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Tamina Lebek

@lebektamina.bsky.social

Postdoc at MPI-CBG, Dresden, Germany, studying cell-cell communication in development.

5 Posts105 Follower113 Folgt
Mihaly Badonyi@mbadonyi.bsky.social · 5mo ago

Pinc is now available as a C program, eliminating interpreter overhead and substantially speeding up computation for large-scale structural analyses. It’s still under active development, so please reach out with any questions, feedback, or issues. 🔗 git.mpi-cbg.de/tothpetroczy... #alphafold

Mihaly Badonyi@mbadonyi.bsky.social · 5mo ago

My first manuscript in MPI colours! With @tothpetroczylab.bsky.social, we show that AlphaFold PAE-derived contact probabilities are well calibrated to the fraction of true interface contacts across experimentally determined protein dimers. www.biorxiv.org/content/10.6...

Two-panel calibration plot (two benchmark dimer datasets) comparing predicted interchain contact-probability bins (x-axis) with the observed fraction of native interfacial contacts (y-axis). Points follow the diagonal, indicating close agreement between predicted probabilities and true interface-contact fractions.
Anne Grapin-Botton@anne-grapin.bsky.social · 7mo ago

Congratulations to Rashmi and Karolina and also to the technology development studio of the MPI-CBG without whom the screen would not have been possible. If you are interested in high-content screening in organoid models, you may want to take a look.

Max Planck Institute of Molecular Cell Biology and Genetics@mpi-cbg.de · 7mo ago

The group of @anne-grapin.bsky.social developed methods to create functional acinar cells, which are involved in the formation of pancreatic cancer. Rashmiparvathi Keshara, Karolina Kuodyte, and the TDS facility used image-based screen & robust analysis pipeline. www.mpi-cbg.de/news-outreac...

Mihaly Badonyi@mbadonyi.bsky.social · 12mo ago

We’ve updated the acmgscaler manuscript following reviewer and community feedback. The R package now has a single calibrate() function, and the Colab interface is easier to use. 📄 Manuscript: www.biorxiv.org/content/10.1... 🧪 Colab: edin.ac/4mjzijp #rstats @theacmg.bsky.social

acmgscaler: An R package and Colab for standardised gene-level variant effect score calibration within the ACMG/AMP framework

A genome-wide variant effect calibration method was recently developed under the guidelines of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology (ACMG/A...

biorxiv.org

Mihaly Badonyi@mbadonyi.bsky.social · last yr.

1/ Excited to share our latest work on the "Prevalence of loss-of-function, gain-of-function and dominant-negative mechanisms across genetic disease phenotypes". @marshlab.bsky.social @uoe-igc.bsky.social www.biorxiv.org/content/10.1...

Prevalence of loss-of-function, gain-of-function and dominant-negative mechanisms across genetic disease phenotypes

Molecular disease mechanisms caused by mutations in protein-coding regions are diverse, but they can be broadly categorised into loss-of-function (LOF), gain-of-function (GOF), and dominant-negative (...

biorxiv.org

Tamina Lebek@lebektamina.bsky.social · last yr.

Honored to be featured in #100biologists alongside so many inspiring scientists! @biologists.bsky.social and @bsdb.bsky.social supported my PhD journey through conferences, seminars, and travel grants. Proud to have two publications in CoB journals and to give back as a BSDB committee member!

The Company of Biologists@biologists.bsky.social · last yr.

We are featuring Tamina Lebek, @bsdb.bsky.social ECR representative and a PhD student at @edinburgh-uni.bsky.social, as an extraordinary biologist this week. Tamina has also been interviewed by @the-node.bsky.social and given a Development presents…talk. #100biologists @lebektamina.bsky.social

The Company of Biologists 100 logo to the left and QR code to the right. Portrait of Tamina Lebek to the left, text to the right 100 extraordinary biologists Tamina Lebek BSDB ECR representative Tamina Lebek has been interviewed by the Node and given a Development presents… talk. Tamina is a PhD student at The University of Edinburgh, UK, and has developed a neighbour-labelling system called PUFFFIN to investigate cell communication. #100biologists #biologists100
Mihaly Badonyi@mbadonyi.bsky.social · 2y ago

Happy to see our predictive scores integrated into DECIPHER! We hope they will help clinicians uncover the molecular mechanisms driving dominant disease. Huge thanks to the team at @deciphergenomics.bsky.social for their support. A follow-up study is underway to improve predictions—stay tuned!

@deciphergenomics.bsky.social · 2y ago

Protein predictive scores which predict the likelihood that the protein is associated with a dominant-negative, gain-of-function or loss-of-function mechanism are displayed. Curated literature support for a molecular disease mechanism is also shown jmarshlab.bsky.social @mbadonyi.bsky.social

Tamina Lebek@lebektamina.bsky.social · 2y ago

Looking forward to talking about our PUFFFIN project at Development presents! Have a look at our paper now www.embopress.org/doi/full/10.... and tune in tomorrow! #DevBio #PUFFFIN

PUFFFIN: an ultra-bright, customisable, single-plasmid system for labelling cell neighbourhoods | The EMBO Journal

imageimageWhile there are some options for labeling cellular neighbours, they often have low flexibility, require modification of multiple cells with different plasmids, or are otherwise technically c...

embopress.org

Sally Lowell@cellysally.bsky.social · 2y ago

TOMORROW! Tune in to watch the brilliant @lebektamina.bsky.social talk about illuminating cellular neighbourhoods in model systems of development ..then stay tuned in for three more excellent talks from other BSDB prize winners thenode.biologists.com/development-... #DevBio #PUFFFIN