So nice to see our work out in print! Very special to have two of our eDyNAmiC papers in the same issue. What a beautiful cover! Thank you @elizsmckenna.bsky.social !! @aacrjournals.bsky.social

Elizabeth McKenna@elizsmckenna.bsky.social · 11mo ago

The October issue of Cancer Discovery @aacrjournals.bsky.social is now online! The cover features two papers on the role of #ecDNA heterogeneity in tumor evolution and adaptation to therapy - you can find these papers and much more here: aacrjournals.org/cancerdiscov...

Thank you for inviting me to talk alongside Ido about our work on ecDNA!

CompCancer PhD programme@compcancer.bsky.social · 11mo ago

We continue with Ido Amit who shows how single cell approaches allow to improve immune therapy and Anton Henssen introducing us to the world of extrachromosomal DNA and how this relates to tumor heterogeneity. Fascinating!

Now online in Cancer Discovery @aacrjournals.bsky.social: Extrachromosomal DNA-Driven Oncogene Dosage Heterogeneity Promotes Rapid Adaptation to Therapy in MYCN-Amplified Cancers - by Giulia Montuori, Fengyu Tu, anton-henssen.bsky.social, Jan Dörr, and colleagues doi.org/10.1158/2159...

A huge thank you to all #IEAwards25 winners and nominees for an inspiring evening. We can’t wait to see what’s next on your horizon. Read more: bit.ly/44m94a0 #OnMyHorizon @anton-henssen.bsky.social, @nnennayakanu.bsky.social, @michellecruk.bsky.social @timwitney.bsky.social, @cuh.nhs.uk

I am excited, our collaborative work on tumours driven by ecDNA amplified MYCN and the underlying copy-number dependent fitness landscape just came out in Cancer Discovery @aacrjournals.bsky.social. @anton-henssen.bsky.social @cancergrand.bsky.social aacrjournals.org/cancerdiscov...

@anton-henssen.bsky.social we are looking forward to your presentation at #ecDNA25 in Mexico! Please share with your followers to let them know our early bird registration & talk submission close on 02 June 2025! 💰Grants available ✅More info: bit.ly/42XY0za

🚨🚨Paper out! 🚨🚨 Delighted to share our work, now published in ‪@natgenet.nature.com‬ 🧬! shorturl.at/94s5S We identified a targetable, chromothripsis-associated genetic event in blast phase (BP) MPN, a particularly poor prognostic subtype of acute leukaemia. 1/n Illustration: Hratch Arbach 🧵👇

Congrats Juliane and Monika authors.elsevier.com/sd/article/S...

New @theaacr.bsky.social Cancer Discovery paper on ecDNA in urothelial carcinoma reveals how ecDNAs: 💡 Drive #BladderCancer evolution 💡 Promote immune evasion 💡 Amplify oncogenes 💡 Fuel tumour heterogeneity 💡 May be a biomarker in urine for non-invasive detection aacrjournals.org/cancerdiscov...

Great conference ! I look forward to attending. 🔥🔥👇🏻👇🏻

Fusion Conferences@fusionconf.bsky.social · 2y ago

#ecDNA is reshaping biomedical science. Now recognized as a key player in ~30% of cancer patients, understanding its biology could unlock new therapeutic strategies for #cancer & other diseases. Join us at #ecDNA25 for discussions at the forefront of this rapidly advancing field ➡️ bit.ly/XecDNA25

Exciting new paper 🔥🔥👇🏻👇🏻

Sudarshan Pinglay@sudpinglay.bsky.social · 2y ago

Now out in @science.org w/ @jshendure.bsky.social we present 'Genome-shuffle-seq': a method to shuffle mammalian genomes and characterize the impact of structural variants (SVs) with single-cell resolution in one experiment. www.science.org/doi/10.1126/...

Great conference with expert lineup ! I look forward to attending! 🔥🔥👇🏻👇🏻

Fusion Conferences@fusionconf.bsky.social · 2y ago

🧬🌟We're excited to add an Extrachromosomal Circular DNA conference to our 2025 calendar!🧬🌟 Chairs Birgitte Regenberg (Univ. of Copenhagen) & Zhao Zhang (Duke Univ.) are bringing a fantastic line up of speakers together in Mexico this year. More details➡️https://bit.ly/4az0PbV #ecDNA25 #eccDNA #ecDNA

The Curtis Lab’s latest study on the genomic architecture of breast cancer from the pre-invasive to metastatic setting is now out in Nature! www.nature.com/articles/s41...

Complex rearrangements fuel ER+ and HER2+ breast tumours - Nature

A study identifies three dominant genomic archetypes of breast cancer induced by discrete mutational processes, describing a continuum of genomic profiles and detailing the mechanisms underlying the p...

nature.com

Here's our latest, led by Drs. Riaz Gillani & Ryan Collins - we studied a type of inherited genetic event (structural variants) + risk of developing certain cancers in kids: @danafarber.bsky.social @bostonchildrens.bsky.social @broadinstitute.org @science.org www.science.org/doi/10.1126/...

Rare germline structural variants increase risk for pediatric solid tumors

Pediatric solid tumors are a leading cause of childhood disease mortality. In this work, we examined germline structural variants (SVs) as risk factors for pediatric extracranial solid tumors using ge...

science.org

🔥🔥👇🏻👇🏻

Geoff Macintyre@gmaci.bsky.social · 2y ago

Want to know how inherited genome instability contributes to childhood cancers? Checkout this perspective from Jayne Hehir-Kwa and me www.science.org/doi/10.1126/... on the latest brilliant work from @vanallenlab.bsky.social www.science.org/doi/10.1126/... on rare germline SVs in paediatric cancers

🔥🔥👇🏻👇🏻

Gaetano Gargiulo@ggargiul.bsky.social · 2y ago

End-of-the-year preprint & first 🧵 where the sky is blue! Ever wondered how a cancer driven by a single mutant oncogene becomes molecularly & cellularly heterogeneous? Why metastases share drivers w/primary tumors but are more aggressive?

Important work by Heribert Jürgens and colleagues on how telemedicine can improve the management of patients suffering from sarcoma. 👏🏻👏🏻👇🏻👇🏻 www.sciencedirect.com/science/arti...

Major milestone in ecDNA research!!! 👏🏻👏🏻👏🏻🔥🔥🔥👇🏻👇🏻

AndreaVentura@andreaventura.bsky.social · 2y ago

🧪1/ 🚨New paper on ecDNAs from our lab! We reveal a strategy to engineer extrachromosomal DNA (ecDNA) amplifications in cells & mice. Let's dive in! Let’s dive in! 🧵👇 www.nature.com/articles/s41...

1/ In two back-to-back papers, we present our de novo TRACeR platform for targeting MHC-I and MHC-II antigens TRACeR for MHC-I: go.nature.com/4gcLzn5 TRACeR for MHC-II: go.nature.com/4gj5OQk

Thrilled to share a wonderful collaboration with Scott Armstrong, Florian Perner & Shellaina Gordon - exciting times ahead! www.biorxiv.org/content/10.1...

Catalytic inhibition of KAT6/KAT7 enhances the efficacy and overcomes primary and acquired resistance to Menin inhibitors in MLL leukaemia

Understanding the molecular pathogenesis of MLL fusion oncoprotein (MLL-FP) leukaemia has spawned epigenetic therapies that have improved clinical outcomes in this often-incurable disease. Using genet...

biorxiv.org

Great to see our joint study with @stesantaguida.bsky.social published in this month’s issue of Cancer Discovery: aacrjournals.org/cancerdiscov... With a super-kind Research Highlight written by Sam Bakhoum:

Targeting RNA and Protein Turnover in Aneuploid Cancers

Summary:. Aneuploidy, an imbalance in chromosome number, is a hallmark of human cancers with chromosomal instability, and it remains a major therapeutic challenge. In this issue, Ippolito and colleagu...

aacrjournals.org

👏🏻👏🏻👏🏻🔥🔥👇🏻👇🏻

Anna Obenauf@obenaufa.bsky.social · 2y ago

1/23 Big news for the #ObenaufLab! So excited to finally share our new study providing another puzzle piece, why immunotherapy fails in many tumors, now out in @Nature 🧵👇 www.nature.com/articles/s41...

Social media is in desperate need of innovation. Meta is only letting you have a slice of control over what you see because Bluesky is here building for you.

Will Oremus@willoremus.com · 2y ago

We wrote on Saturday about how Meta is going all-out to meet the threat of Bluesky: wapo.st/3OrYxBj Today they took another step— finally allowing users to set their default feeds to a chronological “following” feed.

Amazing idea ! Hope it works. Would be very valuable method for early detection.

Cancer Research UK Cambridge Centre@crukcamcentre.bsky.social · 2y ago

The BEST4 Screening trial has welcomed its first participants. The trial funded by @cancerresearchuk.org and @nihr.bsky.social will find out if a capsule sponge test can screen for oesophageal cancer. @cuhnhs.bsky.social @cambridgeuni.bsky.social More ➡️ crukcambridgecentre.org.uk/news/pill-th...

The international Curie « Noncoding Genome » course has been revamped! 👉 Dark genome in cell plasticity and heterogeneity. A session on TEs #TEsky with M.E. Torres Padilla, D.Trono and @aktast.bsky.social. Master, PhD and postdoc fellows, a week in Paris during the Spring? Apply before Feb 15th 📌

First Bluesky post - a BIG update to our study on Ewing sarcoma and other FET fusion-driven cancers. FET fusion oncoproteins are aberrantly recruited to DNA breaks and cause ATM defects, which can be targeted with the ATR inhibitor elimusertib. Updates include: www.biorxiv.org/content/10.1...

new out in Nature www.nature.com/articles/s41...

Normal breast tissues harbour rare populations of aneuploid epithelial cells - Nature

Using single-cell DNA sequencing we show that most healthy women harbour rare populations of aneuploid epithelial cells with copy number alteration events in their breast tissue that expand and accumu...

nature.com

Right on time to discuss at #SNO2024: Gliocidin is a nicotinamide-mimetic prodrug that targets glioblastoma. www.nature.com/articles/s41...

Gliocidin is a nicotinamide-mimetic prodrug that targets glioblastoma - Nature

The prodrug gliocidin effectively kills glioblastoma cells by targeting de novo purine synthesis, improving survival in mouse models.

nature.com

This week 11/22 at 4pm: Howard Chang, MD, PhD @stanfordmedicine.bsky.social presents "Cancer genes beyond chromosomes" at our Friday Seminar Series in Basic and Translational Research ow.ly/vbfJ50UaeaX

For my first post here at 🦋, let me tell you about a lovely paper by Richard Koche, @anton-henssen.bsky.social, and colleagues that covers how extrachromosomal DNA (ecDNA) drives cancer genome remodeling in neuroblastoma. It's a great story about cancer biology and genome organization! 🧬