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Karina Jouravleva

@karinajouravleva.bsky.social

4 Posts57 Follower42 Folgt
Terradot lab@laurentterradot.bsky.social · 4w ago

À novel preprint from the lab ! In a study led by Christian Lesterlin’ s we identify a novel plasmid encoded protein, named HerB. HerB is produced upon entry of the plasmid and modifies host biology to facilitate plasmid establishments ! More here ! #Microsky www.biorxiv.org/content/10.6...

Plasmid-encoded host reprogramming promotes plasmid dissemination

Conjugative plasmids are major drivers of antibiotic resistance dissemination, yet how newly transferred plasmids establish in recipient cells remains poorly understood. Here we investigate YfjB, a pr...

biorxiv.org

The Cecere Laboratory@cecerelab.bsky.social · 2mo ago

If you are interested in the story behind our recent study in Nature Structural & Molecular Biology, our accompanying Research Briefing discusses the questions that motivated the work, the main findings, their implications, and the path that led us there. @pasteur.fr rdcu.be/flcpv

Yolk transports miRNAs to embryos and enhances progeny stress resilience

Nature Structural & Molecular Biology - This study shows that yolk, a conserved vehicle for nutrient provisioning to developing eggs, also transports regulatory small RNAs, such as microRNAs,...

rdcu.be

The Cecere Laboratory@cecerelab.bsky.social · 3mo ago

Our latest work is now online in NSMB: maternal yolk carries microRNAs from the intestine to embryos, shaping gene regulation and stress resilience in the next generation. rdcu.be/fj8Er #Epigenetics #microRNA #Inheritance @pasteur.fr @devstempasteur.bsky.social @erc.europa.eu

Soma-to-germline miRNA inheritance through yolk promotes stress resilience in progeny - Nature Structural & Molecular Biology

In this study, the authors use the Caenorhabditis elegans model organism to show that maternal microRNAs are delivered from the intestine to embryos by the yolk, where they regulate gene expression an...

nature.com

Julius Brennecke@juliusbrennecke.bsky.social · 6mo ago

The demystification of piRNA clusters if you wonder how cells generate piRNAs specifically against transposons & you are looking for a weekend read check out @86dominik.bsky.social's opus magna (or Dominik's great thread) a shared project with the one and only Rippei Hayashi, lab alumnus & friend

Dominik Handler@86dominik.bsky.social · 6mo ago

How does the piRNA pathway solve the self vs. non-self problem? 🧬 Since piRNAs come from single-stranded RNA, how does the cell choose the right ones? For years, "piRNA clusters" were seen as THE privileged source. But are they really special and earmarked for biogenesis? (1/19)

Karina Jouravleva@karinajouravleva.bsky.social · 6mo ago

Happy to see our study out! We define the sequence determinants for miRNA-target interactions in flies and provide a foundation for improving computational prediction of miRNA-mediated regulation in Drosophila. www.nature.com/articles/s41... #miRNA, @natcomms.nature.com, @rti-umasschan.bsky.social

Biochemical principles of miRNA targeting in flies - Nature Communications

MicroRNAs guide Argonaute proteins to repress gene expression. Here, the authors define the binding rules for five Drosophila miRNAs, showing a narrow preference for canonical seed sites and identifyi...

nature.com

RNA Therapeutics Institute@rti-umasschan.bsky.social · 6mo ago

Hot off the press from the Zamore & Gainetdinov labs: Cleavage of mRNAs by a minority of pachytene piRNAs improves sperm fitness 🏊️ buff.ly/O40kIi3 #piRNA #mRNA #fertility

Cleavage of mRNAs by a minority of pachytene piRNAs improves sperm fitness - Nature

Most pachytene PIWI-interacting RNAs (piRNAs) have no biological function; however, a small population enhances sperm fitness, which has led to their persistence in mammalian evolution.

nature.com

Anne Chevallereau@annechevallereau.bsky.social · 6mo ago

Un poste de Maître de Conférence est ouvert pour rejoindre notre unité à Lyon ! Possibilité de rejoindre mon équipe pour travailler sur: - caractérisation des mécanismes de défense anti-phage - transfert horizontal et interactions entre éléments génétiques mobiles N'hésitez pas à me contacter

MMSB-Lyon@mmsb-lyon.bsky.social · 6mo ago

📢 Recrutement d’un(e) Maître(sses) de conférence en Biochimie générale, spécialité bactériologie moléculaire à MMSB 🔬Recherche *Immunité anti-phages *Réponse au stress, modulation de la croissance bactérienne ✉️ christophe.grangeasse@cnrs.fr 📚Enseignement : Université Lyon I ✉️ patrice.gouet@ibcp.fr

Cyril Bourgeois@cbourgeois.bsky.social · last yr.

Une mise en avant de nos travaux récents sur le gène DDX17 dans les troubles du neurodéveloppement. @lbmcinlyon.bsky.social @ensdelyon.bsky.social @inserm.fr @jcourchet.bsky.social centre-imind.fr/identificati...

Identification d’un nouveau gène impliqué dans les troubles du neurodéveloppement : le gène DDX17 - IMIND

La recherche sur les troubles du neurodéveloppement (TND) vient de franchir un nouveau cap grâce à cette récente étude sur le rôle du gène DDX17 dans le développement neuronal.

centre-imind.fr

Laboratory of Biology and Modeling of the Cell@lbmcinlyon.bsky.social · last yr.

A écouter: un podcast dans lequel @mirko-francesconi.bsky.social nous parle de nématodes et d'épigénétique. Un grand merci à @cnrs-rhoneauvergne.bsky.social. www.cnrs.fr/fr/podcast-q...

Podcast | Qu'est-ce que tu cherches ?

Avec « Qu’est-ce que tu cherches ? », le podcast science du CNRS, partez à la rencontre des scientifiques, découvrez leur quotidien, leur domaine de recherche, leurs avancées et ce qui les motive. Dan...

cnrs.fr

Laboratory of Biology and Modeling of the Cell@lbmcinlyon.bsky.social · last yr.

smartlink.ausha.co/cnrs-qu-est-...

L’épigénétique au microscope : l’exemple du nématode | Mirko Francesconi (Inserm)

Le patrimoine génétique est propre à chaque individu et c’est ce qui le rend unique ! C’est même le cas pour de vrais jumeaux, bien qu’ayant grandi dans le même environnement, ils se retrouvent souven...

smartlink.ausha.co

Laboratory of Biology and Modeling of the Cell@lbmcinlyon.bsky.social · last yr.

A écouter: un podcast dans lequel @mirko-francesconi.bsky.social nous parle de nématodes et d'épigénétique. Un grand merci à @cnrs-rhoneauvergne.bsky.social. www.cnrs.fr/fr/podcast-q...

@ericci-aeruginosa.bsky.social · last yr.

Our latest work on HIV-1 translational control is out! @naturecomms.bsky.social www.nature.com/articles/s41... Here, we performed a transcriptomics, translatomics and whole proteomics analysis during the course of infection. @lbmcinlyon.bsky.social @ensdelyon.bsky.social @inserm.fr

Non-AUG HIV-1 uORF translation elicits specific T cell immune response and regulates viral transcript expression - Nature Communications

Here, integrating ribosome profiling, RNA-seq and proteomics to reveal transcriptional and post-translational regulation in HIV-infected T cells, the authors show that non-AUG translation of viral ups...

nature.com

Bertrand Mollereau@mollereaulab.bsky.social · last yr.

Check out our new article on #autophagy in #BPAN neurological disease available in bioRxiv. #raredisease #drosophila. www.biorxiv.org/content/10.1... Cheers! @ensdelyon.bsky.social @lbmcinlyon.bsky.social

A dWDR45 knock-out Drosophila model to decipher the role of autophagy in BPAN

Beta-propeller protein-associated neurodegeneration (BPAN) is a rare neurological disease characterized by severe cognitive and motor impairments. BPAN is caused by de novo pathogenic variants in the ...

biorxiv.org