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Susan Logue

@loguesusan.bsky.social

ER stress, Unfolded Protein Response, cancer, inflammation. 🇮🇪 🇨🇦 University of Manitoba Views are my own.

27 Posts542 Follower298 Folgt
Susan Logue@loguesusan.bsky.social · last yr.

Dissecting Branch-Specific Unfolded Protein Response Activation in Drug-Tolerant BRAF-Mutant Melanoma using Data-Independent Acquisition Mass Spectrometry - Molecular & Cellular Proteomics www.mcponline.org/article/S153...

Dissecting Branch-Specific Unfolded Protein Response Activation in Drug-Tolerant BRAF-Mutant Melanoma using Data-Independent Acquisition Mass Spectrometry

Cells rely on the Unfolded Protein Response (UPR) to maintain ER protein homeostasis (proteostasis) when faced with elevated levels of misfolded and aggregated proteins. The UPR is comprised of three ...

mcponline.org

Susan Logue@loguesusan.bsky.social · last yr.

Optogenetic Clustering of Human IRE1 Reveals Differential Regulation of Transcription and mRNA Splice Isoform Abundance by the UPR www.biorxiv.org/content/10.1...

Optogenetic Clustering of Human IRE1 Reveals Differential Regulation of Transcription and mRNA Splice Isoform Abundance by the UPR

Inositol-requiring enzyme 1 (IRE1) is one of three known sensor proteins that respond to homeostatic perturbations in the metazoan endoplasmic reticulum. The three sensors collectively initiate an int...

biorxiv.org

U of M Rady Faculty@um-radyfhs.bsky.social · last yr.

After testing 8,500 drugs, the research team discovered that poziotinib – a drug that already exists and is approved for other cancers – reduced breast cancer brain metastasis tumours in mice after two weeks of treatment. #Medsky #cancerresearch #radyfaculty

UM-led study offers hope that existing drug can target metastatic brain tumours

A University of Manitoba-led study successfully eliminated breast-cancer derived brain tumours in mice, using a drug to penetrate the brain and eliminate metastatic brain tumours. After testing 8,500

news.umanitoba.ca

Joe Chambers@joechambers.bsky.social · last yr.

Delighted to share our latest paper on alpha-1-antitrypsin deficiency, in @naturegenet.bsky.social. A fun collaboration between groups of @matthoare20.bsky.social, @profmarciniak.bsky.social, and Peter Campbell. @thecimr.bsky.social ky.social, @sangerinstitute.bsky.social, Early Cancer Institute

Selection for somatic escape variants in SERPINA1 in the liver of patients with alpha-1 antitrypsin deficiency - Nature Genetics

The expansion of clones with distinct SERPINA1 somatic mutants in the livers of alpha-1 antitrypsin deficiency (A1AT) patients is consistent with convergent evolution. These variants interfere with th...

nature.com

Meaghan Jones@meaghanjones.bsky.social · last yr.

Come be my colleague! We are hiring very broadly in cancer biology. Great colleagues and department, lots of support, sure the winter is cold but our hearts are warm!

Biochemistry & Medical Genetics@umbmg.bsky.social · last yr.

🚨We're hiring! 🚨 BMG is seeking an Assistant/Associate Professor with expertise in Cancer Biology—focusing on genetics and/or biochemistry. 📅 Application review begins March 31, 2025. 🔗More info: viprecprod.ad.umanitoba.ca/DEFAULT.ASPX...

Susan Logue@loguesusan.bsky.social · 2y ago

ER stress peeps I have a question - is there a paper that demonstrates p-PERK ab are not always a reliable method to detect PERK activation? I have a vague recollection of a paper but can’t seem to find it….