🚨📰Now online in its full form www.nature.com/articles/s41...

FidlTrack: high-fidelity structure-aware single particle tracking resolves intracellular molecular motion in organelles sensing APP processing - Nature Communications

Tracking fast molecules in crowded organelles is error-prone, obscuring dynamic processes like Alzheimer’s secretase activity or secretory sorting. Here, authors present FidlTrack, a structure-aware m...

nature.com

Avezov lab@avezovlab.bsky.social · 6mo ago

Our new paper's out: FidlTrack—structure-aware single-particle tracking benchmarks/boost SPT fidelity With it we resolve with sub-organelle res. e.g. BACE1 amyloidogenic APP cleavage #Alzheimers, ER exit events, map nanobody binding in realtime in ER/organelles 🔬🧠#SingleMolecule rdcu.be/e3Ris

🚨📜Our new paper out in @AdvSciNews: ER shape matters for neuronal health - disrupting ER continuity halts neuro-firing as it slows Ca2+ store refill, explaining selective neuronal vulnerability to ER problems in neurodegeneration 🧠 a thread to follow advanced.onlinelibrary.wiley.com/doi/10.1002/...

Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates and Exposes Selective Neuronal Vulnerability

The ER's continuous tubular network is maintained by ER-shaping proteins whose mutation or dysregulation contributes to neurodegenerative diseases. Here, we show that ER morphology sets the speed of ...

advanced.onlinelibrary.wiley.com

Pre-print Alert! Naked mole-rats hold secrets to healthy ageing that may be revealed if we can dissect their cellular mechanisms. Led by Fangze Tong (an amazing MPhil student), we report live-cell findings about NMR autophagy. @phar.cam.ac.uk @psalmotoxin.bsky.social biorxiv.org/content/10.6...

Go Lily! Huge congrats - massively deserved!

Lily Wu@lily-wu.bsky.social · 9mo ago

I'm very honoured to have been chosen for the Alpha-1 Antitrypsin Laurell's Training Award (ALTA), an early-career research fellowship I would like to thank my supervisors @profmarciniak.bsky.social @joechambers.bsky.social, and my wonderful institute @thecimr.bsky.social for making this possible!

Attention membrane traffickers! I'm recruiting a post-doc to my lab in Dundee. We're dissecting the functions of intrinsically disordered domains of COPII coat proteins. We think they control timing of coat assembly and morphology of carriers. www.dundee.ac.uk/work-for-us/...

Postdoctoral Research Assistant - MCDB - UOD2016

Closing date: Thursday 6 November 2025, 23:59

dundee.ac.uk

I may be a little biased here but I think this is SUCH a cool story….a new HCN1-focussed mechanism in Dravet syndrome (infant epilepsy). Helps to explain why current treatments haven’t worked and offers a novel genuinely druggable target.Awesome 🤩🤩🤩 www.biorxiv.org/content/10.1...

Increased HCN1 activity in human excitatory neurons drives excessive network bursting in Dravet syndrome

Dravet syndrome (DS) is a severe childhood epilepsy caused by mutations of the sodium channel NaV1.1. These mutations are thought to compromise the ability of inhibitory interneurons to regulate netwo...

biorxiv.org

Such elegant work, as ever!

MolinariLab-ER@molinarilab-er.bsky.social · last yr.

Selective autophagy of organelles: the “disorder” is key. Intrinsically disordered regions of organellophagy receptors are interchangeable, required, and sufficient for organelle fragmentation and lysosomal delivery … and all about ORGATACs 😉 rdcu.be/ey8iL

Very excited to announce that my first, first author paper, is now on BioRxiv! In this paper we unambiguously show #COPII coated vesicles in unperturbed human cells for the very first time!! Make my day and check it out! www.biorxiv.org/content/10.1... #Cryo-ET #TeamTomo #Cryo-CLEM ❄️🔬❄️🔬❄️🔬❄️🔬

New preprint alert! Endogenous gene editing of alveolar organoids to investigate mechanisms of epithelial dysfunction in familial ILD. Kudos first author @eimearrutherford.bsky.social and thanks @thecimr.bsky.social @labrawlins.bsky.social @profmarciniak.bsky.social www.biorxiv.org/content/10.1...

Endogenous gene editing of alveolar organoids reveals that expression of pathogenic variant SFTPC-I73T disrupts endosomal function, epithelial polarity and wound healing

Background: Idiopathic pulmonary fibrosis is a fatal lung disease of progressive lung parenchymal scarring caused by the aberrant response of an alveolar epithelium repeatedly exposed to injury. Under...

biorxiv.org

Thrilled to collaborate with @zhixingchen2.bsky.social Lab @pku1898.bsky.social ! We tested new PK Mem dyes—gentle, photostable tools to label the plasma membrane in live neurons, making it easier to track growth cone motility & axonal transport. #liveimaging #neuroscience tiny.cc/3qhp001

Great opportunity!

Derivery Lab - MRC LMB@deriverylab.bsky.social · last yr.

🚨 JOB ALERT 🚨 We're hiring a Research Assistant – no PhD needed! Join us to explore the molecular mechanisms of receptor sorting in endosomes. Experience in protein expression/purification, cloning & cell culture desired 🧫🔬 Apply now 👉 www.nature.com/naturecareer... #STEMCareers #ResearchJobs

Fantastic stuff by Sam and team! 3D tracking of individual proteins inside intracellular compartments. An amazing innovation towards understanding cellular environments.

Sam Daly@samofmidworld.bsky.social · last yr.

Excited to share some recent work tracking the 3D movement of individual molecules inside the organelles of living cells (💡+ 🦠 + ⚽️💨) with the best team @joechambers.bsky.social @jamesdmanton.bsky.social @jsbeckwith.bsky.social @dgershlick.bsky.social @stevethechemist.bsky.social

Our paper is out in Nature today! We use Deep Visual Proteomics (DVP) to dissect α1-antitrypsin deficiency (AATD) in human liver at single-cell resolution. Let us take a tour through proteotoxic stress in intact human tissue — one hepatocyte at a time. www.nature.com/articles/s41...

Deep Visual Proteomics maps proteotoxicity in a genetic liver disease - Nature

High-resolution spatial proteomics were used to map molecular events during hepatocyte stress in pseudotime across all fibrosis stages, recapitulating known disease progression markers and revealing e...

nature.com

#newPI and time is running. It has already been a month since I officially joined the University of Warwick as Assistant Professor. I am excited to announce and build the Fluorescence and Membrane Dynamics (FMD) Lab: warwick.ac.uk/fac/sci/med/...

Well done Jessy @jessyzhu-jiayi.bsky.social who gave her #biologists100 flash talk today about her new GCN2 activators @biologists.bsky.social @thecimr.bsky.social

Fantastic Skytorial!

Natalia Brzozowska@nataliabrzozowska.bsky.social · last yr.

Excited to share our new preprint demonstrating somatic rescue mutations in a genetic liver disease! [1/12] www.nature.com/articles/s41...

Congratulations @lily-wu.bsky.social for winning a poster prize at the @biologists.bsky.social #biologists100 conference! What a superstar! @thecimr.bsky.social @profmarciniak.bsky.social @matthoare20.bsky.social

Great to see this published! Congrats on a really beautiful paper!

Jonny Nixon-Abell@abelljonny.bsky.social · last yr.

😊 Very happy to see this out! A real group effort from the Hyslop lab (@thecimr.bsky.social) including brilliant collaborations with @knowleslab.bsky.social, Vendruscolo lab, @michael-e-ward.bsky.social lab, @deriverylab.bsky.social lab, @profmarciniak.bsky.social lab 🎉🎉🎉

I'm thrilled that our paper is now online: www.nature.com/articles/s41... describing an elegant pH-triggered CIE. Thanks to everyone who made it an exciting and successful project @ewanmacdonald.bsky.social @cessvala.bsky.social @christianwunder.bsky.social #fluorescencefriday #microscopymonday

Christian Wunder @ Curie Institute@christianwunder.bsky.social · last yr.

Growth factors trigger receptor desialylation at the plasma membrane, galectin binding and subsequent endocytosis. => A proton pump driven glycoswitch @naturecellbiology.bsky.social : rdcu.be/eaLM9 #glycotime, @institutcurie.bsky.social, @cnrs.fr, @inserm.fr, #NIH, #CellBiol, #Cancer

The 16th ER & Redox club meeting ends. THANK YOU to co-organiser @fenech-lab.bsky.social & to everyone for outstanding presentations, discussions, posters and fun over the last 4 days in Namur. Huge thanks to @unamur.bsky.social @biologists.bsky.social @febspress.bsky.social for support and funding!

Delighted to share our latest paper on alpha-1-antitrypsin deficiency, in @naturegenet.bsky.social. A fun collaboration between groups of @matthoare20.bsky.social, @profmarciniak.bsky.social, and Peter Campbell. @thecimr.bsky.social ky.social, @sangerinstitute.bsky.social, Early Cancer Institute

Selection for somatic escape variants in SERPINA1 in the liver of patients with alpha-1 antitrypsin deficiency - Nature Genetics

The expansion of clones with distinct SERPINA1 somatic mutants in the livers of alpha-1 antitrypsin deficiency (A1AT) patients is consistent with convergent evolution. These variants interfere with th...

nature.com

We present: Direct-view oblique plane microscopy www.biorxiv.org/content/10.1...

Direct-view oblique plane microscopy

The ability to rapidly image mesoscopic samples is critically important for many areas of biological research. Owing to its high throughput and gentle, volumetric imaging nature, light-sheet fluoresce...

biorxiv.org

James Manton@jamesdmanton.bsky.social · last yr.

As a proof-of-concept, Jacob Lamb built a direct-view mesoscopic OPM using a €700 Ximea MU196MR-ON camera with 1.4 μm pixels. We could then image expanded cerebral organoids, created by @miguelcmestre.bsky.social, with a 2 μm × 2 μm × 22 μm resolution over a 5.3 mm × 2.88 mm field of view.

Amazing Conference Alert!! Registration is now open for EUROSERPIN2025. Come and join us in beautiful Brescia, Italy, this May to get excited about the wonderful world of serpin proteins! Visit euroserpin.eu to sign up. Early-bird rates offered until February 28th.

EUROSERPIN@euroserpin.bsky.social · 2y ago

We are pleased to announce #EUROSERPIN2025, to be held in Brescia, Italy on May 28-30th 2025! This meeting will bring together international researchers to share their work on all aspects of serpin-related topics. Visit euroserpin.eu to register and submit an abstract.

Great to see this collaborative effort out! Check out our new alveolar organoid model, ripe for studying disease mechanisms including those involving surfactant proteins: www.embopress.org/doi/full/10.... Front cover image to follow soon! @eimearrutherford.bsky.social @profmarciniak.bsky.social

A novel human fetal lung-derived alveolar organoid model reveals mechanisms of surfactant protein C maturation relevant to interstitial lung disease | The EMBO Journal

imageimageDisorders of surfactant protein biology cause dysfunction of alveolar type 2 cells and can lead to interstitial lung disease. This study describes the development of genetically manipulable, mature human fetal-derived alveolar type 2 ...

embopress.org

We have a postdoc opportunity at the interface of metabolism and epigenetics! 🔥🧬 The project will investigate novel metabolic factors driving diabetic cardiomyopathy🫀, and test targeted dietary interventions 🍽️ For more detail and to apply: babrahaminstitute.livevacancies.co.uk#/job/details...

‼️Deadline 16th January 2025‼️Applications are open for the 2025 Experience Postgrad Life Sciences programme. Paid 8-week summer internships aimed to enhance diversity among life scientists of the future!! @cambridgebiosci.bsky.social @corpuscambridge.bsky.social www.exppg.lifesci.cam.ac.uk

Taking back the ER - rupress.org/jcb/article/...

Hullooooo Cell Biology friends. If you're heading to #CellBio2024 in (hopefully!) sunny San Diego this year, then come and check out our session on 'ER structure and function across cell types' Room28C- Dec18th 09:00am! See you there! **Please RT** 🥳

Golgins support extracellular matrix secretion by collectively maintaining the Golgi structure-function relationship https://www.biorxiv.org/content/10.1101/2024.11.19.624265v1

Golgins support extracellular matrix secretion by collectively maintaining the Golgi structure-function relationship https://www.biorxiv.org/content/10.1101/2024.11.19.624265v1

The secretion of extracellular matrix (ECM) proteins is vital to the maintenance of tissue health. O

biorxiv.org

A bit of microscopy to get me off the mark! Single particle tracking of fluorescent, 20nm spherical protein assemblies (GEMs) as they dance through the ER-lumen of a COS7 cell. One of the tools we used to assess ER-biophysics in α1-antitrypsin deficiency science.org/doi/10.1126/sciadv.abm2094