What's the mechanism? Dendrites. PCA of dendritic voltages shows that harder tasks recruit higher-dimensional dynamics, more semi-independent dendritic branches doing local computations. It's a distributed, high-rank representation across the tree. (9/15)
Katharina Duecker
@katduecker.bsky.social
comp neuro postdoc with Stephanie Jones at the Carney Insitute for Brain Science, Brown University | HNN developer | passionate about oscillatory dynamics and their role in neuronal computation 🧠 https://sites.brown.edu/stephanie-r-jones-lab/
The Milky Way looks like a rave.
Here's the most complete picture of the Milky Way's center ever created www.livescience.com/milky-way-ce... Made from nearly 400 separate observations, the new image reveals strange structures never seen before.
NEW PAPER🚨👀 in Science Advances with a wonderful transatlantic team. (incl @sylvainbaillet.bsky.social @olejensen.bsky.social @katduecker.bsky.social) Using human MEG, we found lower-order and higher-order neural processes that underlie illusory transitions in conscious visual perception. 🧵👇
Hierarchical brain dynamics supporting visual perceptual transitions
Illusory transitions in conscious visual perception involve both early visual cortex and higher-order motor cortices.
science.org
Super glad to have our team's work on clinical applications of neural simulations highlighted in this article! Trying to bring academic work to the real-world has been a great experience and I'm quite excited to continue these efforts with @dvwz.bsky.social and @jonescompneurolab.bsky.social
Meet the trainees co-founding companies to defeat Alzheimer’s disease and other disorders! Larry Heller, Ryan O'Rourke, @dvwz.bsky.social and @ntolley.bsky.social share the story of their entrepreneurial journeys. carney.brown.edu/news/2026-05-05/ad-spin-offs
Meet the trainees co-founding companies to defeat Alzheimer’s disease and other disorders! Larry Heller, Ryan O'Rourke, @dvwz.bsky.social and @ntolley.bsky.social share the story of their entrepreneurial journeys. carney.brown.edu/news/2026-05-05/ad-spin-offs
Lab to launch
Three trainee-led startups are on a mission to fight Alzheimer's disease.
carney.brown.edu
Happy to share a new preprint from the @hnnsolver.bsky.social team!🧠💻🎉 "Uncovering putative neural mechanisms of neurotherapeutic impacts on EEG using the Human Neocortical Neurosolver" 📝 www.biorxiv.org/content/10.6...
The Orange Cat Brain Atlas is here. 🧠🐈 Today, we published the first comprehensive cellular map of the orange cat brain. The new atlas reveals a single, specialized neuron responsible for behaviors like staring at walls, knocking objects off tables, and the 3am "zoomies."
Slight but exciting departure from typical projects for me: I’m happy to share our paper finding that frontal beta event characteristics predict antidepressant response to sertraline (SSRI) has been accepted at J Psychiatric Research! 1/ www.medrxiv.org/content/10.6... #psychscisky #neuroskyence
Transient frontal spectral events from EEG predict antidepressant response to sertraline in depression
Resting-state scalp electroencephalography (EEG) is a promising method for predicting patient outcomes of antidepressant treatments. Machine-learning-based EEG analysis of averaged power features (APF...
medrxiv.org
Almost done with my next lecture, so going back now to work on some new memes
The biggest problem holding neuroscience back right now isn’t data or tools, thanks in large part to the BRAIN Initiative. It’s fragmentation across species. I wrote this to hopefully spark discussion around an issue that can only be solved as a community👇 www.thetransmitter.org/animal-model...
Neuroscience has a species problem
If neuroscience is serious about building general principles of brain function, cross-species dialogue must become a core organizing principle.
thetransmitter.org
main goal for this year: find a new job! 🙂 looking for a role with fun & complex technical challenges & within a great community. my main expertise is in signal processing/EEG/MEG, but topic-wise I am quite flexible. science/industry both great! starting mid-year. nschawor.github.io/cv
🚨 New preprint! Why do some insights from spikes translate to field potentials while others don't? In this paper we compare visual memory representations in spikes and LFPs to propose a general framework that answers this question. www.biorxiv.org/content/10.6... 🧵 (1/10) 🧠🟦 🧠💻
Neural representations of visual memory in inferotemporal cortex reveal a generalizable framework for translating between spikes and field potentials
Translating neurophysiological findings requires understanding the relationship between common measures of brain activity in animals (spiking activity) and humans (local field potentials, LFP). Prior ...
biorxiv.org
Passionate about women's mental health? Interested in brain stimulation? Excited by cutting edge neurotech? Come do a PhD with me! www.findaphd.com/phds/project... (thread)
a woman says we have to work together in front of a wentworth sign
ALT: a woman says we have to work together in front of a wentworth sign
media.tenor.com
I have so many issues with this podcast with @earlkmiller.bsky.social . I think that this podcast nicely shows why I have trouble with such approaches. Lets go through some of the claims.
Giant Shoulders podcast: Meet the MIT Neuroscientist Proving Brainwaves are the Secret to Consciousness. youtu.be/7OFb-NG3jIw #neuroscience
If you are at #SfN2025, come see me at my poster LBP022.7 on Sun 8-12 to talk about the next generation HNN that we have been working on over the past year 🧠🧪also check out our new updated website & textbook built by @asoplata.bsky.social & Dylan Daniels @hnnsolver.bsky.social
@katduecker.bsky.social will present the next-generation HNN with cellular dynamics tuned to human cells & dendritic calcium spikes in the L5 and L2/3 pyramidal cells. Our simulations show that calcium spikes have dominating effects on human E/MEG signals! Sun, Nov 16, 2025, 8 AM – 12 PM, LBP022.07
The Jones comp neuro lab is at #SfN25! Come check out our talks and posters to learn about our latest & greatest Science with HNN! All poster presentation times & locations can be found at jonescompneurolab.github.io/textbook/res...
HNN Textbook
jonescompneurolab.github.io
Joyce Gao will present the application of HNN to simulate single pulse TMS evoked potentials. We show generative predictions for double pulse TMS and pharmacological modulations. Wed, Nov 19, 2025, 1 PM - 5 PM, PSTR478.08
Excited to share our preprint on variability in patch leaving decisions! Check out the 🧵 below
🧪Preprint! How foragers depart from optimal models can tell us a lot about how they compute their decisions. A strong but underexplored departure is that foragers widely vary when they leave identical patches. A 🧵 doi.org/10.1101/2025... With @emmavscholey.bsky.social @brainapps.bsky.social
Delighted to share our new preprint! We show that rhythmic light stimulation produces multiplexed oscillatory responses at fundamental and harmonic frequencies that are spatially, temporally, and functionally distinct. Read on for the details [1/6] www.biorxiv.org/content/10.1... #neuroskyence
Rhythmic light stimulation elicits multiple concurrent neural responses that separably shape human perception
Rhythmic light stimulation offers solutions to innumerable cognitive and neurological disorders. However, like any neuromodulatory technique, responses to rhythmic light stimulation are highly variabl...
biorxiv.org
@dotproduct.bsky.social's first first author paper is finally out in @sfnjournals.bsky.social! Her findings show that content-specific predictions fluctuate with alpha frequencies, suggesting a more specific role for alpha oscillations than we may have thought. With @jhaarsma.bsky.social. 🧠🟦 🧠🤖
Contents of visual predictions oscillate at alpha frequencies
Predictions of future events have a major impact on how we process sensory signals. However, it remains unclear how the brain keeps predictions online in anticipation of future inputs. Here, we combin...
jneurosci.org
Ever wonder how you read so fast? Your brain gets a head start—processing the next word before your eyes move. Our MEG + eye tracking study out in Nature Communications study from @thechbh.bsky.social reveals orthographic & semantic previews predicting reading speed www.nature.com/articles/s41...
Fast hierarchical processing of orthographic and semantic parafoveal information during natural reading - Nature Communications
Combining MEG, eye-tracking, and representational similarity analysis, this study shows that readers rapidly and sequentially extract orthographic and semantic information from upcoming words before fixation, supporting efficient reading.
nature.com
At long last, the pre-print to our MEG study + RIFT study and the final paper from my Ph.D with @olejensen.bsky.social We show that strong pre-search alpha oscillations are associated with faster responses in visual search www.biorxiv.org/content/10.1... @thechbh.bsky.social #neuroskyence
Hellohello again! Tomorrow at 5:15pm I’m giving a short talk on our latest MEG study about our very well-loved oscillating perceptual predictions @meguki2025.bsky.social. Come by and talk brains! There are amazing talks and very cool science happening all around! MEGUKI 2025👌
Programme – MEG UKI
meguk.ac.uk
Finally out in @commsbio.nature.com ! Using MEG and Rapid Invisible Frequency Tagging (RIFT) in a classic visual search paradigm we show that neuronal excitability in V1 is modulated in line with a priority-map-based mechanism to boost targets and suppress distractors!
Guided visual search affects #neuronal excitability in the primary visual cortex, enhancing targets and suppressing distractors. www.nature.com/articles/s42... @katduecker.bsky.social @olejensen.bsky.social @benjamingriffiths.bsky.social
In the physical world, almost all information is transmitted through traveling waves -- why should it be any different in your neural network? Super excited to share recent work with the brilliant @mozesjacobs.bsky.social: "Traveling Waves Integrate Spatial Information Through Time" 1/14
Most amazing piece of science communication by one talented @kermieeart.bsky.social :)
Want a high-level overview of how HNN works? Check out this short comic by our lab manager Joyce (@kermieeart.bsky.social)! tinyurl.com/27xrksez #compneuro #sciart #comics
We invite you to join us at our 2025 Spring Online Human Neocortical Neurosolver (HNN) Workshop! This workshop will be on Wednesday, April 9th from 9 AM - 3 PM (ET). Find out more and sign up 👉 tinyurl.com/hnn-workshop.... Seats are limited! #compneuro
HNN Pre-Workshop Information
Workshop Overview The Human Neocortical Neurosolver (HNN) is a user-friendly software tool for interpreting the cell and circuit level origin of human MEG and EEG signals. In this virtual event, we ...
tinyurl.com
I thank taxpayers for supporting my lab's work. My group has helped map how brains transform "seeing" into "remembering". We've been working to transform what we've learned into a new treatment for individuals with memory impairment (by stimulating the vagus nerve). www.nicolecrust.com/memory
Nicole Rust | Memory
nicolecrust.com
More than ever, researchers need to explain how they use taxpayer money to provide tangible benefits. I'll start: My lab has developed a completely novel way to make cellular therapies a lot more effective. Our approach shows promising results in pancreatic, ovarian and lung cancer.
Less than a week to apply for the Summer Workshop on the Dynamic Brain! 🐋🧠🌊 Apply by Feb. 1 to join us for this intensive, project-based residential course in the beautiful San Juan Islands. 🔗 alleninstitute.org/events/summe... 🧠📈
Summer Workshop on the Dynamic Brain 2025
The Summer Workshop on the Dynamic Brain is an intensive, project-based residential course with a focus on the neurobiology of sensory processing, coding, and neural population dynamics.
alleninstitute.org
The Human Neocortical Neurosolver is on Bluesky! HNN is a user-friendly computational tool to develop & test hypotheses about the neural circuits underlying EEG/MEG signals. Our aim is to make comp neuro accessible to a broad community. Follow for HNN science, workshops & development! 🧠 👩🔬 #compneuro