Rose Z. Hill, Ph.D.
@rose-hill.bsky.social
Interoception, Organ physiology, and Neuronal mechanisms of homeostasis (ION) Lab | Neuroscientist at OHSU | ionlaboratory.com | proud parent of cats | (she/they) 🏳️🌈🧠🧑🔬 views are my own
Thanks for featuring me! @thetransmitter.bsky.social
The Transmitter @thetransmitter.bsky.social · 4w agoIn this month’s “Liftoff,” Teresa Guillamón Vivancos shares how she learned to appreciate the importance of the little things for a functioning lab, and @rose-hill.bsky.social discusses how her lab members embraced their “inner naturalist.” By @franciscorr25.bsky.social bit.ly/4x4Q0sr
It may only be July, but that means end of fiscal year chaos starts. Please be patient..its rough out here.
Congratulations to Dr Rose Hill on becoming a 2026 Editorial Board Fellow for The Journal of Physiology. cc: @jphysiol.bsky.social, @rose-hill.bsky.social
The Journal of Physiology@jphysiol.bsky.social · 2mo agoCongratulations and welcome to Rose Hill @rose-hill.bsky.social of @volluminstitute.bsky.social who joins us as one of our 2026 Editorial Board Fellows! 🎓️
Just in time for the weekend, the 2nd beta for our Surface Morphometrics 2.0 release: github.com/GrotjahnLab/.... Beyond the major API change from the first beta (which used for the michigan class!), this one includes a major overhaul of the dual gaussian fitting for thickness and refinement.
Release 2.0.0b2 · GrotjahnLab/surface_morphometrics
A quality and robustness release on top of 2.0.0b1, focused on the density-profile bilayer fitting (mesh refinement and thickness measurement), a forgiving centralized config system, and packaging ...
github.com
Congratulations and welcome to Rose Hill @rose-hill.bsky.social of @volluminstitute.bsky.social who joins us as one of our 2026 Editorial Board Fellows! 🎓️
Do you struggle with FSGS? Are you a sparsentan fan but asking, what's next? TRPC6 inhibitors completed a phase 2 study! Are we closing in on a common pathway of FSGS pathology? Blog by @drsaivani.bsky.social & @sayalibthakare.bsky.social #NephSky #MedSky www.nephjc.com/news/trcpc6inhibition-fsgs
Is TRPC6 inhibition for FSGS a trick or a treat? — NephJC
This week, we will discuss a phase 2 trial of the TRPC6 inhibitor BI 764198 in FSGS—an early signal for a podocyte-targeted therapy showing proteinuria reduction but set against small numbers, heterog...
nephjc.com
Every $1 from NIH that Oregon gets stimulates $2.50 in economic activity. Better returns than Vegas, kids. We need your support to keep the NIH, the NSF, and other federal agencies supporting science funded and thriving. www.the-scientist.com/nih-funding-...
NIH Funding Led to a 250 Percent Economic Return on Investment | The Scientist
Research advocacy group United for Medical Research reported that NIH grant money stimulated the US economy, but certain funding mechanisms may limit future benefits.
the-scientist.com
It’s well known that inflammation increases cancer risk, but how? The answer: the epigenome "remembers" inflammation and primes stem cells for cancer. Here is our paper: nature.com/articles/s41... And a special shoutout to the lead author @snaga13.bsky.social A 🧵
Epigenetic memory of colitis promotes tumour growth - Nature
Colonic stem cells retain a memory of inflammation following disease resolution and there is a mechanistic link between chronic inflammation and malignancy, suggesting potential strategies to mitigate...
nature.com
Very excited to share our new manuscript – published today! Why are PIEZO1 and PIEZO2 are tuned to transduce different types of mechanical force? I was lucky to work with some extraordinary colleagues to begin to figure out why. www.nature.com/articles/s41... An overview of the results below ⬇️ ⬇️
The molecular basis of force selectivity by PIEZO2 - Nature
PIEZO2 is intrinsically more rigid than PIEZO1, and disparate mechanical stimuli paradoxically evoke opposite conformational and gating responses in each channel.
nature.com
So proud of my lab mate @ericmulhall.bsky.social and honored to help with this amazing project he led using MINFLUX to study why PIEZO2 behaves differently than PIEZO1 from the lab of @ardemp.bskyverified.social share.google/2Uln5O5OyqhM...
The molecular basis of force selectivity by PIEZO2 - Nature
PIEZO2 is intrinsically more rigid than PIEZO1, and disparate mechanical stimuli paradoxically evoke opposite conformational and gating responses in each channel.
share.google
Preliminary Valentine's data from my postdoc work with @ardemp.bskyverified.social - RNAscope of Piezo2 transcript (green) and a nociceptor marker (magenta) in a mouse dorsal root ganglion 💜
🧠⚡️💊New @nature.com publication ! Mimicking opioid analgesia in cortical pain circuits We built a brain-behavior framework to decode spontaneous chronic pain in mice—and to biologically mimic morphine with a synthetic opioid gene therapy nature.com/articles/s41... @pennmedicine.bsky.social
Nature@nature.com · 7mo agoResearchers identify the neurons involved in the emotional distress associated with pain go.nature.com/4qIKkB8
Nice way to end the year being part of this paper in Cell showing that PIEZO2 is an essential regulator of renin by @rose-hill.bsky.social and top scientists including @ardemp.bskyverified.social www.cell.com/cell/fulltex... @cellpress.bsky.social @nu-nephrology.bsky.social@nufeinbergmed.bsky.social
A new @cp-cell.bsky.social study led by @ardemp.bskyverified.social and @rose-hill.bsky.social identifies a kidney mechanism that allows renin to adjust in real time, showing that PIEZO2 enables cells to sense physical forces and fine-tune renin release.
Study reveals a key hormonal circuit in the kidneys
ow.ly
Our story on mechanosensation in baroreceptor cells of the kidney is finally out! Well worth the wait on this project we began in 2020 that turned into a massive collaborative effort within the kidney field. 🫘 www.sciencedirect.com:5037/science/arti...
sciencedirect.com
This is not looking good for early career researchers, or any researchers.
Annika Barber@annikabarber.bsky.social · 9mo agoUp to 323 cancelled CSR study sections. That's more than the 204 sections cancelled earlier this year. Rescheduling is going to be a hot mess with NIH staff reductions and study section members heading into finals and holidays that limit availability. 🧪
The BIG DRG paper is now up on @biorxiv-neursci.bsky.social www.biorxiv.org/content/10.1... so many people worked so hard to make this happen. Props to the whole PRECISION Human Pain Network.
A Reference Atlas of the Human Dorsal Root Ganglion
Somatosensory perception largely emerges from diverse peripheral sensory neurons whose cell bodies reside in dorsal root ganglia (DRG). Damage or dysfunction of DRG neurons is a major cause of chronic...
biorxiv.org
First ION lab Halloween! Left to right: Mint Spice (TRPM8), Ginger Spice (TRPA1), Bactrachotoxin Spice (NaV), Capsaicin Spice (TRPV1) 🧊 🧄 🐸 🌶️
Guess which TRP channel agonist I dressed as? Honored to stand next to my childhood hero @jesshebert.bsky.social Ms. Frizzle
Dr. Jess Hebert@jesshebert.bsky.social · 9mo agoHalloween with OHSU Neph and CPB faculty! @beattylab.bsky.social @rose-hill.bsky.social
Zara Weinberg passed away earlier this week. She joined my lab earlier this year when her postdoc lab formally closed. She was a brilliant scientist, supportive mentor, dear friend, avid music fan, rabid believer in public transit, open science champion, and above all just an amazing human.
Zara Weinberg was a brilliant light both in and out of science. She changed the lives of everyone she interacted and loved for the better. Her legacy will live on through all of us and we will fight for a better world on behalf of her memory.
A tour de force study by my colleague Tianyi Mao's lab @volluminstitute.bsky.social. Must read if one is interested in interoception, the insular cortex, or circuit architecture of associative cortices. www.biorxiv.org/content/10.1...
Neuronal architecture of the mouse insular cortex underlying its diverse functions
The insular cortex integrates interoceptive and exteroceptive information to mediate bodily homeostasis, emotion, learning, and potentially consciousness.[1][1]–[4][2] However, the cellular and circui...
biorxiv.org
Meet the real rainbow fish 🌈🐟 Using Cre-mediated recombination, each zebrafish cell expresses a unique fluorescent color, creating a living rainbow of developmental history 🎨✨ Image by Bret Pearson #FluorescenceFriday #Zebrafish #DevBio
University administration: "We need you to complete 26 hours of lab safety training 🧪 each year so that everyone is safe and responsible." Also university administration:
I’m extremely honored to be a recipient of the NIH Director’s Pioneer Award!
Columbia University's Zuckerman Institute@zuckermanbrain.bsky.social · 10mo agoCongratulations to @ishmailsaboor.bsky.social on receiving the NIH Director’s Pioneer Award, celebrating “scientists with outstanding records of creativity.” His lab will explore how the sense of touch can help build relationships. 🫶🧠💡 See zuckermaninstitute.columbia.edu/zuckerman-in...
I remember discussing the scurfy mouse in immunology class, which initially arose from basic research done at a national lab with government funds (Oak Ridge NL, near where my father grew up)...what an important finding to earn this year's Nobel Prize.
Nature@nature.com · 10mo agoBREAKING: The Nobel Prize in Physiology or Medicine has been awarded jointly to Mary E. Brunkow, Fred Ramsdell, and Shimon Sakaguchi "for their discoveries concerning peripheral immune tolerance" Stay tuned for more. #NobelPrize
Congratulations to Mary Brunkow, Fred Ramsdell and Shimon Sakaguchi for this year's Nobel Prize in Physiology or Medicine. It also demonstrates the fairness of the prize, as Mary Brunkow is a Senior Program Manager (not a professor) at the @isbscience.org hood.isbscience.org/people/mary-...
Sharing this excellent review now out from postdoc Sarah McLarnon! Lots of useful info on 3D imaging, quantification of imaging data, and how this has been applied to the kidney. And since it's #FluorescenceFriday, sharing a figure with our own imaging data! www.sciencedirect.com/science/arti...
