New review article Exceeding expectations: factors contributing to the potency of human papillomavirus vaccines www.thelancet.com/journals/lan... #IDSky #ClinMicro #ViroSky #HPV #OpenAccess #OA

01-Jul: On this day in 1858, Charles Darwin finally went public with his theory of evolution by means of natural selection, with the publication of back-to-back papers by Darwin and Alfred Russel Wallace, who had independently arrived at the same idea… friendsofdarwin.com/articles/dar... #HistSci

01-Jul-1858: Darwin goes public

Charles Darwin finally went public with his theory of evolution by means of Natural Selection on 1st July 1858.

friendsofdarwin.com

Big congratulations to the authors! 🎉🦠 Using RNA-seq, this study uncovers overlooked viral RNA species and supports a premature termination model for astrovirus subgenomic RNA synthesis, resolving a long-standing replication mystery. 🔬✨ #NARMolecularMedicine #Virology @universitypress.cambridge.org

Valeria Lulla@valerialulla.bsky.social · 4mo ago

🚨 New paper from the lab! 🚀 We explore “The dynamics and strategy of RNA replication in astroviruses”, now out in NAR Molecular Medicine. Many thanks to all co-authors and congratulations to David Noyvert on his first first-author paper🎉 doi.org/10.1093/narm...

🔬 Lund University (@lund-university.bsky.social) is hiring 3 Assistant Professors in cancer immunotherapy, immunotechnology & immune cell engineering! ✅ Start-up package | tenure track | world-class infrastructure 📅 Deadlines: 26 May & 10 June 2026 🎥 youtu.be/z-PQU9qknZc Apply links 👇

Lund University programme for excellence – three positions within Immunotherapy

YouTube video by Lund University

youtu.be

Heart-nosed bat alphacoronaviruses use human CEACAM6 to enter cells @nature.com @pirbrightinst.bsky.social @morbillivirus.bsky.social @atomicvirology.bsky.social @universitypress.cambridge.org www.nature.com/articles/d41... www.nature.com/articles/s41...

The FDA has asked Raw Farm to recall the cheddar cheese linked to the outbreak and "it has declined." But E.coli 0157 H7 is a very pathogenic bacteria. So buyer be aware and beware here. 1/3

Outbreak Investigation of E. coli O157:H7: Raw Cheddar Cheese

RAW FARM-brand Raw Cheddar Cheese linked to ongoing outbreak. FDA’s investigation is ongoing.

fda.gov

This recently happened to us, with similar tells… infuriating.. you can see how it unfolded in the public peer review file: static-content.springer.com/esm/art%3A10...

Nice to be a part of this excellent study from the Walczak lab where K11 ubiquitin chains added by ANKIB1 are identified as being essential for TBK1-IRF3-driven interferon production downstream of pattern recognition receptors including TLR3 and cGAS. www.nature.com/articles/s41...

Gianmaria Liccardi@gianmaria-liccardi.bsky.social · 5mo ago

Congratulations to the Walczak lab for this amazing piece of work just pulisbed on @natcellbio.nature.com A must read!!! This work adds a new letter of the ubiquitin code to immune signaling regulations! www.nature.com/articles/s41...

Critical role for ANKIB1-generated K11-linked ubiquitination in the immune response activated by cGAS–STING, TLR3 and TLR4 www.nature.com/articles/s41... @natcellbio.nature.com @walczaklab.bsky.social

Phylogenetic-based selection analysis of viral evolution before+after spillover reveals that viral adaptation in host reservoirs is not a necessary precursor of novel zoonotic virus epidemics, including SARS-CoV-2 @cellcellpress.bsky.social www.cell.com/cell/fulltex...

We are hiring a computational biology postdoc for a new project on zoonotic diseases, host pathogen interactions and pandemic risk. Please take a look and get in touch for more details www.cam.ac.uk/jobs/postdoc...

Avian flu has decimated world's largest breeding colony of southern elephant seals www.cidrap.umn.edu/avian-influe...

Avian flu has decimated world's largest breeding colony of southern elephant seals

cidrap.umn.edu

Anti-vax in the tweets, fully-vaxed between the sheets

Kyle Griffin@kylegriffin1.bsky.social · 10mo ago

The Trump administration has been spreading anti-vaccine propaganda for months. Tonight, Trump's physician announced he just received a flu shot and a COVID booster.

This is huge: “A drug that provides near-perfect protection against H.I.V. with shots just twice a year will be made available at $40 per patient annually in low- and middle-income countries, offering new hope… making lenacapavir a realistic choice in countries with constrained resources.”

Philanthropies Strike a Promising Deal to Turn Back H.I.V.

nytimes.com

New online: Computational design of sequence-specific DNA-binding proteins

Computational design of sequence-specific DNA-binding proteins

Nature Structural & Molecular Biology, Published online: 12 September 2025; doi:10.1038/s41594-025-01669-4The authors develop a computational method to design small DNA-binding proteins (DBPs) that target specific sequences. Designed DBPs show structural accuracy and function in both bacterial and mammalian cells for transcriptional regulation.

go.nature.com

Our first post on here and it's a doozy 😍🤩. Our epic piece on #sarbecovirus host range. #virology #sars2 #covid #vaccines. Enjoy and please repost. www.biorxiv.org/content/10.1...

Understanding the future risk of bat coronavirus spillover into humans: correlating sarbecovirus receptor usage, host range, and antigenicity.

Sarbecoviruses interact with their receptor, angiotensin converting enzyme 2 (ACE2), via the receptor binding domain (RBD) of Spike, the immunodominant target for neutralising antibodies. Understandin...

biorxiv.org

Hi everybody! I am super excited to share the work done during my PhD published in @nature today! We describe a new mechanism of self- vs. non-self RNA discrimination by showing how N-glycans shield glycoRNAs from stimulating endosomal RNA sensors www.nature.com/articles/s41...

RNA N-glycosylation enables immune evasion and homeostatic efferocytosis - Nature

N-glycans on glycoRNAs prevent innate immune sensing of endogenous small RNAs, and the natural mechanism they use demonstrates how glycoRNAs exist on the cell surface and in the endosomal network with...

nature.com

Excised DNA circles from V(D)J recombination promote relapsed leukaemia Cutting your own DNA has a risk of leukaemia. www.nature.com/artic... 1/7

Excised DNA circles from V(D)J recombination promote relapsed leukaemia

Nature - Excised signal circles are circular DNA by-products of V(D)J recombination that form a complex with the V(D)J recombinase, and when increased in abundance, result in increased mutagenesis,...

nature.com

‘The doses of rAAV used in clinical trials for DMD have ranged from 5×10^13 to 2×10^14 vector genomes (vg) per kilogram of body weight. After treatment with doses within this range, a number of toxic syndromes have been observed’ www.nejm.org/doi/full/10....

Death after High-Dose rAAV9 Gene Therapy in a Patient with Duchenne’s Muscular Dystrophy | NEJM

We treated a 27-year-old patient with Duchenne’s muscular dystrophy (DMD) with recombinant adeno-associated virus (rAAV) serotype 9 containing dSaCas9 (i.e., “dead” Staphylococcus aureus Cas9, in w...

nejm.org

Thiago Carvalho@cyrilpedia.bsky.social · last yr.

'The problem is that AAV-based therapies inevitably come with their own risks, and (in my opinion) these should be balanced by impressive efficacy data to make a convincing profile. Obviously this wasn’t present here, which sort of leaves everyone out there to soak up the risk part'

Research Associate in Viral #Immunology ✨ University of Bristol -School of Cellular and Molecular Medicine #Applynow www.bristol.ac.uk/jobs/find/de... * #Hiring* ! Research Jobs: Golden Opportunity! #PhD & #Postdoc Latest Updates: jobnewstimes.com/phd-postdoc/ #UKJOBS #BiologicalSciences

**JOBS ALERT** The Virology Unit at @PasteurCambodia hiring 1 Scientist and 2 Postdocs to join our fast-moving, field-connected, research-driven team on emerging viruses and zoonoses. 🧪🧬🥼🦠🔬🐓💉🦇😷 Limited time to apply — and we need people to start ASAP.**👇

***JOB OFFER*** The Protein Design and Modeling lab at IBMB offers a postdoc position at the intersection of computational protein design, biophysics and structural biology. Please share with colleagues and anyone you know that might be interested. ibmb.csic.es/en/jobs/post...

The "reproducibility crisis" in science constantly makes headlines. Repro efforts are often limited. What if you could assess reproducibility of an entire field? That's what @brunolemaitre.bsky.social et al. have done. Fly immunity is highly replicable & offers lessons for #metascience A 🧵 1/n

Microglial cGAS-STING-TBK1 activation in paraventricular thalamus mediates sleep and emotional disturbances in lupus mice www.sciencedirect.com/science/arti...

ICYMI: Junior PI positions in Kyoto at @ccii-kyoto.bsky.social, a new center led by Tasuku Honjo (DIrector) & Sidonia Fagarasan (Vice Director) #Immunology #Immunotherapy #ScienceJobs

Center for Cancer Immunotherapy and Immunobiology@ccii-kyoto.bsky.social · last yr.

Our streamlined Junior PI application process asks you to submit: a cover letter; a research plan; a current curriculum vitae; brief narrative summary of your main research achievements; Contact information for three references #Immunology #Immunotherapy www.ccii.med.kyoto-u.ac.jp/en/careers-e...

Super cool long lasting ADC-based anti-flu drug with great new trial data: 'CD388 is an antibody that targets neuraminidase (NA). Zanamivir, a neuraminidase inhibitor, is conjugated to the Fc fragment to create CD388' biz.chosun.com/en/en-scienc...

Cidara's CD388 flu drug outperforms vaccines, shows 76% prevention rate

Cidaras CD388 flu drug outperforms vaccines, shows 76% prevention rate Cidaras new flu treatment shows promise as a single-dose alternative to vaccines with strong results.

biz.chosun.com

Honoured to receive this prize alongside an inspiring group of scientists. This will support our work to improve mRNA therapies for precision medicine. #mRNA #immunoSky #Science

The Lister Institute of Preventive Medicine@thelisterinstitute.bsky.social · last yr.

We are very proud to introduce our brand new 2025 #ListerFellows! This year there are eight Prize recipients. lister-institute.org.uk/a-warm-welco...

Weizmann Institute rn

#drosophila @flybase.bsky.social request emergency funding: "As it stands, by the end of July, 2025, there will be no future updates to FlyBase, and in the worst case scenario access to the website will also be lost" => please donate! www.philanthropy.cam.ac.uk/give-to-camb...

Drosophila Genetic Database

The Drosophila Genetic Database, FlyBase, is on the brink of collapse due to the sudden termination of the FlyBase NIH grant, which includes salaries for 5 literature curators based at the University ...

philanthropy.cam.ac.uk

Good fun to contribute to this super paper from Yorgo Modis' lab where we looked at the impact of disease-associated MDA5 mutations on its structure, biochemistry and antiviral functions #immunosky www.cell.com/cell-reports...

Molecular basis of autoimmune disease protection by MDA5 variants

Loss-of-function MDA5 variants increase the risk of chronic inflammation but protect against autoimmune disease. Singh et al. show that autoimmune-protective variants impair MDA5 signaling via differe...

cell.com