Just published in @plosbiology.org: researchers in @labgrosshans.bsky.social reveal how LIN28 keeps development on schedule in C. elegans through just two key targets. www.fmi.ch/news-events/...

A small molecular module helps time development

Animal development depends on precise biological timing. FMI scientists have now uncovered a mechanism that helps keep this process on schedule. Their work in the tiny worm <em>C. elegans</em> shows t...

fmi.ch

⬇️ Check out this preprint from our floor friends @mariahondele.bsky.social , with a small (but mighty) fruit fly 🪰 contribution from our team / Drosophila whisperer Martin @biozentrum.unibas.ch

Maria Hondele@mariahondele.bsky.social · 2d ago

🚀 New preprint 🥳 Fantastic work by our recent PhD graduate Daan ! How are mRNPs remodeled as they exit the nucleus? We identify PAIP1 as a factor that promotes exchange of the nuclear poly(A)-binding protein PABPN1 for cytoplasmic PABPC1, coupling mRNA export to cytoplasmic mRNP maturation.

Job posting: Associate Professor in behavioral ecology and cultural evolution within the Department of Ecology and Evolution (DEE) at the University of Lausanne. Deadline for applications is 30.09.2026: wwwfbm.unil.ch/releve/appli... (there is a button to switch to English at the top right)

New preprint 📢 Thrilled to share our long-awaited work on the role of RSX in marsupial X-inactivation. This was a huge team effort over the years, led by @aureliencourtois.bsky.social @sermenchero.bsky.social Sugako Ogushi and Waz Varsally, that allowed us to set up genome editing in opossum embryos

Genome editing of marsupial RSX reveals conserved and divergent principles in mammalian X-inactivation

X-chromosome inactivation balances X-gene dosage between the sexes in eutherians and marsupials. The lncRNA Xist mediates X-inactivation in eutherians but is absent from marsupials. An evolutionarily ...

biorxiv.org

A MUST READ! Congrats @a-radzisheuskaya.bsky.social and team!

Alex Radzisheuskaya@a-radzisheuskaya.bsky.social · 4w ago

1/ Very excited to share the first publication from my lab! In this work, we developed an efficient strategy to precisely mutate mammalian histone genes in their native genomic context using CRISPR prime editing: www.nature.com/articles/s41...

Excited to be able to advertise 1x postdoc and 2x technician positions to join my group in Cambridge working on an exciting ARIA funded project to help bring a plant artificial chromosome into existence! Reposts very welcome please 🙏 (1/2)

I had a fantastic time @imbavienna.bsky.social @viennabiocenter.bsky.social @impvienna.bsky.social Thanks for the invite @pauligroup.bsky.social 🙂 and see you next time!

We are looking for a colleague 👇👇👇

Biozentrum, University of Basel@biozentrum.unibas.ch · last mo.

New Assistant (tenure-track) or Associate Professor position in Climate #Biophysics! Join our international research community to explore fundamental molecular mechanisms underlying climate-relevant biological processes. Apply by 7 Sept 2026! www.biozentrum.unibas.ch/de/open-posi...

There is more to transcriptional readthrough than meets the eye, and it could even provide a therapeutic opportunity in cancer. Check out our new perspective, inspired by recent work from Neugebauer and Grzechnik labs! #RNABiology #RNASky #Epigenetics

Agata Stepien@agatakstepien.bsky.social · last mo.

Studying gene ends is becoming even more fascinating! Curious why? Read our News & Views "Transcriptional readthrough progresses from incidental byproduct to therapeutic opportunity" inspired by the recent publication by Podszywałow-Bartnicka and @karlaneugebauer.bsky.social @natsmb.nature.com

What if an embryo made immune cells before it finished building the tissue they usually come from? In our new preprint, we show that annual killifish embryos specify neutrophils before germ layers are fully resolved. www.biorxiv.org/content/10.6... Huge thanks to my PI, @ohnolog.bsky.social ! 🧵

Early immune cell development precedes gastrulation in annual killifish

During embryogenesis, cell types arise in a predictable order because developmental regulators act sequentially. But how evolutionary changes in morphogenesis reshape the signaling environments that a...

biorxiv.org

My first PhD paper is out in Nucleic Acids Research! We describe "Ab-trapping" - an antibody artifact that distorts assays relying on antibody diffusion (microscopy, CUT&Tag, CUT&RUN). The revisions made the story much stronger. Check it out! doi.org/10.1093/nar/...

Antibody-trapping presents a widespread pitfall for microscopy and genomics in the nucleus

Abstract. Chromatin has a complex 3D structure and diverse binding proteins that coordinate the genome’s most essential functions. Many microscopy and geno

doi.org

Congratulations to Prof. Sebastian Hiller and all newly elected EMBO members! This lifelong membership recognizes outstanding scientific achievements. 🧪 #EMBOMembers2026 @hillerlab.bsky.social @unibas.ch @embo.org www.biozentrum.unibas.ch/news/detail/...

Sebastian Hiller elected EMBO member

The prestigious European Molecular Biology Organization (EMBO) has elected Prof. Sebastian Hiller from the Biozentrum as a new member.

biozentrum.unibas.ch

Our evil ORFeome paper is out! In collaboration with @alex-stark.bsky.social, we screened ~4,000 viral proteins and secreted effectors from bacteria and parasites, covering hundreds of diverse pathogens, for phenotypes in human cells.

Happy to finally share that I will be starting my independent group at the @fmiscience.bsky.social in Feb 2027 in a vibrant new environment. We will use integrative in situ structural cell biology methods to investigate ciliary structure and dynamics in several model (and non-model 👀) systems!!

A big preprint from my group! Muller Elements are considered to be conserved in flies. We tested it by reconstructing the ancestral dipteran karyotype using 340 chromosomal genomes and suprise suprise, they're not... Led by @juliagries.bsky.social and Sam Ebdon. www.biorxiv.org/content/10.6... 🧵👇

Happy to share our preprint! Using massively parallel reporter assays, single-molecule imaging, deep learning and cryo-EM, we decode the sequence requirements for translation initiation and describe the “extended translation initiation sequence” (eTIS) that modulates start codon recognition. 🧵👇

For 40 years the 8-nt ‘Kozak Sequence’ was thought to mark sites of translation initiation. In a new study, we revise this model by identifying an ~80-nt sequence—the extended Translation Initiation Sequence (eTIS)— that guides ribosomes to correct start sites. 🧵 www.biorxiv.org/content/10.6...

Two new papers 📖 from our lab 1️⃣ What is epigenetics (and why X inactivation is?) rdcu.be/fhzSz and 2️⃣ A Baculovirus-based tool to express any gene of interest with high efficiency in Anopheles cells rdcu.be/fhzTy

Female mice grow testes after this single DNA tweak www.nature.com/articles/d41...

We are excited to be recruiting into 3 Associate Professorship's in @oxfordbiochemistry.bsky.social. Come join us as a colleague and benefit from our vibrant and multidisciplinary environment. Reach out to me if you have any questions. Please repost! (tinyurl.com/48deybuu) (tinyurl.com/4pdvjaft).

Very happy to see this out. 👏 @yinanwan.bsky.social Bogdan Bintu and team. Whole-embryo spatial transcriptomics at subcellular resolution from gastrulation to organogenesis | free link Science www.science.org/eprint/5MHTM...

Whole-embryo spatial transcriptomics at subcellular resolution from gastrulation to organogenesis

Gene expression patterns underlie development, but their systematic detection in whole embryos has remained elusive. We introduce a whole-embryo imaging platform using multiplexed error-robust fluores...

science.org

Cool paper, turning evolutionary theory on its head - gene conversion overcomes the cost of asexual reproduction… Gene conversion empowers natural selection in a clonal fish species www.nature.com/articles/s41...

Gene conversion empowers natural selection in a clonal fish species - Nature

Analysis of the asexually reproducing Amazon molly Poecilia formosa and its sexually reproducing progenitors Poecilia mexicana and Poecilia latipinna reveals that it maintains a divergent mutational l...

nature.com

Very excited to announce the FIRST symposium on epigenome editing! These tools are becoming widely used in mol bio, ag & therapy. It's time to bring leaders together to discuss this rapidly growing and exciting field. And why not in Paris! Please register & share! (1/2) ctrlepiedit.sciencesconf.org

Our Lab is searching a postdoc for an exciting ERC-funded project that will start this summer. Apply if you’re passionate about multi-omics, cutting-edge computational approaches, and exploring biological questions across the animal 🪼 🪱 🐞 🦎 🦋 🕷️ tree of life www.biozentrum.unibas.ch/open-positio...

Salinity tunes mode of multicellularity in a tidepool choanoflagellate www.nature.com/articles/s41... - paper in @nature.com

Clonal-aggregative multicellularity tuned by salinity in a choanoflagellate - Nature

The choanoflagellate Choanoeca flexa forms motile and contractile cell monolayers purely clonally, purely aggregatively or through a combination of both processes&nbsp;depending on environmental condi...

nature.com

Congratulations Dr. Fritz Garcia! You can be proud of all what you achieved!

New Preprint www.biorxiv.org/content/10.6... from our lab - work by (now) Dr. Feyza Polat Haas with fabulous contributions from many. We show that mammals have a 💪 POWER-Spliceoeome in the 🧠 optimized for metabolic functions. This happens because SNRPB (SmB) is replaced by its paralogue SNRPN (SmN).

For once an article about the "how to get to Rome" and not "Rome" itself. Collaboration with my "partner-in-crime" @felibas.bsky.social has been a key ingredient of my research over the years. Sara Miller at Molecular Cell spoke with us of how we got there and what we think about collaborations.

Molecular Cell @cp-molcell.bsky.social · 6mo ago

Fun fuels collaboration

Stunning lecture („Antrittsvorlesung“) by @hilgerslab.bsky.social - friend, mentor and scientific inspiration at the very same time 😀 Happy that our paths join again in #Basel

When you work in #Switzerland and Conference Organizers choose the most stunning place #engadin @nccr-rna-disease.bsky.social