Happy to receive funding from Damon Runyon Fellowship / HHMI for the next 4 years! We're working on some fundamental questions in tissue biology and I'm excited to share more soon. Grateful to @ardemp.bskyverified.social for the mentorship! www.damonrunyon.org/news/damon-r...

Congrats to @kinglhung.bsky.social from my lab on receiving a @damonrunyon.org Postdoctoral Fellowship! I was a Damon Runyon Fellow early in my career and know how much this recognition means. So proud! www.damonrunyon.org/news/damon-r...

Our story on mechanosensation in baroreceptor cells of the kidney is finally out! Well worth the wait on this project we began in 2020 that turned into a massive collaborative effort within the kidney field. 🫘 www.sciencedirect.com:5037/science/arti...

Very nice news coverage on my scientific journey by Christie Wilcox in @science.org and #ScienceAdviser: www.science.org/content/arti...

ScienceAdviser: Unassuming frogs snack on murder hornets

Today in Science and science: An impressive bugbot, extrachromosomal DNA in cancer, and more

science.org

Our paper is out in @nature.com! Oncogenes are often copy-number amplified on extrachromosomal DNA (ecDNA) in cancer, but how is ecDNA inherited by dividing cells? Here we identified elements within ecDNA that promote its retention in dividing cells. 1/11 www.nature.com/articles/s41...

Genetic elements promote retention of extrachromosomal DNA in cancer cells - Nature

A combination of genome-wide functional screening, imaging and chromatin profiling identifies a new class of highly prevalent genomic elements that help retain extrachromosomal DNA copies in dividing ...

nature.com

🎉 Congratulations to @kinglhung.bsky.social‬ from team eDyNAmiC for receiving the prestigious prize and for having his essay, “Oncogenes out of context: Cancer genes break free from the regulatory constraints of chromosomes”, published in @science.org. 📖 Read more - lnkd.in/ekMqXC6J

King L Hung@kinglhung.bsky.social · 9mo ago

Honored to receive the Science & SciLifeLab Prize! Very grateful to all my mentors and colleagues. I wrote an article in @science.org about my PhD thesis research on extrachromosomal DNA at Stanford @stanfordmedicine.bsky.social. www.science.org/doi/10.1126/...

Congrats King Hung, Science & SciLifeLabs award winner @stanfordmedicine.bsky.social, collaborating with @stanford-chemh.bsky.social institute scholar @paulmischel.bsky.social www.science.org/doi/10.1126/...

Oncogenes out of context: Cancer genes break free from the regulatory constraints of chromosomes

Cancer genes break free from the regulatory constraints of chromosomes

science.org

Honored to receive the Science & SciLifeLab Prize! Very grateful to all my mentors and colleagues. I wrote an article in @science.org about my PhD thesis research on extrachromosomal DNA at Stanford @stanfordmedicine.bsky.social. www.science.org/doi/10.1126/...

And here is the story after peer review. This work highlights our current approach, which is to use Piezo channels to uncover new areas of biology that are shaped by mechanical forces: www.science.org/doi/10.1126/...

PIEZO channels link mechanical forces to uterine contractions in parturition

Mechanical forces are extensively involved in pregnancy and parturition, but their precise roles and mechanisms remain poorly understood. We identified mechanically activated ion channels PIEZO1 and P...

science.org

Ardem Patapoutian@ardemp.bskyverified.social · 11mo ago

New preprint alert! The uterus expands ~500-fold in pregnancy, yet we know little about how pressures are sensed. Led by @yunxiao-dr.bsky.social, we show PIEZOs are required for contractions and birth in mice, with dual roles of PIEZO1 in muscle and PIEZO2 in neurons www.biorxiv.org/content/10.1...

The community of Drosophila researchers is amazing, mutually supportive and collaborative. Right now a key resource for our community, @flybase.bsky.social , is threatened by the cancellation of its NIH grant and is seeking community help in raising short term funds 1/n 🧪 please share

Published an op-ed for @cnn.com: “Nobel laureate: I owe America my success. Today, its scientific future is in danger.” A personal reflection on what’s at stake as science funding gets slashed. I’d be grateful if you could amplify both in and beyond the science world. www.cnn.com/2025/04/09/h...

Nobel laureate: I owe America my success. Today, its scientific future is in danger | CNN

Dr. Ardem Patapoutian says he watches “with deep sadness as the United States’ remarkable scientific enterprise, which took generations of hard work and national investment to build, faces a concerted...

cnn.com

Cool approach to isolate extrachromosomal DNA: karyotyping by FACS! Wish I had thought of it. www.biorxiv.org/content/10.1...

1/ Transposable elements are often called "jumping genes" because they mobilize within genomes. 🧬 But did you know they can also jump 𝘣𝘦𝘵𝘸𝘦𝘦𝘯 cells? 🤯 Our new study reveals how retrotransposons invade the germline directly from somatic cells. www.biorxiv.org/content/10.1... A short thread 🧵👇

if you've had an NIH grant terminated, I want to hear about it. Signal: katherinejwu.12

The Patapoutian lab started 25 years ago on March 1, 2000. A quarter-century of science with brilliant trainees, colleagues & collaborators. Cheers to my mentors & mentees! Excited to celebrate with past & present lab members in November. Here’s to more great science 🧪 and better times ahead!

a cat is laying on top of the number 25

ALT: a cat is laying on top of the number 25

media.tenor.com

Flooding BlueSky with good news today. Neal lab received a NoA! Grateful our NIH R35 MIRA renewal is funded to support our ongoing work on membrane protein quality! 🙏🙏

Opportunity to work with an amazing scientist!

Rose Z. Hill, Ph.D.@rose-hill.bsky.social · 2y ago

My group is hiring at Oregon Health & Science University. Come work with us in beautiful Portland to study interoception and physiology. Check out the lab view! 🌲👩‍🔬 Research Assistant 2: externalcareers-ohsu.icims.com/jobs/32602/r... Postdoc applicants: please email me your CV and 3-4 references.

Join our lab! We're hiring a research technician—a great opportunity for individuals with a Bachelor's degree who want to gain valuable research experience before heading to medical or graduate school. recruiting2.ultipro.com/SCR1003TSRI/...

recruiting2.ultipro.com

Hi bluesky! A re-introduction: I am a cell biologist interested in cellular signaling logic and decision making. I worked on cancer genomes in my PhD at Stanford, and am now a postdoc working on how cells interpret force at Scripps in the Patapoutian lab. Excited to reconnect here!

Two back-to-back papers in Nature comms from mylab explore the link between destabilization of the actin cytoskeleton and aberrant base excision repair - passing through nuclear actin and the actin-dependent nucleosome remodeler INO80C.

First re-post on @bsky.app . Great collaboration between @kinglhung.bsky.social and team eDyNAmiC !! 🔥🔥👇🏻👇🏻

King L Hung@kinglhung.bsky.social · 2y ago

Cancer cells often harbor oncogenes outside chromosomes on extrachromosomal DNA (ecDNA), which is unevenly inherited by dividing cells. We reported in Nature last week that collectives of ecDNAs are inherited together by dividing cancer cells. 1/ www.nature.com/articles/s41...

Lovely paper showing co-segregation and co-selection of multiple species of ecDNA within cancer cells. Nice computational modelling and inference of segregation and selection coefficients too @benjaminwerner.bsky.social and Weini Huang!

King L Hung@kinglhung.bsky.social · 2y ago

Cancer cells often harbor oncogenes outside chromosomes on extrachromosomal DNA (ecDNA), which is unevenly inherited by dividing cells. We reported in Nature last week that collectives of ecDNAs are inherited together by dividing cancer cells. 1/ www.nature.com/articles/s41...

Cancer cells often harbor oncogenes outside chromosomes on extrachromosomal DNA (ecDNA), which is unevenly inherited by dividing cells. We reported in Nature last week that collectives of ecDNAs are inherited together by dividing cancer cells. 1/ www.nature.com/articles/s41...

Coordinated inheritance of extrachromosomal DNAs in cancer cells - Nature

Cooperative species of extrachromosomal DNAs are coordinately inherited through mitotic co-segregation.

nature.com

Now we're all here; I think this paper need more attention! journals.biologists.com/dev/article/...

The case against simplistic genetic explanations of evolution

Summary: Extreme traits in animals, from the origin of limbs to the loss of tails, capture public attention. This Review argues that scientists should not seek simple explanations for how they evolved...

journals.biologists.com

Sharing my latest preprint as a re-introduction to bsky! biorxiv.org/content/10.1... ---- Everyday, cells like this crawl through your body to protect you. While we know that their front 🔴 and back 🔵 polarity programs work together, how exactly do these two processes communicate?

High-resolution of cancer. Unprecedented. A brief review of what we've just learned from 17 new papers in the latest edition of Ground Truths. It's free, open-access. erictopol.substack.com/p/cancer-sci...

Cancer Science in On a Tear

New insights on evolution, resistance, and therapies

erictopol.substack.com

Waves of new BlueSky arrivals in last few days! I’ve been tracking starter packs relevant to molecular/mechanistic/genetic/cellular…etc biology Hope it’s helpful but warning: now a v long thread! Probably the last time I can do this...

Republicizing my preprint from earlier this year! We found that mitochondrial Raf1 upregulates glutamine catabolism in cancer cells. www.biorxiv.org/content/10.1...

Mitochondrial Raf1 Regulates Glutamine Catabolism

Raf1 is present within the mitochondrial matrix, where it binds GLS to regulate glutamine catabolism and tumorigenesis. In cancer, Raf1 activation occurs via mechanisms that include mutation of upstr...

biorxiv.org