Louise Reilly, PhD
@louisereillyphd.bsky.social
Scientist II at UW-Madison | Cellular and Molecular Arrhythmia Research Program | Cardiac #ionchannel patch clamp extraordinaire | Corgi mum | 👩🏻🔬| She/Her
New study from Lopez-Mateos, Narang, and @vyy-sf.bsky.social @ucd-physiology.bsky.social reveals potential of #DeepLearning methods to model multiple states of human voltage-gated sodium channels and their interactions with β-subunits and calmodulin. rupress.org/jgp/article/... #IonChannels
Check out our most recent publication on functional assessment of Kir2.1 clinical variants 🧪 doi.org/10.1016/j.jb...
Redirecting
doi.org
Celebrating 10 years of great science and friendship between labs Eckhardt and Glukhov 🧪
This is a great graphic: all of the studies with a dot in the corner were conducted by the Geiers -- one of whom, David Geier, practiced medicine without a license
Megan Ranney MD MPH@meganranney.bsky.social · last yr.A must-read, must-share piece - clearly deconstructing the shoddy science of the Geiers (who are inexplicably in charge of studies at HHS). Consider this an early warning for what lies ahead. 🛟🩺🧪 www.nytimes.com/interactive/...
Thanks. Also FYI this was Berg's post I had meant to share. $270mm difference is still equivalent to ~400 new R01's, so not trivial. But in general surprised me that the difference was relatively small (only 6.5% less funding for new and competitive renewals than in 2024). bsky.app/profile/jere...
Jeremy Berg@jeremymberg.bsky.social · last yr.FY 2025 Total funding received for new and competitive renewal awards Anticipated (based on FY2023 and FY2024: $4.1 B (8574 awards) Actual: $3.83 B (7245 awards) Difference $0.27 B Last month difference $1.63 B $1.36 B of the difference has been made up 5/7
Our most recent publication detailing the impact of arrhythmogenic KCNJ2 mutations on channel structure 🧪 @nature.com www.nature.com/articles/s41...
Atomic-level investigation of KCNJ2 mutations associated with ventricular arrhythmic syndrome phenotypes - Scientific Reports
Scientific Reports - Atomic-level investigation of KCNJ2 mutations associated with ventricular arrhythmic syndrome phenotypes
nature.com
🚨ATTENTION CDC AND ALLIES!🚨 We have power together. To see our strength and build community, we ask that you wear something 💚green💚 to work this WEDNESDAY to show solidarity and readiness to defend public health. Please spread the word! #courageiscontagious #wearthecolor #spreadthecolor
This month is Heart Month! Professor Will Fuller explains what his research is about. Will Fuller’s research group works on cellular and molecular mechanisms that control normal physiology in the heart, and how these things stop working properly to cause disease. (1/4)
Dynein light chains 1 and 2 are auxiliary proteins of pH-sensitive Kir4.1 channels pubmed.ncbi.nlm.nih.gov/40074079/ #cryoEM
In Science, researchers detail a nanoscale-resolution reconstruction of a millimeter-scale fragment of human cerebral cortex, giving an unprecedented view into the structural organization of brain tissue at the supracellular, cellular, and subcellular levels. scim.ag/3FvpAKy #BrainAwarenessWeek
This is a fantastic meeting for people interested in lipid post translational modifications!
DMartin@drddom.bsky.social · 2y agoHey all you lipid freaks, join me & other lipid obsessed people talk about protein lipidation! If you've never attended, first drink is on me or @pjenkinslab.bsky.social Roles and regulation of protein lipidation in health and disease 27-29 August 2025 Exeter College, Oxford @biochemsoc.bsky.social
Some good-ish news from NIH “Federal Register notices for study sections run by CSR (but not those by ICs) will start being permitted again” As far as I know, the timing for this is not clear, but I will be checking the Federal Register.
a man in a red suit and tie is holding a piece of paper that says breaking news on it
ALT: a man in a red suit and tie is holding a piece of paper that says breaking news on it
media.tenor.com
"‘Science can and should as a community organise itself to maximise its ability to act collectively, ethically and – when necessary – politically.’ The scientific community needs to speak up – not just for the sake of science, but of human decency, dignity and morality." - @philipcball.bsky.social.🧪
Philip Ball@philipcball.bsky.social · 2y agoI have run out of patience with the apparent silence of most US science institutions (and not just US) in the face of Trump & Musk's rampage. There are of so many facets of that, but in this column for @chemistryworld.com I talk about the assaults on inclusion. www.chemistryworld.com/opinion/scie...
A breakdown of what's happened so far to #Science in the US. Truly horrifying 🧪 www.nature.com/articles/d41...
Black in Biophysics symposium today at the 69th Annual Meeting highlights Black scientists and honor Black History Month in the United States and elsewhere #bps2025
BPS2025 Black in Biophysics Symposium | Biophysical Society
The Biophysical Society has been a change agent for members of groups historically underrepresented in the physical and life sciences, women, and international scientists. We serve all members and…
buff.ly
ATTENTION If you are on a study section that was scheduled to meet, please post or DM me with information regarding: 1. The name of the study section 2. The scheduled date 3. Whether the meeting actually occurred THANK YOU
a man wearing a top hat and a purple jacket is asking for more .
ALT: a man wearing a top hat and a purple jacket is asking for more .
media.tenor.com
It’s been buried in all the news today, but every scientist in the US should pay attention to this: Mike Lauer went out on a limb for us all, sending out a memo saying institutes should start awarding grants. And it looks like Trump/Musk fired him for that. 🧪
Max Kozlov@maxkozlov.bsky.social · 2y agoNEW: In a further sign of turmoil at the NIH, Mike Lauer, who oversees the agency's $39 billion extramural budget that goes to research outside the NIH, has resigned effective tomorrow. This comes after top NIH official Larry Tabak abruptly retired yesterday.
From reddit: a letter from a postdoc who survived the Bolsonaro years. This is helpful framing for how to science in this administration. 🧪 www.reddit.com/r/labrats/s/...
From the labrats community on Reddit
Explore this post and more from the labrats community
reddit.com
Thanks to @ucd-physiology.bsky.social @elegrand.bsky.social @morottilab.bsky.social for allowing us to attend the UC Davis Cardiovascular Symposium! Our lab was able to watch our incredible PI, Lee Eckhardt, give you all an insight into the work we do up in Wisconsin! 🧪
RFK Jr was confirmed. There is a lesson here for the future. The only chance that science had to stop RFK was a public relations strategy—to mobilize enough of the public that people not paying attention to politics would learn that he is a disaster. We failed at that. Let’s fix it and do better. 🧪
BREAKING On Monday, Popular Information broke the news that the NIH had frozen virtually all grant funding in violation of 2 federal court orders On Wednesday, NIH leadership distributed a memo, acknowledging that its funding freeze was illegal and directing staff to resume issuing grants.
BREAKING: NIH admits funding freeze is illegal, will resume issuing grants
An internal memo issued February 12 was obtained by Popular Information.
popular.info
Here's a good infographic from AAUP on what indirect costs fund. It's a lot of important things!
98% of NIH grants that should have gone out this month, didn't. Despite court orders 'unfreezing' the funds, they are frozen. Biomedical research will grind to a halt. Clinical trials will end. All for no reason: the total impact on the US budget is miniscule
The no cost extension button is back and at least some are being granted. If this applies to you, go for it. PLEASE SHARE
a man in a suit and tie says go for it in white letters
ALT: a man in a suit and tie says go for it in white letters
media.tenor.com
Forensics: Comic books. Somewhat funny tactic to teach juries about science. Those of us who testify as experts talk too fast and use fancy tech words and archaic language. 🧪 www.forbes.com/sites/larsda...
Comics Help Jurors Understand Forensic Testimony, New Study Finds
Comics could be the answer to clarifying forensic testimony for jurors—here's why.
forbes.com
Not sure how many realize that NIH funding is still frozen. This article details an almost complete dropoff (97%) in NIH funding between Feb3-10 this year and last. Our institution's numbers are consistent with those cited here. If yours are as well, please share! popular.info/p/trump-main...
Trump maintains funding freeze at NIH, defying court order
The Trump administration is still prohibiting National Institutes of Health (NIH) staff from issuing virtually all grant funding, an NIH official tells Popular Information.
popular.info
Nice review from our collaborator and friend, @elegrand.bsky.social
UC Davis Pharmacology@ucdavispharm.bsky.social · 2y agoFaculty is on 🔥 this week! This comprehensive review highlights sex differences in the #heart! @elegrand.bsky.social, @ucdavis.bsky.social, @ucdavishealth.bsky.social Sex Differences in Electrophysiology and Calcium Handling in Atrial Health and Fibrillation | Annual Reviews - go.shr.lc/3UpL3cq
Freeze on NIH cuts now nationwide. By @jonathanwosen.bsky.social www.statnews.com/2025/02/11/j...
Halt on Trump administration’s cuts to NIH research payments expanded nationwide
A federal judge issued a nationwide temporary pause on plans by the NIH to substantially slash research overhead payments.
statnews.com
