian biochemist, known for her work in enzymology. With Michaelis, she developed an equation that explain the rate of reversible enzymatic reactions & substrate concentration, the Michaelis-Menten equation definingmomentscanada.ca/insulin100/s...
It's only fit to share this as my first interaction on this platform.
Thiago Carvalho@cyrilpedia.bsky.social · 3y ago“You can’t have meaningful and productive scientific collaboration on a platform run by a right-wing troll who denies science when its results are inconvenient to him and just simply to hear his audience cheer,” Bergstrom wrote' www.latimes.com/business/sto...