Kanika Jain
@kanika0386.bsky.social
🎓 Faculty( research track) @ Yale School of Medicine | AHA CDA & TPA Awardee | Passionate about Platelets, Proteostasis, CVD, Alzheimer’s & Aging. ECEB member at ATVB, Circ Res, and FASEB. ✍️ Scientist in job & writer at❤️! 🌟 Open to new job opportunities!
ER remodelling is a feature of ageing and depends on ER-phagy www.nature.com/articles/s41...
ER remodelling is a feature of ageing and depends on ER-phagy - Nature Cell Biology
Donahue et al. show that ageing is associated with changes in ER morphology. ER-phagy drives age-associated ER remodelling through tissue-specific factors.
nature.com
Our new paper is out now in Nature Communications! We uncovered the function of XBP1 in beta cells of a preclinical model of T1D and identified unique and shared gene regulatory networks driven by IRE1 and XBP1. www.nature.com/articles/s41...
Defining the role of β-cell IRE1α/XBP1 pathway and its gene regulatory network components in non-obese diabetic mice - Nature Communications
Modulating the unfolded protein response (UPR) can induce protective dedifferentiation of β-cells in non-obese diabetic mice. Here, the authors show that β-cell deletion of UPR transcription factor XB...
nature.com
Grateful for the invitation to speak at Emerging Leaders in Neuroscience Seminar @weillcornell.bsky.social My talk , “Beyond the Brain: Clues from Platelets in Alzheimer’s Pathology,” explored what platelets can tell us about AD disease progression/prognosis. #Neuroscience #Alzheimers #platelet
Thrilled to be awarded a 3 yr @ahascience.bsky.social Transformational Project Award to investigate how platelet UPR drives functional fidelity in aging/CVD. This takes forward my research on platelet protein aggregates in Alzheimer (AHA CDA).❤️↔️🧠 @yaleschoolofmed.bsky.social @yalecvrc.bsky.social
MEK1/2 inhibitors suppress pathological α-synuclein and neurotoxicity in cell models and a humanized mouse model of Parkinson’s disease | Science Translational Medicine www.science.org/doi/10.1126/...
MEK1/2 inhibitors suppress pathological α-synuclein and neurotoxicity in cell models and a humanized mouse model of Parkinson’s disease
MEK1/2 inhibitors lowered pathological αsyn in a humanized mouse model, suggesting an oral treatment strategy for Parkinson’s disease.
science.org
We’re the heroes in our own blockbuster life movies—the genre may be action, drama, comedy or tragedy. Dont judge the music of one with the special effects of another. Cheer for the effort, not just the award…
Omfg It’s Bunsz !@copaceticbunsz.com · 2y agoIf you’re over 30, quote this with some life advice 🤌🏼
Honored to be a Finalist for the Brinkhous Award recognizing excellence in #Thrombosis research at #Vasculardiscovery25 & an opportunity to share our research on #platelets in #Alzheimer’s Disease. @yaleschoolofmed.bsky.social @ahascience.bsky.social @yalecvrc.bsky.social
Choosing the Right Lens: Pf4 vs. Gp1b in Viewing Platelet COX-1. An ATVB blog article where we discuss the recent ATVB study comparing Pf4-Cre & Gp1ba-Cre models, highlighting how COX-1 depletion affects thrombogenesis & atherogenesis differently. AHA Blogs www.ahajournals.org/do/10.1161/b...
American Heart Association Journals
ahajournals.org
Interesting review! www.nature.com/articles/s41...
Biomarkers of aging: functional aspects still trump molecular parameters - npj Aging
Biomarkers of aging are indispensable for testing interventions. While promising, the recent focus on molecular aspects should not detract from the functional parameters for which excellent correlatio...
nature.com
These are testing times for all scientists ...Let's keep doing what we can, keeping fingers crossed ... #Hibluesky #research #platelets
💊 Thrombocytopenia + antiplatelet therapy = a tricky balance. New study from Wolfgang Bergmeier team shows clopidogrel increases bleeding risk, while aspirin may be safer. What does this mean for patients? Find out: www.rpthjournal.org/article/S247...
In their Review, @jontytownson.bsky.social and Cinzia Progida @biovitenskap.bsky.social discuss the emerging roles of the endoplasmic reticulum in mechanosensing and mechanotransduction. journals.biologists.com/jcs/article/...
No added sugar: CCDC134 stabilizes ER chaperone Gp96 for TLR biogenesis. Leslie Domínguez Cadena and Antje Blumenthal discuss new study from @lbernaleau.bsky.social et al. @@rebsamenlab.bsky.social (https://buff.ly/3ZrE70d) in Insights: https://buff.ly/4gwjt5N
New publication from my PhD research looking at influences of sex on brain health outcomes in a rodent model of Alzheimer’s disease (AD) risk 🎉: link.springer.com/article/10.1... Big thank you to the best co-authors, @liisagalea.bsky.social, Melike Cevizci, and Stephanie Lieblich 🙏
Sex-specific influences of APOEε4 genotype on hippocampal neurogenesis and progenitor cells in middle-aged rats - Biology of Sex Differences
Background Alzheimer’s disease (AD) disproportionately and uniquely affects females, and these sex differences are further exacerbated by the presence of Apolipoprotein (APOE) ε4 alleles, the top gene...
link.springer.com
Hello from the Yale Cardiovascular Research Center! We look forward to interacting with the science community on blue sky!
Don’t know if it’s the cold or the weather (IYKYK)…could be the gradual loss of enthusiasm under the constant state of stress, deadlines and uncertainty about the future…or maybe just some internal goals which haven’t been accomplished….with no clear en in sight… But 2025 till now has been tough…
We are on the cover! ❤️represents cardiovascular health, & 👐hands holding platelets & medications, symbolize the interplay between pathological platelet activation & therapeutic strategies crucial for CVD management. Diverse individuals highlight the importance of demographic factors on CVD risk.
Wishing everyone a very Happy New Year 2025! 🎉 May this year bring the rise of unbiased science, innovative research, and the growth of academia. Here’s to a remarkable year ahead! 🌟 #HappyNewYear #Research #Academia
In our recent review, we explore how demographic diversity—due to age, gender, race, ethnicity—significantly influences platelet phenotypes & responses to antiplatelet therapies. www.cell.com/trends/pharm... #Platelets #Age #Gender #Race #Ethnicity #Demographicdiversity #PopulationDiversity #CVD
Demographic diversity in platelet function and response to antiplatelet therapy
Recent studies have highlighted the complexity of platelet biology, revealing their diverse roles beyond hemostasis. Pathological platelet activation is now recognized as a key contributor to thrombosis and inflammation that are both central to cardiovascular disease (CVD). Emerging research emphasizes the significant impact of demographic factors – such as age, sex, race, and ethnicity – on CVD risk and responses to antiplatelet therapies. These population-based differences, shaped by genetic and non-genetic factors, highlight the need for reevaluation of antiplatelet strategies. We address current knowledge and emphasize the pressing need for further research into platelet biology and cardiovascular outcomes across diverse populations. In this review we advocate for tailored therapeutic approaches in CVD based on the recent demographic-focused findings.
cell.com
How to get invited to give talks as an early career investigator? Any tips/opportunities would be appreciated!
SPATIAL PROTEOMICS is the Method of the Year 2024!!! 🤩🤩🤩 www.nature.com/articles/s41...
Method of the Year 2024: spatial proteomics - Nature Methods
Approaches for profiling the spatial proteome in tissues are the basis of atlas-scale projects that are delivering on their promise for understanding biological complexity in health and disease.
nature.com
Started a hemostasis & thrombosis starter pack but I know I’m missing a bunch of accounts. Let me know who else to add! go.bsky.app/4reAetF
"Negative reinforcement, such as receiving overly harsh criticism or being scolded by a research mentor, and being held to unreasonable expectations were two of the most detrimental aspects of research affecting student mental health." www.nature.com/articles/s41...
Behind the graduate mental health crisis in science - Nature Biotechnology
Survey results identify how scientific research and teaching contribute to the graduate student mental health crisis.
nature.com
Atlas of the plasma proteome in health and disease in 53,026 adults 👩🔬🥼👨🔬🧪. #proteomics #proteome #plasma #MedSky 👇👇 www.cell.com/cell/fulltex...
Atlas of the plasma proteome in health and disease in 53,026 adults
A large-scale proteomics study involving 53,026 individuals maps 2,920 plasma proteins to 406 prevalent diseases, 660 incident diseases, and 986 health-related traits, identifying promising biomarkers...
cell.com
Optimist: The cup is half full Pessimist: The cup is half empty Platelet Scientist:Let me look for aggregates
Andrew Robinson (no, not Garak)@andrewr.bsky.social · 2y agoOptimist: The cup is half full Pessimist: The cup is half empty Physicist: Assume a spherical cup in a vacuum
Faculty mentoring in academic institutions, a thread. As I advance in my academic career (read: as I keep getting more gray hair), I've come to appreciate, even more than before, the profound responsibility we (senior-ish faculty) have to support and nurture emerging talent, not diminish it.
